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61. 发明申请

WO1997016544A1 WATER SOLUBLE CROSS-LINKING AGENTS 审中-公开
标题翻译：水溶性交联剂
公开(公告)号：WO1997016544A1
公开(公告)日：1997-05-09
申请号：PCT/US1996017645
申请日：1996-10-31
申请人： BSI CORPORATION , SWAN, Dale, G. , AMOS, Richard, A. , EVERSON, Terrence, P.
发明人： BSI CORPORATION
IPC分类号： C12N11/00
CPC分类号： C07D295/112 , C07C45/63 , C07C225/16 , C07C309/14 , C07K17/06 , G01N33/54353 , Y10S530/81 , Y10S530/816 , C07C49/813
摘要： A chemical linking agent formed of a di- or higher functional photoactivatable compound and providing at least one group that is charged under the conditions of use in order to provide improved water solubility. The linking agent further provides two or more photoactivatable groups in order to allow the agent to be used as a cross-linking agent in aqueous systems. The charged group can be provided by a radical that includes one or more salts of organic acids, onium compounds, or protonated amines (and optionally one or more additional photoreactive group), and the photoreactive groups can be provided by two or more radicals that include an aryl ketone.
摘要翻译：由二官能或更高官能的可光活化化合物形成的化学连接剂，并提供至少一个在使用条件下加入以提供改善的水溶性的基团。连接剂还提供两个或更多个可光活化基团，以便允许该试剂在含水体系中用作交联剂。带电基团可以由包括一种或多种有机酸，鎓化合物或质子化胺（和任选的一种或多种另外的光反应性基团）的盐的基团提供，并且光反应性基团可以由两个或更多个基团提供，所述基团包括芳基酮。

62. 发明申请

WO9609805A3 CHITOSAN INDUCED IMMUNOPOTENTIATION 审中-公开
标题翻译： CHITOSAN诱导免疫
公开(公告)号：WO9609805A3
公开(公告)日：1996-07-25
申请号：PCT/US9512189
申请日：1995-09-25
申请人： ZONAGEN INC
发明人： PODOLSKI JOSEPH S , HSU KUANG , BHOGAL BALBIR , SINGH GURPREET
IPC分类号： A61K31/722 , A61K39/385 , A61K39/39 , A61K47/48 , A61P37/04 , C07K17/06
CPC分类号： C07K17/06 , A61K31/722 , A61K39/385 , A61K39/39 , A61K47/61 , A61K2039/55505 , A61K2039/55583 , A61K2039/55588 , A61K2039/6087 , A61K2300/00
摘要： Methods and compositions for potentiating an immune response are disclosed which incorporate chitosan as an immunopotentiating adjuvant. Administration of the compositions of the invention is effected by various routes. 00000
摘要翻译：公开了用于增强免疫应答的方法和组合物，其包含壳聚糖作为免疫增强佐剂。本发明组合物的施用通过各种途径进行。 00000

63. 发明申请

WO1989009233A1 MOLECULAR STICKS FOR CONTROLLING PROTEIN CONFORMATION 审中-公开
标题翻译：用于控制蛋白质配合的分子棒
公开(公告)号：WO1989009233A1
公开(公告)日：1989-10-05
申请号：PCT/US1989001195
申请日：1989-03-23
申请人： TERRAPIN DIAGNOSTICS, INC.
发明人： TERRAPIN DIAGNOSTICS, INC. , KAUVAR, Lawrence, M.
IPC分类号： C07K15/00
CPC分类号： C07H21/00 , A61K39/00 , C07K17/06
摘要： Methods of stabilizing the three-dimensional conformations of proteins using "molecular sticks" to bridge and constrain tertiary protein structures are disclosed. These "molecular sticks" contain rigid multimeric spacer portions of various lengths, which are terminated on each end by chemical groups capable of covalent linkages to other designated chemical groups on different segments of the protein or peptide to be constrained. Proteins or peptides with stabilized tertiary structures are useful in diagnosis and therapy, especially under conditions where unstabilized proteins would be denatured.
摘要翻译：公开了使用“分子棒”稳定蛋白质的三维构象以桥接和约束三级蛋白质结构的方法。这些“分子棒”包含各种长度的刚性多聚体间隔物部分，其在每个末端被能够与要约束的蛋白质或肽的不同部分上的其它指定化学基团共价连接的化学基团终止。具有稳定的三级结构的蛋白质或肽可用于诊断和治疗，特别是在不稳定的蛋白质变性的条件下。

