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1. 发明申请

WO1997016544A1 WATER SOLUBLE CROSS-LINKING AGENTS 审中-公开
标题翻译：水溶性交联剂
公开(公告)号：WO1997016544A1
公开(公告)日：1997-05-09
申请号：PCT/US1996017645
申请日：1996-10-31
申请人： BSI CORPORATION , SWAN, Dale, G. , AMOS, Richard, A. , EVERSON, Terrence, P.
发明人： BSI CORPORATION
IPC分类号： C12N11/00
CPC分类号： C07D295/112 , C07C45/63 , C07C225/16 , C07C309/14 , C07K17/06 , G01N33/54353 , Y10S530/81 , Y10S530/816 , C07C49/813
摘要： A chemical linking agent formed of a di- or higher functional photoactivatable compound and providing at least one group that is charged under the conditions of use in order to provide improved water solubility. The linking agent further provides two or more photoactivatable groups in order to allow the agent to be used as a cross-linking agent in aqueous systems. The charged group can be provided by a radical that includes one or more salts of organic acids, onium compounds, or protonated amines (and optionally one or more additional photoreactive group), and the photoreactive groups can be provided by two or more radicals that include an aryl ketone.
摘要翻译：由二官能或更高官能的可光活化化合物形成的化学连接剂，并提供至少一个在使用条件下加入以提供改善的水溶性的基团。连接剂还提供两个或更多个可光活化基团，以便允许该试剂在含水体系中用作交联剂。带电基团可以由包括一种或多种有机酸，鎓化合物或质子化胺（和任选的一种或多种另外的光反应性基团）的盐的基团提供，并且光反应性基团可以由两个或更多个基团提供，所述基团包括芳基酮。

2. 发明申请

WO1995012420A1 BARRIER COATINGS FOR SURFACES 审中-公开
标题翻译：表面遮蔽涂层
公开(公告)号：WO1995012420A1
公开(公告)日：1995-05-11
申请号：PCT/US1994012659
申请日：1994-11-02
申请人： BSI CORPORATION
发明人： BSI CORPORATION , SWANSON, Melvin, John
IPC分类号： A61L27/00
CPC分类号： A61L29/085 , A61L27/34 , A61L31/10 , A61B42/00
摘要： Articles having a surface intended for contact with an external biological environment, at least a portion of the surface comprising a stable coating capable of serving as an effective barrier to the passage of molecules between the surface and the environment.
摘要翻译：具有用于与外部生物环境接触的表面的制品，所述表面的至少一部分包含能够作为表面和环境之间的分子通过的有效屏障的稳定涂层。

3. 发明申请

WO1996037165A1 METHOD AND IMPLANTABLE ARTICLE FOR PROMOTING ENDOTHELIALIZATION 审中-公开
标题翻译：用于促进内皮化的方法和可植入物
公开(公告)号：WO1996037165A1
公开(公告)日：1996-11-28
申请号：PCT/US1996007695
申请日：1996-05-24
申请人： BSI CORPORATION
发明人： BSI CORPORATION , CLAPPER, David, L.
IPC分类号： A61F02/00
CPC分类号： A61L27/56 , A61F2/0077 , A61F2/06 , A61L27/16 , A61L27/18 , Y10S623/924 , C08L27/18 , C08L67/02 , C08L83/04 , C08L75/04
摘要： A porous material with an appropriate surface chemistry that promotes capillary endothelialization is disclosed. The material has a porosity that is sufficient to allow capillary endothelialization and a tenaciously bound adhesion molecule that promotes the ingrowth of endothelial cells into porosity of the material.
摘要翻译：公开了具有促进毛细血管内皮化的适当表面化学物质的多孔材料。该材料具有足以允许毛细血管内皮化的孔隙度和促进内皮细胞向内生长的材料的顽固结合的粘附分子。

