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61. 发明申请

WO98055178A1 METHOD AND APPARATUS FOR TREATING CARDIAC ARRHYTHMIA 审中-公开
标题翻译：治疗心脑血管病的方法和装置
公开(公告)号：WO98055178A1
公开(公告)日：1998-12-10
申请号：PCT/US1998/011166
申请日：1998-06-02
IPC分类号： A61N1/39
CPC分类号： A61N1/3918 , A61N1/395
摘要： An implantable system for the defibrillation or cardioversion of the atria and the ventricles of a patient's heart comprises: a first catheter configured for positioning in the right ventricle of the heart; a second catheter configured for positioning through the coronary sinus ostium and in the coronary sinus of the heart, with the first and second catheters together carrying at least three defibrillation electrodes; a power supply; and a control circuit operatively associated with the power supply and the electrodes. The control circuit is configured for delivering an atrial defibrillation pulse through at least two of the electrodes, or a ventricular defibrillation pulse through at least two of the electrodes.
摘要翻译：用于病人心脏的心房和心室的除颤或心脏复律的可植入系统包括：配置用于定位在心脏右心室中的第一导管; 构造成用于定位穿过冠状窦口和心脏冠状窦的第二导管，其中第一和第二导管一起携带至少三个除颤电极; 电源; 以及与电源和电极可操作地相关联的控制电路。控制电路被配置为通过至少两个电极输送心房除颤脉冲，或者通过至少两个电极的心室除颤脉冲。

62. 发明申请

WO1998018519A1 DEVICE FOR CARRYING OUT A TRANSOESOPHAGEAL ECHOCARDIOGRAPHY AND A CARDIOVERSION 审中-公开
标题翻译：执行转移性心电图和放射治疗的手段
公开(公告)号：WO1998018519A1
公开(公告)日：1998-05-07
申请号：PCT/FR1997001958
申请日：1997-10-31
申请人： BENHALIMA, Bouziane , LALAOUI, Zohra
IPC分类号： A61N01/05
CPC分类号： A61N1/0517 , A61N1/395
摘要： The invention concerns a device for carrying out a transoesophageal echocardiography and a cardioversion comprising a single endoscope (1) provided at its distal end with a ultrasonic sensor (3) and in the proximity of its distal end with at least en electrode (8) for generating electric shocks. The invention is useful for the treatment of auricular fibrillation.
摘要翻译：本发明涉及用于进行经食道超声心动图和心脏复律的装置，其包括在其远端处设置有超声波传感器（3）的单个内窥镜（1），并且在其远端附近至少具有电极（8），用于产生电击。本发明可用于治疗耳纤颤。

63. 发明申请

WO1994000183A2 AUTOMATIC FIBRILLATION DETECTOR AND DEFIBRILLATOR APPARATUS AND METHOD 审中-公开
标题翻译：自动纤维检测器和除颤器装置及方法
公开(公告)号：WO1994000183A2
公开(公告)日：1994-01-06
申请号：PCT/US1993006123
申请日：1993-06-25
申请人： INDIANA UNIVERSITY FOUNDATION
发明人： INDIANA UNIVERSITY FOUNDATION , ZIPES, Douglas, P. , ADAMS, David, E.
IPC分类号： A61N0
CPC分类号： A61N1/3956 , A61N1/395
摘要： The present invention involves an apparatus (10) and method for detecting and treating fibrillation in the heart. Electrodes (36, 38) sense electrical activity in two distinct locations of the heart. The electrocardiac activations (Lx, Rx) are monitored and the interval (Tx) between activations at the two locations is measured and checked for variation ((Delta)T). Upon detection of significant variation in the length of the intervals, the fibrillation condition is determined and a defibrillator (16) is activated, so that a defibrillating shock may be delivered to the heart (40). For atrial fibrillation, the first defibrillating shock is relatively low and is increased until the fibrillation is no longer detected.
摘要翻译：本发明涉及用于检测和治疗心脏颤动的装置（10）和方法。电极（36,38）在心脏的两个不同位置感测电活动。监测心电图激活（Lx，Rx），测量两个位置的激活间隔（Tx），并检查变化（（Delta）T）。当检测到间隔长度的显着变化时，确定原纤维状态并且除颤器（16）被激活，使得去颤颤的休克可能被递送到心脏（40）。对于心房颤动，第一次除颤冲击相对较低并且增加直到不再检测到原纤维颤动。

