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1. 发明申请

WO2009070605A1 NEEDLE-FREE INJECTION DEVICE WITH NOZZLE AUTO-DISABLE 审中-公开
标题翻译：无喷嘴自动注射装置，带有喷嘴自动禁用
公开(公告)号：WO2009070605A1
公开(公告)日：2009-06-04
申请号：PCT/US2008/084737
申请日：2008-11-25
申请人： BIOJECT INC. , LANDAU, Sergio , WILLIAMSON, Daniel, E. , MARSHALL, John, R.
发明人： LANDAU, Sergio , WILLIAMSON, Daniel, E. , MARSHALL, John, R.
IPC分类号： A61M5/50
CPC分类号： A61M5/30 , A61M5/31511 , A61M5/5066
摘要： A nozzle assembly for a needle-free injection device. The nozzle assembly includes a nozzle body including an injectate chamber and one or more outlet orifices and a plunger configured to move through the injectate chamber toward the one or more outlet orifices. In some embodiments, the plunger includes a first portion and a second portion removably joined by a frangible region. In some embodiments, the plunger includes extensions configured to couple the plunger to a drive assembly of a needle-free injection device.
摘要翻译：用于无针注射装置的喷嘴组件。喷嘴组件包括喷嘴主体，喷嘴主体包括注射室和一个或多个出口孔以及配置成朝向一个或多个出口孔移动通过注射室的柱塞。在一些实施例中，柱塞包括可拆卸地由易碎区域连接的第一部分和第二部分。在一些实施例中，柱塞包括构造成将柱塞耦合到无针注射装置的驱动组件的延伸部。

2. 发明申请

WO2008045161A3 TRIGGERING MECHANISM FOR NEEDLE-FREE INJECTOR 审中-公开
标题翻译：无针注射器的触发机制
公开(公告)号：WO2008045161A3
公开(公告)日：2008-11-13
申请号：PCT/US2007018853
申请日：2007-08-27
申请人： BIOJECT INC , WILLIAMSON DANIEL E , BEYLUND RYAN R
发明人： WILLIAMSON DANIEL E , BEYLUND RYAN R
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2053 , A61M5/50 , A61M2005/3123
摘要： Needle-free hypodermic jet injection devices having an actuation system to effect an injection from a drug delivery system. The actuation system includes an injection force assembly adapted to transmit a driving force to the drug delivery system. The actuation system further includes a trigger assembly adapted to alter the actuation system between a plurality of configurations including a fired configuration in which the injection force assembly transmits a driving force to the drug delivery system. In some embodiments, the device has a recoil restriction system including a restriction member adapted to couple the recoil restriction system to the trigger assembly and a recoil member coupled to the injection force assembly and movable relative to the restriction member. The restriction member limits movement of the recoil member once the recoil member moves a predetermined distance relative to the restriction member.
摘要翻译：无针皮下射流注射装置具有致动系统以实现来自药物输送系统的注射。致动系统包括适于将驱动力传递到药物输送系统的注射力组件。所述致动系统还包括触发器组件，所述触发器组件适于在包括所述注射力组件向所述药物输送系统传输驱动力的击发构造的多个构造之间改变所述致动系统。在一些实施例中，所述装置具有后坐限制系统，所述后坐限制系统包括适于将所述后坐限制系统联接到所述扳机组件的限制构件以及联接到所述注射力组件并且可相对于所述限制构件移动的反冲构件。一旦反冲构件相对于限制构件移动预定距离，限制构件限制反冲构件的移动。

3. 发明申请

WO2005120607A3 NEEDLE-FREE SINGLE-USE CARTRIDGE AND INJECTION SYSTEM 审中-公开
标题翻译：无需单独使用的盒子和注射系统
公开(公告)号：WO2005120607A3
公开(公告)日：2006-11-09
申请号：PCT/US2005019274
申请日：2005-06-01
申请人： BIOJECT INC , LANDAU SERGIO
发明人： LANDAU SERGIO
IPC分类号： A61M5/30 , A61J1/00 , A61J1/20 , A61M5/178
CPC分类号： A61M5/30 , A61J1/201 , A61J1/2096 , A61M5/1782
摘要： A needle-free injection system, including an injection device and a vial adapter. The injection device is configured to be loaded with a dose of injectable fluid and forcibly inject such dose into an injection site. The vial adapter is configured to secure to and selectively seal a vial containing an external supply of injectable fluid. The vial adapter also includes a flexible adapter structure biased into a blocking position. The injection device includes a filling adapter configured to move the flexible adapter structure out of the blocking position to thereby permit the vial adapter and injection device to be secured together in an engaged configuration. In this engaged configuration, a dose of injectable fluid may be drawn from the external supply of injectable fluid into the injection device.
摘要翻译：无针注射系统，包括注射装置和小瓶适配器。注射装置被配置为装载一定剂量的可注射流体，并将这种剂量强制地注入注射部位。小瓶适配器被配置为固定并选择性地密封容纳有可注射流体的外部供应的小瓶。小瓶适配器还包括偏置到阻挡位置的柔性适配器结构。注射装置包括填充适配器，其配置成将柔性适配器结构移动离开阻塞位置，从而允许小瓶适配器和注射装置以接合构型固定在一起。在该接合构造中，可注射流体的剂量可以从外部可注射流体供应到注射装置中。

