专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010078258A1 COMPOUNDS COMPRISING TWO OR MORE BIOLOGICALLY FUNCTIONAL IONS AND METHOD OF TREATING PARKINSON'S DISEASE 审中-公开
标题翻译：包含两种或更多生物功能性离子的化合物和治疗帕金森病的方法
公开(公告)号：WO2010078258A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/069595
申请日：2009-12-28
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA , ROGERS, Robin, D. , RIJKSEN, Christian , DALY, Daniel, T. , CALDWELL, Kim , CALDWELL, Guy , HOUGH-TROUTMAN, Whitney, L. , BICA, Katharina
发明人： ROGERS, Robin, D. , RIJKSEN, Christian , DALY, Daniel, T. , CALDWELL, Kim , CALDWELL, Guy , HOUGH-TROUTMAN, Whitney, L. , BICA, Katharina
IPC分类号： A61K31/555
CPC分类号： A61K45/06 , A61K31/167 , A61K31/196 , A61K31/43 , A61K31/4741 , A61K31/554 , A61K2300/00
摘要： Disclosed are compounds and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.
摘要翻译：公开了制备活性药物，生物，营养和能量成分的离子液体组合物的化合物和方法。还公开了使用本文所述的组合物克服多晶型，克服溶解性和递送问题，控制释放速率，添加功能，增强功效（协同作用）以及改善易于使用和制造的方法。

2. 发明申请

WO2006091964A3 REGULATORS OF PROTEIN MISFOLDING AND AGGREGATION AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：WO2006091964A3
公开(公告)日：2006-08-31
申请号：PCT/US2006/007002
申请日：2006-02-27
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA , CALDWELL, Guy, A. , CALDWELL, Kim, A.
发明人： CALDWELL, Guy, A. , CALDWELL, Kim, A.
IPC分类号： G01N33/53 , C12Q1/68 , A61K31/00 , A01K67/00
摘要： Polynucleotide molecules and the proteins encoded by the molecules, diagnostic and treatment methods for neurological disorders characterized by protein aggregation are provided. Genes are described herein that affect the misfolding of, and subsequent aggregation of, aggregation-prone proteins such as alpha-synuclein and have implications for the diagnosis and treatment of neurological diseases related to protein aggregation such as Parkinson's disease. Knockdown of expression of the genes described herein using RNAi results in alpha-synuclein protein aggregation in a C. elegans model of protein aggregation. Dopaminergic neuroprotection after exposure to the neurotoxin 6-OHDA or overexpression of alpha-synuclein may also be provided by overexpression of proteins. Knowledge of genes relating to protein misfolding and aggregation provides powerful means to develop diagnostic screening methods, mutation analysis and drug design information for the development of novel therapeutic and neuroprotective compounds to treat neurodegenerative diseases such as Parkinson's disease.

3. 发明申请

WO2006091964A2 REGULATORS OF PROTEIN MISFOLDING AND AGGREGATION AND METHODS OF USING THE SAME 审中-公开
标题翻译：蛋白质失调和聚集的调节剂及其使用方法
公开(公告)号：WO2006091964A2
公开(公告)日：2006-08-31
申请号：PCT/US2006007002
申请日：2006-02-27
申请人： UNIV ALABAMA , CALDWELL GUY A , CALDWELL KIM A
发明人： CALDWELL GUY A , CALDWELL KIM A
IPC分类号： C12N9/64
CPC分类号： G01N33/6896 , A01K67/0336 , A01K2227/703 , A01K2267/0318 , G01N2500/00
摘要： Polynucleotide molecules and the proteins encoded by the molecules, diagnostic and treatment methods for neurological disorders characterized by protein aggregation are provided. Genes are described herein that affect the misfolding of, and subsequent aggregation of, aggregation-prone proteins such as alpha-synuclein and have implications for the diagnosis and treatment of neurological diseases related to protein aggregation such as Parkinson's disease. Knockdown of expression of the genes described herein using RNAi results in alpha-synuclein protein aggregation in a C. elegans model of protein aggregation. Dopaminergic neuroprotection after exposure to the neurotoxin 6-OHDA or overexpression of alpha-synuclein may also be provided by overexpression of proteins. Knowledge of genes relating to protein misfolding and aggregation provides powerful means to develop diagnostic screening methods, mutation analysis and drug design information for the development of novel therapeutic and neuroprotective compounds to treat neurodegenerative diseases such as Parkinson's disease.
摘要翻译：提供多核苷酸分子和由分子编码的蛋白质，以蛋白质聚集为特征的神经障碍的诊断和治疗方法。本文描述了影响易聚集的蛋白质如α-突触核蛋白的错误折叠和随后的聚集的基因，并且涉及诊断和治疗与蛋白质聚集相关的神经疾病如帕金森病。使用RNAi敲除本文所述基因的表达导致蛋白质聚集的线虫模型中的α-突触核蛋白聚集。暴露于神经毒素6-OHDA或α-突触核蛋白的过表达后的多巴胺能神经保护也可以通过蛋白质的过表达来提供。关于蛋白质错折叠和聚集相关基因的知识为开发用于治疗神经变性疾病如帕金森病的新型治疗和神经保护化合物开发诊断筛选方法，突变分析和药物设计信息提供了有力手段。

