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51. 发明申请

WO2017046625A1 NEW CHELATORS FOR AFFINITY PURIFICATION OF RECOMBINANT PROTEINS 审中-公开
标题翻译：新型重组蛋白的亲和性纯化剂
公开(公告)号：WO2017046625A1
公开(公告)日：2017-03-23
申请号：PCT/IB2015/002003
申请日：2015-06-25
申请人： CUBE BIOTECH GMBH
IPC分类号： B01J45/00 , B01J20/289 , B01J20/32
CPC分类号： B01J20/289 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3265 , B01J45/00
摘要： The present invention relates to a method of preparing a solid-phase bound multimeric chelator where the chelator is coupled via one carboxylic group. The chelator consists of aminopolycarboxylic acid, connected to other aminocarboxylic acids via di-or trifunctional linkers. Examples for this invention have the formulas (I): Wherein Z is a solid phase, S is an optional spacer molecule, able to bind both to the solid phase and the chelator, APA1 is a tetradentate aminopolycarboxylic acid, K is a bifunctional linker molecule, L is a trifunctional linker molecule, APA2 is a pentadentate aminopolycarboxylic acid, n is 1 - 50. Furthermore, the invention relates to a method for purifying his-tagged recombinant polypeptides and proteins, phosphoproteins and metal-coordinating proteins with solid phase-bound di-, tri- and tetra- and polymeric chelators. These chelators are polycarboxylates, such as EDTA, DTPA, and the like, and they are connected via linkers, forming chains. Coupling groups to the linker are selected from ester-, thioester- or amide functionalities. The chelator chains are bound to a solid phase via an ester-, thioester- or amide group of one terminal chelator. The solid-phase bound chelator chains, loaded with metal ions, provide a strong metal binding, high stability against chelators and reductants, high affinity and an extremely high binding capacity.
摘要翻译：本发明涉及一种制备固相结合的多聚体螯合剂的方法，其中螯合剂通过一个羧基连接。螯合剂由氨基多羧酸组成，通过二 - 或三官能接头与其它氨基羧酸连接。本发明的实例具有式（I）：其中Z是固相，S是能够结合固相和螯合剂的任选的间隔分子，APA1是四齿氨基多羧酸，K是双官能连接分子，L是三官能连接分子，APA2是五齿多氨基多羧酸，n为1-50。此外，本发明涉及一种用于纯化其标签的重组多肽和蛋白质，磷蛋白和具有固相结合的金属配位蛋白的方法二，三和四和聚合螯合剂。这些螯合剂是多羧酸盐，例如EDTA，DTPA等，它们通过连接体连接形成链。连接基团与连接体的偶联选自酯 - ，硫酯 - 或酰胺官能团。螯合剂链通过一个末端螯合剂的酯 - ，硫酯 - 或酰胺基团结合到固相。负载有金属离子的固相螯合剂链提供强烈的金属结合，对螯合剂和还原剂的高稳定性，高亲和力和极高的结合能力。

52. 发明申请

WO2017041868A1 ADSORPTIONSMEDIUM, VERFAHREN ZU DESSEN HERSTELLUNG, SOWIE VERWENDUNG DESSELBEN ZUR AUFREINIGUNG VON BIOMOLEKÜLEN 审中-公开
标题翻译：吸附，的制造方法及其用途用于净化生物分子
公开(公告)号：WO2017041868A1
公开(公告)日：2017-03-16
申请号：PCT/EP2016/001168
申请日：2016-07-07
申请人： SARTORIUS STEDIM BIOTECH GMBH
发明人： VILLAIN, Louis , TAFT, Florian , SCHWELLENBACH, Jan
IPC分类号： B01J20/289 , B01D15/36 , B01J20/32 , C07K1/18
CPC分类号： B01J20/289 , B01D15/362 , B01J20/321 , B01J20/3219 , B01J20/3278 , B01J20/328 , B01J20/3293 , C07K1/16 , C07K1/18
摘要： Die vorliegende Erfindung betrifft ein Adsorptionsmedium, insbesondere ein Chromatographiemedium, ein Verfahren zu dessen Herstellung, sowie die Verwendung des erfindungsgemäßen Adsorptionsmediums bzw. eines erfindungsgemäß hergestellten Adsorptionsmediums zur Aufreinigung von Biomolekülen.
摘要翻译：本发明涉及一种吸附介质，尤其是色谱介质，其制造方法，以及根据本发明的或根据本发明的用于生物分子的纯化的吸附介质使用吸附介质的。

