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1. 发明申请

WO2006042252A2 VIRAL COMPLEMENT CONTROL PROTEINS FOR EYE DISORDERS 审中-公开
标题翻译：眼睛疾病的病毒补体控制蛋白
公开(公告)号：WO2006042252A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/036547
申请日：2005-10-08
申请人： POTENTIA PHARMECEUTICALS, INC. , FRANCOIS, Cedric , DESCHATELETS, Pascal , OLSON, Paul
发明人： FRANCOIS, Cedric , DESCHATELETS, Pascal , OLSON, Paul
CPC分类号： A61K38/162 , C07K14/005 , C07K2319/33 , C12N2710/24122
摘要： The present invention provides compositions and methods for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration or choroidal neovascularization. Certain of the compositions comprise a poxvirus complement control protein or a complement binding fragment or variant thereof. Other compositions comprise a poxvirus complement control protein linked to a moiety that binds to a component present on or at the surface of cell or noncellular molecular entity, e.g., a component present in the eye of a subject at risk of or suffering from age related macular degeneration or a related condition or choroidal neovascularization. Certain of the methods comprise administering a poxvirus complement control protein or complement binding fragment or variant thereof to a subject.
摘要翻译：本发明提供用于治疗和/或预防年龄相关性黄斑变性和涉及黄斑变性或脉络膜新生血管形成的其它病症的组合物和方法。某些组合物包含痘病毒补体对照蛋白或其补体结合片段或变体。其他组合物包含与结合存在于细胞或非细胞分子实体的表面或其表面上的组分连接的部分的痘病毒补体对照蛋白，例如存在于患有年龄相关性黄斑的风险的患者的眼睛中的组分变性或相关病症或脉络膜新生血管形成。某些方法包括向受试者施用痘病毒补体对照蛋白或补体结合片段或其变体。

2. 发明申请

WO2005097969A1 APPARATUS AND METHODS FOR SIMULTANEOUS OPERATION OF MINIATURIZED REACTORS 审中-公开
标题翻译：微型反应器同时运行的装置和方法
公开(公告)号：WO2005097969A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/011295
申请日：2005-04-01
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BOCCAZZI, Paolo , CHEN, Angela, Y. , JENSEN, Klavs, F. , SZITA, Nicolas , ZANZOTTO, Andrea , ZHANG, Zhiyu
发明人： BOCCAZZI, Paolo , CHEN, Angela, Y. , JENSEN, Klavs, F. , SZITA, Nicolas , ZANZOTTO, Andrea , ZHANG, Zhiyu
IPC分类号： C12M1/34
CPC分类号： C12M1/12 , B01F13/0059 , B01F13/0827 , B01J2219/00283 , B01J2219/00317 , B01J2219/00479 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00691 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L9/527 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0877 , B01L2300/10 , B01L2400/0466 , B01L2400/0487 , C12M23/16 , C12M35/08 , C12M41/48 , G01N2035/00326 , Y10S435/808 , Y10S435/809
摘要： The present invention provides a variety of microscale bioreactors (microfermentors) and microscale bioreactor arrays for use in culturing cells. The microfermentors include a vessel (2) for culturing cells and means for providing oxygen (6) to the interior of the vessel at a concentration sufficient to support cell growth, e.g., growth of bacterial cells. Depending on the embodiment, the microfermentor vessel may have various interior volumes less than approximately 1 ml. The microfermentors may include an aeration membrane (6) and optionally a variety of sensing devices (12). The invention further provides a chamber to contain the microfermentors and microfermentor arrays and to provide environmental control. The invention provides microreactors having a variety of different designs, some of which incorporate active stirring and/or have the capability to operate in batch or fed-batch mode. The invention further provides an apparatus and methods for simultaneous operation of a plurality of microreactors, with monitoring of the individual microreactors during a run. The invention further provides methods of performing gene expression analysis on cells cultured in microreactors.
摘要翻译：本发明提供用于培养细胞的各种微量生物反应器（微发酵器）和微生物生物反应器阵列。微发酵器包括用于培养细胞的容器（2）和用于以足以支持细胞生长（例如细菌细胞生长）的浓度向容器内部提供氧（6）的装置。根据实施方案，微发酵罐容器可以具有小于约1ml的各种内部容积。微发酵器可以包括曝气膜（6）和可选的各种感测装置（12）。本发明进一步提供了容纳微发射体和微发光体阵列并提供环境控制的腔室。本发明提供具有各种不同设计的微反应器，其中一些具有主动搅拌和/或具有以分批或分批模式操作的能力。本发明还提供了一种用于同时操作多个微反应器的装置和方法，其中在运行期间监测各个微反应器。本发明还提供了对在微反应器中培养的细胞进行基因表达分析的方法。

