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1. 发明申请

WO2013133685A8 EXTRACT FORMULATIONS OF RHODAMNIA CINEREA AND USES THEREOF 审中-公开
标题翻译：罗丹明氏菌的提取制剂及其用途
公开(公告)号：WO2013133685A8
公开(公告)日：2013-10-10
申请号：PCT/MY2012000048
申请日：2012-03-09
申请人： BIOTROPICS MALAYSIA BERHAD , GEHLING MATTHIAS , KOEPCKE BAERBEL , KUEPER THOMAS , REINHARDT KATHRIN , REINEMER PETER , GEORGE ANNIE , CHINNAPPAN SASIKALA , MD AKIR MAZRIA HASLINA
发明人： GEHLING MATTHIAS , KOEPCKE BAERBEL , KUEPER THOMAS , REINHARDT KATHRIN , REINEMER PETER , GEORGE ANNIE , CHINNAPPAN SASIKALA , MD AKIR MAZRIA HASLINA
IPC分类号： A61K36/61 , A61P3/10
CPC分类号： A61K36/61 , A23L33/105 , A23V2002/00 , A61K45/06 , A61K2236/33
摘要： The present invention primarily relates to the use of certain extract formulations of Rhodamnia cinerea as defined herein as alpha-amylase inhibitors and as actives for the therapeutic (including prophylactic) treatment of a carbohydrate metabolic disorder or of a disease attendant on hyperglycemia, preferably selected from the group consisting of prediabetes, obesity, hyperlipemia, arteriosclerosis, arteriolosclerosis, atherosclerosis, diabetes, postprandial hyperglycemia, and metabolic syndrome. The present invention also relates to corresponding methods. The invention further relates to specific extract formulations obtainable from Rhodamnia cinerea and to compositions, in particular orally consumable compositions, comprising an effective amount of such an extract formulation.
摘要翻译：本发明主要涉及本文定义的灰葡萄糖苷的某些提取物制剂在α-淀粉酶抑制剂中的用途，以及用于治疗（包括预防）治疗碳水化合物代谢紊乱或伴随高血糖症的疾病的活性物质，优选选自由糖尿病前期，肥胖，高脂血症，动脉硬化，动脉硬化，动脉粥样硬化，糖尿病，餐后高血糖症和代谢综合征组成的组。本发明还涉及相应的方法。本发明还涉及可从灰葡萄球菌获得的特定提取物制剂以及包含有效量的这种提取物制剂的组合物，特别是口服消耗品组合物。

2. 发明申请

WO2012134258A1 CLERODANE DERIVATIVES FOR MODULATION OF LEUKOTRIENE RECEPTOR ACTIVITY AND RELATED DISEASES 审中-公开
标题翻译：调节白介素受体活性和相关疾病的CLDEODANE衍生物
公开(公告)号：WO2012134258A1
公开(公告)日：2012-10-04
申请号：PCT/MY2012/000033
申请日：2012-02-28
申请人： BIOTROPICS MALAYSIA BERHAD , GEHLING, Matthias , GROTHE, Torsten , ROEMER, Ernst , REINEMER, Peter , REINHARDT, Kathrin , GEORGE, Annie , MOHTAR, Nur Hanisah , SAPIAI, Noorsyarida Mohd
发明人： GEHLING, Matthias , GROTHE, Torsten , ROEMER, Ernst , REINEMER, Peter , REINHARDT, Kathrin , GEORGE, Annie , MOHTAR, Nur Hanisah , SAPIAI, Noorsyarida Mohd
IPC分类号： A61K31/34 , A61K31/37 , A61P29/00 , C07D307/40
CPC分类号： C07D407/08 , C07D407/04 , C07H17/08
摘要： The use or methods of use of extracts comprising one or more special clerodane compounds against inflammatory (including allergic) diseases or conditions, as well as novel compounds of this type, said clerodane derivatives for use against inflammatory (including allergic) diseases or conditions, pharmaceutical formulations comprising them especially for use against inflammatory disease or conditions, and related embodiments; said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disease or condition, as well as their preparation; pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment, and related embodiments.
摘要翻译：使用或使用包含一种或多种抗炎症（特别是过敏性）疾病或病症的特殊克洛膦酸化合物的提取物以及这种新型化合物的用途或用途，所述用于抗炎症（包括过敏性）疾病或病症的氯化丹烷衍生物，药物包含它们的制剂，特别是用于抗炎性疾病或病症，以及相关实施方案; 所述提取物和/或化合物用于治疗或制备用于预防和/或治疗所述疾病或病症的药物（包括营养药物）及其制备; 包含可用于所述预防和/或治疗性治疗的所述提取物和/或天然化合物的药物或营养制剂以及相关实施方案。

