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1. 发明申请

WO2019099838A1 COMBINATION THERAPIES 审中-公开
公开(公告)号：WO2019099838A1
公开(公告)日：2019-05-23
申请号：PCT/US2018/061534
申请日：2018-11-16
申请人： NOVARTIS AG , SABATOS-PEYTON, Catherine, Anne , MATARAZA, Jennifer, Marie , MACISAAC, Kenzie , KWAK, Eunice , FARIS, Jason , DRANOFF, Glenn , WIESMANN, Marion , SHARP, Fiona , CRYSTAL, Adam , CAMERON, John, Scott , STRIETER, Robert, Martin , PETRUZZELLI, Lilli , KAZANI, Shamsah , SANDHAM, David, Andrew , PRESS, Neil, John , HOFFMASTER, Keith
发明人： SABATOS-PEYTON, Catherine, Anne , MATARAZA, Jennifer, Marie , MACISAAC, Kenzie , KWAK, Eunice , FARIS, Jason , DRANOFF, Glenn , WIESMANN, Marion , SHARP, Fiona , CRYSTAL, Adam , CAMERON, John, Scott , STRIETER, Robert, Martin , PETRUZZELLI, Lilli , KAZANI, Shamsah , SANDHAM, David, Andrew , PRESS, Neil, John , HOFFMASTER, Keith
IPC分类号： A61K39/395 , C07K16/28 , A61P35/00
摘要： Combination therapies comprising PD-1 inhibitors and other therapeutic agents used to treat or prevent cancerous conditions and disorders as follow. Combination therapies of three agents which are a PD-1 inhibitor, a CXCR2 inhibitor and a CSF-1/1R binding agent for treating a pancreatic cancer or a colorectal cancer. Combination therapies of three agents which are a PD-1 inhibitor, a CXCR2 inhibitor and an inhibitor of either TIM-3, C-MET or A2aR for treating a pancreatic cancer or a colorectal cancer. Combination therapies of three agents which are a PD-1 inhibitor, a LAG -3 inhibitor and (i) an inhibitor of either TGF-beta, TIM-3, C-MET, IL-lb or MEK or (ii) a GITR agonist or (iii) an A2aR antagonist or (iv) a CSF-1/1R binding agent for treating a breast cancer. Combination therapies of two agents which are a PD-1 inhibitor and a CXCR2 inhibitor for treating a pancreatic cancer, a colorectal cancer, a lung cancer or a breast cancer.

2. 发明申请

WO2018023025A8 COMBINATION THERAPIES OF CHIMERIC ANTIGEN RECEPTORS AND PD-1 INHIBITORS 审中-公开
公开(公告)号：WO2018023025A8
公开(公告)日：2018-02-01
申请号：PCT/US2017/044425
申请日：2017-07-28
申请人： NOVARTIS AG , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , ANAK, Oezlem , BILIC, Sanela , BROGDON, Jennifer , CAMERON, John, Scott , CHOU, William , HOWARD, Danny, Roland, Jr. , ISAACS, Randi , JUNE, Carl, H. , LACEY, Simon , MAUDE, Shannon , MELENHORST, Jan, J. , SHUSTER, Stephen , QUINTAS-CARDAMA, Alfonso
发明人： BROGDON, Jennifer , CAMERON, John, Scott , CHOU, William , HOWARD, Danny, Roland, Jr. , ISAACS, Randi , JUNE, Carl, H. , LACEY, Simon , MAUDE, Shannon , MELENHORST, Jan, J. , SHUSTER, Stephen , QUINTAS-CARDAMA, Alfonso , GRUPP, Stephan
IPC分类号： C07K14/725 , A61K39/00 , A61K39/395 , A61K35/17 , C12N5/0783
摘要： Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.

3. 发明申请

WO2017106810A3 COMBINATION OF C-MET INHIBITOR WITH ANTIBODY MOLECULE TO PD-1 AND USES THEREOF 审中-公开
公开(公告)号：WO2017106810A3
公开(公告)日：2017-06-22
申请号：PCT/US2016/067430
申请日：2016-12-19
申请人： NOVARTIS AG , BILIC, Sanela , HOWARD, JR., Danny Roland , CAMERON, John Scott
发明人： BILIC, Sanela , HOWARD, JR., Danny Roland , CAMERON, John Scott
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
摘要： The present invention relates to a pharmaceutical combination which comprises (a) at least one antibody molecule (e.g., humanized antibody molecules) that bind to Programmed Death 1 (PD-1), and (b) at least one c-Met receptor tyrosine kinase inhibitor or pharmaceutically acceptable salt thereof, for simultaneous, separate or sequential administration for the treatment of a proliferative disease, particularly a c-Met dependent proliferative disease; a pharmaceutical composition comprising such combination; a method of treating a subject having a proliferative disease comprising administration of said combination to a subject in need thereof; use of such combination for the treatment of proliferative disease; and a commercial package comprising such combination.

