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1. 发明申请

WO2008056117A1 DETECTION SYSTEM APPARATUS 审中-公开
标题翻译：检测系统设备
公开(公告)号：WO2008056117A1
公开(公告)日：2008-05-15
申请号：PCT/GB2007/004211
申请日：2007-11-05
申请人： CAMPBELL, James, Gordon , TOUQUET, Robin
发明人： CAMPBELL, James, Gordon , TOUQUET, Robin
IPC分类号： C12Q1/26 , G01N33/52 , G01N33/543 , G01N33/98 , G01N33/558
CPC分类号： G01N33/98 , G01N33/523 , G01N2333/90206
摘要： A test apparatus for alcohol, the apparatus comprising a matrix having an observation zone subject to a colour change dependent upon the presence of alcohol, the observation zone having an embedded reactant to alcohol to provide the colour change and the matrix arranged to regulate presentation of a test liquid to the observation zone.
摘要翻译：一种用于酒精的测试装置，该装置包括具有取决于醇的存在的具有颜色变化的观察区的基质，该观察区具有嵌入的反应物至醇以提供颜色变化，以及布置成调节测试液体到观察区。

2. 发明申请

WO2017046594A1 COMPOSITIONS AND METHODS FOR POLYNUCLEOTIDE ASSEMBLY 审中-公开
标题翻译：多核苷酸组合物的组合物和方法
公开(公告)号：WO2017046594A1
公开(公告)日：2017-03-23
申请号：PCT/GB2016/052886
申请日：2016-09-15
申请人： LABGENIUS LTD
发明人： FIELD, James Edward John , RICKERBY, Harrison Frederick
IPC分类号： C12N15/10 , C12N15/64 , C12N15/66
CPC分类号： C12N15/64 , C12N15/10 , C12N15/1027 , C12N15/1031 , C12N15/66 , G01N2333/90206
摘要： Methods are provided for assembly of a target polynucleotide sequence comprising at least a first double stranded polynucleotide (DSP) and at least second DSP, and optionally further DSPs. The method comprises an assembly reaction comprising steps including providing a first single stranded polynucleotide (SSP) comprising the polynucleotide sequence of one strand of the first DSP, and a second SSP comprising the polynucleotide sequence of one strand of the second DSP and converting the SSPs to double stranded form via a primer and polymerase-mediated extension reaction. The DSPs comprise polynucleotide sequences that are complementary to other polynucleotide sequences within the assembly reaction such that the ordering and directionality of each of the first and second, and further DSPs is determined by unique overhang pairing. Nucleic acid libraries and methods of making such libraries are also provided.
摘要翻译：提供了用于组装包含至少第一双链多核苷酸（DSP）和至少第二DSP的靶多核苷酸序列以及可选地另外的DSP的方法。该方法包括组装反应，其包括提供包含第一DSP的一条链的多核苷酸序列的第一单链多核苷酸（SSP）和包含第二DSP的一条链的多核苷酸序列的第二SSP，并将SSP转化为双链形式通过引物和聚合酶介导的延伸反应。 DSP包括与组装反应中的其他多核苷酸序列互补的多核苷酸序列，使得第一和第二和其它DSP中的每一个的排序和方向性由独特的突出配对确定。还提供了核酸文库和制备这种文库的方法。

3. 发明申请

WO2017023778A1 METHODS AND COMPOSITIONS FOR HERBICIDE TOLERANCE IN PLANTS 审中-公开
标题翻译：植物耐除草剂的方法和组合物
公开(公告)号：WO2017023778A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/044774
申请日：2016-07-29
申请人： MONSANTO TECHNOLOGY LLC
发明人： EVDOKIMOV, Artem, G. , LARUE, Clayton, T. , MOSHIRI, Farhad , ZHOU, Xuefeng , REAM, Joel, E.
IPC分类号： C12N9/02 , C12N15/82 , C12N5/04 , A01H5/00
CPC分类号： C12N15/8274 , C12N9/001 , C12Q1/32 , C12Y103/03004 , G01N2333/90206 , G01N2430/20
摘要： The invention relates to biotechnology and provides novel recombinant DNA molecules and engineered proteins for conferring tolerance to protoporphyrinogen oxidase-inhibitor herbicides. The invention also provides herbicide tolerant transgenic plants, seeds, cells, and plant parts containing the recombinant DNA molecules, as well as methods of using the same.
摘要翻译：本发明涉及生物技术，并提供新的重组DNA分子和工程蛋白质，以赋予对原卟啉原氧化酶抑制剂除草剂的耐受性。本发明还提供了含有重组DNA分子的除草剂耐受性转基因植物，种子，细胞和植物部分，以及使用该重组DNA分子的方法。

