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1. 发明申请

WO03081261A2 MICRODEVICES HAVING A PREFERENTIAL AXIS OF MAGNETIZATION AND USES THEREOF 审中-公开
标题翻译：具有磁化优选轴的MICRODEVICES及其用途
公开(公告)号：WO03081261A2
公开(公告)日：2003-10-02
申请号：PCT/US0307468
申请日：2003-03-12
申请人： AVIVA BIOSCIENCES CORP
发明人： HUANG MINGXIAN , WU LEI , WANG XIAOBO , XU JUNQUAN , TAO GUO LIANG , ROTHWARF DAVID M
IPC分类号： B01J19/00 , B01L3/00 , C07B61/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B40/12 , G01N33/543 , G06K19/06 , G01R
CPC分类号： C40B40/12 , B01J19/0046 , B01J2219/00457 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00556 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5027 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2300/0819 , B01L2400/0415 , B01L2400/043 , B03C5/028 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07K1/047 , C40B40/06 , C40B40/10 , G01N33/54366 , G01N33/54386 , G06K19/06009 , G06K19/06046 , G06K19/06196 , Y10T428/24917
摘要： The invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.
摘要翻译：本发明一般涉及部分或分子分离，检测和操作以及文库合成领域。特别地，本发明提供一种微型装置，其微型装置包括：a）可磁化物质; 以及b）可识别的编码图案，其中所述微器件具有优先磁化轴。还提供用于使用微器件分离检测和操作部分并合成文库的系统和方法。

2. 发明申请

WO0229400A3 APPARATUSES AND METHODS FOR FIELD FLOW FRACTIONATION OF PARTICLES USING ACOUSTIC AND OTHER FORCES 审中-公开
标题翻译：使用声音和其他力的现场流动分离颗粒的装置和方法
公开(公告)号：WO0229400A3
公开(公告)日：2003-04-17
申请号：PCT/US0142280
申请日：2001-09-20
申请人： AVIVA BIOSCIENCES CORP
发明人： WANG XIAO-BO , CHENG JING , WU LEI , XU JUNQUAN
IPC分类号： G01N30/00 , G01N30/02
CPC分类号： G01N30/0005 , A61M1/3678 , A61M1/3693 , G01N30/02 , G01N2030/006 , G01N2030/0065 , B01D2015/389
摘要： This invention relates generally to the field of field-flow-fractionation. In particular, the invention provides apparatuses and methods for the discrimination of mattes utilizing acoustic force, or utilizing acoustic force with electrophoretic or dielectrophoretic force, in field flow fractionation.
摘要翻译：本发明一般涉及现场流分馏领域。特别地，本发明提供了用于在现场流分馏中利用声力或利用具有电泳或介电电泳力的声力来辨别哑光的装置和方法。

3. 发明申请

WO02073159A3 MICROELECTROMAGNETIC DISPENSER HEADS AND USES THEREOF 审中-公开
标题翻译：微电子分配器头及其用途
公开(公告)号：WO02073159A3
公开(公告)日：2003-02-20
申请号：PCT/US0207464
申请日：2002-03-12
申请人： AVIVA BIOSCIENCES CORP , XU JUNQUAN , LAI YAMING , LI ZHIMING , LIU LITIAN , ZHOU YUXIANG
发明人： XU JUNQUAN , LAI YAMING , LI ZHIMING , LIU LITIAN , ZHOU YUXIANG
IPC分类号： B01J19/00 , B01L3/02 , C40B60/14 , G01N35/00 , G01N35/10 , B01D35/06 , G01N33/553
CPC分类号： G01N35/1065 , B01J19/0046 , B01J2219/00315 , B01J2219/00351 , B01J2219/00468 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00648 , B01J2219/00659 , B01J2219/0072 , B01L3/02 , B01L3/0244 , B01L2200/0647 , B01L2400/043 , C40B60/14 , G01N35/0098 , G01N2035/00207 , G01N2035/00237 , G01N2035/00425
摘要： This invention relates generally to the field of moiety or molecule transfer. In particular, the invention provides a microelectromagnetic dispenser head, which head comprises: a core comprising a magnetizable substance, said core surrounded by a microcoil suitable for transmitting electrical current and generating a magnetic field via said magnetizable substance and said core having a tip suitable for attracting a magnetic or magnetically labeled moiety; and preferably further comprising one or both of the following: i) a shell that substantially shields magnetic field, generated via said microcoil, from the non-tip portion of said core; and/or ii) a cooling means for cooling said tip. Microelectromagnetic dispensers comprising the heads and methods for transferring moieties using the heads and the microelectromagnetic dispensers are also provided.
摘要翻译：本发明一般涉及部分或分子转移领域。特别地，本发明提供了一种微电磁分配器头，其包括：包含可磁化物质的芯，所述芯由适于传输电流并由所述可磁化物质产生磁场的微线圈围绕，所述芯具有适于吸引磁性或磁性标记的部分; 并且优选地还包括以下中的一个或两个：i）基本上屏蔽通过所述微线圈产生的磁场与所述芯的非尖端部分的壳体; 和/或ii）用于冷却所述尖端的冷却装置。还提供了包括头部的微电磁分配器和使用头部和微电磁分配器转移部件的方法。