4. 发明申请

WO1996039821A1 VIRUS INACTIVATING COATINGS 审中-公开
标题翻译：病毒灭绝涂层
公开(公告)号：WO1996039821A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008797
申请日：1996-06-05
申请人： BSI CORPORATION
发明人： BSI CORPORATION , SWANSON, Melvin, J.
IPC分类号： A01N25/08
CPC分类号： A61L31/10 , A01N25/10 , A01N25/34 , A61B46/40 , A61L2/0082 , A61L15/24 , Y10S428/913 , Y10T442/2525 , C08L39/06 , C08L33/26
摘要： Reagents and methods are disclosed for modifying a fabric substrate in order to inactivate viruses, and particularly lipid-enveloped viruses, upon contact. Such substrates can be modified by photochemically immobilizing hydrophilic polymers containing both quaternary ammonium groups and hydrocarbon chains, resulting in a localized surfactancy capable of disrupting lipid-enveloped viruses upon contact with the substrate. Substrates of the invention can be fabricated into the form of articles for medical and related use.
摘要翻译：公开了用于修饰织物底物的试剂和方法，以便在接触时灭活病毒，特别是脂质包膜的病毒。可以通过光化学固定含有季铵基团和烃链的亲水性聚合物来修饰这样的底物，导致当与底物接触时能够破坏脂质包膜的病毒的局部表面活性。本发明的基材可以制成用于医疗和相关用途的制品的形式。

5. 发明申请

WO1997034935A1 PHOTOACTIVATABLE CHAIN TRANSFER AGENTS 审中-公开
标题翻译：可转换链转移代理
公开(公告)号：WO1997034935A1
公开(公告)日：1997-09-25
申请号：PCT/US1997005344
申请日：1997-03-20
申请人： BSI CORPORATION
发明人： BSI CORPORATION , SWANSON, Melvin, J. , AMOS, Richard, A. , SWAN, Dale, G. , OPPERMAN, Gary, W.
IPC分类号： C08F02/50
CPC分类号： C08J7/047 , C07C323/12 , C07C323/22 , C07C323/41 , C07C323/42 , C08F2/38 , C08J2323/12 , C08J2433/00 , C08J2439/00 , C08J2485/00 , Y10S522/904 , Y10S522/905
摘要： A photoactivatable reagent useful as a chain transfer reagent for providing a semitelechelic polymer having one or more terminal photoactivatable groups. The reagent provides one or more photoactivatable groups and one or more sulfhydryl (or other chain transfer) groups, the photoactivatable and chain transfer groups optionally being joined together by a spacer group. The reagent can be used to prepare a polymer by serving to initiate the polymerization of ethylenically unsaturated monomers. The reagent itself becomes an integral part of the resultant polymer, thereby providing the polymer with a terminal photoactivatable nature. The method provides a number of benefits, including the ability to provide homogeneous photoactivatable polymer compositions, e.g., in terms of the uniform location of the photogroup(s) on the terminal portion of each polymer molecule and the ability to build a desired nonpolar quality, and in turn improved surfactancy, into otherwise polar polymers.
摘要翻译：可用作链转移试剂的可光活化试剂，用于提供具有一个或多个末端可光活化基团的半夺食聚合物。试剂提供一个或多个可光活化基团和一个或多个巯基（或其它链转移基团），光可活化链和链转移基团任选地通过间隔基团连接在一起。该试剂可用于通过用于引发烯属不饱和单体的聚合来制备聚合物。试剂本身成为所得聚合物的组成部分，从而为聚合物提供端可光活化的性质。该方法提供了许多益处，包括提供均匀可光活化的聚合物组合物的能力，例如，就各组分在每个聚合物分子的末端部分的均匀位置而言，以及建立期望的非极性质量的能力，并进而改善表面活性，成为其他极性聚合物。

6. 发明申请

WO1996018904A1 DEVICE FOR PERFORMING ONE OR MORE COMPETITIVE IMMUNOASSAYS 审中-公开
标题翻译：用于执行一个或多个竞争性免疫球蛋白的装置
公开(公告)号：WO1996018904A1
公开(公告)日：1996-06-20
申请号：PCT/US1995016333
申请日：1995-12-13
申请人： BSI CORPORATION , CHUDZIK, Stephen, J. , HAMILTON, Martha, J. , CHAPPA, Ralph, A.
发明人： BSI CORPORATION
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , Y10S435/81 , Y10S435/97 , Y10S435/973 , Y10S436/805 , Y10S436/81 , Y10S436/815 , Y10S436/816 , Y10S436/901
摘要： A device and related method for performing one or more immunoassays to detect the presence of respective analytes in a sample. The device involves the use of a unitary bibulous material providing one or more flow paths having a common origin site and a plurality of respective reagent zones providing the reagents necessary for performing a visual readout, competitive immunoassay for the presence of the respective analyte.
摘要翻译：用于执行一种或多种免疫测定以检测样品中各个分析物的存在的装置和相关方法。该装置涉及使用提供具有共同原点位置的一个或多个流动路径的单一吸水材料，以及提供执行视觉读数所需的试剂的多个相应试剂区域，用于存在各自分析物的竞争性免疫测定。

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