64. 发明申请

WO2017070411A1 ATRIAL ARRYTHMIA DETECTION USING A PRESSURE SIGNAL IN AN IMPLANTABLE MEDICAL DEVICE AND MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：一种植入式医疗器械和医疗器械系统中使用压力信号的房颤检测
公开(公告)号：WO2017070411A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058015
申请日：2016-10-21
申请人： MEDTRONIC, INC.
发明人： CHO, Yong K. , HILL, Michael R.S.
IPC分类号： A61B5/021 , A61B5/00 , A61B5/024 , A61N1/365 , A61N1/37 , A61N1/39 , A61B5/046
CPC分类号： A61B5/0215 , A61B5/02108 , A61B5/02405 , A61B5/046 , A61B5/4836 , A61B5/686 , A61B5/6869 , A61B5/7282 , A61N1/36564 , A61N1/3702 , A61N1/395 , A61N1/3987
摘要： A medical device system and method for monitoring a cardiovascular pressure signal to identify an atrial arrhythmia that includes a sensor sensing a cardiovascular pressure signal and a pressure analysis module that is configured to determine at least one of an interval dispersion and an amplitude dispersion of the sensed pressure signal, compare the at least one of an interval dispersion and an amplitude dispersion of the sensed pressure signal to a dispersion threshold, and determine whether the atrial arrhythmia is occurring in response to the comparing.
摘要翻译：用于监测心血管压力信号以识别房性心律失常的医疗设备系统和方法，所述心房心律失常包括感测心血管压力信号的传感器和压力分析模块，所述压力分析模块被配置为确定间隔分散和感测的压力信号的幅度色散，将感测到的压力信号的间隔色散和幅度色散中的至少一个与色散阈值进行比较，并且响应于比较来确定房性心律失常是否正在发生。 p>

65. 发明申请

WO2016134161A1 APPARATUS FOR ATRIAL ARRHYTHMIA EPISODE DETECTION 审中-公开
标题翻译： ATRIAL ARRHYTHMIA EPISODE检测装置
公开(公告)号：WO2016134161A1
公开(公告)日：2016-08-25
申请号：PCT/US2016/018496
申请日：2016-02-18
申请人： MEDTRONIC, INC.
发明人： SARKAR, Shantanu , HANSEN, Daniel L. , NEITZELL, Grant A.
IPC分类号： A61N1/362 , A61B5/04
CPC分类号： A61B5/046 , A61B5/04 , A61B5/04012 , A61B5/04014 , A61B5/04017 , A61B5/0452 , A61B5/0456 , A61B5/0464 , A61B5/686 , A61N1/3624 , A61N1/36507 , A61N1/36592 , A61N1/395 , A61N1/3987
摘要： A method and implantable medical device for determining a flutter event in response to a cardiac signal that includes sensing the cardiac signal, determining a sensing window in response to the sensed cardiac signal, the sensing window having a first portion and a second portion. A first derivative signal and a second derivative signal are determined in response to the sensed cardiac signal within the first portion and the second portion of the sensing window, and a sum of amplitudes of the second derivative signal within one or both of the first portion and the second portion of the sensing window is determined, and the flutter event is determined in response to the determined sum of amplitudes.
摘要翻译：一种用于响应于包括感测心脏信号的心脏信号来确定颤动事件的方法和可植入医疗装置，响应于感测到的心脏信号确定感测窗口，感测窗口具有第一部分和第二部分。响应于感测窗口的第一部分和第二部分内的感测到的心脏信号，以及第一部分和第二部分之一或两者内的二阶导数信号的幅度之和来确定第一导数信号和二阶导数信号确定感测窗口的第二部分，并且响应于所确定的幅度的和来确定颤动事件。

