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1. 发明申请

WO2013171100A1 POLYHYDROXYLATED PENTACYCLIC TRITERPENE ACIDS AS HMG-COA REDUCTASE INHIBITORS 审中-公开
标题翻译：作为HMG-COA还原酶抑制剂的聚羟基化的PENTACYCLIC TRITERPENE
公开(公告)号：WO2013171100A1
公开(公告)日：2013-11-21
申请号：PCT/EP2013/059513
申请日：2013-05-07
申请人： HANS, Joachim , GROTHE, Torsten , WÖHRLE, Ingo , MOLDENHAUER, Jana , KÖPCKE, Bärbel , KÜPER, Thomas , BITZER, Jens , REINHARDT, Kathrin
发明人： HANS, Joachim , GROTHE, Torsten , WÖHRLE, Ingo , MOLDENHAUER, Jana , KÖPCKE, Bärbel , KÜPER, Thomas , BITZER, Jens , REINHARDT, Kathrin
IPC分类号： A61K31/56 , A61K36/73
CPC分类号： C07C62/32 , A21D2/165 , A21D2/36 , A21D8/047 , A23C9/1315 , A23C9/1322 , A23C9/133 , A23C9/156 , A23C9/1565 , A23C11/02 , A23C15/16 , A23C2260/152 , A23D7/0056 , A23G9/32 , A23L2/39 , A23L2/40 , A23L2/52 , A23L7/126 , A23L27/10 , A23L27/60 , A23L33/105 , A61K9/0007 , A61K9/0095 , A61K9/2018 , A61K9/2027 , A61K9/485 , A61K9/4866 , A61K9/4891 , A61K31/01 , A61K31/015 , A61K31/191 , A61K31/192 , A61K31/352 , A61K31/7048 , A61K36/73 , A61K45/06 , A61K47/26 , A61K47/46 , A61K2300/00
摘要： The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-Co A reductase inhibitors in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the HMG-Co A reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio. Further, the present invention also relates to a formulation, preferably pharmaceutical or nutraceutical formulation, comprising one or more of said compounds of formula (I), a composition according to the present invention or a plant extract according to the present invention. Also, the present invention relates to a process for obtaining certain polyhydroxylated pentacyclic triterpene acids of formula (I), a composition according to the present invention or a plant extract according to the present invention.
摘要翻译：本发明涉及用于HMG-CoA还原酶抑制剂的某些多羟基化五环三萜酸，用于预防和/或治疗治疗对HMG-Co A降低的疾病，病症或病状的治疗哺乳动物，优选人类中的还原酶活性。本发明进一步涉及某些混合物和植物提取物，其中包含苹果酸和折酮酸，其中欧托卡酸与折酮酸的量超过一定比例。此外，本发明还涉及包含一种或多种所述式（I）化合物，根据本发明的组合物或根据本发明的植物提取物的制剂，优选药物或营养制剂。此外，本发明涉及一种获得式（I）的某些多羟基化五环三萜酸，根据本发明的组合物或根据本发明的植物提取物的方法。

