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1. 发明申请

WO2013126897A1 SYSTEMS AND METHODS FOR DETERMINING CONTAINER CONTENTS, LOCATIONS, AND SURROUNDINGS 审中-公开
标题翻译：用于确定集装箱内容，位置和环境的系统和方法
公开(公告)号：WO2013126897A1
公开(公告)日：2013-08-29
申请号：PCT/US2013/027664
申请日：2013-02-25
申请人： ADHERETECH INC. , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA, FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA IN HUNTSVILLE
发明人： STEIN, Joshua , LANGHAUSER, John , MORENA, Michael , JOVANOV, Emil
IPC分类号： A61J1/03 , A61J7/04
CPC分类号： A61J7/0409 , A61J7/0418 , A61J7/0481 , A61J2200/30 , A61J2200/70 , A61J2200/74 , A61J2200/76 , F04C2270/0421 , G06F19/00 , G06F19/3462 , G06Q10/10
摘要： Systems and methods are provided for determining whether and/or when a patient is taking his or her medication and, when appropriate, providing reminders and/or alerts to the patient to improve adherence to a medication regimen. In some embodiments, a medication container is provided that includes a capacitance sensor for sensing the contents of the medication container (e.g., pill count or quantity of liquid medication). The capacitance sensor may include interleaved or interdigitated electrodes oriented vertically, horizontally, or angularly (e.g., diagonally) relative to an axis of the medication container. Reminders and/or alerts to the patient may be triggered based at least in part on the contents of the medication container, when a cap of the container was last opened and/or closed, the location of the medication container, and/or the container's surroundings.
摘要翻译：提供了系统和方法，用于确定患者是否和/或何时服用他或她的药物，并且在适当时向患者提供提醒和/或警报以改善对药物治疗方案的依从性。在一些实施例中，提供了一种药物容器，其包括用于感测药物容器的内容物的电容传感器（例如，药片计数或液体药物的量）。电容传感器可以包括相对于药物容器的轴线垂直，水平或成角度地（例如，对角线）定向的交错或交叉指向的电极。至少部分地基于药物容器的内容触发对患者的提醒和/或警报，当容器的帽最后打开和/或关闭时，药物容器的位置和/或容器的位置环境。

2. 发明申请

WO2007062186A2 METHODS OF USING SMALL MOLECULE COMPOUNDS FOR NEUROPROTECTION 审中-公开
标题翻译：使用小分子化合物进行神经保护的方法
公开(公告)号：WO2007062186A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/045318
申请日：2006-11-21
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA , CALDWELL, Guy, A. , CALDWELL, Kim, A. , CAO, Songsong
发明人： CALDWELL, Guy, A. , CALDWELL, Kim, A. , CAO, Songsong
IPC分类号： A61K31/7048
CPC分类号： A61K31/7048 , A61K31/00 , A61K31/404 , A61K31/4741 , A61K31/4745 , A61K31/704
摘要： Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and neuronal loss. In one aspect of the invention, the methods and compositions are also useful for treating neurodegenerative diseases. Small molecule compounds provide an important treatment option because of their stability, ease of use in both manufacture and formulation, ease of administration, and patient compliance. The small molecule compound compositions of the present invention may include topoisomerase II inhibitors, bacterial transpeptidase inhibitors, calcium channel antagonists, cyclooxygenase inhibitors, folic acid synthesis inhibitors, or sodium channel blockers and functional analogues thereof that have an effect on neurodegeneration. The compositions of the present invention may be administered prophylactically before the onset of clinical symptoms or after clinical symptoms of a neurodegenerative disease have manifested.
摘要翻译：提供了通过施用包含小分子化合物的组合物来预防神经变性和神经元损失的方法，其具有预防神经变性和神经元损失的作用。在本发明的一个方面，所述方法和组合物也可用于治疗神经变性疾病。小分子化合物提供了重要的治疗选择，因为它们的稳定性，制造和制剂易于使用，易于施用和患者依从性。本发明的小分子化合物组合物可以包括对神经变性有影响的拓扑异构酶II抑制剂，细菌转肽酶抑制剂，钙通道拮抗剂，环加氧酶抑制剂，叶酸合成抑制剂或其钠通道阻滞剂及其功能类似物。本发明的组合物可以在临床症状发作之前或在神经退行性疾病的临床症状已经显现之后进行预防性施用。