64. 发明申请

WO2017042303A1 BINDING OF HYDROPHOBIC ANTIGENS TO SURFACES 审中-公开
标题翻译：将疏水性抗生素与表面结合
公开(公告)号：WO2017042303A1
公开(公告)日：2017-03-16
申请号：PCT/EP2016/071240
申请日：2016-09-08
申请人： DANMARKS TEKNISKE UNIVERSITET
发明人： BOAS, Ulrik
IPC分类号： C07K17/06 , C07K17/14 , G01N33/543
CPC分类号： C07K17/14 , C07K17/06 , G01N33/54313 , G01N33/6854
摘要： A first aspect of the present invention is a method of detecting antibodies comprising the steps of: i) providing a first group of beads comprising a surface modified with C 1 -C 10 alkyl groups comprising amine, ammonium, ether and/or hydroxyl groups, ii) contacting said first group of beads with a first hydrophobic antigen to provide a first group of bead-antigen conjugates by adsorption of the first hydrophobic antigen on the first group of beads, iii) isolating said bead- antigen conjugates, iv) contacting said bead-antigen conjugates with a sample to bind antibodies therein to provide bead-antigen-antibody conjugates, and v) detecting said bead-antigen-antibody conjugates. Further aspects include an antibody detection kit, a bead-antigen conjugate and a composition comprising at least two different groups of bead-antigen-conjugates.
摘要翻译：本发明的第一方面是检测抗体的方法，其包括以下步骤：i）提供第一组珠粒，其包含用包含胺，铵，醚和/或羟基的C 1 -C 10烷基修饰的表面，ii）使所述第一组珠与第一疏水性抗原接触，通过将第一疏水性抗原吸附在第一组珠上提供第一组珠 - 抗原缀合物，iii）分离所述珠 - 抗原缀合物，iv）抗原缀合物与样品结合以在其中结合抗体以提供珠 - 抗原 - 抗体缀合物，和v）检测所述珠 - 抗原 - 抗体缀合物。其它方面包括抗体检测试剂盒，珠 - 抗原缀合物和包含至少两种不同组的珠 - 抗原缀合物的组合物。

65. 发明申请

WO2017020568A1 一种溶解难溶多肽的偶联肽链及其在液相色谱中分离纯化的应用审中-公开
公开(公告)号：WO2017020568A1
公开(公告)日：2017-02-09
申请号：PCT/CN2016/073393
申请日：2016-02-03
申请人：南京斯拜科生化实业有限公司
发明人：周彬 , 查建生 , 康武 , 徐金荣 , 潘奕
IPC分类号： C07K2/00 , C07K1/16
CPC分类号： C07K1/16 , B01J20/292 , B01J2219/00916 , C07C63/06 , C07K2/00 , C07K17/06 , G01N33/6803 , G01N2030/027
摘要：提供了一种溶解难溶多肽的偶联肽链及其在液相色谱中的应用。利用特殊连接臂将亲水多肽链与难溶多肽链连接，使难溶多肽可在液相色谱中操作，然后水解断开难溶多肽和亲水多肽链，使目标肽链析出。