2. 发明申请

WO2012167920A1 LONG CHAIN GLYCOLIPIDS USEFUL TO AVOID PERISHING OR MICROBIAL CONTAMINATION OF MATERIALS 审中-公开
标题翻译：长链甘露糖苷有助于避免物质的微生物污染或微生物污染
公开(公告)号：WO2012167920A1
公开(公告)日：2012-12-13
申请号：PCT/EP2012/002399
申请日：2012-06-06
申请人： INTERMED DISCOVERY GMBH , STADLER, Marc , BITZER, Jens , KÖPCKE, Bärbel , REINHARDT, Kathrin , MOLDENHAUER, Jana
发明人： STADLER, Marc , BITZER, Jens , KÖPCKE, Bärbel , REINHARDT, Kathrin , MOLDENHAUER, Jana
IPC分类号： A01N43/14 , A01N63/02 , C07H15/04 , C12P19/44
CPC分类号： A01N43/16 , A01N63/04 , A23B4/20 , A23B5/14 , A23B7/154 , A23B9/26 , A23L2/44 , A61K8/33 , A61K8/365 , A61K8/37 , A61K8/99 , A61Q5/02 , A61Q17/005 , C07H15/04 , C12P19/44
摘要： The invention relates to the use of, and methods of use employing, certain glycolipid compounds as defined in detail below and having preservative or antimicrobial properties, novel compounds of the glycolipid class, and related invention embodiments. The compounds have the formula (I) wherein m is (3) to (5), n is (2) to (5), o is (0) or (1) and p is (3) to (17), with the proviso that the sum m + n + o + p is not less than (14); and R is a carbohydrate moiety bound via one of its carbon atoms to the binding oxygen, and/or a physiologically, especially pharmaceutically or nutraceutically or cosmetically, acceptable salt thereof, or an ester thereof, as such or in the form of a composition, where the compound may be present in open chain form and/or in the form of a lactone.
摘要翻译：本发明涉及使用以下详细定义的具有防腐或抗微生物性质的某些糖脂化合物的使用和使用方法，糖脂类的新型化合物和相关的发明实施方案。化合物具有式（I）其中m为（3）至（5），n为（2）至（5），o为（0）或（1），p为（3）至（17）条件是总和m + n + o + p不小于（14）; 并且R是通过其碳原子之一与结合氧结合的碳水化合物部分，和/或其生理学上，特别是其药学上或药学上可接受的盐或其酯，或者以组合物的形式，其中化合物可以以开链形式和/或以内酯的形式存在。

3. 发明申请

WO2010110646A1 AURONES AS SELECTIVE PDE INHIBITORS AND THEIR USE IN NEUROLOGICAL CONDITIONS AND DISORDERS 审中-公开
标题翻译： AURONES作为选择性PDE抑制剂及其在神经病症和疾病中的应用
公开(公告)号：WO2010110646A1
公开(公告)日：2010-09-30
申请号：PCT/MY2010/000034
申请日：2010-03-24
申请人： BIOTROPICS MALAYSIA BERHAD , V.K. GEORGE, Annie George , KÖPCKE, Bärdel , ROEMER, Ernst , BITZER, Jens , GRUENWALD, Joerg , GEHLING, Matthias , WABNITZ, Philipp , TENGKU ADNAN, Tengli Shahrir , GROTHE, Torsten
发明人： V.K. GEORGE, Annie George , KÖPCKE, Bärdel , ROEMER, Ernst , BITZER, Jens , GRUENWALD, Joerg , GEHLING, Matthias , WABNITZ, Philipp , TENGKU ADNAN, Tengli Shahrir , GROTHE, Torsten
IPC分类号： C07D307/83 , C07D407/04 , A61K31/343 , A61P25/00
CPC分类号： C07D307/83 , C07D407/04
摘要： The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with a phosphodiesterase (PDE) dependent disease or condition of the central nervous system, as well as methods, uses and other inventions related thereto.
摘要翻译：本发明涉及用于预防和/或治疗具有磷酸二酯酶（PDE）依赖性疾病或中枢神经系统病症的动物（包括人类）的噢ones和包含它们的提取物，以及与之相关的方法，用途和其他发明。

4. 发明申请

WO2013023891A1 OLEANENE-TYPE TRITERPENE GLYCOSIDES AS MASKING AGENTS 审中-公开
标题翻译： OLEANENE型TRITERPENE GLYCOSIDES作为掩蔽剂
公开(公告)号：WO2013023891A1
公开(公告)日：2013-02-21
申请号：PCT/EP2012/064668
申请日：2012-07-26
申请人： SYMRISE AG , HANS, Joachim , MOLDENHAUER, Jana , BITZER, Jens , KÖPCKE, Bärbel , ROEMER, Ernst
发明人： HANS, Joachim , MOLDENHAUER, Jana , BITZER, Jens , KÖPCKE, Bärbel , ROEMER, Ernst
IPC分类号： A23L1/22
CPC分类号： A23G3/36 , A23F3/14 , A23F3/163 , A23F5/40 , A23G1/32 , A23L27/84 , A23L27/86
摘要： The present invention relates to the use of certain oleanene-type triterpene glycosides of formula (I) and/or physiologically acceptable salts thereof formula (I) wherein M is hydrogen or hydroxyl, preferably hydroxyl, and A is a carbohydrate moiety, preferably an oligosaccharide moiety, for modifying (i.e. modulating) or masking (i.e. reducing or suppressing) unpleasant taste impressions, in particular bitter and/or astringent taste impressions and to a corresponding method for modulating or masking an unpleasant taste of a substance or substance mixture. The present invention also relates to compositions, in particular orally consumable compositions, comprising (a) one or more compounds of formula (I) or a physiologically acceptable salt thereof, and (b) one or more substances with unpleasant taste, in particular bitter and/or astringent taste.
摘要翻译：本发明涉及式（I）的某些烯烃型三萜糖苷和/或式（I）的生理学上可接受的盐，其中M是氢或羟基，优选羟基，A是碳水化合物部分，优选低聚糖部分，用于改变（即调节）或掩蔽（即，减少或抑制）令人不快的味觉印象，特别是苦味和/或涩味的印象，以及用于调节或掩蔽物质或物质混合物的不愉快味道的相应方法。本发明还涉及组合物，特别是口服消耗品组合物，其包含（a）一种或多种式（I）化合物或其生理学上可接受的盐，和（b）一种或多种具有不愉快味道的物质，特别是苦味和 /或涩味。