4. 发明申请

WO2006073394A8 NEEDLE-FREE INJECTION SYSTEM 审中-公开
标题翻译：无针注射系统
公开(公告)号：WO2006073394A8
公开(公告)日：2006-08-31
申请号：PCT/US2005000159
申请日：2005-01-04
申请人： BIOJECT INC , LANDAU SERGIO , WILLIAMSON DANIEL E
发明人： LANDAU SERGIO , WILLIAMSON DANIEL E
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2053 , A61M2005/2013
摘要： A needle-free injection device is described. The injection device includes a user-grippable housing and a syringe assembly movably secured to the housing. The syringe assembly is configured to expel injectable fluid out of a nozzle upon application of pressurized gas to the syringe assembly. The injection device also includes a pressurized gas delivery mechanism disposed within the housing and configured to selectively apply pressurized gas to the syringe assembly. The pressurized gas delivery mechanism is at least partly actuated by pressing the nozzle onto an injection site so that the syringe assembly moves relative to the housing.
摘要翻译：描述无针注射装置。注射装置包括用户可握住的壳体和可移动地固定到壳体的注射器组件。注射器组件构造成在将注射液体施加到注射器组件上时将喷射流体排出喷嘴。注射装置还包括设置在壳体内并被构造成选择性地将加压气体施加到注射器组件的加压气体输送机构。加压气体输送机构至少部分地通过将喷嘴压到注射部位来致动，使得注射器组件相对于壳体移动。

5. 发明申请

WO2006088630A2 NEEDLE-FREE INJECTION DEVICE FOR INDIVIDUAL USERS 审中-公开
标题翻译：针对个体用户的无针注射装置
公开(公告)号：WO2006088630A2
公开(公告)日：2006-08-24
申请号：PCT/US2006/003167
申请日：2006-01-27
申请人： BIOJECT INC. , LANDAU, Sergio , SAUTTER, Christopher , STAYLOR, John, L.
发明人： LANDAU, Sergio , SAUTTER, Christopher , STAYLOR, John, L.
IPC分类号： A61M5/30 , A61M5/00 , A61M5/20 , A61M5/315
CPC分类号： A61M5/30 , A61J1/201 , A61J1/2096 , A61M5/1782 , A61M5/24
摘要： A needle-free injector for injecting fluid from an injection cartridge that has a longitudinal axis, an injection orifice at a distal end and a displaceable plunger. The needle-free injector includes an injector body having a longitudinal axis and a side opening to receive the cartridge from a position laterally offset from the injector body longitudinal axis. The needle-free injector further includes a system disposed in the injector body for providing injection power and a ram for transferring power from the system to the plunger. The ram is disposed in the injector body and is axially aligned with the longitudinal axis of the cartridge when the cartridge is in position in the injector body. The needle-free injector further includes a closure mechanism for closing the side opening of the injector body after the cartridge is in position in the injector body to lock the cartridge in place in the injector body. The disclosure also includes other apparatus and methods as discussed in detail herein.
摘要翻译：用于从具有纵向轴线的注射筒注射流体的无针注射器，在远端的注射孔和可移位的柱塞。无针注射器包括具有纵向轴线和侧面开口的注射器主体，以从从注射器主体纵向轴线横向偏移的位置接收药筒。无针注射器还包括设置在喷射器主体中用于提供喷射功率的系统和用于将功率从系统传递到柱塞的冲头。当药筒在注射器主体中就位时，冲头设置在注射器主体中并且与药筒的纵向轴线轴向对准。无针注射器还包括封闭机构，用于在药筒在注射器主体中的适当位置之后关闭注射器主体的侧开口，以将药筒锁定在注射器主体中的适当位置。本公开还包括如本文详细讨论的其它装置和方法。