3. 发明申请

WO2005086954A2 CONDUCTANCE OF IMPROPERLY FOLDED PROTEINS THROUGH THE SECRETORY PATHWAY AND RELATED METHODS FOR TREATING DISEASE 审中-公开
标题翻译：通过秘密路径导致的不正确折叠蛋白质的导管及相关治疗疾病的方法
公开(公告)号：WO2005086954A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/008184
申请日：2005-03-11
申请人： YALE UNIVERSITY , CAPLAN, Michael, J. , EGAN, Marie, E.
发明人： CAPLAN, Michael, J. , EGAN, Marie, E.
IPC分类号： A61K9/00 , A61K9/20 , A61K31/00 , A61K31/02 , A61K31/122 , A61K31/343 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/407 , A61K31/47 , A61K31/713 , C12Q1/48 , G01N33/50
CPC分类号： A61K31/343 , A61K9/0031 , A61K9/0053 , A61K9/0078 , A61K9/2022 , A61K31/00 , A61K31/02 , A61K31/12 , A61K31/122 , A61K31/351 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/407 , A61K31/47 , A61K31/713 , C12Q1/48 , G01N33/5076 , A61K2300/00
摘要： This invention provides the methodology and agents for treating any disease or clinical condition which is at least partly the result of endoplasmic reticulum-associated retention of proteins. Thus, the methods and agents of the present invention provide for the release of normally retained proteins form the endoplasmic reticulum. The present invention is particularly useful for treating any disease or clinical condition which is at least partly the result of endoplasmic reticulum-associated retention or degradation of mis-assembled or mis-folded proteins. In certain embodiments of the invention the agents include at least one curcuminoid.
摘要翻译：本发明提供用于治疗任何疾病或临床病症的方法和试剂，其至少部分是蛋白质内质网相关保留的结果。因此，本发明的方法和试剂提供从内质网形成的正常保留的蛋白质的释放。本发明特别可用于治疗至少部分由内质网相关的残留或错误组合或错误折叠的蛋白质降解的结果的疾病或临床病症。在本发明的某些实施方案中，所述药剂包括至少一种姜黄素。

4. 发明申请

WO2005065396A2 IMPROVED BONE MATRIX COMPOSITIONS AND METHODS 审中-公开
标题翻译：改进骨基质组合物和方法
公开(公告)号：WO2005065396A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/043999
申请日：2004-12-31
申请人： OSTEOTECH, INC. , BEHNAM, Keyvan
发明人： BEHNAM, Keyvan
IPC分类号： A61L27/22 , A61L27/36 , A61L27/54
CPC分类号： A61K38/01 , A61L27/227 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/3683 , A61L27/3687 , A61L27/3847 , A61L27/3852 , A61L27/54 , A61L2300/254 , A61L2300/412 , A61L2300/432 , A61L2430/02 , A61L2430/06 , Y10S623/901
摘要： The present invention provides methods of improving the osteogenic and/or chondrogenic activity of a bone matrix, e.g., a dermineralized bone matrix (DBM), by exposing the bone matrix to one or more treatments or conditions. In preferred embodiments the bone matrix is derived from human bone. The treatment or condition may alter the structure of the bone matrix and/or cleave one or more specific proteins. Cleavage may generate peptides or protein fragments that have osteoinductive, osteogenic, or chondrogenic activity. Preferred treatments include collagenase and various other proteases. The invention further provides improved bone and cartilage matrix compositions that have been prepared according to the inventive methods and methods of treatment using the compositions. The invention further provides methods of preparing, testing, and using the improved bone matrix compositions. Ona assay comprises exposing relatively undifferentiated mesenchymal cells to a bone matrix composition and measuring expression of a marker characteristic of osteoblast or chondrocyte lineage(s). Increased expression of the marker relative to the level of the marker in cells that have been exposed to a control matrix (e.g., an inactivated or untreated matrix) indicates that the treatment or condition increased the osteogenic and/or chondrogenic activity of the bone matrix. Suitable cells include C2C12 cells. A suitable marker is alkaline phosphatase. The inventive methods increase the osteogenic and/or chondrogenic activity of human DBM when tested using this assay system.
摘要翻译：本发明提供通过将骨基质暴露于一种或多种治疗或病症来改善骨基质例如脱矿骨基质（DBM）的成骨和/或软骨形成活性的方法。在优选实施方案中，骨基质衍生自人骨。治疗或病症可改变骨基质的结构和/或切割一种或多种特异性蛋白质。切割可能产生具有骨诱导，成骨或软骨形成活性的肽或蛋白质片段。优选的治疗包括胶原酶和各种其它蛋白酶。本发明还提供了根据本发明的方法和使用该组合物的治疗方法制备的改进的骨和软骨基质组合物。本发明还提供了制备，测试和使用改进的骨基质组合物的方法。 Ona测定包括将相对未分化的间充质细胞暴露于骨基质组合物并测量成骨细胞或软骨细胞谱系特征性标志物的表达。已经暴露于对照基质（例如，灭活或未经处理的基质）的细胞中标志物相对于标记物水平的增加表明该治疗或病症增加了骨基质的成骨和/或软骨形成的活性。合适的细胞包括C2C12细胞。合适的标记是碱性磷酸酶。当使用该测定系统测试时，本发明的方法增加人DBM的成骨和/或软骨形成活性。