3. 发明申请

WO2012068178A1 MAGNETIC EXCHANGE COUPLED CORE-SHELL NANOMAGNETS 审中-公开
标题翻译：磁性交换耦合核心纳米级网络
公开(公告)号：WO2012068178A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/060879
申请日：2011-11-15
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA , HONG, Yang-ki , BAE, Seok
发明人： HONG, Yang-ki , BAE, Seok
IPC分类号： G11B5/00
CPC分类号： H01F1/0302 , G11B5/706 , H01F1/0054 , H01F1/061 , H01F3/00
摘要： A permanent magnet (12) is fabricated such that it has a magnetically hard core (14) surrounded by a thin magnetically soft shell (15). The magnetically hard core provides a relatively high intrinsic coercivity (H ci ), and the magnetically soft shell provides a relatively high magnetic flux density (B). Due to magnetic exchange coupling between the core and shell, a relatively high maximum energy product (5H) max is achievable over a wide temperature range, including temperatures above 150 °C. Further, such effects can be achieved without using rare-earth metals or precious metals helping to keep the manufacturing costs of the magnet low. To allow sufficient exchange magnetic coupling between the core and shell, the width of the shell is less than about 40 nanometers, and the overall dimensions are controlled such that the width of the shell is less than two times the Bloch domain wall thickness of the core.
摘要翻译：制造永磁体（12），使得其具有被薄磁软壳（15）包围的磁性硬芯（14）。磁性硬芯提供相对较高的固有矫顽力（Hci），并且磁软壳提供较高的磁通密度（B）。由于芯和壳之间的磁交换耦合，在宽温度范围（包括高于150℃的温度）下可实现相对较高的最大能量乘积（5H）max。此外，可以在不使用稀土金属或贵金属的情况下实现这样的效果，有助于保持磁体的制造成本低。为了允许芯和壳之间的充分的交换磁耦合，壳的宽度小于约40纳米，并且整体尺寸被控制，使得壳的宽度小于芯的Bloch畴壁厚度的两倍。

4. 发明申请

WO2011041792A1 WATER PURIFICATION SYSTEMS AND METHODS 审中-公开
标题翻译：水净化系统和方法
公开(公告)号：WO2011041792A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/051351
申请日：2010-10-04
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA , WOFSEY, Mike
发明人： WOFSEY, Mike
IPC分类号： B01D1/00
CPC分类号： B01D1/0035 , B01D1/22 , C02F1/14 , C02F1/18 , C02F2103/08 , Y02A20/128 , Y02A20/211 , Y02A20/212
摘要： An exemplary water purification system has a base and a cover that is coupled (e.g., heat sealed) to the base to form a chamber. Raw water, such as seawater or polluted water, is inserted into the base. The raw water evaporates and condenses on an inner surface of the cover, which is inclined to cause the condensed water to flow to a collection channel so that potable water may be drawn from such channel. The base and cover are formed of a lightweight, flexible material to allow the system to be collapsed for easy transport. In addition, the base and cover are supported by a collapsible frame. Accordingly, the system can be easily packaged and shipped at a relatively low cost.
摘要翻译：示例性的水净化系统具有底座和与底座联接（例如，热密封）以形成室的盖。原水，如海水或污水，被插入基地。原水蒸发并冷凝在盖的内表面上，该内表面倾向于使冷凝的水流到收集通道，从而可以从这种通道中抽取饮用水。基座和盖板由轻质柔软的材料形成，以允许系统折叠以便于运输。此外，底座和盖子由可折叠的框架支撑。因此，该系统可以以相对较低的成本容易地包装和运输。