6. 发明申请

WO2006009839A2 INTRADERMAL INJECTION SYSTEM FOR INJECTING DNA-BASED INJECTABLES INTO HUMANS 审中-公开
标题翻译：将基于DNA的注射器注入人体的内镜注射系统
公开(公告)号：WO2006009839A2
公开(公告)日：2006-01-26
申请号：PCT/US2005/021453
申请日：2005-06-17
申请人： BIOJECT INC. , STOUT, Richard, R. , MILLER, Robert, A. , BONICATTO, James, M.
发明人： STOUT, Richard, R. , MILLER, Robert, A. , BONICATTO, James, M.
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/46 , C12M35/00 , C12M35/04
摘要： A system for injecting DNA-based medications into humans is provided by the present invention. The system includes a needle-free injector with an injection orifice of approximately .004 inches for supplying DNA.-based medication at an initial pressure of from 3900 to 4300 psi, and then immediately declining to a level of about 2800 to 3800 psi, and then immediately cutting off pressure to terminate the injection. The injector includes an annular adapter for spacing the injection orifice from the skin of the patient. The adapter includes an abutment against which the injector is disposed so that the orifice is spaced approximately 0.76-1.0 inch from the skin of the patient, the adapter having an inner diameter at the distal end of approximately 0.50-0.70 inches.
摘要翻译：本发明提供了一种将基于DNA的药物注入人体的系统。该系统包括具有大约0.004英寸的注射孔的无针注射器，以在3900至4300psi的初始压力下提供基于DNA的药物，然后立即下降到约2800至3800psi的水平，以及然后立即切断压力以终止注射。注射器包括用于将注射孔与患者皮肤间隔开的环形适配器。适配器包括抵靠件，注射器设置在支座上，使得孔口与患者皮肤间隔大约0.76-1.0英寸，适配器在远端具有大约0.50-0.70英寸的内径。

7. 发明申请

WO2005118033A2 NEEDLE-FREE INJECTION SYSTEM 审中-公开
标题翻译：无针注射系统
公开(公告)号：WO2005118033A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/017927
申请日：2005-05-20
申请人： BIOJECT INC. , LANDAU, Sergio , BEYLUND, Ryan, R. , BONICATTO, James, M. , DAELLENBACH, Keith, K. , MILLER, Robert, A. , SEDLER, Theodore, Walaka , STAYLOR, John, L.
发明人： LANDAU, Sergio , BEYLUND, Ryan, R. , BONICATTO, James, M. , DAELLENBACH, Keith, K. , MILLER, Robert, A. , SEDLER, Theodore, Walaka , STAYLOR, John, L.
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2053 , A61M5/24 , A61M2005/2407 , A61M2005/2488 , A61M2005/287 , A61M2005/3104
摘要： A needle-free injection device in which a gas cartridge or other source of pressurized gas is used to advance a piston and forcibly expel injectable fluid out through an injection orifice. When a gas cartridge is used, the gas cartridge may be moveable from an initial position to an actuating position in which gas is released to drive the injection, and a recoil inhibiter may be employed to prevent the gas cartridge from moving back to the initial position. A gas cartridge seal may be disposed on the gas cartridge and moveable with the gas cartridge to seal the gas cartridge against an interior wall of a gas cartridge housing. The needle-free injection device may also be configured so that sealing is compromised upon full advancement of the piston, so as to depressurize the device after delivery of an injection.
摘要翻译：无针注射装置，其中使用气瓶或其他加压气体源来推进活塞并强制地通过注射口排出可注射流体。当使用气体盒时，气体盒可以从初始位置移动到释放气体的致动位置以驱动喷射，并且可以采用反冲抑制器来防止气体盒回到初始位置。气瓶密封件可以设置在气体盒上，并且可与气体盒一起移动，以将气体盒密封在气体盒壳体的内壁上。无针注射装置也可以被配置为使得在活塞完全前进时密封受到影响，以便在注射输送之后使装置减压。

8. 发明申请

WO2004035107A2 DRUG CARTRIDGE ASSEMBLY AND METHOD OF MANUFACTURE 审中-公开
标题翻译：药物盒组件和制造方法
公开(公告)号：WO2004035107A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/027192
申请日：2003-08-28
申请人： BIOJECT, INC. , LANDAU, Sergio
发明人： LANDAU, Sergio
IPC分类号： A61M
CPC分类号： A61L2/081 , A61L2202/24 , A61M5/002 , A61M5/1782 , A61M5/24 , A61M5/2459 , A61M5/30 , A61M2005/2462 , A61M2005/2488 , A61M2005/287 , A61M2005/3104 , A61M2005/3132 , A61M2207/00 , Y10T29/49904
摘要： A method of manufacture for a drug cartridge assembly. The method includes providing a drug cartridge, providing a nozzle sub-assembly, and sterilizing the drug cartridge and nozzle sub-assembly. The method further includes assembling the drug cartridge and nozzle sub-assembly together in a configuration that enables ejection of liquid out of the drug cartridge through the nozzle sub-assembly. The method further includes filling the drug cartridge with a liquid, such as an injectable drug. The method may include separate sterilization of the drug cartridge and nozzle sub-assembly, using different sterilization processes. Portions of the method may be performed prior to sterilization within a first cleanroom, with subsequent steps being performed in a second cleanroom having a substantially lower particulate-per-volume rating than the first cleanroom.
摘要翻译：一种用于药筒组件的制造方法。该方法包括提供药筒，提供喷嘴子组件，以及灭菌药筒和喷嘴子组件。该方法进一步包括将药筒和喷嘴子组件组装在一起，使得液体能够通过喷嘴子组件从药筒中排出。该方法还包括用液体（例如可注射药物）填充药筒。该方法可以包括使用不同的灭菌过程分开灭菌药筒和喷嘴子组件。该方法的一部分可以在第一洁净室内灭菌之前进行，随后的步骤在第二洁净室中进行，该第二洁净室具有比第一洁净室小得多的颗粒/体积的额定值。

