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    • 64. 发明申请
    • METHOD AND APPARATUS FOR RELIABLY PLACING AND ADJUSTING A LEFT VENTRICULAR PACEMAKER LEAD
    • 可靠安置方法和装置,调整左心室平滑肌引导
    • WO2006055556B1
    • 2007-04-12
    • PCT/US2005041350
    • 2005-11-15
    • WOOLLETT IAN
    • WOOLLETT IAN
    • A61N1/05
    • A61N1/056A61N2001/0585
    • A left ventricular stimulation lead (14) construction and a technique for lead (14) placement that provides for improved anchoring and positioning of the electrode (20) located on the distal end (27) of the lead (14), while also including a method for readjusting the positioning of the lead (14) as necessary. The lead (14) includes a small diameter guide wire (22) wherein the distal end (24) of the guide wire (22) serves as an anchor for the pacing lead (14). The lead (14) structure includes a central hollow lumen (30) to allow passage of the guide wire (22) and a locking mechanism (32) positioned on the proximal end (29) of the pacing lead (14) to fix the ends of the guide wire (22) and pacing lead (14) relative to one another. The method provides for advancing the guide wire (22) until it is anchored, positioning the pacing lead (14) along the guide wire (22) into the desired position relative to the cardiac tissue, releasably fixing the lead (14) relative to the guide wire (22), wherein the guide wire (22) is permanently retained to serve as an anchor.
    • 左心室刺激引线(14)结构和用于引线(14)放置的技术,其提供位于引线(14)的远端(27)上的电极(20)的改进的锚定和定位,同时还包括 根据需要重新调整引线(14)的定位的方法。 引线(14)包括小直径导丝(22),其中导丝(22)的远端(24)用作起搏引线(14)的锚。 引线(14)结构包括中心中空管腔(30),以允许引导线(22)通过;以及定位在起搏引线(14)的近端(29)上的锁定机构, 的引导线(22)和起搏引线(14)。 该方法提供使引导线(22)前进直到其被锚定,将起搏引线(14)沿导丝(22)定位到相对于心脏组织的期望位置,可释放地将引线(14)相对于 导丝(22),其中导丝(22)被永久地保持以用作锚。
    • 65. 发明申请
    • CORONARY SINUS LEAD FOR PACING THE LEFT ATRIUM
    • 冠状动脉粥样硬化斑块
    • WO2006132702A2
    • 2006-12-14
    • PCT/US2006/013439
    • 2006-04-11
    • WORLEY, Seth, J.
    • A61N1/05
    • A61N1/056A61N1/057A61N2001/0585
    • A pacing lead for implantation in a coronary sinus having an opening and a wall defining an interior and presenting a diameter dimension. The pacing lead includes an elongated lead body, a resilient fixation element, and at least one electrode on either the lead body or the fixation element. The fixation element extends from the pacing portion and defines a loop structure laterally adjacent the pacing portion. The loop structure presents a predetermined width dimension greater than the diameter dimension of the coronary sinus, wherein when the loop structure is inserted into the opening of the coronary sinus, the loop structure is laterally compressed by the wall of the coronary sinus and the electrode is biased against the wall of the coronary sinus.
    • 用于植入冠状窦的起搏引线,其具有限定内部并具有直径尺寸的开口和壁。 起搏引线包括细长引线体,弹性固定元件,以及引线本体或固定元件上的至少一个电极。 固定元件从起搏部分延伸并且在起搏部分侧面相邻地限定环形结构。 环形结构具有比冠状窦的直径尺寸大的预定宽度尺寸,其中当环形结构插入冠状窦的开口中时,环结构被冠状窦的壁横向压缩,并且电极是 偏向冠状窦壁。
    • 68. 发明申请
    • DEVICES AND METHODS FOR ACCELEROMETER-BASED CHARACTERIZATION OF CARDIAC FUNCTION AND MONITORING OF THE FREQUENCY DYNAMICS OF THE ISOVOLUMIC CONTRACTION PHASE AND PATHOLOGIC CARDIAC VIBRATIONS
    • 用于基于加速度计的心脏功能特征和视觉压力相位和病理心脏振动的频率动态监测的装置和方法
    • WO2006086435A2
    • 2006-08-17
    • PCT/US2006/004369
    • 2006-02-07
    • CARDIOSYNC, INC.DOBAK, John, D. III
    • DOBAK, John, D. III
    • A61N1/368A61B5/02
    • A61B5/02A61B5/0456A61B2562/0219A61B2562/028A61N1/056A61N1/3627A61N1/36542A61N1/36585A61N2001/0585
    • Systems according to the invention employ an acceleration sensor to characterize displacement and vibrational LV motion, and use this motion data to characterize the different phases of the LV cycle for analyzing LV function. Systems may identify a target pacing region or regions in the LV or RV using the acceleration sensor by localizing regions of late onset of motion relative to the QRS, or isovolumic contraction, or mitral valve closure, or by pacing of target regions and measuring LV function in response to pacing. Systems further provide an implantable or non- implantable acceleration sensor device for measuring LV motion and characterizing LV function. An implantable myocardial acceleration sensing system ("IAD") includes at least one acceleration sensor, a data acquisition and processing device, and an electromagnetic, e.g., RF, communication device. The IAD may be integrated into the pacing lead of a CRT device and can operate independently of the CRT IPG. The acceleration sensors may also be used to acquire and analyze the frequency dynamics associated with the isovolumic contraction phase ("ICP"). This information can be used to characterize heart function; optimize therapy for cardiomyopathy, including CRT therapy (including pacing intervals and required pharmacologic therapy); and to optimize CCM therapy. In addition, this information can be used to identify target pacing regions for CRT lead placement. Further, analyzing the frequency dynamics can be used to characterize pathologic heart vibrational motion, such as mitral regurgitation and the third or fourth heart sound, and the response of this motion to therapy for cardiomyopathy.
    • 根据本发明的系统采用加速度传感器来表征位移和振动LV运动,并且使用该运动数据来表征用于分析LV功能的LV循环的不同相位。 系统可以使用加速度传感器来识别LV或RV中的目标起搏区域或区域,其通过将相对于QRS,或等容收缩或二尖瓣闭合的迟发性运动区域定位,或通过目标区域的起搏和测量LV功能来定位 响应起搏。 系统还提供用于测量LV运动和表征LV功能的可植入或不可植入的加速度传感器装置。 可植入心肌加速度感测系统(“IAD”)包括至少一个加速度传感器,数据采集和处理装置以及电磁(例如RF)通信装置。 IAD可以集成到CRT设备的起搏引线中,并且可独立于CRT IPG进行操作。 加速度传感器也可用于获取和分析与等容收缩期(“ICP”)相关的频率动力学。 该信息可用于表征心脏功能; 优化治疗心肌病,包括CRT治疗(包括起搏间隔和所需药物治疗); 并优化CCM治疗。 此外,该信息可用于识别CRT引线放置的目标起搏区域。 此外,分析频率动力学可用于表征病理性心脏振动运动,例如二尖瓣反流和第三或第四心脏声音,以及该运动对心肌病治疗的反应。