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1. 发明申请

WO2007103568A3 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF DISEASES OF THE AORTA 审中-公开
公开(公告)号：WO2007103568A3
公开(公告)日：2007-09-13
申请号：PCT/US2007/006091
申请日：2007-03-09
申请人： BIOSITE, INC. , MCPHERSON, Paul, H. , VIJAYENDRAN, Ravi, A.
发明人： MCPHERSON, Paul, H. , VIJAYENDRAN, Ravi, A.
IPC分类号： G01N33/53
摘要： The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to the use of biomarkers, either individually or in combinations with one another to rule in or out diseases of the aorta and its branches, most particularly aortic aneurysm and/or aortic dissection, and for risk stratification in such conditions. Preferred markers include one or more of creatine kinase-BB (CK-BB), creatine kinase-MB (CK-MB), acidic calponin, basic calponin, B-type natriuretic peptide (BNP), NT-proBNP, proBNP, BNP 79-I08 , BNP 3-108 , caldesmon, caspase-3, D-dimer, soluble elastin fragments, endothelial cell-selective adhesion molecule (ESAM), fibrillin-1, heart-type fatty acid binding protein, MMP -9, myeloperoxidase, myoglobin, smooth muscle myosin, smooth muscle myosin heavy chain, TIMP-I, free cardiac troponin I, complexed cardiac troponin I, free and complexed cardiac troponin I, free cardiac troponin T, complexed cardiac troponin T, and free and complexed cardiac troponin T, and preferred assays are configured to detect these markers.

2. 发明申请

WO2007041623A3 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND/OR PROGNOSIS IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROMES 审中-公开
公开(公告)号：WO2007041623A3
公开(公告)日：2007-04-12
申请号：PCT/US2006/038755
申请日：2006-10-03
申请人： BIOSITE INCORPORATED , BUECHLER, Kenneth, F. , ANDERBERG, Joseph, M. , MCPHERSON, Paul, H.
发明人： BUECHLER, Kenneth, F. , ANDERBERG, Joseph, M. , MCPHERSON, Paul, H.
IPC分类号： G01N33/53 , G01N33/50
摘要： Provided are methods and compositions for symptom-based differential diagnosis, prognosis and determination of treatment regimens in subjects In particular, the methods and compositions provided are selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, septic shock and/or MODS from each other and/or from non-infectious SIRS.

3. 发明申请

WO2007028070A3 USE OF SOLUBLE FLT-1 AND ITS FRAGMENTS IN CARDIOVASCULAR CONDITIONS 审中-公开
标题翻译：可溶性FLT-1及其片段在心血管病变中的应用
公开(公告)号：WO2007028070A3
公开(公告)日：2009-04-16
申请号：PCT/US2006034315
申请日：2006-08-29
申请人： BIOSITE INC , BUECHLER KENNETH F , MCPHERSON PAUL H
发明人： BUECHLER KENNETH F , MCPHERSON PAUL H
IPC分类号： A61K8/18 , A61Q13/00 , C12P21/06
CPC分类号： G01N33/6893 , G01N2333/71 , G01N2800/32 , G01N2800/324
摘要： The present invention relates to materials and procedures for evaluating patients suffering from cardiovascular conditions, particularly acute coronary syndromes. In particular, an assay configured to measure the level of soluble FLT-1 in a patient sample, alone or in combination with one or more other markers, provides diagnostic and/or prognostic information. While applicable to diseases and conditions in which inflammation is generally manifested, the methods and compositions described herein are particularly applicable to acute coronary syndromes, including conditions selected from the group consisting of stable angina, unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.
摘要翻译：本发明涉及用于评价患有心血管疾病，特别是急性冠状动脉综合征的患者的材料和程序。特别地，配置成单独或与一种或多种其它标记组合测量患者样品中可溶性FLT-1水平的测定提供了诊断和/或预后信息。在适用于通常表现出炎症的疾病和病症的情况下，本文所述的方法和组合物特别适用于急性冠状动脉综合征，包括选自稳定性心绞痛，不稳定型心绞痛，非ST段抬高型非Q波心肌梗塞，ST段抬高非Q波MI，透壁（Q波）MI。