53. 发明申请

WO2016066452A1 CHROMATOGRAPHIC MATERIAL AND METHOD FOR PREPARATION THEREOF 审中-公开
标题翻译：色谱材料及其制备方法
公开(公告)号：WO2016066452A1
公开(公告)日：2016-05-06
申请号：PCT/EP2015/073995
申请日：2015-10-16
申请人： DIONEX CORPORATION , THERMO ELECTRON MANUFACTURING LIMITED
发明人： LIU, Xiaodong , WILLIAMS, Richard T. , CUI, Xiao
IPC分类号： B01D15/36 , B01D15/38 , B01J20/286 , B01J20/289 , B01J20/32
CPC分类号： C07F7/0856 , B01D15/305 , B01D15/325 , B01D15/364 , B01D15/3847 , B01J20/286 , B01J20/289 , B01J20/3204 , B01J20/3246 , B01J20/3259 , B01J20/3285 , C07B63/00 , C07F7/0885
摘要： A chromatographic materialcomprisinga zwitterionic ligand covalently bound to a substrate, the ligand preferably has a formula II: wherein R 1 , R 2 , R 3 are independently selected from an oxygen atom that is configured to connect to a substrate atom in the substrate, an oxygen atom that is configured to connect to a silicon atom of an adjacent ligand, a hydroxyl group, a halogen atom, an alkoxy group, a dialkylamino group, an acyl group, an alkyl group, or an aryl group; L 1 , L 2 and L 3 are independently hydrophobic moieties; each containing 2 to 30 carbon atoms, wherein there are at least 10 carbon atoms in the combined chain lengths of L 1 , L 2 and L 3 ; X is an O atom, S atom, amide group or sulfonamide group; n is 0 or 1; R 4 , R 5 are independently selected from a hydrogen atom or a hydrocarbon moiety containing 1 to 20 carbon atoms; and Rf is a negatively charged moiety comprising a sulfonic, carboxylic, or phosphonic functional group.
摘要翻译：共价键合到底物的两性离子配体的色谱材料，配体优选具有式II：其中R 1，R 2，R 3独立地选自被配置为连接到底物中的底物原子的氧原子，被配置为连接到相邻配体，羟基，卤素原子，烷氧基，二烷基氨基，酰基，烷基或芳基的硅原子; L1，L2和L3独立地是疏水部分; 每个含有2至30个碳原子，其中在L1，L2和L3的组合链长度中存在至少10个碳原子; X是O原子，S原子，酰胺基或磺酰胺基; n为0或1; R 4，R 5独立地选自氢原子或含有1至20个碳原子的烃部分; 并且Rf是包含磺酸，羧酸或膦酸官能团的带负电荷的部分。

54. 发明申请

WO2015053701A1 METHOD FOR PRODUCTION OF A CHROMATOGRAPHY MATERIAL 审中-公开
标题翻译：生产色谱材料的方法
公开(公告)号：WO2015053701A1
公开(公告)日：2015-04-16
申请号：PCT/SE2014/051194
申请日：2014-10-09
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： SÖDERMAN, Tobias, E.
IPC分类号： B01J20/285 , B01J20/287 , C08B37/12 , C08F251/00 , B01D15/32 , B01J20/22 , B01J20/289 , C08F212/08 , G01N33/538
CPC分类号： B01J20/3278 , B01D15/325 , B01J20/287 , B01J20/3212 , C08B37/00 , C08B37/0039 , C08F290/10 , C08F212/08
摘要： The present invention relates to a method for production of a chromatography material. More closely, the invention relates to a method for production of a reverse phase chromatography (RPC) material comprising the following steps: introduction of unsaturated groups onto porous carbohydrate particles and grafting of styrenic monomers on said particles comprising an unsaturated group..
摘要翻译：本发明涉及色谱材料的制造方法。更详细地说，本发明涉及一种生产反相色谱（RPC）材料的方法，包括以下步骤：将不饱和基团引入到多孔碳水化合物颗粒上，并将苯乙烯单体接枝到包含不饱和基团的所述颗粒上。

