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1. 发明申请

WO2010065380A1 METHODS FOR ESTIMATING TARGET NUCLEIC ACID IN A SAMPLE PRIOR TO AMPLIFICATION 审中-公开
标题翻译：在放大前的样品中估计目标核酸的方法
公开(公告)号：WO2010065380A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/065586
申请日：2009-11-23
申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED , ARCHER, Benedict G.
发明人： ARCHER, Benedict G.
IPC分类号： C12Q1/68 , G01N33/48
CPC分类号： G06F19/20 , C12Q1/6851 , G06F19/24 , C12Q2537/165
摘要： Provided are methods for estimating the amount of initial target nucleic acid in a sample prior to nucleic acid amplification by polymerase chain reaction (PCR). The methods generally involve modeling signal intensity data generated across a range of PCR cycles with a phenomenological model in concert with a chemical model, to yield an estimate of the amount of initial target nucleic acid in the sample.
摘要翻译：提供了在通过聚合酶链反应（PCR）进行核酸扩增之前估计样品中初始靶核酸量的方法。所述方法通常涉及建立在一系列PCR循环中产生的信号强度数据，其中具有与化学模型一致的现象学模型，以产生样品中初始靶核酸的量的估计。

2. 发明申请

WO2008045136A2 NUCLEIC ACID SIZE DETECTION METHOD 审中-公开
标题翻译：核酸尺寸检测方法
公开(公告)号：WO2008045136A2
公开(公告)日：2008-04-17
申请号：PCT/US2007/008985
申请日：2007-04-11
申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED , U.S. GENOMICS , HUANG, Donghui , STROM, Charles, M. , POTTS, Steven, J. , ROOKE, Jenny, Ellen
发明人： HUANG, Donghui , STROM, Charles, M. , POTTS, Steven, J. , ROOKE, Jenny, Ellen
IPC分类号： C12Q1/68 , G01N33/00
CPC分类号： C12Q1/6827 , C12Q1/6858 , C12Q2565/629 , C12Q2565/125 , C12Q2525/151
摘要： The present invention provides methods of determining the size of a particular nucleic acid segment of interest in a sample of nucleic acids through fragmentation of DNA, size fractionation, an optional second fragmentation, and identification using a marker sequence. In particular aspects, an expansion or reduction of tandem repeat sequences can be detected. In further aspects, carriers and individuals afflicted with fragile X syndrome or other diseases associated with tandem repeats can be distinguished from normal individuals.
摘要翻译：本发明提供了通过DNA的断裂，大小分级分离，任选的第二片段化和使用标记序列进行鉴定来确定核酸样品中感兴趣的特定核酸片段的大小的方法。在特定方面，可以检测到串联重复序列的扩增或减少。在另外的方面，患有脆弱X综合征或与串联重复相关的其他疾病的携带者和个体可以与正常个体区分开来。

3. 发明申请

WO2007106518A3 SYSTEM FOR AND METHOD FOR PSYCHOLOGICAL ASSESSMENT 审中-公开
公开(公告)号：WO2007106518A3
公开(公告)日：2007-09-20
申请号：PCT/US2007/006398
申请日：2007-03-13
申请人： SPHERICAL DYNAMICS, INC. , STURM, W., Michael , WELLS, Melissa, Meredith , HOLT, Bruce , YOKLEY, Edward, M. , MURPHY, John
发明人： STURM, W., Michael , WELLS, Melissa, Meredith , HOLT, Bruce , YOKLEY, Edward, M. , MURPHY, John
IPC分类号： A61B5/16
摘要： In systems, methods and program products relating to the assessment of individuals, a subject can be provided with an assessment through software and a computer for improved functionality. The software may be directly installed on the subject's computer or may be on a remote server accessible through a communication network, such as a local network or the Internet. Stimuli to be presented to subject are selected in real time and may be selected randomly from a database of stimuli. Further, in the event of borderline cases, a refinement process may be used to provide an accurate assessment of the subject. Methods for the assessment of teams, comprising subject individuals, for the construction of ideal process profiles, and for coaching individuals are provided.