5. 发明申请

WO2012079721A8 TERPENOID SPIRO KETAL COMPOUNDS WITH LXR AGONISTS ACTIVITY, THEIR USE AND FORMULATIONS WITH THEM 审中-公开
公开(公告)号：WO2012079721A8
公开(公告)日：2012-06-21
申请号：PCT/EP2011/006157
申请日：2011-12-08
申请人： INTERMED DISCOVERY GMBH , GROTHE, Torsten , STADLER, Marc , KÖPCKE, Bärbel , ROEMER, Ernst , BITZER, Jens , WABNITZ, Philipp , KÜPER, Thomas
发明人： GROTHE, Torsten , STADLER, Marc , KÖPCKE, Bärbel , ROEMER, Ernst , BITZER, Jens , WABNITZ, Philipp , KÜPER, Thomas
IPC分类号： A61K9/00 , A61K9/08 , A61K9/10 , A61K31/56 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P25/28
摘要： The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, respectively, of an extract and/or especially one or more natural spiro triterpenoids and derivatives thereof, especially from the blazeispirol family, obtainable from Agaricus species, alone or as supplement, as active ingredient in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, either in humans or in other mammals, and/or to the use of said extract and/or natural compound(s) or mixtures for the treatment of said disease, disorder or condition, as well as corresponding methods of treatment, or their use in the manufacture of a pharmaceutical or nutraceutical formulation for said treatment. The invention relates also to said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disorder, disorder or condition, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment. They can also be used for non-therapeutic, e.g. cosmetic, purposes only.

6. 发明申请

WO2010110646A8 AURONES AS SELECTIVE PDE INHIBITORS AND THEIR USE IN NEUROLOGICAL CONDITIONS AND DISORDERS 审中-公开
标题翻译：作为选择性PDE抑制剂的AURONES及其在神经病学和病症中的使用
公开(公告)号：WO2010110646A8
公开(公告)日：2010-10-28
申请号：PCT/MY2010000034
申请日：2010-03-24
申请人： BIOTROPICS MALAYSIA BERHAD , V K GEORGE ANNIE GEORGE , KOEPCKE BAERDEL , ROEMER ERNST , BITZER JENS , GRUENWALD JOERG , GEHLING MATTHIAS , WABNITZ PHILIPP , TENGKU ADNAN TENGKU SHAHRIR , GROTHE TORSTEN
发明人： V K GEORGE ANNIE GEORGE , KOEPCKE BAERDEL , ROEMER ERNST , BITZER JENS , GRUENWALD JOERG , GEHLING MATTHIAS , WABNITZ PHILIPP , TENGKU ADNAN TENGKU SHAHRIR , GROTHE TORSTEN
IPC分类号： C07D307/83 , A61K31/343 , A61P25/00 , C07D407/04
CPC分类号： C07D307/83 , C07D407/04
摘要： The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with a phosphodiesterase (PDE) dependent disease or condition of the central nervous system, as well as methods, uses and other inventions related thereto.
摘要翻译：本发明涉及包含它们的可用于预防和/或治疗具有磷酸二酯酶（PDE）依赖性疾病或中枢神经系统状况的动物（包括人）以及方法，用途和其它与此相关的发明。

