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1. 发明申请

WO2013023891A1 OLEANENE-TYPE TRITERPENE GLYCOSIDES AS MASKING AGENTS 审中-公开
标题翻译： OLEANENE型TRITERPENE GLYCOSIDES作为掩蔽剂
公开(公告)号：WO2013023891A1
公开(公告)日：2013-02-21
申请号：PCT/EP2012/064668
申请日：2012-07-26
申请人： SYMRISE AG , HANS, Joachim , MOLDENHAUER, Jana , BITZER, Jens , KÖPCKE, Bärbel , ROEMER, Ernst
发明人： HANS, Joachim , MOLDENHAUER, Jana , BITZER, Jens , KÖPCKE, Bärbel , ROEMER, Ernst
IPC分类号： A23L1/22
CPC分类号： A23G3/36 , A23F3/14 , A23F3/163 , A23F5/40 , A23G1/32 , A23L27/84 , A23L27/86
摘要： The present invention relates to the use of certain oleanene-type triterpene glycosides of formula (I) and/or physiologically acceptable salts thereof formula (I) wherein M is hydrogen or hydroxyl, preferably hydroxyl, and A is a carbohydrate moiety, preferably an oligosaccharide moiety, for modifying (i.e. modulating) or masking (i.e. reducing or suppressing) unpleasant taste impressions, in particular bitter and/or astringent taste impressions and to a corresponding method for modulating or masking an unpleasant taste of a substance or substance mixture. The present invention also relates to compositions, in particular orally consumable compositions, comprising (a) one or more compounds of formula (I) or a physiologically acceptable salt thereof, and (b) one or more substances with unpleasant taste, in particular bitter and/or astringent taste.
摘要翻译：本发明涉及式（I）的某些烯烃型三萜糖苷和/或式（I）的生理学上可接受的盐，其中M是氢或羟基，优选羟基，A是碳水化合物部分，优选低聚糖部分，用于改变（即调节）或掩蔽（即，减少或抑制）令人不快的味觉印象，特别是苦味和/或涩味的印象，以及用于调节或掩蔽物质或物质混合物的不愉快味道的相应方法。本发明还涉及组合物，特别是口服消耗品组合物，其包含（a）一种或多种式（I）化合物或其生理学上可接受的盐，和（b）一种或多种具有不愉快味道的物质，特别是苦味和 /或涩味。

2. 发明申请

WO2010110647A1 AURONES AS ESTROGEN RECEPTOR MODULATORS AND THEIR USE IN SEX HORMONE DEPENDENT DISEASES 审中-公开
标题翻译：作为雌激素受体调节剂的神经元及其在性别依赖性疾病中的应用
公开(公告)号：WO2010110647A1
公开(公告)日：2010-09-30
申请号：PCT/MY2010/000035
申请日：2010-03-24
申请人： BIOTROPICS MALAYSIA BERHAD , V.K. GEORGE, Annie, George , KÖPCKE, Bärbel , ROEMER, Ernst , BITZER, Jens , HANS, Joachim , GRUENWALD, Joerg , GEHLING, Matthias , WABNITZ, Philipp , TENGKU ADNAN, Tengku, Shahrir , GROTHE, Torsten
发明人： V.K. GEORGE, Annie, George , KÖPCKE, Bärbel , ROEMER, Ernst , BITZER, Jens , HANS, Joachim , GRUENWALD, Joerg , GEHLING, Matthias , WABNITZ, Philipp , TENGKU ADNAN, Tengku, Shahrir , GROTHE, Torsten
IPC分类号： C07D307/83 , C07D407/04 , A61K31/343 , A61P25/00
CPC分类号： C07D307/83 , C07D407/04
摘要： The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with an estrogen receptor (ER) related disease or condition of the animal or human body, as well as methods, uses and other inventions related thereto.
摘要翻译：本发明涉及包含它们可用于预防和/或治疗具有雌激素受体（ER）相关疾病或动物或人体的病症的动物（包括人））的赭色和提取物以及方法，用途和其他有关的发明。