5. 发明申请

WO2006091964A3 REGULATORS OF PROTEIN MISFOLDING AND AGGREGATION AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：WO2006091964A3
公开(公告)日：2006-08-31
申请号：PCT/US2006/007002
申请日：2006-02-27
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA , CALDWELL, Guy, A. , CALDWELL, Kim, A.
发明人： CALDWELL, Guy, A. , CALDWELL, Kim, A.
IPC分类号： G01N33/53 , C12Q1/68 , A61K31/00 , A01K67/00
摘要： Polynucleotide molecules and the proteins encoded by the molecules, diagnostic and treatment methods for neurological disorders characterized by protein aggregation are provided. Genes are described herein that affect the misfolding of, and subsequent aggregation of, aggregation-prone proteins such as alpha-synuclein and have implications for the diagnosis and treatment of neurological diseases related to protein aggregation such as Parkinson's disease. Knockdown of expression of the genes described herein using RNAi results in alpha-synuclein protein aggregation in a C. elegans model of protein aggregation. Dopaminergic neuroprotection after exposure to the neurotoxin 6-OHDA or overexpression of alpha-synuclein may also be provided by overexpression of proteins. Knowledge of genes relating to protein misfolding and aggregation provides powerful means to develop diagnostic screening methods, mutation analysis and drug design information for the development of novel therapeutic and neuroprotective compounds to treat neurodegenerative diseases such as Parkinson's disease.

6. 发明申请

WO2014085659A1 DUAL-POLARIZED MAGNETIC ANTENNAS 审中-公开
标题翻译：双极磁性天线
公开(公告)号：WO2014085659A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/072341
申请日：2013-11-27
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA
发明人： HONG, Yang-ki , LEE, Woncheo
IPC分类号： H01Q1/36
CPC分类号： H01Q1/36 , H01Q1/38 , H01Q7/08
摘要： The present disclosure generally pertains to dual-polarized magnetic antennas that may be used in various applications and are particularly suited for use in mobile devices and systems. In one exemplary embodiment, a dual-polarized antenna has a ferrite substrate that provides for the use of small antenna elements and also provides broad bandwidth and good impedance matching and isolation making the antenna attractive for use in mobile applications. Such antenna also has nearly omnidirectional radiation patterns and orthogonal polarizations. Further, the radiator type may be selected depending on the desired effective permeability in order to control return loss, isolation, and fractional bandwidth (FBW).
摘要翻译：本公开通常涉及可以用于各种应用中并且特别适用于移动设备和系统的双极化磁性天线。在一个示例性实施例中，双极化天线具有提供使用小天线元件的铁氧体衬底，并且还提供宽带宽和良好的阻抗匹配和隔离，使天线具有吸引力用于移动应用。这种天线也具有近乎全向的辐射图和正交偏振。此外，可以根据期望的有效磁导率来选择散热器类型，以便控制回波损耗，隔离和分数带宽（FBW）。

7. 发明申请

WO2014134054A1 ANTENNA MODULES HAVING FERRITE SUBSTRATES 审中-公开
标题翻译：具有铁素体基片的天线模块
公开(公告)号：WO2014134054A1
公开(公告)日：2014-09-04
申请号：PCT/US2014/018360
申请日：2014-02-25
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA for and on behalf of THE UNIVERSITY OF ALABAMA
发明人： HONG, Yang-Ki , LEE, Jae-jin
IPC分类号： H01Q1/24
CPC分类号： H01Q17/004 , H01Q1/243 , H01Q1/38 , H01Q7/00
摘要： An antenna module (22) has an antenna (21 ) that is formed on a ferrite substrate (31 ), and the ferrite substrate is positioned within a small direct current (DC) magnetic field. The magnetic loss tangent of the ferrite is controlled by application of the small DC magnetic field, thereby improving antenna radiation efficiency and increasing the bandwidth of the antenna.
摘要翻译：天线模块（22）具有形成在铁素体基板（31）上的天线（21），铁氧体基板位于小直流（DC）磁场内。通过施加小直流磁场来控制铁氧体的磁损耗正切，从而提高天线辐射效率并增加天线的带宽。