4. 发明申请

WO2009133379A3 DIHYDROOROTATE DEHYDROGENASE AS ANTIFUNGAL DRUG TARGET AND QUINAZOLINONE-BASED INHIBITORS THEREOF 审中-公开
标题翻译： DIHYDROOROTETE DEHYDROGENASE作为抗真菌药物靶标和基于喹唑啉酮的抑制剂
公开(公告)号：WO2009133379A3
公开(公告)日：2009-12-23
申请号：PCT/GB2009001114
申请日：2009-05-01
申请人： F2G LTD , OLIVER JASON DAVID , THAIN JOHN LESLIE , BROMLEY MICHAEL JOHN , SIBLEY GRAHAM EDWARD MORRI , BIRCH MICHAEL
发明人： OLIVER JASON DAVID , THAIN JOHN LESLIE , BROMLEY MICHAEL JOHN , SIBLEY GRAHAM EDWARD MORRI , BIRCH MICHAEL
IPC分类号： C12Q1/32 , A61P31/10 , C07D239/72 , C12N9/02
CPC分类号： C12Q1/32 , C07D239/95 , C12N9/001 , C12Y103/05002 , G01N2333/90206 , G01N2500/02
摘要： A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.
摘要翻译：鉴定靶向真菌的DHODH蛋白（别名PyrE，二氢叶酸脱氢酶，EC：1.3.99.11）的抗真菌剂的方法，其包括将候选物质与真菌DHODH蛋白质接触，并确定候选物质是否结合或调节DHODH蛋白其中结合或调节表明候选物质是抗真菌剂。具体实例涉及烟曲霉和白色念珠菌DHODH蛋白。还公开了具有喹唑啉酮核心的DHODH抑制剂。

5. 发明申请

WO2005033277A3 METHODS OF MODULATING CELL CYCLE AND CELL SIGNALING PATHWAYS USING BILIVERDIN REDUCTASE 审中-公开
标题翻译：调节细胞周期和细胞信号途径的方法使用利多卡因减少
公开(公告)号：WO2005033277A3
公开(公告)日：2007-12-06
申请号：PCT/US2004031866
申请日：2004-09-29
申请人： UNIV ROCHESTER , MAINES MAHIN D
发明人： MAINES MAHIN D
IPC分类号： A61K31/70 , A61K48/00 , C07H21/04 , C12N20060101 , C12N15/113 , C12N15/861 , C12N15/867 , C12Q1/26
CPC分类号： C12N15/86 , A61K48/005 , C12N9/001 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2710/10343 , C12N2740/13043 , C12Q1/26 , C12Y103/01024 , C12Y103/01042 , G01N2333/90206
摘要： The present invention relates to a method of modifying expression of cell cycle or cell signaling proteins. This method involves modifying the nuclear or cellular concentration of biliverdin reductase, or fragments or variants thereof, in a cell, whereby a change in the nuclear or cellular concentration of biliverdin reductase, or fragments or variants thereof, modifies the transcription or expression of cell cycle or cell signaling proteins.
摘要翻译：本发明涉及一种修饰细胞周期或细胞信号传导蛋白表达的方法。该方法包括修饰细胞中胆红素还原酶或其片段或变体的核或细胞浓度，由此胆红素还原酶或其片段或变体的核或细胞浓度的变化修饰细胞周期的转录或表达或细胞信号传导蛋白。

