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1. 发明申请

WO2005084263A2 REAGENT DELIVERY SYSTEM, DISPENSING DEVICE AND CONTAINER FOR A BIOLOGICAL STAINING APPARATUS 审中-公开
标题翻译：试剂递送系统，生物染色装置的分配装置和容器
公开(公告)号：WO2005084263A2
公开(公告)日：2005-09-15
申请号：PCT/US2005006383
申请日：2005-02-28
申请人： DAKOCYTOMATION DENMARK AS , FAVUZZI JOHN A , BUCHANAN KRISTOPHER , MARTIN MERRITT M JR , BLAND LOREN L , SWEDA JONATHAN R , LATHROP ROBERT L , VAN BOSCH JOHN E
发明人： FAVUZZI JOHN A , BUCHANAN KRISTOPHER , MARTIN MERRITT M JR , BLAND LOREN L , SWEDA JONATHAN R , LATHROP ROBERT L , VAN BOSCH JOHN E
IPC分类号： B01L3/00 , G01N1/31 , G01N35/10
CPC分类号： G01N1/30 , B01L3/508 , G01N1/312 , G01N35/1002 , G01N35/109 , Y10T436/2575
摘要： The invention concerns reagent delivery system for an apparatus for processing of biological samples arranged on microscope slides, comprising a reagent section having one or more reagent containers; a slide section in which at least one microscope slide is arranged; a probe for dispensing a portion of reagent onto a predetermined microscope slide, and means for handling the probe. The probe comprises a continuous prove tubing element extending through a rigid probe member and connecting the probe tip to a pneumatic pressure regulation device. The reagent containers are adapted for cooperation with the probe tip. In this manner a high though-put and a very low carry over of fluid tresidues is achieved since there is no assembled parts making up the inside volume of the probe in which the fluid may be retained.
摘要翻译：本发明涉及用于处理布置在显微镜载片上的生物样品的装置的试剂递送系统，包括具有一个或多个试剂容器的试剂部分; 其中布置有至少一个显微镜载玻片的滑动部分; 用于将一部分试剂分配到预定显微镜载玻片上的探针和用于处理探针的装置。探针包括连续证明管道元件，其延伸穿过刚性探针构件并将探针尖端连接到气动调压装置。试剂容器适于与探针尖端配合。以这种方式，由于没有组装部件构成探针的内部容积，可以保持流体，所以实现了很高的保持和非常低的流体滞留输送。

2. 发明申请

WO2005084263A3 REAGENT DELIVERY SYSTEM, DISPENSING DEVICE AND CONTAINER FOR A BIOLOGICAL STAINING APPARATUS 审中-公开
公开(公告)号：WO2005084263A3
公开(公告)日：2005-09-15
申请号：PCT/US2005/006383
申请日：2005-02-28
申请人： DAKOCYTOMATION DENMARK A/S , FAVUZZI, John, A. , BUCHANAN, Kristopher , MARTIN, Merritt, M., Jr. , BLAND, Loren, L. , SWEDA, Jonathan, R. , LATHROP, Robert, L. , VAN BOSCH, John, E.
发明人： FAVUZZI, John, A. , BUCHANAN, Kristopher , MARTIN, Merritt, M., Jr. , BLAND, Loren, L. , SWEDA, Jonathan, R. , LATHROP, Robert, L. , VAN BOSCH, John, E.
IPC分类号： G01N1/10
摘要： The invention concerns reagent delivery system for an apparatus for processing of biological samples arranged on microscope slides, comprising a reagent section having one or more reagent containers; a slide section in which at least one microscope slide is arranged; a probe for dispensing a portion of reagent onto a predetermined microscope slide, and means for handling the probe. The probe comprises a continuous prove tubing element extending through a rigid probe member and connecting the probe tip to a pneumatic pressure regulation device. The reagent containers are adapted for cooperation with the probe tip. In this manner a high though-put and a very low carry over of fluid tresidues is achieved since there is no assembled parts making up the inside volume of the probe in which the fluid may be retained.