3. 发明申请

WO2012079721A8 TERPENOID SPIRO KETAL COMPOUNDS WITH LXR AGONISTS ACTIVITY, THEIR USE AND FORMULATIONS WITH THEM 审中-公开
公开(公告)号：WO2012079721A8
公开(公告)日：2012-06-21
申请号：PCT/EP2011/006157
申请日：2011-12-08
申请人： INTERMED DISCOVERY GMBH , GROTHE, Torsten , STADLER, Marc , KÖPCKE, Bärbel , ROEMER, Ernst , BITZER, Jens , WABNITZ, Philipp , KÜPER, Thomas
发明人： GROTHE, Torsten , STADLER, Marc , KÖPCKE, Bärbel , ROEMER, Ernst , BITZER, Jens , WABNITZ, Philipp , KÜPER, Thomas
IPC分类号： A61K9/00 , A61K9/08 , A61K9/10 , A61K31/56 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P25/28
摘要： The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, respectively, of an extract and/or especially one or more natural spiro triterpenoids and derivatives thereof, especially from the blazeispirol family, obtainable from Agaricus species, alone or as supplement, as active ingredient in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, either in humans or in other mammals, and/or to the use of said extract and/or natural compound(s) or mixtures for the treatment of said disease, disorder or condition, as well as corresponding methods of treatment, or their use in the manufacture of a pharmaceutical or nutraceutical formulation for said treatment. The invention relates also to said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disorder, disorder or condition, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment. They can also be used for non-therapeutic, e.g. cosmetic, purposes only.

4. 发明申请

WO2010110646A1 AURONES AS SELECTIVE PDE INHIBITORS AND THEIR USE IN NEUROLOGICAL CONDITIONS AND DISORDERS 审中-公开
标题翻译： AURONES作为选择性PDE抑制剂及其在神经病症和疾病中的应用
公开(公告)号：WO2010110646A1
公开(公告)日：2010-09-30
申请号：PCT/MY2010/000034
申请日：2010-03-24
申请人： BIOTROPICS MALAYSIA BERHAD , V.K. GEORGE, Annie George , KÖPCKE, Bärdel , ROEMER, Ernst , BITZER, Jens , GRUENWALD, Joerg , GEHLING, Matthias , WABNITZ, Philipp , TENGKU ADNAN, Tengli Shahrir , GROTHE, Torsten
发明人： V.K. GEORGE, Annie George , KÖPCKE, Bärdel , ROEMER, Ernst , BITZER, Jens , GRUENWALD, Joerg , GEHLING, Matthias , WABNITZ, Philipp , TENGKU ADNAN, Tengli Shahrir , GROTHE, Torsten
IPC分类号： C07D307/83 , C07D407/04 , A61K31/343 , A61P25/00
CPC分类号： C07D307/83 , C07D407/04
摘要： The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with a phosphodiesterase (PDE) dependent disease or condition of the central nervous system, as well as methods, uses and other inventions related thereto.
摘要翻译：本发明涉及用于预防和/或治疗具有磷酸二酯酶（PDE）依赖性疾病或中枢神经系统病症的动物（包括人类）的噢ones和包含它们的提取物，以及与之相关的方法，用途和其他发明。

5. 发明申请

WO2010063451A3 PRODUCTION OF OMEGA-3 FATTY ACIDS BY MYXOBACTERIA 审中-公开
公开(公告)号：WO2010063451A3
公开(公告)日：2010-06-10
申请号：PCT/EP2009/008560
申请日：2009-12-01
申请人： INTERMED DISCOVERY GMBH , STADLER, Marc , ROEMER, Ernst , MÜLLER, Rolf , GARCIA, Ronald O. , PISTORIUS, Dominik , BRACHMANN, Alexander
发明人： STADLER, Marc , ROEMER, Ernst , MÜLLER, Rolf , GARCIA, Ronald O. , PISTORIUS, Dominik , BRACHMANN, Alexander
IPC分类号： C12P7/64 , C12N1/20
摘要： The present invention provides a method for producing ω-3 polyunsaturated fatty acids by culturing specific myxobacterial stains and myxobacterial strains suitable for said method.