4. 发明申请

WO2017106656A1 ANTIBODY MOLECULES TO PD-1 AND USES THEREOF 审中-公开
标题翻译： PD-1的抗体分子及其用途
公开(公告)号：WO2017106656A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/067200
申请日：2016-12-16
申请人： NOVARTIS AG , BILIC, Sanela , HOWARD, Danny, Ronald, Jr. , CAMERON, John, Scott , DRANOFF, Glenn
发明人： BILIC, Sanela , HOWARD, Danny, Ronald, Jr. , CAMERON, John, Scott , DRANOFF, Glenn
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2818 , A61K39/39558 , A61K2039/545 , A61K2300/00
摘要： Antibody molecules that specifically bind to PD-1 are disclosed. The antibody molecules can be used to treat or prevent cancerous or infectious conditions and disorders.
摘要翻译：公开了特异性结合PD-1的抗体分子。抗体分子可用于治疗或预防癌症或感染性疾病和病症。

5. 发明申请

WO2017053953A1 BATTERY SYSTEM FOR ELECTRONIC VAPOR COMMUNICATION DEVICE 审中-公开
标题翻译：电子蒸汽通讯装置用电池系统
公开(公告)号：WO2017053953A1
公开(公告)日：2017-03-30
申请号：PCT/US2016/053746
申请日：2016-09-26
申请人： CAMERON, John
发明人： CAMERON, John
IPC分类号： H02J7/00
CPC分类号： A24F47/008 , H01M10/0525 , H01M10/0565 , H01M10/06 , H01M10/30 , H01M10/345 , H02J7/0052 , H02J7/025 , H02J7/34 , H02J7/35 , H02J2007/0062
摘要： A system, method, and device comprising a hybrid electronic communication vapor device comprising an electronic communication device and an electronic vapor device wherein the electronic vapor device is powered by at least one of battery, charging, and power system.
摘要翻译：一种包括混合电子通信蒸气装置的系统，方法和装置，包括电子通信装置和电子蒸气装置，其中电子蒸气装置由电池，充电和电力系统中的至少一个供电。

6. 发明申请

WO2017017623A1 COMBINED USE OF ANTI PD-1 AND ANTI M-CSF ANTIBODIES IN THE TREATMENT OF CANCER 审中-公开
标题翻译：联合使用抗PD-1和抗M-CSF抗体治疗癌症
公开(公告)号：WO2017017623A1
公开(公告)日：2017-02-02
申请号：PCT/IB2016/054487
申请日：2016-07-27
申请人： NOVARTIS AG , FJAELLSKOG, Marie-Louise , CAMERON, John , CAO, Zhu , CIPOLLETTA, Daniela , MACISAAC, Kenzie
发明人： FJAELLSKOG, Marie-Louise , CAMERON, John , CAO, Zhu , CIPOLLETTA, Daniela , MACISAAC, Kenzie
IPC分类号： A61K39/395 , C07K16/24 , C07K16/28
CPC分类号： C07K16/243 , A61K39/395 , C07K16/2818 , C07K2317/565
摘要： The present application n relates to a pharmaceutical composition comprising a PD-1 antibody and an M-CSF antibody. The combination can be administered independently or separately, in a quantity which is therapeutically effective for the treatment of cancer.
摘要翻译：本申请涉及包含PD-1抗体和M-CSF抗体的药物组合物。该组合可以以治疗癌症治疗有效量的量独立地或分开施用。

7. 发明申请

WO2016187115A1 HYBRID VAPOR DELIVERY SYSTEM UTILIZING NEBULIZED AND NON-NEBULIZED ELEMENTS 审中-公开
标题翻译：混合蒸汽输送系统利用NEBULIZED和非NEBULED元素
公开(公告)号：WO2016187115A1
公开(公告)日：2016-11-24
申请号：PCT/US2016/032693
申请日：2016-05-16
申请人： CAMERON, John
发明人： CAMERON, John
IPC分类号： A24B15/18 , A24D1/00 , A24F47/00 , A61M16/14 , A61M16/18 , C23C18/02 , F02M15/04
CPC分类号： A24F47/008 , H04L67/12
摘要： An electronic vapor device is disclosed comprising a vapor outlet, a first container for storing a vaporizable material, a second container for storing a non-vaporizable material, a vaporizer component coupled to the first container configured for vaporizing the vaporizable material at a vaporization rate to generate a first vapor and for providing the first vapor to the vapor outlet, and a nebulizer component coupled to the second container configured for nebulizing the non-vaporizable material at a nebulization rate to generate a second vapor and for providing the second vapor to the vapor outlet.
摘要翻译：公开了一种电子蒸气装置，其包括蒸汽出口，用于储存可蒸发材料的第一容器，用于储存不可蒸发材料的第二容器，耦合到第一容器的蒸发器部件，该第一容器被配置成以蒸发速率蒸发可蒸发材料，产生第一蒸气并将第一蒸气提供到蒸汽出口，以及联接到第二容器的喷雾器部件，其构造成以雾化速率雾化不可汽化材料以产生第二蒸气并将第二蒸气提供给蒸汽出口。