4. 发明申请

WO2007087336A2 METHODS FOR DETECTING NUCLEIC ACIDS USING MULTIPLE SIGNALS 审中-公开
标题翻译：使用多个信号检测核酸的方法
公开(公告)号：WO2007087336A2
公开(公告)日：2007-08-02
申请号：PCT/US2007/001859
申请日：2007-01-23
申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED , EXNER, Maurice , ROGERS, Amy
发明人： EXNER, Maurice , ROGERS, Amy
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6818 , C12Q2563/173 , C12Q2527/107
摘要： Disclosed is are methods for identifying a nucleic acid in a sample. In one example, the method includes: (a) contacting the nucleic acid in the sample with an oligonucleotide that is specific for the nucleic acid in the sample and that is labeled with at least a first fluorescent dye; (b) contacting the nucleic acid in the sample with a second fluorescent dye that is different from the first fluorescent dye, such that the second fluorescent dye interacts with the nucleic acid; (c) amplifying the nucleic acid if present in the sample; and (d) detecting the nucleic acid if present in the sample by observing fluorescence from the first fluorescent dye after the oligonucleotide hybridizes to the amplified nucleic acid and determining the melting temperature of the amplified nucleic acid by measuring the fluorescence of the second fluorescent dye. The second fluorescent dye may include a fluorescent intercalating agent.
摘要翻译：公开了用于鉴定样品中的核酸的方法。在一个实例中，该方法包括：（a）使样品中的核酸与样品中核酸特异的寡核苷酸接触，并用至少第一荧光染料标记; （b）使样品中的核酸与不同于第一荧光染料的第二荧光染料接触，使得第二荧光染料与核酸相互作用; （c）如果存在于样品中则扩增核酸; 和（d）在寡核苷酸与扩增的核酸杂交后，通过观察来自第一荧光染料的荧光检测样品中的核酸，并通过测量第二荧光染料的荧光来测定扩增的核酸的解链温度。第二荧光染料可以包括荧光插入剂。

5. 发明申请

WO2007030574A2 PPAR ACTIVE COMPOUNDS 审中-公开
标题翻译： PPAR活性化合物
公开(公告)号：WO2007030574A2
公开(公告)日：2007-03-15
申请号：PCT/US2006/034780
申请日：2006-09-06
申请人： PLEXXIKON, INC. , LIN, Jack , SHI, Shenghua , ZHANG, Chao , ZUCKERMAN, Rebecca , ARTIS, Dean, R. , IBRAHIM, Prabha, N. , LEE, Byunghun
发明人： LIN, Jack , SHI, Shenghua , ZHANG, Chao , ZUCKERMAN, Rebecca , ARTIS, Dean, R. , IBRAHIM, Prabha, N. , LEE, Byunghun
IPC分类号： C07D409/12 , C07D409/14 , C07D209/08 , A61K31/405 , A61P3/10
CPC分类号： C07D409/12 , C07D209/08 , C07D409/14
摘要： Compounds are described that are active on at least one of PP ARa, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARa5 PPARδ, and PPARγ.
摘要翻译：描述了对PPARα，PPARd和PPARγ中的至少一种有活性的化合物，其可用于涉及调节PPARα5PPARd和PPARγ中的至少一种的治疗和/或预防方法。

6. 发明申请

WO2007013896A2 COMPOUNDS MODULATING C-KIT AND C-FMS ACTIVITY AND USES THEREFOR 审中-公开
标题翻译：化合物调节C-CIT和C-FMS活性及其用途
公开(公告)号：WO2007013896A2
公开(公告)日：2007-02-01
申请号：PCT/US2006/018726
申请日：2006-05-16
申请人： PLEXXIKON, INC. , ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha, N. , HURT, Clarence, R. , ZUCHKERMAN, Rebecca , ARTIS, Dean, R. , BREMER, Ryan , SPEVAK, Wayne , WU, Guoxian , ZHU, Hongyao
发明人： ZHANG, Chao , ZHANG, Jiazhong , IBRAHIM, Prabha, N. , HURT, Clarence, R. , ZUCHKERMAN, Rebecca , ARTIS, Dean, R. , BREMER, Ryan , SPEVAK, Wayne , WU, Guoxian , ZHU, Hongyao
CPC分类号： C07D471/04
摘要： Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.
摘要翻译：本文提供了对受体蛋白酪氨酸激酶c-kit和c-fms有活性的化合物。本文还提供了可用于治疗c-kit介导的疾病或病症和c-fms介导的疾病或病症的组合物及其使用方法。

7. 发明申请

WO2006135781A3 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF VENOUS THROMBOEMBOLIC DISEASE 审中-公开
公开(公告)号：WO2006135781A3
公开(公告)日：2006-12-21
申请号：PCT/US2006/022544
申请日：2006-06-09
申请人： BIOSITE, INC. , MCPHERSON, Paul, H. , BUECHLER, Kenneth, F.
发明人： MCPHERSON, Paul, H. , BUECHLER, Kenneth, F.
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/00 , G01N33/543
摘要： The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out venous thromboembolic disease, pulmonary embolism, and/or deep vein thrombosis, and for risk stratification in such conditions.