3. 发明申请

WO2010110647A1 AURONES AS ESTROGEN RECEPTOR MODULATORS AND THEIR USE IN SEX HORMONE DEPENDENT DISEASES 审中-公开
标题翻译：作为雌激素受体调节剂的神经元及其在性别依赖性疾病中的应用
公开(公告)号：WO2010110647A1
公开(公告)日：2010-09-30
申请号：PCT/MY2010/000035
申请日：2010-03-24
申请人： BIOTROPICS MALAYSIA BERHAD , V.K. GEORGE, Annie, George , KÖPCKE, Bärbel , ROEMER, Ernst , BITZER, Jens , HANS, Joachim , GRUENWALD, Joerg , GEHLING, Matthias , WABNITZ, Philipp , TENGKU ADNAN, Tengku, Shahrir , GROTHE, Torsten
发明人： V.K. GEORGE, Annie, George , KÖPCKE, Bärbel , ROEMER, Ernst , BITZER, Jens , HANS, Joachim , GRUENWALD, Joerg , GEHLING, Matthias , WABNITZ, Philipp , TENGKU ADNAN, Tengku, Shahrir , GROTHE, Torsten
IPC分类号： C07D307/83 , C07D407/04 , A61K31/343 , A61P25/00
CPC分类号： C07D307/83 , C07D407/04
摘要： The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with an estrogen receptor (ER) related disease or condition of the animal or human body, as well as methods, uses and other inventions related thereto.
摘要翻译：本发明涉及包含它们可用于预防和/或治疗具有雌激素受体（ER）相关疾病或动物或人体的病症的动物（包括人））的赭色和提取物以及方法，用途和其他有关的发明。

4. 发明申请

WO2021020961A1 EXTRACT OF PERSICARIA MINOR AND USE FOR TREATING OR ALLEVIATING SYMPTOMS AND/OR CONDITIONS ASSOCIATED WITH HYPERURICEMIA 审中-公开
公开(公告)号：WO2021020961A1
公开(公告)日：2021-02-04
申请号：PCT/MY2019/050039
申请日：2019-07-31
申请人： BIOTROPICS MALAYSIA BERHAD
发明人： TENGKU ADNAN, Tengku Shahrir , GEORGE, Annie , M. CHINNAPPAN, Sasikala
IPC分类号： A61K36/70 , A61P19/06 , A23L33/105
摘要： The present invention is directed to a new kind of medicinal value or health care function of Persicaria minor extracts, particularly in the treatment or alleviation symptoms and/or conditions associated to hyperuricemia, including gout and its related symptoms. In one aspect, the present invention discloses the use of a composition comprising a therapeutically effective amount of Persicaria minor extract in the manufacture of a medicament for the alleviation or treatment of symptoms and/or conditions associated to hyperuricemia, including gout and its related symptoms. The alleviation or treatment of the symptoms and/or conditions according to the present invention is characterised by inducing a change in the uric acid content of the blood. Also disclosed is the use of a pharmaceutical composition comprising the therapeutically effective amount of Persicaria minor extract.