4. 发明申请

WO2006071583A3 METHODS AND COMPOSITIONS FOR DETERMINING TREATMENT REGIMENS IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROMES 审中-公开
标题翻译：用于确定系统性炎症反应综合症中治疗方案的方法和组合物
公开(公告)号：WO2006071583A3
公开(公告)日：2007-10-11
申请号：PCT/US2005045711
申请日：2005-12-16
申请人： BIOSITE INC , BUECHLER KENNETH F , ANDERBERG JOSEPH MICHAEL , MCPHERSON PAUL H
发明人： BUECHLER KENNETH F , ANDERBERG JOSEPH MICHAEL , MCPHERSON PAUL H
IPC分类号： G01N33/53 , C12Q1/68 , G01N33/00 , G01N33/543 , G01N33/554 , G01N33/569
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , G01N33/68 , G01N2333/525 , G01N2333/54 , G01N2333/58 , G01N2333/585 , G01N2800/26 , G01N2800/60
摘要： The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, septic shock and/or MODS from each other and/or from non-infectious SIRS.
摘要翻译：本发明涉及用于受试者的基于症状的鉴别诊断，预后和治疗方案的方法和组合物。特别地，本发明涉及选择用于规定或排除SIRS的方法和组合，或用于将败血症，严重败血症，败血性休克和/或MODS彼此分化和/或来自非传染性SIRS。

5. 发明申请

WO2007103568A2 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF DISEASES OF THE AORTA 审中-公开
标题翻译：用于诊断AORTA疾病的方法和组合
公开(公告)号：WO2007103568A2
公开(公告)日：2007-09-13
申请号：PCT/US2007006091
申请日：2007-03-09
申请人： BIOSITE INC , MCPHERSON PAUL H , VIJAYENDRAN RAVI A
发明人： MCPHERSON PAUL H , VIJAYENDRAN RAVI A
IPC分类号： G01N33/53 , G06F19/00
CPC分类号： G01N33/6893 , G01N2800/329
摘要： The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to the use of biomarkers, either individually or in combinations with one another to rule in or out diseases of the aorta and its branches, most particularly aortic aneurysm and/or aortic dissection, and for risk stratification in such conditions. Preferred markers include one or more of creatine kinase-BB (CK-BB), creatine kinase-MB (CK-MB), acidic calponin, basic calponin, B-type natriuretic peptide (BNP), NT-proBNP, proBNP, BNP 79-I08 , BNP 3-108 , caldesmon, caspase-3, D-dimer, soluble elastin fragments, endothelial cell-selective adhesion molecule (ESAM), fibrillin-1, heart-type fatty acid binding protein, MMP -9, myeloperoxidase, myoglobin, smooth muscle myosin, smooth muscle myosin heavy chain, TIMP-I, free cardiac troponin I, complexed cardiac troponin I, free and complexed cardiac troponin I, free cardiac troponin T, complexed cardiac troponin T, and free and complexed cardiac troponin T, and preferred assays are configured to detect these markers.
摘要翻译：本发明涉及用于受试者的基于症状的鉴别诊断，预后和治疗方案的方法和组合物。特别地，本发明涉及生物标志物的使用，其单独地或彼此组合来规定主动脉及其分支，特别是主动脉瘤和/或主动脉夹层的疾病，以及在这种病症中的风险分层。优选的标记物包括肌酸激酶-BB（CK-BB），肌酸激酶-MB（CK-MB），酸性钙调蛋白，碱性钙调蛋白，B型利尿钠肽（BNP），NT-proBNP，proBNP，BNP，钙粘蛋白-3，D-二聚体，可溶性弹性蛋白片段，内皮细胞选择性粘附分子（ESAM），原纤维蛋白-1，心脏脂肪酸结合蛋白，MMP-9，髓过氧化物酶，肌红蛋白，平滑肌肌球蛋白，平滑肌肌球蛋白重链，TIMP-1，游离心肌肌钙蛋白I，复合心肌肌钙蛋白I，游离和复合心肌肌钙蛋白I，游离心肌肌钙蛋白 T，复合心肌肌钙蛋白T和游离和复合的心肌肌钙蛋白T，并且优选的测定被配置为检测这些标记。

6. 发明申请

WO2009006347A3 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND/OR PROGNOSIS IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROMES 审中-公开
标题翻译：全身炎症反应综合征诊断和/或预后的方法和组合物
公开(公告)号：WO2009006347A3
公开(公告)日：2009-04-09
申请号：PCT/US2008068667
申请日：2008-06-27
申请人： BIOSITE INC , LEE SEOK-WON , RODEMS KELLINE M , OELSCHLAGER DAVID W , VEERAMALLU UDAY KUMAR , BUECHLER JOSEPH F , MCPHERSON PAUL H
发明人： LEE SEOK-WON , RODEMS KELLINE M , OELSCHLAGER DAVID W , VEERAMALLU UDAY KUMAR , BUECHLER JOSEPH F , MCPHERSON PAUL H
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/521 , G01N2800/50 , G01N2800/56
摘要： The present invention relates to methods and compositions for diagnosing SIRS, sepsis, severe sepsis, septic shock, or MODS in a subject, or assigning a prognostic risk for one or more clinical outcomes for a subject suffering from SIRS, sepsis, severe sepsis, septic shock, or MODS, the method comprising performing an immunoassay for CCL23 splice variant.
摘要翻译：本发明涉及用于诊断受试者中的SIRS，败血症，严重败血症，败血症性休克或MODS，或为患有SIRS，败血症，严重败血症，败血症的受试者指定一种或多种临床结果的预后风险的方法和组合物休克或MODS，所述方法包括对CCL23剪接变体进行免疫测定。