8. 发明申请

WO2006122153A1 MULTI-LENS ZOOM SYSTEM AND METHOD FOR FLASHLIGHTS 审中-公开
标题翻译：多镜头变焦系统和闪光灯方法
公开(公告)号：WO2006122153A1
公开(公告)日：2006-11-16
申请号：PCT/US2006/017987
申请日：2006-05-09
申请人： UNDERWATER KINETICS, INC. , UKE, Alan , WRIGHT, Steven
发明人： UKE, Alan , WRIGHT, Steven
IPC分类号： F21L4/00
CPC分类号： F21V29/70 , F21L4/027 , F21V5/006 , F21V5/008 , F21V14/045 , F21V21/32 , F21Y2115/10 , G02B15/14 , G03B15/06
摘要： An efficient system and method for zooming the light from a flashlight is disclosed. Multiple refractive lenses are translated in unison to allow zooming of the light while reducing the size and weight of the required lenses. In another aspect, a meniscus lens is used to reduce the amount of light lost from a light-emitting diode (LED). One method includes providing a light source in a housing and translating a lens arrangement substantially along a light path of a light beam generated by the light source. The lens arrangement includes at least two refractive lenses separated by a gap, a size of the gap being maintained during translation of the lens arrangement.
摘要翻译：公开了一种用于缩放来自手电筒的光的有效系统和方法。多个折射透镜被一致地平移以允许光的变焦，同时减少所需透镜的尺寸和重量。另一方面，弯月透镜用于减少从发光二极管（LED）损失的光量。一种方法包括在壳体中提供光源并且基本上沿着由光源产生的光束的光路平移透镜装置。透镜装置包括由间隙分开的至少两个折射透镜，在透镜装置平移过程中保持间隙的尺寸。

9. 发明申请

WO2006060535A3 INDOLE DERIVATIVES FOR USE AS PPAR ACTIVE COMPOUNDS 审中-公开
公开(公告)号：WO2006060535A3
公开(公告)日：2006-06-08
申请号：PCT/US2005/043412
申请日：2005-11-29
申请人： PLEXXIKON, INC. , LIN, Jack , IBRAHIM, Prabha, N. , ARTIS, Dean, R. , ZHANG, Chao , WANG, Weiru , SHI, Shenghua
发明人： LIN, Jack , IBRAHIM, Prabha, N. , ARTIS, Dean, R. , ZHANG, Chao , WANG, Weiru , SHI, Shenghua
IPC分类号： C07D209/30 , A61K31/405 , A61P3/04
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.

10. 发明申请

WO2006058031A2 MICROARRAY QUALITY CONTROL 审中-公开
标题翻译：微控制器质量控制
公开(公告)号：WO2006058031A2
公开(公告)日：2006-06-01
申请号：PCT/US2005/042377
申请日：2005-11-22
申请人： QUEST DIAGNOSTICS INCORPORATED , MOHAMMED, Mansoor, S. , DZIDIC, Natasa
发明人： MOHAMMED, Mansoor, S. , DZIDIC, Natasa
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837
摘要： The present invention relates to methods of quality control of manufactured nucleic acid arrays. Fluorescence detection is used to evaluate the quality of a printed nucleic acid array prior to its use in hybridization without the need to add or otherwise link a fluorescent compound or dye to the nucleic acid. Nucleic acid arrays suitable for this method are those where the spots of the array are formed by printing a solution that contains the nucleic acid in an ion containing solution. Printing quality may be evaluated by measuring the intensity of fluorescence at the location of each printed sample, and/or by measuring the "morphology" (i.e. shape) of the printed sample. Printed spots can be "imaged" by measuring fluorescence across a spotted sample in two dimensions. The resulting image of a printed spot can be compared with a reference printed image expected for the printing equipment and solid phase used.
摘要翻译：本发明涉及制造的核酸阵列的质量控制方法。使用荧光检测来评估打印的核酸阵列在用于杂交之前的质量，而不需要添加或以其他方式将荧光化合物或染料连接至核酸。适用于该方法的核酸阵列是通过在含有离子的溶液中印刷包含核酸的溶液而形成阵列的斑点的阵列。印刷质量可以通过测量每个印刷样品的位置处的荧光强度和/或通过测量每个印刷样品的“形态”来评估。（即，形状）。印刷的斑点可以被“成像” 通过测量二维斑点样品上的荧光。打印点的图像可以与预期用于打印设备和固相的参考打印图像进行比较。

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