5. 发明申请

WO2003093406A2 MICROFERMENTORS FOR RAPID SCREENING AND ANALYSIS OF BIOCHEMICAL PROCESSES 审中-公开
标题翻译：微生物快速筛选和生物化学过程分析
公开(公告)号：WO2003093406A2
公开(公告)日：2003-11-13
申请号：PCT/US2003/013479
申请日：2003-05-01
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： ZANZOTTO, Andrea , JENSEN, Klavs, F. , SINSKEY, Anthony, J. , SCHMIDT, Martin, A. , LAIBINIS, Paul , RAM, Rajeev, J. , SZITA, Nicolas
IPC分类号： C12M
CPC分类号： G01N21/648 , B01J2219/00283 , B01J2219/00317 , B01J2219/00479 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00691 , B01J2219/00743 , B01L3/5027 , B01L2200/027 , B01L2200/10 , B01L2300/0816 , B01L2300/0822 , B01L2300/0867 , B01L2300/10 , C12M23/16 , C12M23/58 , C12M29/04 , C12M29/10 , G01N21/31 , G01N21/6408 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N35/0099 , G01N2021/6484 , G01N2021/7783 , G01N2021/7786
摘要： The present invention provides a variety of microscale bioreactors (microfermentors) and microscale bioreactor arrays for use in culturing cells. The microfermentors include a vessel for culturing cells and means for providing oxygen to the interior of the vessel at a concentration sufficient to support cell growth, e.g., growth of bacterial cells. Depending on the embodiment, the microfermentor vessel may have various interior volumes less than approximately 1 ml. The microfermentors may include an aeration membrane and optionally a variety of sensing devices. The invention further provides a chamber to contain the microfermentors and microfermentor arrays and to provide environmental control. Certain of the microfermentors include a second chamber that may be used, e.g., to provide oxygen, nutrients, pH control, etc., to the culture vessel and/or to remove metabolites, etc. Various methods of using the microfermentors, e.g., to select optimum cell strains or bioprocess parameters are provided.
摘要翻译：本发明提供用于培养细胞的各种微量生物反应器（微发酵器）和微生物生物反应器阵列。微发酵器包括用于培养细胞的容器和用于以足以支持细胞生长（例如细菌细胞生长）的浓度向容器内部提供氧气的装置。根据实施方案，微发酵罐容器可以具有小于约1ml的各种内部容积。微发酵器可以包括曝气膜和任选的各种感测装置。本发明进一步提供了容纳微发射体和微发光体阵列并提供环境控制的腔室。某些微发酵器包括第二室，其可以用于例如向培养容器提供氧气，营养物质，pH控制等，和/或去除代谢物等。使用微发酵器的各种方法，例如，选择最佳细胞株或生物过程参数。

6. 发明申请

WO2003079757A3 HIV THERAPEUTIC 审中-公开
公开(公告)号：WO2003079757A3
公开(公告)日：2003-10-02
申请号：PCT/US2003/008653
申请日：2003-03-20
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE CENTER FOR BLOOD RESEARCH, INC. , BERESFORD, Paul, J. , LIEBERMAN, Judy , MURRAY, Michael, F. , NOVINA, Carl, D. , SHARP, Phillip, A.
发明人： BERESFORD, Paul, J. , LIEBERMAN, Judy , MURRAY, Michael, F. , NOVINA, Carl, D. , SHARP, Phillip, A.
IPC分类号： C12Q1/68
摘要： The present invention provides siRNA methods and compositions for inhibiting HIV and/or replication, as well as systemsfor identifying effective siRNAs for inhibiting HIV and systems for studying HIV infective mechanisms. The invention also provides methods and compositions for inhibiting infection, pathogenecityand/or replication of an infectious agent; for example, by using siRNAs to inhibit host cell gene expression.