66. 发明申请

WO2014181254A3 DETECTING ENDOCRINE DISRUPTING COMPOUNDS 审中-公开
标题翻译：检测内皮细胞破坏化合物
公开(公告)号：WO2014181254A3
公开(公告)日：2015-03-12
申请号：PCT/IB2014061242
申请日：2014-05-06
申请人： UNIV STELLENBOSCH
发明人： SWART PIETER , TRUEBODY BARRY ERIC
IPC分类号： G01N33/74 , C07K14/72 , C07K17/00
CPC分类号： G01N33/743 , C07K14/721 , C07K17/06 , G01N2333/723
摘要： The invention relates to detecting endocrine disrupting compounds. Specifically the invention provides for a detection device for detecting endocrine disrupting compounds, which includes a support structure and ligand binding domains (LBD) of at least one sex hormone receptor, immobilised on the support structure. The detection device further includes a linker molecule between the support structure and the ligand binding domains, for immobilising the LBD's on the support structure.
摘要翻译：本发明涉及检测内分泌干扰化合物。具体地，本发明提供了用于检测内分泌干扰化合物的检测装置，其包含固定在支持结构上的至少一种性激素受体的支持结构和配体结合结构域（LBD）。检测装置还包括在支持结构和配体结合结构域之间的连接分子，用于将LBD固定在支持结构上。

67. 发明申请

WO2012126788A1 METHODS FOR SYNTHESIS OF AN OLIGOPEPTIDE MICROARRAY 审中-公开
标题翻译：合成寡核苷酸微阵列的方法
公开(公告)号：WO2012126788A1
公开(公告)日：2012-09-27
申请号：PCT/EP2012/054503
申请日：2012-03-15
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , NIMBLEGEN SYSTEMS GMBH
发明人： ALBERT, Thomas , BUELHER, Jochen , OTT, Markus , RICHMOND, Todd , RODESCH, Matthew , STENGELE, Klaus-Peter
IPC分类号： C07K17/06
CPC分类号： C07K17/06 , B01J19/0046 , B01J2219/00432 , B01J2219/00439 , B01J2219/00596 , B01J2219/0061 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C40B50/18
摘要： An oligopeptide microarray and methods for the synthesis thereof are presented. Further presented is a microarray on a solid support comprising at least about 10,000 oligopeptide features per cm2 and preferably at least about 50,000 oligopeptide features per cm 2 .
摘要翻译：提出了寡肽微阵列及其合成方法。还提出了一种固体支持物上的微阵列，其包含每cm 2至少约10,000个寡肽特征，优选每cm 2至少约50,000个寡肽特征。

68. 发明申请

WO2012083425A1 NOVEL ALKALI-RESISTANT VARIANTS OF PROTEIN A AND THEIR USE IN AFFINITY CHROMATOGRAPHY 审中-公开
标题翻译：蛋白A的新型抗碱性变体及其在亲和色谱中的应用
公开(公告)号：WO2012083425A1
公开(公告)日：2012-06-28
申请号：PCT/CA2011/001370
申请日：2011-12-21
申请人： THE UNIVERSITY OF WESTERN ONTARIO , LI, Shun-Cheng , LI, Xing , VOSS, Courtney , NAKAMURA, Satoshi , FUKUTA, Tetsuo , OKANO, Yuusuke , SHIOTANI, Tomonori , TAMORI, Kouji , WANG, Yong
发明人： LI, Shun-Cheng , LI, Xing , VOSS, Courtney , NAKAMURA, Satoshi , FUKUTA, Tetsuo , OKANO, Yuusuke , SHIOTANI, Tomonori , TAMORI, Kouji , WANG, Yong
IPC分类号： C07K14/31 , C07K1/22 , C07K16/00 , C07K17/00
CPC分类号： C07K14/31 , B01D15/3809 , B01J20/28057 , B01J20/28078 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3274 , C07K1/22 , C07K17/06
摘要： The present invention relates to immunoglobulin (Ig)-binding proteins with alkali- resistance properties. In one embodiment, the present invention provides for a variant of an Ig-binding protein, the variant comprising the Ig-binding protein having at least one asparagine residue substituted with a histidine, a serine, an aspartic acid or a threonine residue. The at least one substitution may confer to the variant Ig-binding protein an increased stability in alkaline solutions when compared to the wild-type Ig-binding. The present invention relates also to matrices for affinity separation of immunoglobulins comprising the Ig-binding proteins of the present invention, and to methods of using the Ig-binding proteins of the present invention to separate immunoglobulins from mixture compositions.
摘要翻译：本发明涉及具有耐碱性的免疫球蛋白（Ig）结合蛋白。在一个实施方案中，本发明提供Ig结合蛋白的变体，所述变体包含具有至少一个被组氨酸取代的天冬酰胺残基，丝氨酸，天冬氨酸或苏氨酸残基的Ig结合蛋白。当与野生型Ig结合相比时，至少一种取代可赋予变体Ig结合蛋白在碱性溶液中增加的稳定性。本发明还涉及用于亲和分离包含本发明的Ig结合蛋白的免疫球蛋白的基质，以及使用本发明的Ig结合蛋白质从混合物组合物中分离免疫球蛋白的方法。