6. 发明申请

WO2018029336A1 METHODS FOR DETERMINING WHETHER A SUBJECT WAS ADMINISTERED WITH AN ACTIVATOR OF THE PPAR BETA/DELTA PATHWAY. 审中-公开
标题翻译：确定受试者是否接受过PPAR BETA / DELTA途径激活剂的方法。
公开(公告)号：WO2018029336A1
公开(公告)日：2018-02-15
申请号：PCT/EP2017/070419
申请日：2017-08-11
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE NICE SOPHIA ANTIPOLIS
发明人： NEELS, Jacobus , ROUSSEAU, Anne-Sophie , SIBILLE, Brigitte , MOTHE-SATNEY, Isabelle , MURDACA, Joseph , GRIMALDI, Paul
IPC分类号： G01N33/569 , A61K31/00 , C12Q1/68
CPC分类号： G01N33/56972 , A61K31/192 , A61K31/381 , A61K31/426 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N2333/70567 , G01N2333/90206 , G01N2333/91051 , G01N2333/91057 , G01N2800/52
摘要： The inventors have investigated the effect of overexpressing PPARβ on T cell biology in vivo by using mice that overexpress PPARβ in a T cell specific manner. Using this transgenic mouse model, and also by systemic treatment of wild-type mice with a PPARβ agonist, they have demonstrated that activation/overexpression of PPARβ increases the fatty acid oxidation capacity of developing T cells, thereby inhibiting the proliferative burst at the DN4 stage. Accordingly, he present invention relates to a method for identifying whether a subject was administered with an activator of the PPARβ/δ pathway comprising: i) quantifying the expression level of Acaa2, Acadvl and Cpt1a in a blood sample obtained from said subject; ii) comparing the expression determined at step i) with a predetermined reference value, and iii) concluding that the subject was administered with an activator of the PPARβ/δ pathway when the expression level of Acaa2, Acadvl and Cpt1a determined at step i) is higher than the predetermined reference value.
摘要翻译：本发明人已经通过使用以T细胞特异性方式过表达PPARβ的小鼠研究了过度表达PPARβ对体内T细胞生物学的影响。使用这种转基因小鼠模型，以及通过用PPARβ激动剂对野生型小鼠进行全身治疗，他们已经证明PPARβ的激活/过表达增加了发育中的T细胞的脂肪酸氧化能力，从而抑制了DN4阶段的增殖性爆发。因此，本发明涉及一种用于鉴定受试者是否与PPARβ/δ途径的激活剂一起施用的方法，其包括：i）定量从所述受试者获得的血液样品中的Acaa2，Acadv1和Cpt1a的表达水平; ii）将步骤i）测定的表达与预定的参考值进行比较，并且iii）当步骤i）测定的Acaa2，Acadv1和Cpt1a的表达水平是对照时，推断受试者与PPARβ/δ途径的激活剂一起施用高于预定参考值。

7. 发明申请

WO2015093932A1 MÉTODO DE DIAGNÓSTICO TEMPRANO DE CARCINOMA HEPATOCELULAR 审中-公开
标题翻译：早期诊断肝细胞癌的方法
公开(公告)号：WO2015093932A1
公开(公告)日：2015-06-25
申请号：PCT/MX2014/000207
申请日：2014-12-16
申请人： INSTITUTO NACIONAL DE MEDICINA GENÓMICA
发明人： PÉREZ CARREÓN, Julio Isael , SÁNCHEZ RODRÍGUEZ, Ricardo
IPC分类号： G01N33/68 , C12Q1/68 , C12Q1/26
CPC分类号： C12Q1/6886 , C12Q2600/158 , G01N33/57438 , G01N2333/90206
摘要： La presente invención provee nuevos métodos de diagnóstico temprano del carcinoma hepatocelular (CHC) mediante la detección de los productos génicos (ARNm o proteína) de la prostaglandina reductasa 1 (Ptgr1 ) en muestras biológicas y nuevos métodos para determinar si un paciente con CHC es candidato para ser tratado con compuestos antitumorales que sean bioactivados por la Ptgr1.
摘要翻译：本发明涉及通过检测生物样品中前列腺素还原酶1（Ptgr1）的基因产物（mRNA或蛋白质）的早期诊断肝细胞癌（CHC）的新方法，以及用于确定是否具有 CHC是由Ptgr1生物活化的抗肿瘤化合物治疗的候选者。

8. 发明申请

WO2009135908A1 MODULATORS OF ISOVALERYL-COENZYME A DEHYDROGENASE IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPER SEBORRHOEA 审中-公开
标题翻译： ISOVALERYL-COENZYME的治疗剂治疗ACNE，SEBORRHOEIC DERMATITIS或者HYPER SEBORRHOEA的治疗
公开(公告)号：WO2009135908A1
公开(公告)日：2009-11-12
申请号：PCT/EP2009/055553
申请日：2009-05-07
申请人： GALDERMA RESEARCH & DEVELOPMENT , AUBERT, Jérôme
发明人： AUBERT, Jérôme
IPC分类号： G01N33/68 , C12Q1/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , G01N2333/90206 , G01N2500/10 , G01N2800/20
摘要： The invention relates to an in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, comprising the determination of the ability of a compound to modulate the expression or the activity of isovaleryl-coenzyme A dehydrogenase (IVD), and also to the use of modulators of the expression or of the activity of this enzyme, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea. The invention also relates to methods for the in vitro diagnosis of or in vitro prognosis for these pathologies.
摘要翻译：本发明涉及用于筛选候选化合物以用于预防或治疗痤疮，脂溢性皮炎或与超星球症相关的皮肤病症的体外或体内方法，其包括测定化合物调节表达的能力或异戊酰辅酶A脱氢酶（IVD）的活性，以及使用这种酶的表达或活性的调节剂，用于治疗痤疮，脂溢性皮炎或与上呼吸道相关的皮肤疾病。本发明还涉及用于这些病理学的体外诊断或体外预后的方法。