7. 发明申请

WO2003077062A3 SYSTEMS AND METHODS FOR REVERSE ENGINEERING MODELS OF BIOLOGICAL NETWORKS 审中-公开
公开(公告)号：WO2003077062A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/006491
申请日：2003-03-05
申请人： TRUSTEES OF BOSTON UNIVERSITY , GARDNER, Timothy, S. , COLLINS, James, J. , DI BERNARDO, Diego , TEGNER, Jesper , YEUNG, Man, Kit, Stephen
发明人： GARDNER, Timothy, S. , COLLINS, James, J. , DI BERNARDO, Diego , TEGNER, Jesper , YEUNG, Man, Kit, Stephen
IPC分类号： G01N33/53
摘要： The present invention provides methods and accompanying computer-based systems and computer-executable code stored on a computer-readable medium for constructing a model of a biological network. The invention further provides methods for performing sensitivity analysis on a biological network and for identifying major regulators of species in the network and of the network as a whole. In addition, the invention provides methods for identifying targets of a perturbation such as that resulting from exposure to a compound or an environmental change. The invention further provides methods for identifying phenotypic mediators that contribute to differences in phenotypes of biological systems.

8. 发明申请

WO2002074923A2 TARGETS AND SCREENS FOR AGENTS USEFUL IN CONTROLLING PARASITIC NEMATODES 审中-公开
标题翻译：用于控制PARASITIC NEMATODES的试剂的目标和筛选
公开(公告)号：WO2002074923A2
公开(公告)日：2002-09-26
申请号：PCT/US2002/008336
申请日：2002-03-20
申请人： CAMBRIA BIOSCIENCES
发明人： LIU, Leo, X. , SLUDER, Ann , PROVOST, Chris , LINDBLOM, Timothy , SUTHERLIN, Marie
IPC分类号： C12N
CPC分类号： G01N33/5308 , C07K14/4354 , C07K14/43545 , G01N33/5097 , G01N33/573 , G01N2500/10
摘要： The invention provides methods and reagents for identifying compounds that exhibit anti-nematode activity and compounds that potentiate the effects of other anti-nematode agents. The invention provides methods foridentifying modulators of nematode xenobiotic sensing nuclear receptors. The invention also provides methods for screening for anti-nematode compounds using sensitized nematode strains and further provides such sensitized strains. The invention further provides methods and screens for identifying new biological targets for anti-nematode compounds, e.g., for identifying nematode genes and proteins towards which anti-nematode compounds can be developed. The invention provides methods for controlling parasitic nematodes using compounds identified in the inventive screens. In addition, the invention provides sensitized nematode strains and methods for using such strains to enhance identification of compounds in the context of a wide variety of nematode model screening systems and strains.
摘要翻译：本发明提供用于鉴定显示抗线虫活性的化合物的方法和试剂，以及增强其它抗线虫剂效果的化合物。本发明提供了鉴定线虫异生物感受核受体调节剂的方法。本发明还提供了使用致敏线虫菌株筛选抗线虫化合物并进一步提供这种致敏菌株的方法。本发明还提供用于鉴定抗线虫化合物的新生物靶标的方法和筛选，例如用于鉴定可以开发抗线虫化合物的线虫基因和蛋白质。本发明提供了使用本发明筛选中鉴定的化合物来控制寄生线虫的方法。此外，本发明提供致敏线虫菌株和使用这些菌株在多种线虫模型筛选系统和菌株的背景下增强化合物鉴定的方法。