5. 发明申请

WO2014035233A1 A COMPOSITION FOR COGNITION AND COSMESTIC PURPOSES 审中-公开
标题翻译：用于认知和成人用途的组合物
公开(公告)号：WO2014035233A1
公开(公告)日：2014-03-06
申请号：PCT/MY2013/000033
申请日：2013-02-26
申请人： BIOTROPICS MALAYSIA BERHAD
发明人： V. K. GEORGE, Annie George , YEE, Kar Ming
IPC分类号： A61K8/97 , A61Q19/08 , A61Q19/00
CPC分类号： A61K36/704 , A61K8/498 , A61K8/602 , A61K8/97 , A61K31/352 , A61K31/7048 , A61K2800/522 , A61K2800/84 , A61Q19/00 , A61Q19/08
摘要： The present invention is related to a composition containing an extract from the Polygonum minus for cognition and cosmetic purposes. The method of obtaining the said extract from the Polygonum minus is also disclosed. In another preferred embodiment, the cognition and cosmetic composition contains extract of Polygonum minus comprise a combination of compounds characterized by presence of quercetin-3-glucuronide and quercitrin. In another preferred embodiment, wherein the amount of said extract of Polygonum minu s is selected based on its having efficacy in prevention of oxidative damage demonstrated by a high antioxidant value and Cell-based Antioxidant Protection in an Erythrocyte model (CAP-e assay). In another preferred embodiment, there is provided a process for isolation of an active extract from Polygonum minus comprising the steps of a) subjecting the said Polygonum minus including aerial parts of the plant including stem and/or leaves to solvent extraction preferably with a material solvent ratio of 1: 10-20 by percolation at a temperature range of 70-105° C preferably 80° C to obtain the extract; and b) filtering the extract obtained from step (a) above followed by concentration and drying involving freeze drying, spray drying or vacuum belt drying to obtain therefrom the dry extract powder.
摘要翻译：本发明涉及含有Poly提取物减去认知和美容目的的组合物。还公开了从um子减去获得所述提取物的方法。在另一个优选的实施方案中，认知和化妆品组合物含有contains contains提取物，其中包括以槲皮素-3-葡糖苷酸和槲皮素的存在为特征的化合物的组合。在另一个优选实施方案中，其中所述um said提取物的量基于其在预防由高抗氧化剂值和红细胞模型中的基于细胞的抗氧化保护（CAP-e测定）证实的氧化损伤方面的功效而选择。在另一个优选的实施方案中，提供了一种从Poly for中分离活性提取物的方法，包括以下步骤：a）优选用物质溶剂对所述um素包括植物（包括茎和/或叶）的包括地上部分进行溶剂萃取比例为1:10-20，通过在70-105℃，优选80℃的温度范围内渗滤，得到提取物; 和b）过滤由上述步骤（a）获得的提取物，然后进行浓缩和干燥，包括冷冻干燥，喷雾干燥或真空带干燥，由此获得干提取物粉末。

6. 发明申请

WO2010110646A8 AURONES AS SELECTIVE PDE INHIBITORS AND THEIR USE IN NEUROLOGICAL CONDITIONS AND DISORDERS 审中-公开
标题翻译：作为选择性PDE抑制剂的AURONES及其在神经病学和病症中的使用
公开(公告)号：WO2010110646A8
公开(公告)日：2010-10-28
申请号：PCT/MY2010000034
申请日：2010-03-24
申请人： BIOTROPICS MALAYSIA BERHAD , V K GEORGE ANNIE GEORGE , KOEPCKE BAERDEL , ROEMER ERNST , BITZER JENS , GRUENWALD JOERG , GEHLING MATTHIAS , WABNITZ PHILIPP , TENGKU ADNAN TENGKU SHAHRIR , GROTHE TORSTEN
发明人： V K GEORGE ANNIE GEORGE , KOEPCKE BAERDEL , ROEMER ERNST , BITZER JENS , GRUENWALD JOERG , GEHLING MATTHIAS , WABNITZ PHILIPP , TENGKU ADNAN TENGKU SHAHRIR , GROTHE TORSTEN
IPC分类号： C07D307/83 , A61K31/343 , A61P25/00 , C07D407/04
CPC分类号： C07D307/83 , C07D407/04
摘要： The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with a phosphodiesterase (PDE) dependent disease or condition of the central nervous system, as well as methods, uses and other inventions related thereto.
摘要翻译：本发明涉及包含它们的可用于预防和/或治疗具有磷酸二酯酶（PDE）依赖性疾病或中枢神经系统状况的动物（包括人）以及方法，用途和其它与此相关的发明。