4. 发明申请

WO0227909A8 APPARATUS FOR SWITCHNG AND MANIPULATING PARTICLES AND METHOD OF USE THEREOF 审中-公开
标题翻译：用于开关和操作颗粒的装置及其使用方法
公开(公告)号：WO0227909A8
公开(公告)日：2003-11-20
申请号：PCT/US0142426
申请日：2001-09-24
申请人： AVIVA BIOSCIENCES CORP
发明人： WANG XIAO-BO , YANG WEIPING , XU JUNQUAN , CHENG JING , WU LEI
IPC分类号： B01D57/02 , B03C5/02 , H02N1/00 , H02N11/00 , B01D75/02
CPC分类号： H02N1/004 , B01D57/02 , B03C5/028 , H02N11/006
摘要： A device (103, 106, 112, 113, 110, 152, 158, 168, 170A, 170B, 170C, 182, 184, 250, 295) acts as a particle switch to transport and/or re-direct microparticles which are in a fluid suspension. The switch (103, 107, 112, 113, 110, 152, 158, 168, 170A, 170B, 170C, 182, 184, 250, 295) comprises at least three structural branches (e.g., 103a/103b/103c, 107a/107b/107c/107d, 110a/110b/110c, 110d/110e/110f, 110g/110h/110i, 152a/152b/152c, etc.); and the branches may be connected at a common junction (103, 107, 150, 158, 258). Particles (160, 164) can be transported along the branches as a result of the forces generated along that branch. Particles are transported into or out of the particle switch via the ends (e.g., 105a, 105b, 105c, 108a, 108b, 108c) of the branches. Particles can be switched from one branch into one of the other branches. Depending on the properties of the particles, the transportation mechanism may be traveling-wave-dielectrophoresis or traveling-wave-electrophoresis.
摘要翻译：装置（103,106,112,113,110,152,158,168,170A，170B，170C，182,184,250,295）用作颗粒开关以输送和/或重新引导微粒液体悬浮液。开关（103,107,112,113,110,152,158,168,170A，170B，170C，182,184,250,295）包括至少三个结构分支（例如，103a / 103b / 103c，107a / 107b / 107c / 107d，110a / 110b / 110c，110d / 110e / 110f，110g / 110h / 110i，152a / 152b / 152c等）并且分支可以连接在公共接点（103,107,150,158,258）上。颗粒（160,164）可以沿着沿着该分支的力产生的力沿分支传送。颗粒通过分支的端部（例如，105a，105b，105c，108a，108b，108c）被输送到或离开颗粒开关。颗粒可以从一个分支切换到其他分支之一。根据颗粒的性质，运输机制可以是行波介电电泳或行波电泳。

5. 发明申请

WO0228523A8 APPARATUSES CONTAINING MULTIPLE FORCE GENERATING ELEMENTS AND USES THEREOF 审中-公开
标题翻译：包含多种生成元素的装置及其用途
公开(公告)号：WO0228523A8
公开(公告)日：2002-05-30
申请号：PCT/US0129762
申请日：2001-09-20
申请人： AVIVA BIOSCIENCES CORP
发明人： WANG XIAO-BO , WU LEI , CHENG JING , YANG WEIPING , XU JUNQUAN
IPC分类号： B01J19/00 , B03C1/00 , B03C5/00 , B81B1/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00873 , B01J2219/0093 , B01J2219/00932 , B01J2219/00934 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0454 , B01L2400/0487 , B03C1/00 , B03C5/005