8. 发明申请

WO2011094764A3 LIFTING DEVICE EFFICIENT LOAD DELIVERY, LOAD MONITORING, COLLISION AVOIDANCE, AND LOAD HAZARD AVOIDANCE 审中-公开
标题翻译：提升装置有效的装载运输，负载监测，碰撞避免和负载危害避免
公开(公告)号：WO2011094764A3
公开(公告)日：2012-03-01
申请号：PCT/US2011023415
申请日：2011-02-01
申请人： TRIMBLE NAVIGATION LTD , MAYNARD KURT , CAMERON JOHN
发明人： MAYNARD KURT , CAMERON JOHN
IPC分类号： B66C13/16 , B66C1/40 , B66C13/40
CPC分类号： B66C15/045 , B66C13/46 , B66C15/04 , G01C21/00
摘要： A lifting device sensor unit is disclosed. In one embodiment, the sensor unit comprises a housing configured to removably couple about a load line of a lifting device. A first global navigation satellite system (GNSS) receiver is coupled with the housing and is configured for determining a sensor unit position in three dimensions. A load monitor is coupled with the housing and is configured for monitoring a load coupled with the load line, including monitoring a load position and a load orientation of the load. A wireless transceiver is coupled with the housing and is configured for wirelessly providing information including the load position, the load orientation, and the sensor unit position, to a display unit located apart from the sensor unit.
摘要翻译：公开了提升装置传感器单元。在一个实施例中，传感器单元包括构造成可移除地耦合在提升装置的负载线周围的壳体。第一全球导航卫星系统（GNSS）接收机与壳体耦合并且被配置用于在三维中确定传感器单元位置。负载监视器与壳体耦合并且被配置用于监视与负载线耦合的负载，包括监视负载的负载位置和负载取向。无线收发器与壳体耦合并且被配置用于向位于远离传感器单元的显示单元无线地提供包括负载位置，负载取向和传感器单元位置的信息。

9. 发明申请

WO2011053960A1 COMPACT ISOCENTRIC GANTRY 审中-公开
标题翻译：紧密的中央甘蔗
公开(公告)号：WO2011053960A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/055087
申请日：2010-11-02
申请人： PROCURE TREATMENT CENTERS, INC. , CAMERON, John, M. , ANFEROV, Vladimir, A. , ANTAYA, Timothy, A.
发明人： CAMERON, John, M. , ANFEROV, Vladimir, A. , ANTAYA, Timothy, A.
IPC分类号： H01J1/50
CPC分类号： A61N5/1077 , A61N5/1043 , A61N5/1081 , A61N2005/1087
摘要： A gantry for administering proton beam therapy with improvements which reduce the size, weight, costs and radiation beam loss associated with proton beam therapy systems currently commercially available. The gantry utilizes achromatic superconducting multi-function electromagnet systems wherein the magnets can include dipoles and quadrupoles. The achromatic properties of the rampable magnet systems allow for ease of transmission of the beam whose energy is rapidly changed through a large range of different energies without changing of the strength of the magnetic fields or dipole settings. The magnets may be made with either low or high temperature superconductors. The gantry design further integrates beam scanning but keeps the gantry isocentric. A much greater fraction of the beam can be transmitted through the gantry than with current art, thereby reducing radiation shielding requirements and the demand put on the accelerator to produce large quantities of proton beam.
摘要翻译：用于施用质子束治疗的台架，其具有减少与当前可商购的质子束治疗系统相关联的尺寸，重量，成本和辐射束损失的改进。龙门架采用消色差超导多功能电磁铁系统，其中磁铁可包括偶极和四极。可倾斜磁体系统的消色差性质允许能量在不改变磁场强度或偶极子设置的情况下通过大范围的不同能量快速变化的光束的传输。磁体可以由低温或高温超导体制成。龙门架设计进一步集成了梁扫描，但保持了龙门式的中心。与目前的技术相比，梁的大部分可以通过机架传输，从而减少辐射屏蔽要求，并且增加对加速器产生大量质子束的要求。

10. 发明申请

WO2009151570A1 COMPOSITIONS FOR TREATING MATERIALS AND METHODS OF TREATING SAME 审中-公开
标题翻译：用于处理材料的组合物及其处理方法
公开(公告)号：WO2009151570A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/003450
申请日：2009-06-08
申请人： WOODHOLDINGS ENVIRONMENTAL, INC. , NEAL, Edwin, A. , CAMERON, John, Christopher
发明人： NEAL, Edwin, A. , CAMERON, John, Christopher
IPC分类号： B32B5/16 , C04B41/49
CPC分类号： C04B41/4933 , B27K3/156 , B27K2240/30 , B27K2240/70 , C04B41/009 , C09D15/00 , C09K8/5086 , C04B41/46 , C04B2103/0094 , C04B14/048 , C04B14/16 , C04B41/463 , C04B41/50 , C04B33/00 , C04B14/00 , C04B14/301
摘要： Material treatment compositions for various materials and methods of treating the same is disclosed. A material treatment composition includes at least one silane-containing material, at least one base-containing material, and at least one solvent to enhance the strength of a material contacted by the composition.
摘要翻译：公开了用于各种材料的材料处理组合物及其处理方法。材料处理组合物包括至少一种含硅烷的材料，至少一种含碱材料和至少一种溶剂，以增强与组合物接触的材料的强度。

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