66. 发明申请

WO2016134099A1 APPARATUS FOR ATRIAL ARRHYTHMIA EPISODE DETECTION 审中-公开
标题翻译： ATRIAL ARRHYTHMIA EPISODE检测装置
公开(公告)号：WO2016134099A1
公开(公告)日：2016-08-25
申请号：PCT/US2016/018389
申请日：2016-02-18
申请人： MEDTRONIC, INC.
发明人： SARKAR, Shantanu , HANSEN, Daniel L. , NEITZELL, Grant A.
IPC分类号： A61N1/39 , A61B5/04
CPC分类号： A61B5/046 , A61B5/04 , A61B5/04012 , A61B5/04014 , A61B5/04017 , A61B5/0452 , A61B5/0456 , A61B5/0464 , A61B5/686 , A61N1/3624 , A61N1/36507 , A61N1/36592 , A61N1/395 , A61N1/3987
摘要： Techniques and devices for implementing the techniques for identifying Pwaves are described. An implantable medical device identifies one or more Rwaves within the cardiac signal, determines one or more Pwave sensing windows associated with the one or more Rwaves, determines a characteristic Pwave sensing window based on the one or more determined Pwave sensing windows, determines a first and second derivatives of the cardiac signal within the characteristic Pwave sensing window, analyzes the first derivative and the second derivative of the cardiac signal within the characteristic Pwave window to determine a first set of signal characteristics of the cardiac signal within a first portion of the characteristic Pwave sensing window and a second set of signal characteristics of the cardiac signal within a second portion of the characteristic Pwave sensing window, and detects the Pwave based on the first and the second set of signal characteristics.
摘要翻译：描述用于实现用于识别P波的技术的技术和设备。可植入医疗设备识别心脏信号内的一个或多个Rw，确定与一个或多个Rwaves相关联的一个或多个P波感测窗口，基于一个或多个确定的P波感测窗口确定特征P波感测窗口，确定第一和在特征波浪感测窗口内的心脏信号的二阶导数分析特征波浪窗口内的心脏信号的一阶导数和二阶导数，以确定特征波浪的第一部分内的心脏信号的第一组信号特征感测窗口和第二组心脏信号在特征波浪感测窗口的第二部分内的信号特征，并且基于第一和第二组信号特征来检测P波。

67. 发明申请

WO2014149806A1 A SYSTEM FOR AVOIDING UNDERSENSING OF VENTRICULAR FIBRILLATION 审中-公开
标题翻译：用于避免心脏纤维化不全的系统
公开(公告)号：WO2014149806A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/020998
申请日：2014-03-06
申请人： MEDTRONIC, INC.
发明人： ZHANG, Xusheng , BROWN, Mark L. , DEGROOT, Paul J. , GREENHUT, Saul E. , JACKSON, Troy E.
IPC分类号： A61B5/046 , A61B5/0464 , A61N1/39 , A61N1/362 , A61B5/0452 , A61B5/00
CPC分类号： A61B5/0464 , A61B5/04525 , A61B5/046 , A61B5/6869 , A61B5/7264 , A61N1/3621 , A61N1/395 , A61N1/3956
摘要： A medical device for detecting and treating tachyarrhythmias acquires a cardiac signal using electrodes coupled to a sensing module. Cardiac events are sensed from the cardiac signal and a first processing module computes a first morphology metric for each sensed cardiac event occurring during a time segment of the cardiac signal. The first morphology metrics corresponding to an event originating in a ventricular chamber are counted. The first processing module computes a second morphology metric for the time segment of the cardiac signal in response to the count of the first morphology metrics meeting a threshold number of events. The time segment is classified as a shockable segment in response to the second morphology metric meeting a detection criterion.
摘要翻译：用于检测和治疗快速性心律失常的医疗装置使用耦合到感测模块的电极获取心脏信号。从心脏信号感测心脏事件，并且第一处理模块计算在心脏信号的时间段期间发生的每个感测的心脏事件的第一形态度量。计算对应于起始于心室的事件的第一形态学指标。第一处理模块响应于满足阈值数量事件的第一形态学量度的计数，计算心脏信号的时间段的第二形态度量。响应于符合检测标准的第二形态度量，该时间段被分类为可震击段。

68. 发明申请

WO2014110071A2 NON-INVASIVE VAGUS NERVE STIMULATION DEVICES AND METHODS TO TREAT OR AVERT ATRIAL FIBRILLATION 审中-公开
标题翻译：非侵入性VAGUS神经刺激装置和治疗或AVERT ATRIAL FIBRILLATION的方法
公开(公告)号：WO2014110071A2
公开(公告)日：2014-07-17
申请号：PCT/US2014010589
申请日：2014-01-08
申请人： ELECTROCORE LLC
发明人： SIMON BRUCE J , ERRICO JOSEPH P , RAFFLE JOHN T
IPC分类号： A61N1/362
CPC分类号： A61N1/395 , A61N1/36014 , A61N1/37 , A61N1/40 , A61N2/02
摘要： Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.
摘要翻译：使用基于电极的刺激装置或被设计为非侵入性地刺激神经的磁刺激装置将能量非侵入地传播给患者。该装置通过刺激患者的迷走神经产生用于治疗房颤的脉冲。这些装置也用于预测心房颤动即将发生，然后通过刺激迷走神经来避免。

