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1. 发明申请

WO2006081353A3 RAPID COMPARATIVE GENOME HYBRIDIZATION 审中-公开
公开(公告)号：WO2006081353A3
公开(公告)日：2006-08-03
申请号：PCT/US2006/002780
申请日：2006-01-26
申请人： QUEST DIAGNOSTICS INCORPORATED , MOHAMMED, Mansoor, S. , DZIDIC, Natasa , MCCASKILL, Christopher
发明人： MOHAMMED, Mansoor, S. , DZIDIC, Natasa , MCCASKILL, Christopher
IPC分类号： G01N33/00
摘要： Disclosed is a method for performing nucleic acid hybridization assays, such as assays used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or associated with predisposition to various diseases. In a particular aspect, the present method relates to the use of rapid nucleic acid hybridization methods for comparing nucleic acid segments of one genome to corresponding nucleic acid segments in another genome(s).

2. 发明申请

WO2003001181A3 DETECTION OF CLONAL T-CELL RECEPTOR-GAMMA GENE REARRANGEMENT BY PCR/TEMPORAL TEMPERATURE GRADIENT GEL ELECTROPHORESIS (TIGE) 审中-公开
公开(公告)号：WO2003001181A3
公开(公告)日：2003-01-03
申请号：PCT/US2002/019696
申请日：2002-06-21
申请人： QUEST DIAGNOSTICS INCORPORATED , SAMOSZUK, Michael , ZHU, Dan
发明人： SAMOSZUK, Michael , ZHU, Dan
IPC分类号： C12Q1/68
摘要： The present invention provides methods and compositions for detecting and analyzing clonal T-cell receptor (TCR) gene rearrangement using temporal temperature gradient gel electrophoresis (TTGE), which employs a gradual and uniform increase in the temperature of a constant denaturing gel to resolve different DNA molecules based on base pair composition. The present invention also provides methods and compositions for providing appropriate DNA migration markers for TTGE analysis.

3. 发明申请

WO2006058031A2 MICROARRAY QUALITY CONTROL 审中-公开
标题翻译：微控制器质量控制
公开(公告)号：WO2006058031A2
公开(公告)日：2006-06-01
申请号：PCT/US2005/042377
申请日：2005-11-22
申请人： QUEST DIAGNOSTICS INCORPORATED , MOHAMMED, Mansoor, S. , DZIDIC, Natasa
发明人： MOHAMMED, Mansoor, S. , DZIDIC, Natasa
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837
摘要： The present invention relates to methods of quality control of manufactured nucleic acid arrays. Fluorescence detection is used to evaluate the quality of a printed nucleic acid array prior to its use in hybridization without the need to add or otherwise link a fluorescent compound or dye to the nucleic acid. Nucleic acid arrays suitable for this method are those where the spots of the array are formed by printing a solution that contains the nucleic acid in an ion containing solution. Printing quality may be evaluated by measuring the intensity of fluorescence at the location of each printed sample, and/or by measuring the "morphology" (i.e. shape) of the printed sample. Printed spots can be "imaged" by measuring fluorescence across a spotted sample in two dimensions. The resulting image of a printed spot can be compared with a reference printed image expected for the printing equipment and solid phase used.
摘要翻译：本发明涉及制造的核酸阵列的质量控制方法。使用荧光检测来评估打印的核酸阵列在用于杂交之前的质量，而不需要添加或以其他方式将荧光化合物或染料连接至核酸。适用于该方法的核酸阵列是通过在含有离子的溶液中印刷包含核酸的溶液而形成阵列的斑点的阵列。印刷质量可以通过测量每个印刷样品的位置处的荧光强度和/或通过测量每个印刷样品的“形态”来评估。（即，形状）。印刷的斑点可以被“成像” 通过测量二维斑点样品上的荧光。打印点的图像可以与预期用于打印设备和固相的参考打印图像进行比较。

4. 发明申请

WO1998016234A1 LONG CHAIN CARBOXYBETAINES IN ANTIMICROBIAL FORMULATIONS 审中-公开
标题翻译：长链碳羧酸在抗微生物制剂中的应用
公开(公告)号：WO1998016234A1
公开(公告)日：1998-04-23
申请号：PCT/US1997018256
申请日：1997-10-10
申请人： QUEST DIAGNOSTICS INCORPORATED , CHILDRENS HOSPITAL LOS ANGELES , THORNTON, Charles, G. , NASH, Kevin, A.
发明人： QUEST DIAGNOSTICS INCORPORATED , CHILDRENS HOSPITAL LOS ANGELES
IPC分类号： A61K31/685
CPC分类号： A61K31/205 , Y02A50/473 , Y02A50/481
摘要： Compositions containing long chain carboxybetaines, and their use in antimicrobial formulations, are described. The compositions and methods are especially useful against gram positive microorganisms such as Staphylococcus and gram negative microorganisms such as Escherichia, Salmonella and Pseudomonas.
摘要翻译：描述了含有长链羧基甜菜碱的组合物及其在抗微生物制剂中的用途。组合物和方法对于革兰氏阳性微生物如葡萄球菌和革兰氏阴性微生物如大肠杆菌，沙门氏菌和假单胞菌是特别有用的。

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