3. 发明申请

WO2005047858A2 ON-LINE APPARATUS AND METHOD FOR DETERMINING ENDOTOXIN LEVELS 审中-公开
标题翻译：在线装置和确定内毒素水平的方法
公开(公告)号：WO2005047858A2
公开(公告)日：2005-05-26
申请号：PCT/US2004/037097
申请日：2004-11-08
申请人： CAMBREX BIO SCIENCE WALKERSVILLE, INC. , BONEN, Matthew, Richard , BERZOFSKY, Ronald, Norman , RICHARDSON, Bruce, J. , LATHROP, Robert, L., III , DEN DULK, Bruce, Rodney
发明人： BONEN, Matthew, Richard , BERZOFSKY, Ronald, Norman , RICHARDSON, Bruce, J. , LATHROP, Robert, L., III , DEN DULK, Bruce, Rodney
IPC分类号： G01N
CPC分类号： G01N1/18 , G01N33/5302 , G01N35/1097 , G01N2035/103
摘要： An apparatus and method for on-line testing for the presence of an endotoxin within a fluid sample from a fluid line. The apparatus is positioned in fluid communication with a fluid line to perform the on-line fluid testing for the presence of at least one endotoxin. The apparatus can include a housing and a fluid sampling system positioned in fluid communication with the fluid line. The fluid sampling system can comprise a valve for controlling the fluid flow from the fluid line into the fluid sampling system. A fluid flow well is positioned within the housing and in fluid communication with the fluid sampling system. A removable assembly can also be secured within the housing. The removable assembly comprises a plurality of wells for receiving used and unused fluid carrying members that can receive samples from the fluid flow well, a plurality of fluid sample receiving wells, and a plurality of vessel retention positions comprising recesses for securely receiving portions of respective fluid vessels. A detecting system is provided for testing a control sample and a sample of the fluid from the fluid line. The results of these tests are compared in order to determine if the fluid sample is carrying any endotoxins. In an embodiment, fluorescence testing of the sample is compared to that of the control in order to determine if the sample includes an endotoxin.
摘要翻译：用于在线测试来自流体管线的流体样品内存在内毒素的装置和方法。该装置定位成与流体管线流体连通，以进行在线流体测试以存在至少一种内毒素。该装置可以包括壳体和定位成与流体管线流体连通的流体采样系统。流体采样系统可以包括用于控制从流体管线流入流体采样系统的流体流量的阀。流体流动井位于壳体内并与流体采样系统流体连通。可拆卸的组件也可以固定在壳体内。可移除的组件包括多个井，用于接收可以从流体井接收样品的多余的未使用流体承载构件，多个流体样品接收孔，以及多个容器保持位置，其包括用于牢固地接收各个流体的部分的凹部船只。提供了一种用于从流体管线测试对照样品和流体样品的检测系统。比较这些测试的结果以确定流体样品是否携带任何内毒素。在一个实施方案中，将样品的荧光测试与对照的荧光测试进行比较，以确定样品是否包含内毒素。