4. 发明申请

WO2009009378A3 CATHEPSIN-D NEUROPROTECTION 审中-公开
公开(公告)号：WO2009009378A3
公开(公告)日：2009-01-15
申请号：PCT/US2008/069041
申请日：2008-07-02
申请人： THE UAB RESEARCH FOUNDATION , THE UNIVERSITY OF ALABAMA , ZHANG, Jianhua , CALDWELL, Guy
发明人： ZHANG, Jianhua , CALDWELL, Guy
IPC分类号： A61K31/47 , A61K38/00 , C07D277/36 , C07K5/12
摘要： Provided herein are methods and compositions for promoting neuroprotection in a subject and for treating a neural disorder associated with protein aggregation comprising administering to the subject an agent that increases expression or activity of cathepsin-D. Also provided are methods of screening for agents that increase expression or activity of cathepsin-D and methods of screening for neuroprotective agents.

5. 发明申请

WO2007062186A3 METHODS OF USING SMALL MOLECULE COMPOUNDS FOR NEUROPROTECTION 审中-公开
标题翻译：使用小分子化合物进行神经保护的方法
公开(公告)号：WO2007062186A3
公开(公告)日：2008-10-16
申请号：PCT/US2006045318
申请日：2006-11-21
申请人： UNIV ALABAMA , CALDWELL GUY A , CALDWELL KIM A , CAO SONGSONG
发明人： CALDWELL GUY A , CALDWELL KIM A , CAO SONGSONG
IPC分类号： A61K31/497 , A61K31/00 , A61K31/43 , A61K31/44
CPC分类号： A61K31/7048 , A61K31/00 , A61K31/404 , A61K31/4741 , A61K31/4745 , A61K31/704
摘要： Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and neuronal loss. In one aspect of the invention, the methods and compositions are also useful for treating neurodegenerative diseases. Small molecule compounds provide an important treatment option because of their stability, ease of use in both manufacture and formulation, ease of administration, and patient compliance. The small molecule compound compositions of the present invention may include topoisomerase II inhibitors, bacterial transpeptidase inhibitors, calcium channel antagonists, cyclooxygenase inhibitors, folic acid synthesis inhibitors, or sodium channel blockers and functional analogues thereof that have an effect on neurodegeneration. The compositions of the present invention may be administered prophylactically before the onset of clinical symptoms or after clinical symptoms of a neurodegenerative disease have manifested.
摘要翻译：提供了通过施用包含小分子化合物的组合物来预防神经变性和神经元损失的方法，其具有预防神经变性和神经元损失的作用。在本发明的一个方面，所述方法和组合物也可用于治疗神经变性疾病。小分子化合物提供了重要的治疗选择，因为它们的稳定性，制造和制剂易于使用，易于施用和患者依从性。本发明的小分子化合物组合物可以包括对神经变性有影响的拓扑异构酶II抑制剂，细菌转肽酶抑制剂，钙通道拮抗剂，环加氧酶抑制剂，叶酸合成抑制剂或其钠通道阻滞剂及其功能类似物。本发明的组合物可以在临床症状发作之前或在神经退行性疾病的临床症状已经显现之后进行预防性施用。

6. 发明申请

WO2009020624A1 REGULATORS OF PROTEIN MISFOLDING AND NEUROPROTECTION AND METHODS OF USE 审中-公开
标题翻译：蛋白质失调和神经保护的调节剂及其使用方法
公开(公告)号：WO2009020624A1
公开(公告)日：2009-02-12
申请号：PCT/US2008/009458
申请日：2008-08-07
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA , CALDWELL, Guy , CALDWELL, Kim, A.
发明人： CALDWELL, Guy , CALDWELL, Kim, A.
IPC分类号： C12Q1/68
CPC分类号： G01N33/6896 , C07K14/47 , C12N9/001 , G01N2333/90206
摘要： Polynucleotide molecules and the proteins encoded by the molecules, diagnostic and treatment methods for neurological disorders characterized by protein aggregation are provided. Genes are described herein that affect the misfolding of, and subsequent aggregation of, aggregation-prone proteins such as alpha-synuclein and have implications for the diagnosis and treatment of neurological diseases related to protein aggregation such as Parkinson's disease. Knockdown of expression of the genes described herein using RNAi results in alpha-synuclein protein aggregation in a C. elegans model of protein aggregation. Dopaminergic neuroprotection after overexpression of alpha-synuclein may also be provided by overexpression of proteins. Knowledge of genes relating to protein misfolding and aggregation provides powerful means to develop diagnostic screening methods, mutation analysis and drug design information for the development of novel therapeutic and neuroprotective compounds to treat neurodegenerative diseases such as Parkinson's disease.
摘要翻译：提供多核苷酸分子和由分子编码的蛋白质，以蛋白质聚集为特征的神经障碍的诊断和治疗方法。本文描述了影响易聚集的蛋白质如α-突触核蛋白的错误折叠和随后的聚集的基因，并且涉及诊断和治疗与蛋白质聚集相关的神经疾病如帕金森病。使用RNAi敲除本文所述基因的表达导致蛋白质聚集的线虫模型中的α-突触核蛋白聚集。 α-突触核蛋白过度表达后的多巴胺能神经保护也可以通过蛋白质的过表达来提供。关于蛋白质错折叠和聚集相关基因的知识为开发用于治疗神经变性疾病如帕金森病的新型治疗和神经保护化合物开发诊断筛选方法，突变分析和药物设计信息提供了有力手段。