55. 发明申请

WO2015039247A1 SWITCHABLE MATERIALS, METHODS AND USES THEREOF 审中-公开
标题翻译：可切换材料，方法及其用途
公开(公告)号：WO2015039247A1
公开(公告)日：2015-03-26
申请号：PCT/CA2014/050897
申请日：2014-09-18
申请人： QUEEN'S UNIVERSITY AT KINGSTON , GREENCENTRE CANADA
发明人： BONIFACE, Kyle J. , CLARK, Timothy James , CUNNINGHAM, Michael F. , JESSOP, Philip G. , MARIAMPILLAI, Brian Ernest , MERCER, Sean M. , RESENDES, Rui , ROBERT, Tobias
IPC分类号： C08L101/12 , B01D53/26 , B01J19/02 , B01J20/289 , C09F9/00
CPC分类号： C08F292/00 , B01D15/10 , B01D15/40 , B01D15/426 , B01D53/26 , B01D53/261 , B01J19/02 , B01J20/265 , B01J20/286 , B01J20/289 , B01J20/3204 , B01J20/3219 , B01J20/3259 , B01J20/3293 , B01J2219/00024 , B01J2219/0245 , B01J2220/54 , C08L101/12 , G01N30/02 , G01N2030/027
摘要： The present application provides a composite material that comprises a solid and solid-supported non-polymeric switchable moiety, wherein the switchable moiety comprises a functional group that is switchable between a first form and a second form, said first form being neutral and hydrophobic, and said second form being ionized and hydrophilic. The composite material converts to, or is maintained in, said second form when the switchable moiety is exposed to CO 2 at amounts sufficient to maintain the ionized form. The composite material converts to, or is maintained in, said first form when CO 2 is removed or reduced to an amount insufficient to maintain the ionized form. CO 2 is removed or reduced by exposing the composite material to heat and/or a flushing inert gas such as N 2 , Ar, or air. Envisioned uses of these composite materials includes removing water from non-aqueous solvents, removing water vapour from gaseous mixtures, and cleaning industrial reaction vessels and/or pipelines.
摘要翻译：本申请提供了一种复合材料，其包含固体和固体支持的非聚合物可切换部分，其中可切换部分包括可在第一形式和第二形式之间切换的官能团，所述第一形式是中性和疏水性的，以及所述第二形式被离子化和亲水化。当可切换部分以足以维持电离形式的量暴露于CO 2时，复合材料转化为或保持在所述第二形式中。当将CO 2除去或减少到不足以维持电离形式的量时，复合材料转化为或保持在所述第一形式中。通过将复合材料暴露于加热和/或冲洗惰性气体如N 2，Ar或空气来除去或减少CO 2。这些复合材料的设想用途包括从非水溶剂中除去水分，从气体混合物中除去水蒸气，以及清洁工业反应容器和/或管道。

56. 发明申请

WO2014077762A1 MULTIMODAL ANION EXCHANGE MATRICES 审中-公开
标题翻译：多模式阴离子交换矩阵
公开(公告)号：WO2014077762A1
公开(公告)日：2014-05-22
申请号：PCT/SE2013/051325
申请日：2013-11-11
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： MALOISEL, Jean-Luc , RODRIGO, Gustav , NORÉN, Bjorn , KUMBHAR, Virendra
IPC分类号： B01J20/26 , B01D15/08 , B01J20/285 , B01J20/289 , G01N30/02 , G01N33/544 , G01N33/548
CPC分类号： C07K1/165 , B01D15/3847 , B01D15/3885 , B01J20/265 , B01J20/28016 , B01J20/289 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J20/3285 , B01J41/20 , B01J2220/80 , C07K1/36 , G01N33/544 , B01D15/363 , B01D15/327
摘要： The invention discloses a separation matrix which comprises a plurality of separation ligands, defined by the formula R 1 - L 1 – N (R 3 ) – L 2 –R, immobilized on a support, wherein R 1 is a five-or six-membered, substituted or non-substituted ring structure or a hydroxyethyl or hydroxypropyl group; L 1 is either a methylene group or a covalent bond; R 2 is a five-or six-membered, substituted or non-substituted ring structure; L 2 is either a methylene group or a covalent bond;R 3 is a methyl group; and wherein if R 1 is a hydroxyethyl group and L 1 is a covalent bond, R 2 is a substituted aromatic ring structure or a substituted or non-substituted aliphatic ring structure.
摘要翻译：本发明公开了一种分离基质，其包含固定在载体上的式R1-L1-N（R3）-L2-R定义的多个分离配体，其中R1是五或六元的取代或非取代的取代的环结构或羟乙基或羟丙基; L1是亚甲基或共价键; R2是五或六元，取代或未取代的环结构; L2是亚甲基或共价键; R3是甲基; 并且其中如果R 1是羟乙基并且L 1是共价键，则R 2是取代的芳环结构或取代或未取代的脂族环结构。

57. 发明申请

WO2014067605A1 SURFACE MODIFICATION OF POROUS BASE SUPPORTS 审中-公开
标题翻译：多孔支撑的表面改性
公开(公告)号：WO2014067605A1
公开(公告)日：2014-05-08
申请号：PCT/EP2013/002967
申请日：2013-10-02
申请人： MERCK PATENT GMBH
发明人： RAHANE, Santosh , BIAN, Nanying , SCHEID, Daniel
IPC分类号： B01J20/283 , B01D15/38 , B01J20/289 , B01J20/32
CPC分类号： B01J20/283 , B01D15/3809 , B01J20/286 , B01J20/289 , B01J20/3085 , B01J20/3204 , B01J20/3219 , B01J20/3227 , B01J20/3236 , B01J20/3278 , C08F292/00
摘要： The present invention relates to new separation materials with improved binding capacity, its manufacturing, and application, especially for binding protein A.
摘要翻译：本发明涉及具有改善的结合能力，其制造和应用，特别是用于结合蛋白A的新分离材料。