6. 发明申请

WO2014008487A2 METHODS AND COMPOSITIONS FOR SEPARATING OR ENRICHING CELLS 审中-公开
标题翻译：用于分离或增强细胞的方法和组合物
公开(公告)号：WO2014008487A2
公开(公告)日：2014-01-09
申请号：PCT/US2013049476
申请日：2013-07-05
申请人： AVIVA BIOSCIENCES CORP
发明人： GUIA ANTONIO , YAMANISHI DOUGLAS T , GHETTI ANDREA , TAO GUOLIANG , TAO HUIMIN , TRUONG KY , WU LEI , WANG XIAOBO
IPC分类号： B01L3/00
CPC分类号： G01N27/44791 , A61M1/34 , A61M1/3618 , A61M1/362 , A61M1/3679 , A61M2205/3375 , B01D29/0093 , B01D57/02 , B01D61/147 , B01D61/18 , B01D63/087 , B01D63/088 , B01D67/0034 , B01D67/0062 , B01D67/0072 , B01D67/0088 , B01D67/009 , B01D69/144 , B01D71/02 , B01D71/027 , B01D71/04 , B01D71/28 , B01D71/38 , B01D71/44 , B01D71/52 , B01D71/72 , B01D2313/20 , B01D2313/345 , B01D2325/021 , B01D2325/028 , B01L3/502 , B01L3/502753 , B01L3/502761 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2400/0409 , B01L2400/0457 , B01L2400/0478 , B01L2400/0644 , B01L2400/065 , B03C1/01 , B03C1/288 , B03C5/005 , B03C5/028 , B03C2201/26 , B05D1/62 , C23C8/06 , C23C14/3414 , C23C16/06 , C23C16/08 , C23C16/50 , G01N1/34 , G01N33/491
摘要： The present invention provides a filtration chamber comprising a microfabricated filter enclosed in a housing, wherein the surface of said filter and/or the inner surface of said housing are modified by vapor deposition, sublimation, vapor-phase surface reaction, or particle sputtering to produce a uniform coating; and a method for separating cells of a fluid sample, comprising: a) dispensing a fluid sample into the filtration chamber disclosed herein; and b) providing fluid flow of the fluid sample through the filtration chamber, wherein components of the fluid sample flow through or are retained by the filter based on the size, shape, or deformability of the components.
摘要翻译：本发明提供了一种过滤室，其包括封闭在壳体中的微加工过滤器，其中所述过滤器的表面和/或所述壳体的内表面通过气相沉积，升华，气相表面反应或颗粒溅射进行改性以产生均匀涂层; 以及用于分离流体样品的细胞的方法，包括：a）将流体样品分配到本文公开的过滤室中; 以及b）提供流体样品通过过滤室的流体流动，其中流体样品的组分基于组分的尺寸，形状或可变形性流过过滤器或被过滤器保持。