7. 发明申请

WO2013112040A1 USE OF CERTAIN TRIOXYGENATED BENZENE DERIVATIVES IN BODY FAT MANAGEMENT 审中-公开
标题翻译：某些三氧化硫苯甲酸衍生物在体内脂肪管理中的应用
公开(公告)号：WO2013112040A1
公开(公告)日：2013-08-01
申请号：PCT/MY2012/000008
申请日：2012-01-27
申请人： BIOTROPICS MALAYSIA BERHAD , BITZER, Jens , GEHLING, Matthias , GROTHE, Torsten , KÖPCKE, Bärbel , WÖHRLE, Ingo , V.K. GEORGE, Annie George , CHINNAPPAN, Sasikala , MD AKIR, Mazria Haslina
发明人： BITZER, Jens , GEHLING, Matthias , GROTHE, Torsten , KÖPCKE, Bärbel , WÖHRLE, Ingo , V.K. GEORGE, Annie George , CHINNAPPAN, Sasikala , MD AKIR, Mazria Haslina
IPC分类号： A61K8/34 , A61K8/37 , A61K8/97 , A61Q19/06
CPC分类号： A61Q19/06 , A61K8/347 , A61K8/375 , A61K8/97
摘要： The invention primarily relates to the use of certain trioxygenated benzene derivatives of formula (I) or a corresponding plant extract as body fat modulating agents, preferably as anti-cellulite actives and/or for the reduction of the body fat content, in particular for reduction of body weight and/or for the management of obesity. The present invention also relates to corresponding methods and to certain novel compounds of formula (I). The invention further relates to specific plant extract formulations obtainable from a plant of the family Myrsinaceae, preferably from the genus Labisia, and to compositions, in particular cosmetic or pharmaceutical formulations, comprising an effective amount of one or more compounds of formula (I) or of a corresponding plant extract formulation.
摘要翻译：本发明主要涉及式（I）的某些三氧化苯衍生物或相应的植物提取物作为体内脂肪调节剂的用途，优选作为抗脂肪团活性物质和/或用于减少体内脂肪含量，特别是用于还原的体重和/或用于肥胖的管理。本发明还涉及相应的方法和某些新的式（I）化合物。本发明还涉及从芝麻科（Myrsinaceae）的植物，优选来自Labisia的植物获得的特定植物提取物制剂，以及包含有效量的一种或多种式（I）化合物或其组合物，特别是化妆品或药物制剂的组合物，的相应的植物提取物制剂。

8. 发明申请

WO2012105823A1 COSMETIC NON THERAPEUTIC USE OF EXTRACTS FROM FICUS DELTOIDEA 审中-公开
标题翻译：来自FICUS DELTOIDEA的提取物的化妆品非治疗用途
公开(公告)号：WO2012105823A1
公开(公告)日：2012-08-09
申请号：PCT/MY2011/000008
申请日：2011-02-02
申请人： BIOTROPICS MALAYSIA BERHAD , BITZER, Jens , WABNITZ, Philipp , GEHLING, Matthias , REINEMER, Peter
发明人： BITZER, Jens , WABNITZ, Philipp , GEHLING, Matthias , REINEMER, Peter
IPC分类号： A61K8/97 , A61Q19/00
CPC分类号： A61K8/97 , A61Q19/08
摘要： The present invention is focused on the use of a topic dermatologic composition for improving the cosmetic appearance of skin, comprising improving the microcirculation in skin by applying said composition to skin where the composition comprises a hydrophilic extract from Ficus deltoidea or parts thereof.
摘要翻译：本发明专注于使用主题皮肤病学组合物来改善皮肤的美容外观，包括通过将所述组合物施用于组合物包含来自榕属的亲水性提取物或其部分的皮肤来改善皮肤微循环。