7. 发明申请

WO2013112040A1 USE OF CERTAIN TRIOXYGENATED BENZENE DERIVATIVES IN BODY FAT MANAGEMENT 审中-公开
标题翻译：某些三氧化硫苯甲酸衍生物在体内脂肪管理中的应用
公开(公告)号：WO2013112040A1
公开(公告)日：2013-08-01
申请号：PCT/MY2012/000008
申请日：2012-01-27
申请人： BIOTROPICS MALAYSIA BERHAD , BITZER, Jens , GEHLING, Matthias , GROTHE, Torsten , KÖPCKE, Bärbel , WÖHRLE, Ingo , V.K. GEORGE, Annie George , CHINNAPPAN, Sasikala , MD AKIR, Mazria Haslina
发明人： BITZER, Jens , GEHLING, Matthias , GROTHE, Torsten , KÖPCKE, Bärbel , WÖHRLE, Ingo , V.K. GEORGE, Annie George , CHINNAPPAN, Sasikala , MD AKIR, Mazria Haslina
IPC分类号： A61K8/34 , A61K8/37 , A61K8/97 , A61Q19/06
CPC分类号： A61Q19/06 , A61K8/347 , A61K8/375 , A61K8/97
摘要： The invention primarily relates to the use of certain trioxygenated benzene derivatives of formula (I) or a corresponding plant extract as body fat modulating agents, preferably as anti-cellulite actives and/or for the reduction of the body fat content, in particular for reduction of body weight and/or for the management of obesity. The present invention also relates to corresponding methods and to certain novel compounds of formula (I). The invention further relates to specific plant extract formulations obtainable from a plant of the family Myrsinaceae, preferably from the genus Labisia, and to compositions, in particular cosmetic or pharmaceutical formulations, comprising an effective amount of one or more compounds of formula (I) or of a corresponding plant extract formulation.
摘要翻译：本发明主要涉及式（I）的某些三氧化苯衍生物或相应的植物提取物作为体内脂肪调节剂的用途，优选作为抗脂肪团活性物质和/或用于减少体内脂肪含量，特别是用于还原的体重和/或用于肥胖的管理。本发明还涉及相应的方法和某些新的式（I）化合物。本发明还涉及从芝麻科（Myrsinaceae）的植物，优选来自Labisia的植物获得的特定植物提取物制剂，以及包含有效量的一种或多种式（I）化合物或其组合物，特别是化妆品或药物制剂的组合物，的相应的植物提取物制剂。

8. 发明申请

WO2013023942A1 FOOD COMPOSITIONS COMPRISING FLAVAN-3-OLS 审中-公开
标题翻译：包含FLAVAN-3-OLS的食品组合物
公开(公告)号：WO2013023942A1
公开(公告)日：2013-02-21
申请号：PCT/EP2012/065291
申请日：2012-08-03
申请人： UNILEVER PLC , UNILEVER N.V. , HINDUSTAN UNILEVER LIMITED , BITZER, Jens , GOUKA, Robertus, Johannes , HANS, Joachim , KÖPCKE, Bärbel , MOLDENHAUER, Jana
发明人： BITZER, Jens , GOUKA, Robertus, Johannes , HANS, Joachim , KÖPCKE, Bärbel , MOLDENHAUER, Jana
IPC分类号： A23L1/22 , A23F3/14 , A23F3/16 , A23F5/40
CPC分类号： A23G3/36 , A23F3/14 , A23F3/163 , A23F5/40 , A23G1/32 , A23G9/32 , A23L27/86
摘要： Disclosed are food compositions comprising certain compounds and flavan-3-ols such as catechins and other tea-derived flavan-3-ols. Also disclosed are methods for manufacturing the compositions and use of the compounds for reducing or eliminating an unpleasant taste caused by the flavan-3-ols in food compositions. The compounds are those of formula (I) or a physiologically acceptable salt thereof, wherein M is hydrogen or hydroxyl, preferably hydroxyl, and A is a carbohydrate moiety, preferably an oligosaccharide moiety.
摘要翻译：公开了包含某些化合物和黄烷-3-醇的食物组合物，例如儿茶素和其它茶衍生的黄烷-3-醇。还公开了制备组合物的方法以及用于减少或消除由食品组合物中的黄烷-3-醇引起的不愉快味道的化合物的用途。化合物是式（I）化合物或其生理上可接受的盐，其中M是氢或羟基，优选羟基，A是碳水化合物部分，优选寡糖部分。

