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1. 发明申请

WO2010110646A8 AURONES AS SELECTIVE PDE INHIBITORS AND THEIR USE IN NEUROLOGICAL CONDITIONS AND DISORDERS 审中-公开
标题翻译：作为选择性PDE抑制剂的AURONES及其在神经病学和病症中的使用
公开(公告)号：WO2010110646A8
公开(公告)日：2010-10-28
申请号：PCT/MY2010000034
申请日：2010-03-24
申请人： BIOTROPICS MALAYSIA BERHAD , V K GEORGE ANNIE GEORGE , KOEPCKE BAERDEL , ROEMER ERNST , BITZER JENS , GRUENWALD JOERG , GEHLING MATTHIAS , WABNITZ PHILIPP , TENGKU ADNAN TENGKU SHAHRIR , GROTHE TORSTEN
发明人： V K GEORGE ANNIE GEORGE , KOEPCKE BAERDEL , ROEMER ERNST , BITZER JENS , GRUENWALD JOERG , GEHLING MATTHIAS , WABNITZ PHILIPP , TENGKU ADNAN TENGKU SHAHRIR , GROTHE TORSTEN
IPC分类号： C07D307/83 , A61K31/343 , A61P25/00 , C07D407/04
CPC分类号： C07D307/83 , C07D407/04
摘要： The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with a phosphodiesterase (PDE) dependent disease or condition of the central nervous system, as well as methods, uses and other inventions related thereto.
摘要翻译：本发明涉及包含它们的可用于预防和/或治疗具有磷酸二酯酶（PDE）依赖性疾病或中枢神经系统状况的动物（包括人）以及方法，用途和其它与此相关的发明。

2. 发明申请

WO2012079721A1 TERPENOID SPIRO KETAL COMPOUNDS WITH LXR AGONISTS ACTIVITY, THEIR USE AND FORMULATIONS WITH THEM 审中-公开
标题翻译：具有LXR激动剂的TERPENOID SPIRO KETAL化合物活性，与他们的使用和配方
公开(公告)号：WO2012079721A1
公开(公告)日：2012-06-21
申请号：PCT/EP2011006157
申请日：2011-12-08
申请人： INTERMED DISCOVERY GMBH , GROTHE TORSTEN , STADLER MARC , KOEPCKE BAERBEL , ROEMER ERNST , BITZER JENS , WABNITZ PHILIPP , KUEPER THOMAS
发明人： GROTHE TORSTEN , STADLER MARC , KOEPCKE BAERBEL , ROEMER ERNST , BITZER JENS , WABNITZ PHILIPP , KUEPER THOMAS
IPC分类号： A61K9/00 , A61K9/08 , A61K9/10 , A61K31/56 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P25/28
CPC分类号： C07D471/10 , A61K31/56 , A61K31/58 , A61K36/07
摘要： The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, respectively, of an extract and/or especially one or more natural spiro triterpenoids and derivatives thereof, especially from the blazeispirol family, obtainable from Agaricus species, alone or as supplement, as active ingredient in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, either in humans or in other mammals, and/or to the use of said extract and/or natural compound(s) or mixtures for the treatment of said disease, disorder or condition, as well as corresponding methods of treatment, or their use in the manufacture of a pharmaceutical or nutraceutical formulation for said treatment. The invention relates also to said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disorder, disorder or condition, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment. They can also be used for non-therapeutic, e.g. cosmetic, purposes only.
摘要翻译：本发明涉及分别使用提取物和/或特别是一种或多种天然螺三萜类化合物及其衍生物的用途或方法（特别是涉及动物，特别是人类，需要这种治疗）特别是从作为活性成分的单独或作为补充剂的姬松茸物种获得的风疹家族，用于预防和/或治疗治疗响应肝脏X受体的调节的疾病，病症或病症，在人或其他哺乳动物和/或使用所述提取物和/或天然化合物或混合物来治疗所述疾病，病症或病症，以及相应的治疗方法或其在制造药物或制剂中的用途用于所述治疗的营养制剂。本发明还涉及用于治疗或制备用于预防和/或治疗所述病症，障碍或病症的药物（包括营养药物）的所述提取物和/或化合物，以及他们的准备。它还涉及包含可用于所述预防和/或治疗性治疗的所述提取物和/或天然化合物的药物或营养制剂。它们也可以用于非治疗性的，例如，化妆品，用途。

3. 发明申请

WO2011085979A4 USE OF TRICYCLIC SESQUITERPENE LACTONES IN THE TREATMENT OF OBESITY AND RELATED DISEASES AND NON-THERAPEUTIC TREATABLE CONDITIONS 审中-公开
标题翻译：三环十二碳烯内酯在治疗肥胖和相关疾病中的用途以及非治疗性治疗条件
公开(公告)号：WO2011085979A4
公开(公告)日：2011-09-29
申请号：PCT/EP2011000110
申请日：2011-01-13
申请人： INTERMED DISCOVERY GMBH , GROTHE TORSTEN , ROEMER ERNST , WABNITZ PHILIPP
发明人： GROTHE TORSTEN , ROEMER ERNST , WABNITZ PHILIPP
IPC分类号： C07D307/93 , A61K8/49 , A61K31/343 , A61P3/04 , A61P3/06
CPC分类号： C07D307/93 , A61K8/4973 , A61K8/97 , A61K31/365 , A61K36/28 , A61Q19/06
摘要： A compound of the formula I, wherein the symbols are as defined in the remaining specification, or a mixture of two or more compounds of the formula I, for use as active ingredient in the therapeutic - including prophylactic - treatment of a warm-blooded animal for the regulation of body weight (preferred) and/or fat loss (preferred) and/or for the management of obesity and/or for improving the total cholesterol HDL/LDL ratio; where the compound(s) of the formula I may be present in free form, in the form of a pharmaceutically and/or nutraceutically acceptable salt, in the form of tautomers, in the form of esters and/or in the form of solvates, as well as related invention embodiments.
摘要翻译：其中符号如其余说明书中所定义的式I化合物或两种或多种式I化合物的混合物用作治疗剂（包括预防性治疗温血动物）中的活性成分用于调节体重（优选）和/或脂肪损失（优选）和/或用于控制肥胖和/或用于改善总胆固醇HDL / LDL比率; 其中式I化合物可以以游离形式存在，以药学和/或营养食品可接受的盐形式，以互变异构体形式，以酯形式和/或以溶剂合物形式存在，以及相关的发明实施例。

4. 发明申请

WO2010063451A2 PRODUCTION OF OMEGA-3 FATTY ACIDS BY MYXOBACTERIA 审中-公开
标题翻译：通过MYXOBACTERIA生产OMEGA-3脂肪酸
公开(公告)号：WO2010063451A2
公开(公告)日：2010-06-10
申请号：PCT/EP2009008560
申请日：2009-12-01
申请人： INTERMED DISCOVERY GMBH , STADLER MARC , ROEMER ERNST , MUELLER ROLF , GARCIA RONALD O , PISTORIUS DOMINIK , BRACHMANN ALEXANDER
发明人： STADLER MARC , ROEMER ERNST , MUELLER ROLF , GARCIA RONALD O , PISTORIUS DOMINIK , BRACHMANN ALEXANDER
IPC分类号： C12P7/64
CPC分类号： C12P7/6427 , C12R1/01
摘要： The present invention provides a method for producing ?-3 polyunsaturated fatty acids by culturing specific myxobacterial stains and myxobacterial strains suitable for said method.
摘要翻译：本发明提供通过培养适用于所述方法的特异性粘液细菌染色剂和粘液菌菌株来生产α-3多不饱和脂肪酸的方法。

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