9. 发明申请

WO2011078652A1 ORTHOSIPHON STAMINEUS EXTRACTS WITH BENEFICIAL USE AS COGNITION ENHANCER 审中-公开
标题翻译： ORTHOSIPHON STAMINEUS提取物作为加强剂的有益使用
公开(公告)号：WO2011078652A1
公开(公告)日：2011-06-30
申请号：PCT/MY2010/000327
申请日：2010-12-20
申请人： BIOTROPICS MALAYSIA BERHAD , GEHLING, Matthias , GROTHE, Torsten , HANS, Joachim , WABNITZ, Philipp , V.K. GEORGE, Annie, George , TENGKU ADNAN, Tengku, Shahrir , ZAMRI, Rozita
发明人： GEHLING, Matthias , GROTHE, Torsten , HANS, Joachim , WABNITZ, Philipp , V.K. GEORGE, Annie, George , TENGKU ADNAN, Tengku, Shahrir , ZAMRI, Rozita
IPC分类号： A61K36/53 , A61P25/28
CPC分类号： A61K36/53 , A61K31/235
摘要： The present invention relates to the use of compounds of isopimarane diterpene type, e.g. obtainable as or from extracts from Orthosiphon species, especially certain enriched or purified specific compounds therefrom, as well as said compounds or extracts for use or methods of using said compounds or extracts in the management of cognitive performance; in mammals, especially humans, respectively. The isopimarane diterpene type compounds can be of the formula wherein the symbols are as defined in the description and claims.
摘要翻译：本发明涉及异戊二烯二萜类化合物的用途，例如，可从Orthosiphon物种的提取物获得，特别是其中一些富集或纯化的特异性化合物，以及用于使用的所述化合物或提取物或使用所述化合物或提取物来管理认知表现的方法; 分别在哺乳动物，特别是人类。异戊二烯二萜类化合物可以具有下式，其中符号如说明书和权利要求书中所定义。

10. 发明申请

WO2016036232A3 EURYCOMA LONGIFOLIA EXTRACT AND ITS USE IN ENHANCING AND/OR STIMULATING IMMUNE SYSTEM 审中-公开
标题翻译： EURYCOMA LONGIFOLIA提取物及其在增强和/或刺激免疫系统中的用途
公开(公告)号：WO2016036232A3
公开(公告)日：2016-04-28
申请号：PCT/MY2015050094
申请日：2015-08-28
申请人： BIOTROPICS MALAYSIA BERHAD
发明人： GEORGE ANNIE , KAWASAKI YUUKI , ABAS AZREENA
IPC分类号： A61K36/185 , A61K8/97 , A61P37/00 , A61Q19/08
CPC分类号： A61K36/185
摘要： The present invention discloses the use of a composition comprising an effective amount of an extract of Eurycoma longifolia for the production of a preparation to stimulate and/or enhance the immune system. In a preferred embodiment, the extract comprises active ingredients, which include eurycomanone, protein, polysaccharide and glycosaponin in appropriate amounts. In, another preferred embodiment, the extract has an activity selected from the group consisting of: * increasing the number of T-ceils; * improving Scoring of Immunological Vigor (SIV), a comprehensive index of overall immune function; * lowering the immunological age, a comprehensible form of immune function based on T-celi number and proliferative activity; * reducing fatigue; and * alleviating or reducing stress. Also disclosed is a method of for treating an individual to achieve an outcome selected from the group consisting of increasing the number of T-celis, improving SIV (i.e. a comprehensive index of overall immune function), lowering the immunological age (i.e. a comprehensible form of immune function), reducing fatigue and alleviating or reducing stress comprising administering to the individual an effective amount of an extract of Eurycoma longifolia.
摘要翻译：本发明公开了包含有效量的Eurycoma longifolia提取物的组合物用于制备刺激和/或增强免疫系统的制剂的用途。在一个优选的实施方案中，提取物包含活性成分，其包括适量的eurycomanone，蛋白质，多糖和糖皂苷。在另一个优选的实施方案中，提取物具有选自以下的活性：*增加T-细胞的数量; *提高免疫活力的评分（SIV），这是综合免疫功能的综合指标; *降低免疫年龄，这是基于T细胞数量和增殖活性的免疫功能的可理解形式; *减少疲劳; *减轻或减轻压力。还公开了用于治疗个体以实现选自以下的结果的方法：增加T-细胞的数量，改善SIV（即总体免疫功能的综合指数），降低免疫年龄（即可理解的形式免疫功能），减轻疲劳和减轻或减轻压力，包括给予个体有效量的Eurycoma longifolia提取物。

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