7. 发明申请

WO2006091964A8 REGULATORS OF PROTEIN MISFOLDING AND AGGREGATION AND METHODS OF USING THE SAME 审中-公开
标题翻译：蛋白质错误折叠和聚集的调节器及其使用方法
公开(公告)号：WO2006091964A8
公开(公告)日：2007-03-22
申请号：PCT/US2006007002
申请日：2006-02-27
申请人： UNIV ALABAMA , CALDWELL GUY A , CALDWELL KIM A
发明人： CALDWELL GUY A , CALDWELL KIM A
IPC分类号： C12N9/64
CPC分类号： G01N33/6896 , A01K67/0336 , A01K2227/703 , A01K2267/0318 , G01N2500/00
摘要： Polynucleotide molecules and the proteins encoded by the molecules, diagnostic and treatment methods for neurological disorders characterized by protein aggregation are provided. Genes are described herein that affect the misfolding of, and subsequent aggregation of, aggregation-prone proteins such as alpha-synuclein and have implications for the diagnosis and treatment of neurological diseases related to protein aggregation such as Parkinson's disease. Knockdown of expression of the genes described herein using RNAi results in alpha-synuclein protein aggregation in a C. elegans model of protein aggregation. Dopaminergic neuroprotection after exposure to the neurotoxin 6-OHDA or overexpression of alpha-synuclein may also be provided by overexpression of proteins. Knowledge of genes relating to protein misfolding and aggregation provides powerful means to develop diagnostic screening methods, mutation analysis and drug design information for the development of novel therapeutic and neuroprotective compounds to treat neurodegenerative diseases such as Parkinson's disease.
摘要翻译：提供了由分子编码的多核苷酸分子和蛋白质，以蛋白质聚集为特征的神经障碍的诊断和治疗方法。本文描述的基因影响聚集倾向性蛋白质如α-突触核蛋白的错误折叠和随后的聚集，并且对与蛋白质聚集有关的神经疾病如帕金森氏病的诊断和治疗具有影响。使用RNAi敲低本文所述基因的表达导致蛋白质聚集的秀丽隐杆线虫模型中的α-突触核蛋白聚集。暴露于神经毒素6-OHDA或过度表达α-突触核蛋白后的多巴胺能神经保护作用也可以通过蛋白质的过表达来提供。与蛋白质错误折叠和聚集有关的基因知识为开发诊断性筛选方法，突变分析和药物设计信息提供了强有力的手段，用于开发治疗神经退行性疾病如帕金森病的新型治疗性和神经保护性化合物。

8. 发明申请

WO2009009378A2 CATHEPSIN-D NEUROPROTECTION 审中-公开
标题翻译： CATHEPSIN-D神经保护
公开(公告)号：WO2009009378A2
公开(公告)日：2009-01-15
申请号：PCT/US2008069041
申请日：2008-07-02
申请人： UAB RESEARCH FOUNDATION , UNIV ALABAMA , ZHANG JIANHUA , CALDWELL GUY
发明人： ZHANG JIANHUA , CALDWELL GUY
IPC分类号： A61K31/47 , A61K38/00 , C07K5/12
CPC分类号： A61K31/47 , A61K38/488 , G01N33/5023 , G01N33/5088
摘要： Provided herein are methods and compositions for promoting neuroprotection in a subject and for treating a neural disorder associated with protein aggregation comprising administering to the subject an agent that increases expression or activity of cathepsin-D. Also provided are methods of screening for agents that increase expression or activity of cathepsin-D and methods of screening for neuroprotective agents.
摘要翻译：本文提供用于促进受试者中的神经保护并用于治疗与蛋白质聚集相关的神经疾病的方法和组合物，所述方法和组合物包含向所述受试者施用增加组织蛋白酶-D表达或活性的试剂。还提供筛选增加组织蛋白酶-D的表达或活性的试剂的方法和筛选神经保护剂的方法。