69. 发明申请

WO2012079030A2 BIOCONJUGATION USING BIFUNCTIONAL LINKERS 审中-公开
标题翻译：使用双功能链接的BIOCONJUGATION
公开(公告)号：WO2012079030A2
公开(公告)日：2012-06-14
申请号：PCT/US2011064253
申请日：2011-12-09
申请人： UNIV CALIFORNIA , LIAO JIAYU , ZHAO YONGFENG
发明人： LIAO JIAYU , ZHAO YONGFENG
IPC分类号： G01N33/543 , C12Q1/68 , G01N33/52 , G01N33/532 , G01N33/544 , G01N33/553 , G01N33/68
CPC分类号： G01N33/552 , C07F7/1868 , C07K17/06 , G01N33/54353
摘要： A bifunctional linker and method of use is provided that has a spacer molecule with a functional group on one end configured to couple to the surface of a substrate and a function group on the other end that is configured couple to a biomolecule and methods of use. The preferred bifunctional linker has a poly(ethylene glycol) spacer ranging from 3 to 20 ethylene glycol units that has a silane functional group to react with a substrate and an azide functional group that can couple to a biomolecule that includes an alkyne group. The preferred linker can produce an azide-derivatized glass surface in one step and the azide functional group of the spacer can in sequence conjugate with a biomolecule using click chemistry, which can be conducted at low temperature and in aqueous solution.
摘要翻译：提供了双功能接头和使用方法，其具有间隔分子，所述间隔分子在一端上具有配置成耦合至基底表面的官能团，另一端上配置有偶联于生物分子的官能团以及使用方法。优选的双功能接头具有范围为3至20个乙二醇单元的聚乙二醇间隔基，其具有与基底反应的硅烷官能团和可以偶联至包含炔基的生物分子的叠氮化物官能团。优选的连接体可以在一个步骤中产生叠氮化物衍生化的玻璃表面，并且间隔体的叠氮化物官能团可以使用点击化学与生物分子序列缀合，这可以在低温下和在水溶液中进行。

70. 发明申请

WO2011060528A8 HETEROPEPTIDES USEFUL FOR REDUCING NONSPECIFIC ADSORPTION 审中-公开
标题翻译：有用的减少非特异性吸收的有效方法
公开(公告)号：WO2011060528A8
公开(公告)日：2012-06-07
申请号：PCT/CA2010001778
申请日：2010-11-16
申请人： UNIV MONTREAL , BOLDUC OLIVIER , PELLETIER JOELLE N , MASSON JEAN-FRANCOIS
发明人： BOLDUC OLIVIER , PELLETIER JOELLE N , MASSON JEAN-FRANCOIS
IPC分类号： C07K7/06 , B01J20/28 , C07K17/00 , C08G69/10 , C40B30/04 , C40B40/10 , C40B50/18 , G01N33/50
CPC分类号： C07K17/06 , C07K7/06 , C08G69/10 , G01N33/54353 , G01N33/54393
摘要： Reagents, kits, uses and methods useful for example fo decreasing nonspecific adsorption of biomolecules at the surface of a solid support are disclosed. Such reagents and methods, which are based on short heteropeptides, may be used to decrease nonspecific adsorption in for example biosensing applications.
摘要翻译：公开了可用于例如降低固体支持物表面上生物分子的非特异性吸附的试剂，试剂盒，用途和方法。基于短杂多肽的这些试剂和方法可用于降低例如生物传感应用中的非特异性吸附。

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