7. 发明申请

WO2008061149A2 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL ARTERY STENOSIS 审中-公开
标题翻译：肾动脉狭窄诊断和预后的方法和组合物
公开(公告)号：WO2008061149A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/084700
申请日：2007-11-14
申请人： BIOSITE INCORPORATED , VALKIRS, Gunars , MCPHERSON, Paul, H.
发明人： VALKIRS, Gunars , MCPHERSON, Paul, H.
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/323 , G01N2800/347
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects in the context of renal artery stenosis (RAS). In particular, the invention relates to using assays that detect NGAL, their use to diagnose RAS in subjects suffering from hypertension, and their use in prognosis, particularly of mortality and worsening renal function.
摘要翻译：本发明涉及用于监测，诊断，预后和确定肾动脉狭窄（RAS）背景中的受试者的治疗方案的方法和组合物。具体而言，本发明涉及使用检测NGAL的测定法，它们用于诊断患有高血压的受试者中的RAS，以及它们在预后，特别是死亡率和肾功能恶化中的用途。

8. 发明申请

WO2008060607A2 METHODS AND COMPOSITIONS FOR MONITORING AND RISK PREDICTION IN CARDIORENAL SYNDROME 审中-公开
标题翻译：心脏综合征监测和风险预测的方法和组合
公开(公告)号：WO2008060607A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/024033
申请日：2007-11-14
申请人： BIOSITE INCORPORATED , VALKIRS, Gunars , MCPHERSON, Paul H.
发明人： VALKIRS, Gunars , MCPHERSON, Paul H.
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N33/74 , G01N2333/58 , G01N2800/347
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to monitor cardiorenal syndrome using assays that detect NGAL, preferably together with assays that detect natriuretic peptides such as BNP. Such methods and compositions can provide early indications of a deterioration in cardiorenal syndrome status, including prognosis regarding mortality and worsening renal function.
摘要翻译：本发明涉及用于受试者的治疗方案的监测，诊断，预后和测定的方法和组合物。特别地，本发明涉及选择用于使用检测NGAL的测定法监测心肾综合征的方法和组合物，优选与检测利尿钠肽如BNP的测定法一起使用。这些方法和组合物可以提供心脏综合征状态恶化的早期迹象，包括关于死亡率和恶化的肾功能的预后。

9. 发明申请

WO2006135781A3 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF VENOUS THROMBOEMBOLIC DISEASE 审中-公开
公开(公告)号：WO2006135781A3
公开(公告)日：2006-12-21
申请号：PCT/US2006/022544
申请日：2006-06-09
申请人： BIOSITE, INC. , MCPHERSON, Paul, H. , BUECHLER, Kenneth, F.
发明人： MCPHERSON, Paul, H. , BUECHLER, Kenneth, F.
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/00 , G01N33/543
摘要： The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out venous thromboembolic disease, pulmonary embolism, and/or deep vein thrombosis, and for risk stratification in such conditions.

10. 发明申请

WO2006135781A2 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF VENOUS THROMBOEMBOLIC DISEASE 审中-公开
标题翻译：用于诊断静脉血栓性疾病的方法和组合物
公开(公告)号：WO2006135781A2
公开(公告)日：2006-12-21
申请号：PCT/US2006022544
申请日：2006-06-09
申请人： BIOSITE INC , MCPHERSON PAUL H , BUECHLER KENNETH F
发明人： MCPHERSON PAUL H , BUECHLER KENNETH F
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/58 , G01N2800/226
摘要： The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out venous thromboembolic disease, pulmonary embolism, and/or deep vein thrombosis, and for risk stratification in such conditions.
摘要翻译：本发明涉及用于受试者的基于症状的鉴别诊断，预后和治疗方案的方法和组合物。特别地，本发明涉及选择用于规定静脉血栓栓塞性疾病，肺栓塞和/或深静脉血栓形成的方法和组合，以及在这种情况下的风险分层。

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