69. 发明申请

WO2013169914A1 USING INTRACARDIAC ELECTROGRAMS TO PREDICT LOCATION OF FIBROSIS AND AUTONOMIC NERVES IN THE HEART 审中-公开
标题翻译：使用内皮细胞电图预测心脏中的纤维化和自主神经位置
公开(公告)号：WO2013169914A1
公开(公告)日：2013-11-14
申请号：PCT/US2013/040162
申请日：2013-05-08
申请人： NORTHWESTERN UNIVERSITY
发明人： ARORA, Rishi , NG, Jason
IPC分类号： A61B5/0402
CPC分类号： A61B5/046 , A61B5/0044 , A61B5/04012 , A61B5/0422 , A61B5/4035 , A61B5/4887 , A61B5/4893 , A61B18/00 , A61B18/14 , A61B34/10 , A61B2018/00351 , A61B2018/00434 , A61B2018/00577 , A61B2018/00839 , A61B2562/046 , A61N1/395
摘要： A method of targeting fibrosis or autonomic nerve tissue for ablation in a subject is described. The method includes at least the following steps. The method includes performing at least one EGM analysis of a plurality of recorded atrial EGMs for a tissue in a region suspected of having fibrosis or autonomic nerve tissue. With regard to targeting fibrosis for ablation, the method includes determining one or more correlations of at least one AF EGM characteristic to a region having fibrosis from the plurality of recorded atrial EGMs for the tissue and determining whether the tissue contains dense fibrosis that would preclude effective ablation of the analysis region of the tissue. With regard to targeting autonomic nerve for ablation, the method includes determining whether one or more significant changes in EG M characteristics with autonomic blockade exist that would indicate the need to perform ablation of the analysis region of the tissue.
摘要翻译：描述了在受试者中靶向纤维化或自主神经组织进行消融的方法。该方法至少包括以下步骤。该方法包括对怀疑有纤维化或自主神经组织的区域中的组织进行多个记录的心房EGM的至少一次EGM分析。关于用于消融的靶向纤维化，所述方法包括确定至少一个AF EGM特征与来自组织的多个记录的心房EGM的纤维化区域的一个或多个相关性，并确定组织是否含有致密纤维化，其将排除有效消融组织的分析区域。关于针对自主神经进行消融的方法，该方法包括确定是否存在表明需要进行组织分析区域的消融的具有自主封锁的EGM特征中的一个或多个显着变化。

70. 发明申请

WO2012057851A2 DIAGNOSIS AND THERAPY OF BIGEMINY AND FREQUENT PREMATURE CONTRACTIONS 审中-公开
标题翻译： BIGEMINY和FREQUEST PREMATURE合同的诊断和治疗
公开(公告)号：WO2012057851A2
公开(公告)日：2012-05-03
申请号：PCT/US2011/033577
申请日：2011-04-22
申请人： MEDTRONIC, INC. , CORBUCCI, Giorgio , BECKERS, Frank , RIEGER, Guido, H.
发明人： CORBUCCI, Giorgio , BECKERS, Frank , RIEGER, Guido, H.
IPC分类号： A61N1/365 , A61B5/0402
CPC分类号： A61B5/0468 , A61B5/0031 , A61B5/02405 , A61B5/0245 , A61N1/3622 , A61N1/3624 , A61N1/3702 , A61N1/3925 , A61N1/395 , A61N1/3962
摘要： The disclosure describes techniques for diagnosing premature contractions of a patient's heart. This system may differentiate premature atrial contractions (PACs) and premature ventricular contractions (PVCs) from atrial fibrillation by identifying changes in R-wave intervals, i.e., R-R intervals, on a Lorenz plot, measuring a coupling interval between R-waves, and analyzing a morphology of the premature contractions, e.g., the QRS complex. These techniques may also identify when severe premature contractions, or bigeminy, are present. In response to the type of premature contractions detected, the system may alert a user of the premature contractions and/or deliver cardiac pacing at an increased pacing rate to eliminate the abnormal intrinsic contractions. The system may also adjust the pacing rate and pacing rate duration for persistent premature contractions.
摘要翻译：本公开描述了用于诊断患者心脏的过早收缩的技术。该系统可以通过在Lorenz图上识别R波间隔（即RR间隔）的变化，测量R波之间的耦合间隔和分析来区分早产性心房收缩（PAC）和早产性心室收缩（PVCs）与房颤早期收缩的形态，例如QRS综合征。这些技术还可以确定何时存在严重的过早收缩或大量收缩。响应于检测到的过早收缩的类型，系统可以提醒用户过早收缩和/或以增加的起搏速率递送心脏起搏以消除异常内在收缩。该系统还可以调整持续性早产收缩的起搏速率和起搏速率持续时间。

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