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41. 发明申请

WO2004051221A3 MEASUREMENT OF TOTAL REACTIVE ISOCYANATE GROUPS IN SAMPLES USING BIFUNCTIONAL NUCLEOPHILES SUCH AS 1,8-DIAMINONAPHTHALENE (DAN) 审中-公开
标题翻译：使用双官能核糖核酸作为1,8-二氨基萘甲酸（DAN）的样品中的总反应异氰酸酯基团的测量
公开(公告)号：WO2004051221A3
公开(公告)日：2004-09-02
申请号：PCT/US0338051
申请日：2003-12-01
申请人： US GOV OFFICE TECH TRANSFER , MASSACHUSETTS LOWELL RESEARCH , STREICHER ROBERT P , BELLO DHIMITER , WOSKIE SUSAN R , GROTE ARDITH A
发明人： MASSACHUSETTS LOWELL RESEARCH , STREICHER ROBERT P , BELLO DHIMITER , WOSKIE SUSAN R , GROTE ARDITH A
IPC分类号： C08G18/10 , C08G18/32 , G01N30/88 , G01N31/22 , G01N33/00 , G01N24/00
CPC分类号： C08G18/3243 , C08G18/10 , C08G18/71 , G01N31/22 , G01N2030/8809 , G01N2030/884
摘要： The present invention provides for a method for detecting the presence of isocyanate in a sample by (a) contacting an isocyanate derivatizing agent with a sample under conditions suitable to the formation of a detectable reaction product, in particular by using catalysts shown in Figure 1, and (b) establishing if isocyanate is present in the sample by determining the presence or absence of the reaction product. 1,8-Diaminonaphthalene (DAN) is utilized as a bifunctional nucleophilic derivitizing agent for detecting isocyanate.
摘要翻译：本发明提供了一种通过（a）在适于形成可检测的反应产物的条件下，特别是通过使用图1所示的催化剂使异氰酸酯衍生化试剂与样品接触来检测样品中异氰酸酯存在的方法，和（b）通过确定反应产物的存在或不存在来确定样品中是否存在异氰酸酯。 1,8-二氨基萘（DAN）用作检测异氰酸酯的双功能亲核衍生物。

42. 发明申请

WO2004042072A9 QUANTITATIVE ANALYSIS OF PROTEIN ISOFORMS USING MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME OF FLIGHT MASS SPECTROMETRY 审中-公开
标题翻译：使用矩阵辅助激光解吸/飞行质谱分析时间的蛋白质质量的定量分析
公开(公告)号：WO2004042072A9
公开(公告)日：2004-08-26
申请号：PCT/US0334386
申请日：2003-10-30
申请人： UNIV COLORADO A BODY , PERRYMAN BENJAMIN M , HELMKE STEVE M , DUNCAN MARK W
发明人： PERRYMAN BENJAMIN M , HELMKE STEVE M , DUNCAN MARK W
IPC分类号： C12Q20060101 , G01N24/00 , G01N33/00 , G01N33/68 , H01J49/00 , C12Q
CPC分类号： G01N33/6848 , G01N33/6851
摘要： The present invention provides for methods of quantitating the amounts of proteins or peptides, including those that are closely related isoforms, using matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). Measurement of protein concentrations in vivo has been extremely difficult and problematic, and protein concentrations have not been shown to correlate well with mRNA levels, the standard used in the past. The present invention overcomes the deficiencies of prior methodologies by taking advantage of MALDI-TOF-MS technology and applying it to proteins and peptides in a way that allows for accurate, quantitative measurement in vivo of protein or peptide concentrations.
摘要翻译：本发明提供了使用基质辅助激光解吸/离子化飞行时间质谱（MALDI-TOF-MS）定量蛋白质或肽的量的方法，包括具有密切相关同种型的那些。蛋白质浓度在体内的测量是非常困难和有问题的，并且蛋白质浓度尚未显示与mRNA水平（以往使用的标准）相关性良好。本发明通过利用MALDI-TOF-MS技术克服现有方法的缺陷，并以允许蛋白质或肽浓度的体内准确，定量测量的方式将其应用于蛋白质和肽。

43. 发明申请

WO2004061407A2 GLYCOPEPTIDE IDENTIFICATION AND ANALYSIS 审中-公开
标题翻译：糖肽识别和分析
公开(公告)号：WO2004061407A2
公开(公告)日：2004-07-22
申请号：PCT/CA2004000007
申请日：2004-01-05
申请人： CAPRION PHARMACEUTICALS INC , SWAMY SAJANI , JAITLY NAVDEEP , FURTOS-MATEI ALEXANDRA , KEARNEY PAUL EDWARD , THIBAULT PIERRE
发明人： SWAMY SAJANI , JAITLY NAVDEEP , FURTOS-MATEI ALEXANDRA , KEARNEY PAUL EDWARD , THIBAULT PIERRE
IPC分类号： G01N24/00 , G01N33/68 , G06F19/00 , H01J49/00 , G01N
CPC分类号： G01N33/6848 , G01N33/6842 , Y10T436/24
摘要： The invention described herein is a tool developed for the analysis of proteomic mass spectrometry (MS) data to identify and characterize glycoproteins. The tool is designed to perform four main tasks, separately, or as needed: optimize the selection of glycopeptides for MS/MS, identify glycopeptide spectra from MS/MS data, characterize the sugar moieties of identified glycopeptide spectra, and match the glycosylated precursor to its parent protein. The design and implementation for each of these components is described in more depth in this patent application.
摘要翻译：本文描述的本发明是开发用于分析蛋白质组质谱（MS）数据以鉴定和表征糖蛋白的工具。该工具可分别或根据需要执行四项主要任务：优化MS / MS糖肽的选择，从MS / MS数据中鉴定糖肽谱，鉴定已鉴定糖肽谱的糖部分，并将糖基化前体与其亲本蛋白质。在这个专利申请中更详细地描述了每个这些组件的设计和实现。