9. 发明申请

WO2007062186A2 METHODS OF USING SMALL MOLECULE COMPOUNDS FOR NEUROPROTECTION 审中-公开
标题翻译：使用小分子化合物进行神经保护的方法
公开(公告)号：WO2007062186A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/045318
申请日：2006-11-21
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA , CALDWELL, Guy, A. , CALDWELL, Kim, A. , CAO, Songsong
发明人： CALDWELL, Guy, A. , CALDWELL, Kim, A. , CAO, Songsong
IPC分类号： A61K31/7048
CPC分类号： A61K31/7048 , A61K31/00 , A61K31/404 , A61K31/4741 , A61K31/4745 , A61K31/704
摘要： Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and neuronal loss. In one aspect of the invention, the methods and compositions are also useful for treating neurodegenerative diseases. Small molecule compounds provide an important treatment option because of their stability, ease of use in both manufacture and formulation, ease of administration, and patient compliance. The small molecule compound compositions of the present invention may include topoisomerase II inhibitors, bacterial transpeptidase inhibitors, calcium channel antagonists, cyclooxygenase inhibitors, folic acid synthesis inhibitors, or sodium channel blockers and functional analogues thereof that have an effect on neurodegeneration. The compositions of the present invention may be administered prophylactically before the onset of clinical symptoms or after clinical symptoms of a neurodegenerative disease have manifested.
摘要翻译：提供了通过施用包含小分子化合物的组合物来预防神经变性和神经元损失的方法，其具有预防神经变性和神经元损失的作用。在本发明的一个方面，所述方法和组合物也可用于治疗神经变性疾病。小分子化合物提供了重要的治疗选择，因为它们的稳定性，制造和制剂易于使用，易于施用和患者依从性。本发明的小分子化合物组合物可以包括对神经变性有影响的拓扑异构酶II抑制剂，细菌转肽酶抑制剂，钙通道拮抗剂，环加氧酶抑制剂，叶酸合成抑制剂或其钠通道阻滞剂及其功能类似物。本发明的组合物可以在临床症状发作之前或在神经退行性疾病的临床症状已经显现之后进行预防性施用。

10. 发明申请

WO2004000996A2 NUCLEOTIDE SEQUENCES THAT CODE FOR TORSIN GENES, TORSIN PROTEINS, AND METHODS OF USING THE SAME TO TREAT PROTEIN-AGGREGATION 审中-公开
标题翻译：核苷酸序列，用于托马斯基因，托马斯蛋白的代码和使用该方法的方法来处理蛋白质聚集
公开(公告)号：WO2004000996A2
公开(公告)日：2003-12-31
申请号：PCT/US2003/016229
申请日：2003-06-24
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA , CALDWELL, Guy, A. , CALDWELL, Kim, A.
发明人： CALDWELL, Guy, A. , CALDWELL, Kim, A.
IPC分类号： C12N
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2500/04
摘要： The invention relates to polynucleotides comprising polynucleotide sequences corresponding to the tor-1, tor-2, ooc-5, DYT1 , and DYT2 genes and parts thereof that encode polypeptide sequences and parts thereof possessing varying degrees of torsin activity, and methods of screening and amplifying polynucleotides encoding polypeptide sequences which encode polypeptides having varying degrees of TOR-1, TOR2, OOC-5 TOR-A, and TOR-B activity. Further, the invention relates to methods of reducing protein aggregation, methods of treating diseases that are caused by protein aggregation, methods of screening potential protein-aggregation-reducing products, methods of screening potential therapeutics of diseases caused by protein aggregation, and pharmaceuticals, therapeutics, and kits comprising polynucleotide sequences corresponding to the tor-1, tor-2, ooc-5, DYT1 and DYT2 genes and/or polypeptides having torsin activity.
摘要翻译：本发明涉及多核苷酸，其包含对应于tor-1，tor-2，ooc-5，DYT1和DYT2基因的多核苷酸序列及其部分，其编码具有不同程度的躯干活性的多肽序列及其部分，以及筛选和扩增编码多肽序列的多核苷酸，其编码具有不同程度的TOR-1，TOR2，OOC-5TOR-A和TOR-B活性的多肽。此外，本发明涉及减少蛋白质聚集的方法，治疗由蛋白质聚集引起的疾病的方法，筛选潜在的蛋白质聚集减少产品的方法，筛选由蛋白质聚集引起的疾病的潜在治疗剂的方法以及药物，治疗剂以及包含与tor-1，tor-2，ooc-5，DYT1和DYT2基因和/或具有干扰素活性的多肽相对应的多核苷酸序列的试剂盒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式