9. 发明申请

WO2003103752A1 NEEDLE-FREE INJECTION SYSTEM 审中-公开
标题翻译：无针注射系统
公开(公告)号：WO2003103752A1
公开(公告)日：2003-12-18
申请号：PCT/US2003/016446
申请日：2003-05-22
申请人： BIOJECT INC. , WILLIAMSON, Dan , LANDAU, Sergio , MARSHALL, John R.
发明人： WILLIAMSON, Dan , LANDAU, Sergio , MARSHALL, John R.
IPC分类号： A61M5/30
CPC分类号： A61M5/30
摘要： A needle-free injection device (22) includes a user-grippable housing (26) and a syringe assembly (28) movably secured to the housing (26). The syringe assembly (28) is configured to expel injectable fluid out of a nozzle (30) upon application of pressurized gas to the syringe assembly (28). The injection device (22) also includes a pressurized gas delivery mechanism (64) disposed within the housing (26) and configured to selectively apply pressurized gas to the syringe assembly (28). The pressurized gas delivery mechanism (64) is at least partly actuated by pressing the nozzle (30) onto an injection site so that the syringe assembly (28) moves relative to the housing (26).
摘要翻译：无针注射装置（22）包括可移动地固定到壳体（26）的用户可抓握的壳体（26）和注射器组件（28）。注射器组件（28）构造成在将注射液体施加到注射器组件（28）上时将可注射流体排出喷嘴（30）。注射装置（22）还包括设置在壳体（26）内的加压气体输送机构（64），并构造成选择性地将加压气体施加到注射器组件（28）。加压气体输送机构（64）至少部分地通过将喷嘴（30）压到注射部位来致动，使得注射器组件（28）相对于壳体（26）移动。

10. 发明申请

WO2011163379A3 HIGH WORKLOAD INJECTION SYSTEM 审中-公开
标题翻译：高工作注射系统
公开(公告)号：WO2011163379A3
公开(公告)日：2012-04-19
申请号：PCT/US2011041471
申请日：2011-06-22
申请人： BIOJECT INC , WILLIAMSON DANIEL E , MARSHALL JOHN R
发明人： WILLIAMSON DANIEL E , MARSHALL JOHN R
IPC分类号： B65B3/12 , A61J1/06 , A61J1/20 , A61J3/00 , B65B3/04
CPC分类号： A61M5/1782 , A61M5/24 , A61M5/30 , B65B3/003
摘要： A filling device for a needle-free injector system is provided that is adapted to sterilely deliver a predetermined amount of an injectate from a vial to a plurality of cartridges. The filling device normally includes a single-use fluid path disposed between the vial and a receiving cartridge. The fluid path may include a vial connector adapted to couple to a vial, a filler head, and a conduit connecting the vial connector and filler head. The filling device typically further includes a pump coupled to the fluid path and adapted to propel the injectate from the vial to the receiving cartridge, and a cartridge-advancing element. Activation of the cartridge-advancing element is adapted to sequentially advance empty cartridges into a position opposite the filler head. Also provided are disposable fluid path kits and methods of using the filling device.
摘要翻译：提供了一种用于无针注射器系统的填充装置，其适于将预定量的注射器从小瓶输送到多个药筒。填充装置通常包括设置在小瓶和接收盒之间的一次性流体路径。流体路径可以包括适于联接到小瓶，填充头和连接小瓶连接器和填充头的导管的小瓶连接器。填充装置通常还包括耦合到流体路径并适于将注射器从小瓶推进到接收盒的泵和盒推进元件。盒前进元件的激活适于将空墨盒顺序地提前到与填充头相对的位置。还提供了一次性流体路径套件和使用填充装置的方法。

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