7. 发明申请

WO2005007866A3 BIOCHIP DEVICES FOR ION TRANSPORT MEASUREMENT, METHODS OF MANUFACTURE, AND METHODS OF USE 审中-公开
标题翻译：用于离子运输测量的生物装置，制造方法和使用方法
公开(公告)号：WO2005007866A3
公开(公告)日：2007-06-14
申请号：PCT/US2004017134
申请日：2004-06-01
申请人： AVIVA BIOSCIENCES CORP , GUIA ANTONIO , XU JIA , WU LEI , SITHIPHONG KHACHONESIN , SPASSOVA MARIA , TAO HUIMIN , WALKER GEORGE , HUANG MINGXIAN , TAO GUOLIANG , SAYA STEVEN , WALKER GLENN , ZOZULYA ZOYA
发明人： GUIA ANTONIO , XU JIA , WU LEI , SITHIPHONG KHACHONESIN , SPASSOVA MARIA , TAO HUIMIN , WALKER GEORGE , HUANG MINGXIAN , TAO GUOLIANG , SAYA STEVEN , WALKER GLENN , ZOZULYA ZOYA
IPC分类号： C12M1/34 , C12Q20060101 , G01N33/68 , G01R19/00
CPC分类号： G01N33/6872 , G01N33/48728 , G01R19/0061
摘要： The present invention provides biochips for ion transport measurement, ion transport measuring devices that comprise biochips, and methods of using ion transport measuring devices and biochips that allow for the direct analysis of ion transport functions or properties. The present invention provides biochips, devices, apparatuses, and methods that allow for automated detection of ion transport functions or properties. The present invention also provides methods of making biochips and devices for ion transport measurement that reduce the cost and increase the efficiency of manufacture, as well as improve the performance of the biochips and devices. These biochips and devices are particularly appropriate for automating the detection of ion transport functions or properties, particularly for screening purposes.
摘要翻译：本发明提供了用于离子传输测量的生物芯片，包括生物芯片的离子传输测量装置，以及使用离子传输测量装置和允许直接分析离子传递功能或性质的生物芯片的方法。本发明提供允许自动检测离子迁移功能或性质的生物芯片，装置，装置和方法。本发明还提供了制造用于离子传输测量的生物芯片和装置的方法，其降低成本并提高制造效率，以及提高生物芯片和装置的性能。这些生物芯片和装置特别适用于自动化离子迁移功能或性质的检测，特别是用于筛选目的。

8. 发明申请

WO0169241A3 APPARATUS AND METHOD FOR HIGH THROUGHPUT ELECTROROTATION ANALYSIS 审中-公开
标题翻译：用于高通量电动分析的装置和方法
公开(公告)号：WO0169241A3
公开(公告)日：2002-04-18
申请号：PCT/US0107495
申请日：2001-03-08
申请人： AVIVA BIOSCIENCES CORP
发明人： CHENG JING , XU JUNQUAN , ZHU XIAOSHAN , LIU LITIAN , WANG XIAO-BO , WU LEI
IPC分类号： G01N33/487 , C12M1/34 , G01N33/543
CPC分类号： G01N33/48707 , B01J2219/00497 , B01J2219/00527 , B01J2219/00529 , B01J2219/00587 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , Y10S436/809
摘要： The present invention concerns a high throughput electrorotation chip having an array of electrorotation units and methods of use thereof. To make the high throughput electrorotation chip, a plurality of electrorotation units (EU) are fabricated on a substrate or support and each EU is capable of producing a rotating electric field upon the application of an appropriate electrical signal. Exemplary embodiments include a row-column configuration of EUs having four electrode elements realized through two conductive-layers. The electrode elements may be linear, concave, or convex. Thin plates having one or multiple holes are bound to high-throughput electrorotation chips to form assay chambers having one or multiple wells. Particles can be introduced to the wells and electrorotation measurements can be performed on the particles. The high throughput electrorotation chip and chamber may be used for cell-based screening for leading drug candidate molecules from a compound library, for high-throughput characterizing particle electric properties, and for high-throughput assaying molecular compositions of unknown solutions.
摘要翻译：本发明涉及一种具有电极单元阵列的高通量电选机芯及其使用方法。为了制造高通量电选芯片，在基板或支撑件上制造多个电极单元（EU），并且每个EU在施加适当的电信号时能够产生旋转电场。示例性实施例包括具有通过两个导电层实现的四个电极元件的EU行的列列配置。电极元件可以是线性的，凹的或凸的。具有一个或多个孔的薄板结合到高通量电旋转切片以形成具有一个或多个孔的测定室。可以将颗粒引入孔中，并且可以对颗粒进行电转化测量。高通量电刺激芯片和腔室可用于来自化合物文库的主要药物候选分子的基于细胞的筛选，用于高通量表征颗粒电性质，以及用于高通量测定未知溶液的分子组成。