58. 发明申请

WO2013020964A1 SEPARATION MATERIAL COMPRISING SACCHARIDE LIGANDS 审中-公开
标题翻译：包含SACCHARIDE LIGANDS的分离材料
公开(公告)号：WO2013020964A1
公开(公告)日：2013-02-14
申请号：PCT/EP2012/065388
申请日：2012-08-07
申请人： GAMBRO LUNDIA AB , REMPFER, Martin , FREUDEMANN, Wolfgang , STORR, Markus , WINZ, Cornelia , FLIEG, Ralf , KLOTZ, Manuela
发明人： REMPFER, Martin , FREUDEMANN, Wolfgang , STORR, Markus , WINZ, Cornelia , FLIEG, Ralf , KLOTZ, Manuela
IPC分类号： A61M1/36 , B01J20/26 , B01J20/289 , B01J20/32
CPC分类号： B01J20/3278 , B01J20/26 , B01J20/289 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J20/3255 , B01J20/3274 , B01J20/3291 , B01J2220/80
摘要： The present disclosure relates to a separation material comprising a saccharide that is bound via a linker to a matrix for enabling the separation of substances from a liquid that selectively bind to saccharide moieties, to a method for preparing such material, to a method for separating substances from a liquid that selectively bind to saccharides, and to a device comprising a separation material for separating substances from a liquid that selectively bind to saccharides.
摘要翻译：本公开内容涉及一种分离材料，其包含通过连接体与基质结合的糖类，用于使物质与选自与糖部分结合的液体分离，制备这种材料的方法，用于分离物质的方法从选择性结合糖的液体，以及包含用于从与选择性结合糖的液体分离物质的分离材料的装置。

59. 发明申请

WO2012112553A1 NANOMETER SIZE CHEMICAL MODIFIED MATERIALS AND USES 审中-公开
标题翻译：纳米尺寸化学改性材料及用途
公开(公告)号：WO2012112553A1
公开(公告)日：2012-08-23
申请号：PCT/US2012/025049
申请日：2012-02-14
申请人： DIONEX CORPORATION , LIU, Xiaodong , POHL, Christopher, A.
发明人： LIU, Xiaodong , POHL, Christopher, A.
IPC分类号： B01J20/32 , B01J20/286 , B01J20/289 , B01J20/287
CPC分类号： G01N1/405 , B01J20/286 , B01J20/287 , B01J20/289 , B01J20/3219 , B01J20/3246 , B01J20/3257 , B01J2220/54 , C07F7/21
摘要： There are provided ligand compositions and stationary phases comprising a polyhedral oligomeric silsequioxane moiety. Also provided are chromatographic devices comprising the stationary phases, and methods of making and using the ligands, stationary phases and chromatographic devices of the invention.
摘要翻译：提供配体组合物和包含多面体低聚硅氧烷部分的固定相。还提供了包含固定相的色谱装置，以及制备和使用本发明的配体，固定相和色谱装置的方法。

60. 发明申请

WO2011046494A1 SEPARATION MATRICES 审中-公开
标题翻译：分离矩阵
公开(公告)号：WO2011046494A1
公开(公告)日：2011-04-21
申请号：PCT/SE2010/051088
申请日：2010-10-08
申请人： GE HEALTHCARE BIO-SCIENCES AB , AXÉN, Andreas , BREKKAN, Eggert , EDGREN, Gunilla , MALMQUIST, Gunnar
发明人： AXÉN, Andreas , BREKKAN, Eggert , EDGREN, Gunilla , MALMQUIST, Gunnar
IPC分类号： B01J20/289 , B01J39/16 , B01J39/26 , B01J41/12 , B01J41/20
CPC分类号： B01J20/289 , B01D15/3847 , B01J20/287 , B01J20/3285 , B01J39/19 , B01J39/26 , B01J41/13 , B01J41/20 , B01D15/327 , B01D15/362 , B01D15/363
摘要： The present invention relates to separation matrices comprising base matrices with first ligands comprising hydrophobic functions covalently bound to said base matrices and with extenders covalently bound to said base matrices, said extenders comprising second ion exchange ligands.
摘要翻译：本发明涉及分离基质，其包含具有第一配位体的基质基质，所述第一配体包含与所述基质基团共价结合的疏水官能团和与所述基础基质共价结合的增量剂，所述增量剂包含第二离子交换配体。

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