专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2002074923A2 TARGETS AND SCREENS FOR AGENTS USEFUL IN CONTROLLING PARASITIC NEMATODES 审中-公开
标题翻译：用于控制PARASITIC NEMATODES的试剂的目标和筛选
公开(公告)号：WO2002074923A2
公开(公告)日：2002-09-26
申请号：PCT/US2002/008336
申请日：2002-03-20
申请人： CAMBRIA BIOSCIENCES
发明人： LIU, Leo, X. , SLUDER, Ann , PROVOST, Chris , LINDBLOM, Timothy , SUTHERLIN, Marie
IPC分类号： C12N
CPC分类号： G01N33/5308 , C07K14/4354 , C07K14/43545 , G01N33/5097 , G01N33/573 , G01N2500/10
摘要： The invention provides methods and reagents for identifying compounds that exhibit anti-nematode activity and compounds that potentiate the effects of other anti-nematode agents. The invention provides methods foridentifying modulators of nematode xenobiotic sensing nuclear receptors. The invention also provides methods for screening for anti-nematode compounds using sensitized nematode strains and further provides such sensitized strains. The invention further provides methods and screens for identifying new biological targets for anti-nematode compounds, e.g., for identifying nematode genes and proteins towards which anti-nematode compounds can be developed. The invention provides methods for controlling parasitic nematodes using compounds identified in the inventive screens. In addition, the invention provides sensitized nematode strains and methods for using such strains to enhance identification of compounds in the context of a wide variety of nematode model screening systems and strains.
摘要翻译：本发明提供用于鉴定显示抗线虫活性的化合物的方法和试剂，以及增强其它抗线虫剂效果的化合物。本发明提供了鉴定线虫异生物感受核受体调节剂的方法。本发明还提供了使用致敏线虫菌株筛选抗线虫化合物并进一步提供这种致敏菌株的方法。本发明还提供用于鉴定抗线虫化合物的新生物靶标的方法和筛选，例如用于鉴定可以开发抗线虫化合物的线虫基因和蛋白质。本发明提供了使用本发明筛选中鉴定的化合物来控制寄生线虫的方法。此外，本发明提供致敏线虫菌株和使用这些菌株在多种线虫模型筛选系统和菌株的背景下增强化合物鉴定的方法。

IPRDB

热门服务

关于我们

友情链接

联系方式