4. 发明申请

WO2005047858A3 ON-LINE APPARATUS AND METHOD FOR DETERMINING ENDOTOXIN LEVELS 审中-公开
标题翻译：用于确定内毒素水平的在线装置和方法
公开(公告)号：WO2005047858A3
公开(公告)日：2005-07-21
申请号：PCT/US2004037097
申请日：2004-11-08
申请人： CAMBREX BIO SCIENCE WALKERSVIL , BONEN MATTHEW RICHARD , BERZOFSKY RONALD NORMAN , RICHARDSON BRUCE J , LATHROP ROBERT L III , DEN DULK BRUCE RODNEY
发明人： BONEN MATTHEW RICHARD , BERZOFSKY RONALD NORMAN , RICHARDSON BRUCE J , LATHROP ROBERT L III , DEN DULK BRUCE RODNEY
IPC分类号： C12M1/34 , G01N20060101 , G01N1/18 , G01N31/00 , G01N33/53 , G01N33/554 , G01N33/569 , G01N35/10
CPC分类号： G01N1/18 , G01N33/5302 , G01N35/1097 , G01N2035/103
摘要： An apparatus and method for on-line testing for the presence of an endotoxin within a fluid sample from a fluid line. The apparatus is positioned in fluid communication with a fluid line to perform the on-line fluid testing for the presence of at least one endotoxin. The apparatus can include a housing and a fluid sampling system positioned in fluid communication with the fluid line. The fluid sampling system can comprise a valve for controlling the fluid flow from the fluid line into the fluid sampling system. A fluid flow well is positioned within the housing and in fluid communication with the fluid sampling system. A removable assembly can also be secured within the housing. The removable assembly comprises a plurality of wells for receiving used and unused fluid carrying members that can receive samples from the fluid flow well, a plurality of fluid sample receiving wells, and a plurality of vessel retention positions comprising recesses for securely receiving portions of respective fluid vessels. A detecting system is provided for testing a control sample and a sample of the fluid from the fluid line. The results of these tests are compared in order to determine if the fluid sample is carrying any endotoxins. In an embodiment, fluorescence testing of the sample is compared to that of the control in order to determine if the sample includes an endotoxin.
摘要翻译：一种用于在线测试来自流体管线的流体样本内存在内毒素的装置和方法。该设备被定位成与流体管线流体连通以对至少一种内毒素的存在进行在线流体测试。该装置可以包括壳体和定位成与流体管线流体连通的流体采样系统。流体采样系统可以包括用于控制流体从流体管线流入流体采样系统的阀。流体流动井位于壳体内并与流体采样系统流体连通。可拆卸组件也可以固定在外壳内。可移除组件包括用于接收可以从流体流动井中接收样本的已使用和未使用的流体承载构件的多个井，多个流体样本接收井和多个容器保持位置，所述多个容器保持位置包括用于将各个流体船只。提供检测系统用于测试来自流体管线的对照样品和流体样品。比较这些测试的结果以确定流体样本是否携带任何内毒素。在一个实施方案中，将样品的荧光测试与对照的测试进行比较以确定样品是否包含内毒素。

5. 发明申请

WO2004026106A3 METHODS AND APPARATUS FOR DELIVERY OF OCULAR IMPLANTS 审中-公开
标题翻译：用于输送眼部植入物的方法和装置
公开(公告)号：WO2004026106A3
公开(公告)日：2004-07-29
申请号：PCT/US0329518
申请日：2003-09-18
申请人： ALLERGAN INC , WEBER DAVID , KANE INGRID , REHAL MIKE , LATHROP ROBERT L III , APTEKAREV KENNY , ETTER JEFFREY
发明人： WEBER DAVID , KANE INGRID , REHAL MIKE , LATHROP ROBERT L III , APTEKAREV KENNY , ETTER JEFFREY
IPC分类号： A61B17/00 , A61F2/14 , A61F2/16 , A61F9/00 , A61F9/007 , A61M37/00
CPC分类号： A61M37/0069 , A61F2/167 , A61F9/0017
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译：用于输送眼部植入物或微量植入物的装置和方法。该装置符合人体工程学设计，易于使用，并且执行器的简单手动按压产生联动装置的成比例的运动，使得植入物或微型植入物通过设置在眼睛中所需位置的套管喷射。提供小尺寸插管用于自密封输送方法。

6. 发明申请

WO2004026106A2 METHODS AND APPARATUS FOR DELIVERY OF OCULAR IMPLANTS 审中-公开
标题翻译：用于递送眼睛植入物的方法和设备
公开(公告)号：WO2004026106A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/029518
申请日：2003-09-18
申请人： OCULEX PHARMACEUTICALS, INC. , WEBER, David , KANE, Ingrid , REHAL, Mike , LATHROP, Robert, L., III , APTEKAREV, Kenny , ETTER, Jeffrey
发明人： WEBER, David , KANE, Ingrid , REHAL, Mike , LATHROP, Robert, L., III , APTEKAREV, Kenny , ETTER, Jeffrey
IPC分类号： A61B
CPC分类号： A61M37/0069 , A61F2/167 , A61F9/0017
摘要： An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.
摘要翻译：用于递送眼植入物或微植入物的装置和方法。该设备符合人体工程学设计以易于使用，并且致动器的简单手动压下产生连杆的成比例移动，导致植入物或微植入物通过设置在眼睛期望位置的套管射出。小号插管提供自动密封的交付方式。

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