9. 发明申请

WO2012105823A1 COSMETIC NON THERAPEUTIC USE OF EXTRACTS FROM FICUS DELTOIDEA 审中-公开
标题翻译：来自FICUS DELTOIDEA的提取物的化妆品非治疗用途
公开(公告)号：WO2012105823A1
公开(公告)日：2012-08-09
申请号：PCT/MY2011/000008
申请日：2011-02-02
申请人： BIOTROPICS MALAYSIA BERHAD , BITZER, Jens , WABNITZ, Philipp , GEHLING, Matthias , REINEMER, Peter
发明人： BITZER, Jens , WABNITZ, Philipp , GEHLING, Matthias , REINEMER, Peter
IPC分类号： A61K8/97 , A61Q19/00
CPC分类号： A61K8/97 , A61Q19/08
摘要： The present invention is focused on the use of a topic dermatologic composition for improving the cosmetic appearance of skin, comprising improving the microcirculation in skin by applying said composition to skin where the composition comprises a hydrophilic extract from Ficus deltoidea or parts thereof.
摘要翻译：本发明专注于使用主题皮肤病学组合物来改善皮肤的美容外观，包括通过将所述组合物施用于组合物包含来自榕属的亲水性提取物或其部分的皮肤来改善皮肤微循环。

10. 发明申请

WO2012079721A1 TERPENOID SPIRO KETAL COMPOUNDS WITH LXR AGONISTS ACTIVITY, THEIR USE AND FORMULATIONS WITH THEM 审中-公开
标题翻译：具有LXR激动剂的TERPENOID SPIRO KETAL化合物活性，与他们的使用和配方
公开(公告)号：WO2012079721A1
公开(公告)日：2012-06-21
申请号：PCT/EP2011006157
申请日：2011-12-08
申请人： INTERMED DISCOVERY GMBH , GROTHE TORSTEN , STADLER MARC , KOEPCKE BAERBEL , ROEMER ERNST , BITZER JENS , WABNITZ PHILIPP , KUEPER THOMAS
发明人： GROTHE TORSTEN , STADLER MARC , KOEPCKE BAERBEL , ROEMER ERNST , BITZER JENS , WABNITZ PHILIPP , KUEPER THOMAS
IPC分类号： A61K9/00 , A61K9/08 , A61K9/10 , A61K31/56 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P25/28
CPC分类号： C07D471/10 , A61K31/56 , A61K31/58 , A61K36/07
摘要： The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, respectively, of an extract and/or especially one or more natural spiro triterpenoids and derivatives thereof, especially from the blazeispirol family, obtainable from Agaricus species, alone or as supplement, as active ingredient in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, either in humans or in other mammals, and/or to the use of said extract and/or natural compound(s) or mixtures for the treatment of said disease, disorder or condition, as well as corresponding methods of treatment, or their use in the manufacture of a pharmaceutical or nutraceutical formulation for said treatment. The invention relates also to said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disorder, disorder or condition, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment. They can also be used for non-therapeutic, e.g. cosmetic, purposes only.
摘要翻译：本发明涉及分别使用提取物和/或特别是一种或多种天然螺三萜类化合物及其衍生物的用途或方法（特别是涉及动物，特别是人类，需要这种治疗）特别是从作为活性成分的单独或作为补充剂的姬松茸物种获得的风疹家族，用于预防和/或治疗治疗响应肝脏X受体的调节的疾病，病症或病症，在人或其他哺乳动物和/或使用所述提取物和/或天然化合物或混合物来治疗所述疾病，病症或病症，以及相应的治疗方法或其在制造药物或制剂中的用途用于所述治疗的营养制剂。本发明还涉及用于治疗或制备用于预防和/或治疗所述病症，障碍或病症的药物（包括营养药物）的所述提取物和/或化合物，以及他们的准备。它还涉及包含可用于所述预防和/或治疗性治疗的所述提取物和/或天然化合物的药物或营养制剂。它们也可以用于非治疗性的，例如，化妆品，用途。

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