8. 发明申请

WO2013158635A1 NON-RARE EARTH MAGNETS HAVING MANGANESE (MN) AND BISMUTH (BI) ALLOYED WITH COBALT (CO) 审中-公开
标题翻译：具有锰（MN）和不锈钢（BI）的非稀土磁铁（CO）
公开(公告)号：WO2013158635A1
公开(公告)日：2013-10-24
申请号：PCT/US2013/036772
申请日：2013-04-16
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA
发明人： HONG, Yang-ki , PARK, Jihoon
IPC分类号： H01F1/047
CPC分类号： H01F1/047 , C22C1/00 , C22C1/02 , C22C22/00 , C22C2202/02
摘要： Permanent and soft magnets that do not depend on rare-earth elements have suitable magnetic properties for electric motor and generator applications. Both saturation magnetization and magneto-crystalline anisotropy of a manganese-bismuth (Mn-Bi) permanent (hard) magnet are increased by alloying the Mn-Bi magnet with cobalt (Co) or cobalt-iron (Co-Fe). Such magnets do not include rare-earth and precious metals ( e.g ., platinum), which are expensive and often limited in supply, but offer high magneto-crystalline anisotropy and magnetization. Therefore, a relatively high maximum energy product (BH) max is achieved.
摘要翻译：不依赖于稀土元素的永久和软磁体对于电动机和发电机应用具有合适的磁性能。通过使Mn-Bi磁体与钴（Co）或钴 - 铁（Co-Fe）合金化，锰 - 铋（Mn-Bi）永久（硬）磁体的饱和磁化强度和磁晶各向异性均提高。这种磁体不包括昂贵的稀土金属和贵金属（例如铂），并且通常限制供应，而是提供高的磁结晶各向异性和磁化强度。因此，实现了相对较高的最大能量乘积（BH）max。

9. 发明申请

WO2013177543A1 MAGNETIC SUPERCAPACITORS 审中-公开
标题翻译：磁力超级
公开(公告)号：WO2013177543A1
公开(公告)日：2013-11-28
申请号：PCT/US2013/042705
申请日：2013-05-24
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA
发明人： HONG, Yang-Ki , LEE, Jae-Jin
IPC分类号： H01G7/00
CPC分类号： H01G7/06 , H01G4/008 , H01G7/00 , Y02T10/7022
摘要： A magnetic supercapacitor has a dielectric layer positioned between magnetic layers. The magnetic layers may comprise hard, soft magnetic material or magnetic exchange coupled magnet (i.e. soft and hard magnet composite). A magnetic flux generated by the magnetic layers increases the permittivity of the dielectric layer, thereby increasing the capacitance and, hence, stored energy of the supercapacitor. When the magnetic layers comprise soft magnetic material, the capacitance of the supercapacitor can be varied. In this regard, current passing through a conductive segment within close proximity to the magnetic layers may be controlled in order to tune the capacitance as may be desired.
摘要翻译：磁性超级电容器具有位于磁性层之间的电介质层。磁性层可以包括硬的，软的磁性材料或磁性交换耦合的磁体（即软和硬磁体复合材料）。由磁性层产生的磁通增加了介电层的介电常数，从而增加了超级电容器的电容，并因此增加了储能。当磁性层包括软磁性材料时，可以改变超级电容器的电容。在这方面，可以控制通过非常接近磁性层的导电段的电流，以便根据需要调节电容。

10. 发明申请

WO2013030299A1 METHOD FOR ENHANCING THE THERMAL STABILITY OF IONIC COMPOUNDS 审中-公开
标题翻译：提高离子化合物热稳定性的方法
公开(公告)号：WO2013030299A1
公开(公告)日：2013-03-07
申请号：PCT/EP2012/066898
申请日：2012-08-30
申请人： DANMARKS TEKNISKE UNIVERSITET , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA , RIISAGER, Anders , FEHRMANN, Rasmus , ROGERS, Robin D. , GURAU, Gabriela
发明人： RIISAGER, Anders , FEHRMANN, Rasmus , ROGERS, Robin D. , GURAU, Gabriela
IPC分类号： A61K9/14
CPC分类号： C07F9/025 , A61K9/143 , C07C51/50 , C07C67/62 , C07D473/18
摘要： This invention relates to a method for enhancing the thermal stability of ionic compounds including ionic liquids, by immobilization on porous solid support materials having a pore diameter of between about 20-200 Å, wherein the solid support does not have a pore size of 90 Å.
摘要翻译：本发明涉及通过固定孔径在约20-200之间的多孔固体支持材料来增强包括离子液体在内的离子化合物的热稳定性的方法，其中固体载体不具有孔径。

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