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1. 发明申请

WO2007062186A3 METHODS OF USING SMALL MOLECULE COMPOUNDS FOR NEUROPROTECTION 审中-公开
标题翻译：使用小分子化合物进行神经保护的方法
公开(公告)号：WO2007062186A3
公开(公告)日：2008-10-16
申请号：PCT/US2006045318
申请日：2006-11-21
申请人： UNIV ALABAMA , CALDWELL GUY A , CALDWELL KIM A , CAO SONGSONG
发明人： CALDWELL GUY A , CALDWELL KIM A , CAO SONGSONG
IPC分类号： A61K31/497 , A61K31/00 , A61K31/43 , A61K31/44
CPC分类号： A61K31/7048 , A61K31/00 , A61K31/404 , A61K31/4741 , A61K31/4745 , A61K31/704
摘要： Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and neuronal loss. In one aspect of the invention, the methods and compositions are also useful for treating neurodegenerative diseases. Small molecule compounds provide an important treatment option because of their stability, ease of use in both manufacture and formulation, ease of administration, and patient compliance. The small molecule compound compositions of the present invention may include topoisomerase II inhibitors, bacterial transpeptidase inhibitors, calcium channel antagonists, cyclooxygenase inhibitors, folic acid synthesis inhibitors, or sodium channel blockers and functional analogues thereof that have an effect on neurodegeneration. The compositions of the present invention may be administered prophylactically before the onset of clinical symptoms or after clinical symptoms of a neurodegenerative disease have manifested.
摘要翻译：提供了通过施用包含小分子化合物的组合物来预防神经变性和神经元损失的方法，其具有预防神经变性和神经元损失的作用。在本发明的一个方面，所述方法和组合物也可用于治疗神经变性疾病。小分子化合物提供了重要的治疗选择，因为它们的稳定性，制造和制剂易于使用，易于施用和患者依从性。本发明的小分子化合物组合物可以包括对神经变性有影响的拓扑异构酶II抑制剂，细菌转肽酶抑制剂，钙通道拮抗剂，环加氧酶抑制剂，叶酸合成抑制剂或其钠通道阻滞剂及其功能类似物。本发明的组合物可以在临床症状发作之前或在神经退行性疾病的临床症状已经显现之后进行预防性施用。

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