6. 发明申请

WO2011085979A1 USE OF TRICYCLIC SESQUITERPENE LACTONES IN THE TREATMENT OF OBESITY AND RELATED DISEASES AND NON-THERAPEUTIC TREATABLE CONDITIONS 审中-公开
标题翻译：在治疗肥胖和相关疾病和非治疗可治疗条件下使用三酯酸酯酶
公开(公告)号：WO2011085979A1
公开(公告)日：2011-07-21
申请号：PCT/EP2011/000110
申请日：2011-01-13
申请人： INTERMED DISCOVERY GMBH , GROTHE, Torsten , ROEMER, Ernst , WABNITZ, Philipp
发明人： GROTHE, Torsten , ROEMER, Ernst , WABNITZ, Philipp
IPC分类号： C07D307/93 , A61K31/343 , A61P3/04 , A61P3/06 , A61K8/49
CPC分类号： C07D307/93 , A61K8/4973 , A61K8/97 , A61K31/365 , A61K36/28 , A61Q19/06
摘要： A compound of the formula I, wherein the symbols are as defined in the remaining specification, or a mixture of two or more compounds of the formula I, for use as active ingredient in the therapeutic - including prophylactic - treatment of a warm-blooded animal for the regulation of body weight (preferred) and/or fat loss (preferred) and/or for the management of obesity and/or for improving the total cholesterol HDL/LDL ratio; where the compound(s) of the formula I may be present in free form, in the form of a pharmaceutically and/or nutraceutically acceptable salt, in the form of tautomers, in the form of esters and/or in the form of solvates, as well as related invention embodiments.
摘要翻译：式I的化合物，其中符号如剩余说明书中所定义，或两种或更多种式I化合物的混合物，用作治疗性包括预防性治疗温血动物的活性成分用于调节体重（优选）和/或脂肪减少（优选）和/或用于管理肥胖症和/或改善总胆固醇HDL / LDL比率; 其中式I的化合物可以以互变异构体的形式，以酯和/或溶剂合物的形式以游离形式存在，以药物和/或营养学上可接受的盐的形式存在，以及相关的发明实施例。

7. 发明申请

WO2009021622A1 EXTRACTS WITH LIVER-X-RECEPTOR MODULATORS, COMPOUNDS AND THEIR USE ESPECIALLY IN WEIGHT CONTROL 审中-公开
标题翻译：与肝脏受体调节剂，化合物及其在体重控制中特别有用的提取物
公开(公告)号：WO2009021622A1
公开(公告)日：2009-02-19
申请号：PCT/EP2008/006226
申请日：2008-07-29
申请人： INTERMED DISCOVERY GMBH , GROTHE, Torsten , ROEMER, Ernst , HENKEL, Thomas
发明人： GROTHE, Torsten , ROEMER, Ernst , HENKEL, Thomas
IPC分类号： A61K31/085 , A61K31/215 , A61K31/343 , A61K36/79 , A61K36/57 , A61P3/04 , A61P3/06
CPC分类号： A61K31/36 , A61K31/085 , A61K31/09 , A61K31/215 , A61K31/222 , A61K31/343 , A61K36/57 , A61K36/79
摘要： The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, of an extract and/or one or more natural compounds from plants or parts of plants, respectively, from a genus selected from the group consisting of Schisandra , Illicium , Kadsura, Steganotaenia and Magnolia , alone or as supplement, as active ingredient in the regulation of body weight and/or fat loss and/or for the management of obesity, either in humans or in animals, to the use of said extract and/or natural compound(s) or mixtures in the manufacture of a pharmaceutical or nutraceutical formulation for the regulation of body weight and/or fat loss and/or for the management of obesity either in humans or in animals. The above extract and/or compound(s) can further be used to reduce one or more adverse metabolic parameters in a subject. The invention relates also to said extract and/or compound(s) for use in the treatment or in the preparation of a medicament for the treatment of obesity, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in the regulation of body weight and/or fat loss and/or for the management of obesity.
摘要翻译：本发明涉及分别使用来自植物或植物部分的提取物和/或一种或多种天然化合物的用途或方法（特别是关于动物，特别是人类），选自五味子，Illicium，Kadsura，Steganotaenia和Magnolia的属，单独或作为补充作为活性成分，用于调节体重和/或脂肪减少和/或用于肥胖的管理，人或动物中使用所述提取物和/或天然化合物或混合物来制造用于调节体重和/或脂肪损失的药物或营养制剂，和/或用于肥胖的管理在人类或动物中。上述提取物和/或化合物还可用于减少受试者中的一种或多种不利代谢参数。本发明还涉及用于治疗或制备用于治疗肥胖症的药物及其制备的所述提取物和/或化合物。它还涉及包含可用于调节体重和/或脂肪减少和/或用于肥胖的管理的所述提取物和/或天然化合物的药物或营养制剂。