9. 发明申请

WO2009020624A1 REGULATORS OF PROTEIN MISFOLDING AND NEUROPROTECTION AND METHODS OF USE 审中-公开
标题翻译：蛋白质失调和神经保护的调节剂及其使用方法
公开(公告)号：WO2009020624A1
公开(公告)日：2009-02-12
申请号：PCT/US2008/009458
申请日：2008-08-07
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA , CALDWELL, Guy , CALDWELL, Kim, A.
发明人： CALDWELL, Guy , CALDWELL, Kim, A.
IPC分类号： C12Q1/68
CPC分类号： G01N33/6896 , C07K14/47 , C12N9/001 , G01N2333/90206
摘要： Polynucleotide molecules and the proteins encoded by the molecules, diagnostic and treatment methods for neurological disorders characterized by protein aggregation are provided. Genes are described herein that affect the misfolding of, and subsequent aggregation of, aggregation-prone proteins such as alpha-synuclein and have implications for the diagnosis and treatment of neurological diseases related to protein aggregation such as Parkinson's disease. Knockdown of expression of the genes described herein using RNAi results in alpha-synuclein protein aggregation in a C. elegans model of protein aggregation. Dopaminergic neuroprotection after overexpression of alpha-synuclein may also be provided by overexpression of proteins. Knowledge of genes relating to protein misfolding and aggregation provides powerful means to develop diagnostic screening methods, mutation analysis and drug design information for the development of novel therapeutic and neuroprotective compounds to treat neurodegenerative diseases such as Parkinson's disease.
摘要翻译：提供多核苷酸分子和由分子编码的蛋白质，以蛋白质聚集为特征的神经障碍的诊断和治疗方法。本文描述了影响易聚集的蛋白质如α-突触核蛋白的错误折叠和随后的聚集的基因，并且涉及诊断和治疗与蛋白质聚集相关的神经疾病如帕金森病。使用RNAi敲除本文所述基因的表达导致蛋白质聚集的线虫模型中的α-突触核蛋白聚集。 α-突触核蛋白过度表达后的多巴胺能神经保护也可以通过蛋白质的过表达来提供。关于蛋白质错折叠和聚集相关基因的知识为开发用于治疗神经变性疾病如帕金森病的新型治疗和神经保护化合物开发诊断筛选方法，突变分析和药物设计信息提供了有力手段。

10. 发明申请

WO2018006009A2 COMPOSITIONS, ASSAYS, AND METHODS FOR DIRECT MODULATION OF FATTY ACID METABOLISM 审中-公开
标题翻译：用于直接调节脂肪酸代谢的组合物，测定和方法
公开(公告)号：WO2018006009A2
公开(公告)日：2018-01-04
申请号：PCT/US2017/040360
申请日：2017-06-30
申请人： DANA-FARBER CANCER INSTITUTE, INC.
发明人： WALENSKY, Loren D. , ESCUDERO, Silvia
IPC分类号： A61K38/16 , G01N33/50
CPC分类号： A61K38/16 , C07K14/00 , C07K14/4747 , G01N33/57484 , G01N2333/90206 , G01N2500/02 , G01N2800/04
摘要： This disclosure relates to the surprising and unexpected finding that the well-known cancer protein, Myeloid Cell Leukemia-1 (MCL-1), binds to and modulates the enzymatic activity of Very Long Chain Acyl CoA Dehydrogenase (VLCAD), thereby regulating fatty acid β-oxidation. This finding is employed in compositions and methods of treating cancer, metabolic diseases, or other conditions characterized by excessive fatty acid β-oxidation by blocking or reducing the energy production of cells (e.g., cancer) through inhibiting the MCL-1/VLCAD interaction and/or directly inhibiting VLCAD enzymatic activity. In addition, the disclosure features methods for identifying such agents that inhibit the interaction between MCL-1 and VLCAD or that inhibit VLCAD enzymatic activity.
摘要翻译：本公开涉及令人惊讶且出人意料的发现，即众所周知的癌症蛋白髓样细胞白血病-1（MCL-1）结合并调节极长链酰基CoA脱氢酶的酶活性（VLCAD），从而调节脂肪酸β-氧化。该发现用于通过抑制MCL-1 / VLCAD相互作用阻断或减少细胞（例如癌症）的能量产生来治疗癌症，代谢疾病或以过度脂肪酸β-氧化为特征的其他病症的组合物和方法中，以及 /或直接抑制VLCAD酶活性。此外，本公开内容的特征在于鉴定抑制MCL-1和VLCAD之间的相互作用或抑制VLCAD酶活性的试剂的方法。

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