9. 发明申请

WO2002062969A2 CELLULAR REPROGRAMMING IN PEPTIDE HYDROGEL AND USES THEREOF 审中-公开
标题翻译：肽水解中的细胞重编码及其用途
公开(公告)号：WO2002062969A2
公开(公告)日：2002-08-15
申请号：PCT/US2002/003607
申请日：2002-02-06
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SEMINO, Carlos, E. , SHERLEY, James , ZHANG, Shuguang
发明人： SEMINO, Carlos, E. , SHERLEY, James , ZHANG, Shuguang
IPC分类号： C12N5/00
CPC分类号： C12N5/0655 , A61K35/12 , C12N5/0012 , C12N5/0618 , C12N5/0672 , C12N2500/25 , C12N2501/11 , C12N2501/13 , C12N2502/1317 , C12N2533/30 , C12N2533/50
摘要： The present invention provides compositions featuring cells, e.g., progenitor cells, stem cells, and their progeny encapsulated within self-assembling three-dimensional peptide hydrogel structures (scaffolds). The scaffolds provide a nanoscale environment. Thus the invention provides a nanoscale environment scaffold encapsulating cells. According to certain embodiments of the invention the progenitor cells and/or their progeny are able to differentiate or transdifferentiate within the structures. According to certain embodiments of the invention the cells are liver lineage cells or neural lineage cells. The peptide hydrogel environment renders the cells permissive for instruction by differentiation-enhancing agents such as growth factors. The invention provides an in vitro culture system for growing stem and progenitor cells, for inducing their differentiation and transdifferentiation, and for studying their properties; an in vitro culture system for growing hepatocyte-like cells and/or mature hepatocytes, which may be used, for example, to propagate hepatotropic viruses; a system for controlling and manipulating cell differentiation and transdifferentiation in vitro, from which cells can be extracted and then either maintained in vitro or administered to a subject, e.g., for treating a tissue defect or other condition; a system for controlling and manipulating cell differentiation and transdifferentiation in vitro within a structure that is to be implanted within a subject, e.g., for treating a tissue defect or other condition, and assay systems for testing compounds.
摘要翻译：本发明提供了组合物，其特征在于，细胞，例如祖细胞，干细胞及其后代，其包封在自组装的三维肽水凝胶结构（支架）内。支架提供了纳米尺度的环境。因此，本发明提供了一种封装细胞的纳米级环境支架。根据本发明的某些实施方案，祖细胞和/或其后代能够在结构内分化或转分化。根据本发明的某些实施方案，细胞是肝谱系细胞或神经谱系细胞。肽水凝胶环境使细胞允许通过分化增强剂如生长因子的指导。本发明提供了用于培养干细胞和祖细胞，用于诱导其分化和转分化并用于研究其性质的体外培养系统。用于生长肝细胞样细胞和/或成熟肝细胞的体外培养系统，其可以用于例如增殖嗜肝病毒; 用于控制和操纵体外细胞分化和转分化的系统，从中可以提取细胞，然后在体外保持或施用于受试者，例如用于治疗组织缺陷或其他病症; 用于在待植入受试者的结构内（例如用于治疗组织缺陷或其他病症）和用于测试化合物的测定系统的体外控制和操纵细胞分化和转分化的系统。

10. 发明申请

WO2006084132A3 REAGENTS, METHODS, AND LIBRARIES FOR BEAD-BASED SQUENCING 审中-公开
公开(公告)号：WO2006084132A3
公开(公告)日：2006-08-10
申请号：PCT/US2006/003845
申请日：2006-02-01
申请人： AGENCOURT BIOSCIENCE CORP. , MCKERNAN, Kevin , BLANCHARD, Alan , KOTLER,Lev , COSTA, Gina
发明人： MCKERNAN, Kevin , BLANCHARD, Alan , KOTLER,Lev , COSTA, Gina
IPC分类号： C12Q1/68
摘要： The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension probes containing phosphorothiolate linkages and employ agents appropriate to cleave such linkages. In certain embodiments the methods make use of extension probes containing an abasic residue or a damaged base and employ agents appropriate to cleave linkages between a nucleoside and an abasic residue and/or agents appropriate to remove a damaged base from a nucleic acid. The invention provides methods of determining information about a sequence using at least two distinguishably labeled probe families. In certain embodiments the methods acquire less than 2 bits of information from each of a plurality of nucleotides in the template in each cycle. In certain embodiments the sequencing reactions are performed on templates attached to beads, which are immobilized in or on a semi-solid support. The invention further provides sets of labeled extension probes containing phosphorothiolate linkages or trigger residues that are suitable for use in the method. In addition, the invention includes performing multiple sequencing reactions on a single template by removing initializing oligonucleotides and extended strands and performing subsequent reactions using different initializing oligonucleotides. The invention further provides efficient methods for preparing templates, particularly for performing sequencing multiple different templates in parallel. The invention also provides methods for performing ligation and cleavage. The invention also provides new libraries of nucleic acid fragments containing paired tags, and methods of preparing microparticles having multiple different templates (e.g., containing paired tags) attached thereto and of sequencing the templates individually. The invention also provides automated sequencing systems, flow cells, image processing methods, and computer-readable media that store computer-executable instructions (e.g., to perform the image-processing methods) and/or sequence information. In certain embodiments the sequence information is stored in a database.

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