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1. 发明申请

WO2006086435A2 DEVICES AND METHODS FOR ACCELEROMETER-BASED CHARACTERIZATION OF CARDIAC FUNCTION AND MONITORING OF THE FREQUENCY DYNAMICS OF THE ISOVOLUMIC CONTRACTION PHASE AND PATHOLOGIC CARDIAC VIBRATIONS 审中-公开
标题翻译：用于基于加速度计的心脏功能特征和视觉压力相位和病理心脏振动的频率动态监测的装置和方法
公开(公告)号：WO2006086435A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/004369
申请日：2006-02-07
申请人： CARDIOSYNC, INC. , DOBAK, John, D. III
发明人： DOBAK, John, D. III
IPC分类号： A61N1/368 , A61B5/02
CPC分类号： A61B5/02 , A61B5/0456 , A61B2562/0219 , A61B2562/028 , A61N1/056 , A61N1/3627 , A61N1/36542 , A61N1/36585 , A61N2001/0585
摘要： Systems according to the invention employ an acceleration sensor to characterize displacement and vibrational LV motion, and use this motion data to characterize the different phases of the LV cycle for analyzing LV function. Systems may identify a target pacing region or regions in the LV or RV using the acceleration sensor by localizing regions of late onset of motion relative to the QRS, or isovolumic contraction, or mitral valve closure, or by pacing of target regions and measuring LV function in response to pacing. Systems further provide an implantable or non- implantable acceleration sensor device for measuring LV motion and characterizing LV function. An implantable myocardial acceleration sensing system ("IAD") includes at least one acceleration sensor, a data acquisition and processing device, and an electromagnetic, e.g., RF, communication device. The IAD may be integrated into the pacing lead of a CRT device and can operate independently of the CRT IPG. The acceleration sensors may also be used to acquire and analyze the frequency dynamics associated with the isovolumic contraction phase ("ICP"). This information can be used to characterize heart function; optimize therapy for cardiomyopathy, including CRT therapy (including pacing intervals and required pharmacologic therapy); and to optimize CCM therapy. In addition, this information can be used to identify target pacing regions for CRT lead placement. Further, analyzing the frequency dynamics can be used to characterize pathologic heart vibrational motion, such as mitral regurgitation and the third or fourth heart sound, and the response of this motion to therapy for cardiomyopathy.
摘要翻译：根据本发明的系统采用加速度传感器来表征位移和振动LV运动，并且使用该运动数据来表征用于分析LV功能的LV循环的不同相位。系统可以使用加速度传感器来识别LV或RV中的目标起搏区域或区域，其通过将相对于QRS，或等容收缩或二尖瓣闭合的迟发性运动区域定位，或通过目标区域的起搏和测量LV功能来定位响应起搏。系统还提供用于测量LV运动和表征LV功能的可植入或不可植入的加速度传感器装置。可植入心肌加速度感测系统（“IAD”）包括至少一个加速度传感器，数据采集和处理装置以及电磁（例如RF）通信装置。 IAD可以集成到CRT设备的起搏引线中，并且可独立于CRT IPG进行操作。加速度传感器也可用于获取和分析与等容收缩期（“ICP”）相关的频率动力学。该信息可用于表征心脏功能; 优化治疗心肌病，包括CRT治疗（包括起搏间隔和所需药物治疗）; 并优化CCM治疗。此外，该信息可用于识别CRT引线放置的目标起搏区域。此外，分析频率动力学可用于表征病理性心脏振动运动，例如二尖瓣反流和第三或第四心脏声音，以及该运动对心肌病治疗的反应。

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