9. 发明申请

WO2008008515A3 METHODS AND COMPOSITIONS FOR DETECTING RARE CELLS FROM A BIOLOGICAL SAMPLE 审中-公开
标题翻译：从生物样品中检测稀有细胞的方法和组合物
公开(公告)号：WO2008008515A3
公开(公告)日：2008-11-06
申请号：PCT/US2007016034
申请日：2007-07-14
申请人： AVIVA BIOSCIENCES CORP , LIN PING , GHETTI ANDREA , SHI WENGE , TANG MENGJIA , HARVIE GIOULNAR , TAO HUIMIN , TAO GUOLIANG , WU LEI , CERNY DAVID , XU JIA
发明人： LIN PING , GHETTI ANDREA , SHI WENGE , TANG MENGJIA , HARVIE GIOULNAR , TAO HUIMIN , TAO GUOLIANG , WU LEI , CERNY DAVID , XU JIA
IPC分类号： C12Q1/04
CPC分类号： C12N5/0693 , G01N33/5094 , G01N33/54346 , G01N33/56972 , G01N33/574 , G01N2015/1006 , G01N2015/1402 , G01N2333/70525 , G01N2333/70589 , G01N2800/52 , Y10T436/25375
摘要： The invention provides methods and compositions for isolating and detecting rare cells from a sample containing other types of cells. In particular, the invention includes a debulking step that can use a microfabricated filter or a cell lysis step or density-based methods to remove certain types of cells, and immobilization methods to remove other types of cells. The invention also includes a method for determining the number or proportion of cancer cells in a biological sample by detecting the presence or amount of telomerase activity or telomerase nucleic acid or telomerase expression after enrichment of rare cells. This invention further provides an efficient and rapid method to specifically remove red blood cells as well as white blood cells from a biological sample, resulting in the enrichment of rare target cells. The presence or level of target cells provides information about various physiological conditions, such as cancer.
摘要翻译：本发明提供了用于从含有其他类型的细胞的样品中分离和检测稀有细胞的方法和组合物。具体而言，本发明包括可使用微制造的过滤器或细胞裂解步骤或基于密度的方法来移除某些类型的细胞的去模糊步骤，以及移除其他类型的细胞的固定方法。本发明还包括通过检测富集稀有细胞后端粒酶活性或端粒酶核酸或端粒酶表达的存在或量来确定生物样品中癌细胞的数量或比例的方法。本发明进一步提供了从生物样品中特异性去除红细胞和白血细胞的有效和快速的方法，导致稀有靶细胞的富集。靶细胞的存在或水平提供关于各种生理状况的信息，例如癌症。

10. 发明申请

WO02077259A3 BIOCHIPS INCLUDING ION TRANSPORT DETECTING STRUCTURES AND METHODS OF USE 审中-公开
标题翻译：包括离子运输检测结构和使用方法的生物芯片
公开(公告)号：WO02077259A3
公开(公告)日：2002-11-14
申请号：PCT/US0211161
申请日：2002-03-22
申请人： AVIVA BIOSCIENCES CORP
发明人： WANG XIAOBO , WU LEI , XU JUNQUAN , HUANG MINGXIAN , YANG WEIPING , CHENG JING , XU JIA
IPC分类号： B01L3/00 , B03C5/02 , B81B1/00 , C08F2/58 , C12Q1/68 , G01N15/10 , G01N33/487 , G01N33/50 , B01D57/02 , B01D59/42 , B01D59/50 , B01D61/42 , B01D61/58 , C02F1/469 , C07K1/26 , C25B7/00 , C25B15/00 , G01F1/64 , G01L1/20 , G01L9/18 , G01N27/26
CPC分类号： G01N33/5005 , B01L3/50273 , B01L3/502761 , B01L3/502792 , B01L2200/06 , B01L2300/0627 , B01L2300/0645 , B01L2300/0819 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0457 , B01L2400/049 , B03C5/026 , B03C5/028 , C12Q1/6869 , G01N15/1031 , G01N33/48728 , C12Q2565/629
摘要： The present invention recognizes that the determination of ion transport function or property using direct detection methods, such as patch-clamps, whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and methods of use that allow for the direct analysis of ion transport function or property using microfabricated structures that can allow for automated detection of ion transport function or property. These biochips and methods of use thereof are particularly appropriate for automating the detection of ion transport function or property, particularly for screening purposes.
摘要翻译：本发明认识到使用诸如膜片钳，全细胞记录或单通道记录的直接检测方法确定离子传递功能或性质优于利用间接检测方法的方法，例如基于FRET的检测系统。本发明提供了生物芯片和使用方法，其允许使用可以允许自动检测离子传递功能或性质的微制造结构来直接分析离子传递功能或性质。这些生物芯片及其使用方法特别适用于自动检测离子转运功能或性质，特别是用于筛选目的。

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