基本信息:
- 专利标题： COMBINATION THERAPIES
- 申请号：PCT/US2018/061534 申请日：2018-11-16
- 公开(公告)号：WO2019099838A1 公开(公告)日：2019-05-23
- 发明人： SABATOS-PEYTON, Catherine, Anne , MATARAZA, Jennifer, Marie , MACISAAC, Kenzie , KWAK, Eunice , FARIS, Jason , DRANOFF, Glenn , WIESMANN, Marion , SHARP, Fiona , CRYSTAL, Adam , CAMERON, John, Scott , STRIETER, Robert, Martin , PETRUZZELLI, Lilli , KAZANI, Shamsah , SANDHAM, David, Andrew , PRESS, Neil, John , HOFFMASTER, Keith
- 申请人： NOVARTIS AG , SABATOS-PEYTON, Catherine, Anne , MATARAZA, Jennifer, Marie , MACISAAC, Kenzie , KWAK, Eunice , FARIS, Jason , DRANOFF, Glenn , WIESMANN, Marion , SHARP, Fiona , CRYSTAL, Adam , CAMERON, John, Scott , STRIETER, Robert, Martin , PETRUZZELLI, Lilli , KAZANI, Shamsah , SANDHAM, David, Andrew , PRESS, Neil, John , HOFFMASTER, Keith
- 申请人地址： Lichtstrasse 35 4056 Basel CH
- 专利权人： NOVARTIS AG,SABATOS-PEYTON, Catherine, Anne,MATARAZA, Jennifer, Marie,MACISAAC, Kenzie,KWAK, Eunice,FARIS, Jason,DRANOFF, Glenn,WIESMANN, Marion,SHARP, Fiona,CRYSTAL, Adam,CAMERON, John, Scott,STRIETER, Robert, Martin,PETRUZZELLI, Lilli,KAZANI, Shamsah,SANDHAM, David, Andrew,PRESS, Neil, John,HOFFMASTER, Keith
- 当前专利权人： NOVARTIS AG,SABATOS-PEYTON, Catherine, Anne,MATARAZA, Jennifer, Marie,MACISAAC, Kenzie,KWAK, Eunice,FARIS, Jason,DRANOFF, Glenn,WIESMANN, Marion,SHARP, Fiona,CRYSTAL, Adam,CAMERON, John, Scott,STRIETER, Robert, Martin,PETRUZZELLI, Lilli,KAZANI, Shamsah,SANDHAM, David, Andrew,PRESS, Neil, John,HOFFMASTER, Keith
- 当前专利权人地址： Lichtstrasse 35 4056 Basel CH
- 代理机构： LU, David et al.
- 优先权： US62/645,588 20180320; US62/703,736 20180726; US62/587,370 20171116
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/28 ; A61P35/00
摘要：
Combination therapies comprising PD-1 inhibitors and other therapeutic agents used to treat or prevent cancerous conditions and disorders as follow. Combination therapies of three agents which are a PD-1 inhibitor, a CXCR2 inhibitor and a CSF-1/1R binding agent for treating a pancreatic cancer or a colorectal cancer. Combination therapies of three agents which are a PD-1 inhibitor, a CXCR2 inhibitor and an inhibitor of either TIM-3, C-MET or A2aR for treating a pancreatic cancer or a colorectal cancer. Combination therapies of three agents which are a PD-1 inhibitor, a LAG -3 inhibitor and (i) an inhibitor of either TGF-beta, TIM-3, C-MET, IL-lb or MEK or (ii) a GITR agonist or (iii) an A2aR antagonist or (iv) a CSF-1/1R binding agent for treating a breast cancer. Combination therapies of two agents which are a PD-1 inhibitor and a CXCR2 inhibitor for treating a pancreatic cancer, a colorectal cancer, a lung cancer or a breast cancer.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/395 | .抗体；免疫球蛋白；免疫血清，例如抗淋巴细胞血清 |