8. 发明申请

WO2012134258A1 CLERODANE DERIVATIVES FOR MODULATION OF LEUKOTRIENE RECEPTOR ACTIVITY AND RELATED DISEASES 审中-公开
标题翻译：调节白介素受体活性和相关疾病的CLDEODANE衍生物
公开(公告)号：WO2012134258A1
公开(公告)日：2012-10-04
申请号：PCT/MY2012/000033
申请日：2012-02-28
申请人： BIOTROPICS MALAYSIA BERHAD , GEHLING, Matthias , GROTHE, Torsten , ROEMER, Ernst , REINEMER, Peter , REINHARDT, Kathrin , GEORGE, Annie , MOHTAR, Nur Hanisah , SAPIAI, Noorsyarida Mohd
发明人： GEHLING, Matthias , GROTHE, Torsten , ROEMER, Ernst , REINEMER, Peter , REINHARDT, Kathrin , GEORGE, Annie , MOHTAR, Nur Hanisah , SAPIAI, Noorsyarida Mohd
IPC分类号： A61K31/34 , A61K31/37 , A61P29/00 , C07D307/40
CPC分类号： C07D407/08 , C07D407/04 , C07H17/08
摘要： The use or methods of use of extracts comprising one or more special clerodane compounds against inflammatory (including allergic) diseases or conditions, as well as novel compounds of this type, said clerodane derivatives for use against inflammatory (including allergic) diseases or conditions, pharmaceutical formulations comprising them especially for use against inflammatory disease or conditions, and related embodiments; said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disease or condition, as well as their preparation; pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment, and related embodiments.
摘要翻译：使用或使用包含一种或多种抗炎症（特别是过敏性）疾病或病症的特殊克洛膦酸化合物的提取物以及这种新型化合物的用途或用途，所述用于抗炎症（包括过敏性）疾病或病症的氯化丹烷衍生物，药物包含它们的制剂，特别是用于抗炎性疾病或病症，以及相关实施方案; 所述提取物和/或化合物用于治疗或制备用于预防和/或治疗所述疾病或病症的药物（包括营养药物）及其制备; 包含可用于所述预防和/或治疗性治疗的所述提取物和/或天然化合物的药物或营养制剂以及相关实施方案。

9. 发明申请

WO2008074420A1 PLANTS EXTRACTS FOR USE IN BRAIN MODULATION 审中-公开
标题翻译：植物提取物用于脑调节
公开(公告)号：WO2008074420A1
公开(公告)日：2008-06-26
申请号：PCT/EP2007/010808
申请日：2007-12-11
申请人： INTERMED DISCOVERY GMBH , ROEMER, Ernst , GROTHE, Torsten
发明人： ROEMER, Ernst , GROTHE, Torsten
IPC分类号： C07C47/542 , A61K31/11 , A61P25/28
CPC分类号： C07C47/57 , C07C47/575 , C07C49/757 , C07C49/83 , C07C49/84
摘要： Compounds obtainable from plants, e.g. of the genus Eucalyptus , or from microorganisms are shown to be useful as CNS activity modulators useful e.g. in the treatment of depression, for lifting mood and/or for increasing behavioural initiative and the like. This use and related aspects form embodiments of the invention. Also compounds as such are presented. The compounds useful are acylphloroglucine derivatives of the formula (I) wherein the substituents are as defined in the description.
摘要翻译：可从植物获得的化合物。的桉树属或微生物被证明可用作CNS活性调节剂，例如有用的。用于治疗抑郁症，提高心情和/或增加行为主动性等。该用途和相关方面形成本发明的实施例。还提出了这样的化合物。可用的化合物是式（I）的酰基衍生物，其中取代基如说明书中所定义。

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