44. 发明申请

WO03038395A8 REMOTE NMR/MRI DETECTION OF LASER POLARIZED GASES 审中-公开
标题翻译：远程NMR / MRI检测激光极化气体
公开(公告)号：WO03038395A8
公开(公告)日：2004-04-29
申请号：PCT/US0232471
申请日：2002-10-09
申请人： UNIV CALIFORNIA , PINES ALEXANDER , SAXENA SUNIL , SPENCE MEGAN , MOULE ADAM , SEELEY JULIETTE A , PIERCE KIMBERLY L , HAN SONG-I , GRANWEHR JOSEPH
发明人： PINES ALEXANDER , SAXENA SUNIL , SPENCE MEGAN , MOULE ADAM , SEELEY JULIETTE A , PIERCE KIMBERLY L , HAN SONG-I , GRANWEHR JOSEPH
IPC分类号： G01N24/08 , A61B5/055 , A61K49/18 , G01N24/00 , G01R33/28 , G01R33/46 , G01N
CPC分类号： G01R33/281 , A61K49/1815 , G01R33/46 , G01R33/5601
摘要： An apparatus and method for remote NMR/MRI spectroscopy having an encoding Gail with a sample chamber, a supply of signal carriers, preferably hyperpolarized xenon and a detector allowing the spatial and temporal separation of signal preparation and signal detection steps, This separation allows the physical conditions and methods of the encoding and detection steps to be optimized independently. The encoding of the carrier molecules may take place in a high or a low magnetic field and conventional NMR pulse sequences can be split between encoding and detection steps. In one embodiment, the detector is a high magnetic field NMR apparatus. In another embodiment, the detector is a superconducting quantum interference device. A further embodiment uses optical detection of Rb-Xe spin exchange. Another embodiment uses an optical magnetometer using non-linear Faraday rotation. Concentration of the signal carriers in the detector can greatly improve the signal to noise ratio.
摘要翻译：一种用于远程NMR / MRI光谱的装置和方法，其具有带有样本室的编码Gail，信号载体的供应，优选为超极化氙，以及允许信号准备和信号检测步骤的空间和时间分离的检测器。该分离允许物理编码和检测步骤的条件和方法要独立优化。载体分子的编码可以在高或低磁场中进行，并且常规NMR脉冲序列可以在编码和检测步骤之间分离。在一个实施例中，检测器是高磁场NMR装置。在另一个实施例中，检测器是超导量子干涉装置。另一实施例使用Rb-Xe自旋交换的光学检测。另一实施例使用使用非线性法拉第旋转的光学磁力计。检测器中信号载波的集中度可以大大提高信噪比。

45. 发明申请

WO2004026114A2 QUANTIFICATION OF CARNITINE LEVELS IN DIALYSIS PATIENTS 审中-公开
标题翻译：透析患者血清胆固醇水平的定量
公开(公告)号：WO2004026114A2
公开(公告)日：2004-04-01
申请号：PCT/US0329821
申请日：2003-09-23
申请人： SIGMA TAU PHARMACEUTICALS INC
发明人： CHACE DONALD H , FORNASINI GIANFRANCO
IPC分类号： A61B20060101 , A61B1/00 , G01N24/00 , G01N33/68 , G01N33/92 , A61B
CPC分类号： G01N33/6848 , G01N33/92 , G01N2800/02 , Y10T436/173845 , Y10T436/24
摘要： Disclosed herein are methods for diagnosing carnitine deficiency in patients and quantifying that deficiency such that carnitine concentrations can be easily and accurately tracked within a given patient over time. Particular embodiments disclosed herein pertain to methods for diagnosing and quantifying the level of carnitine deficiency in patients undergoing dialysis procedures. The diagnosing and quantifying methods allow high throughput and low cost handling while providing high sensitivity and accuracy analysis such that the methods can be used frequently to monitor patient status, diagnose carnitine deficiency , and manage appropriate therapies to treat carnitine deficiency. The preferred embodiments disclosed herein utilize plasma samples taken from patients and dried on filter paper, which samples are then later analyzed using electrospray tandem mass-spectrometry and quantified in a manner that accounts for various complications that can skew free carnitine, acylcarnitine, or total carnitine concentrations.
摘要翻译：本文公开了用于诊断患者肉碱缺乏症的方法，并定量确定缺陷，使得在特定患者内随时间容易且准确地跟踪肉碱浓度。本文公开的特定实施例涉及用于诊断和量化经历透析程序的患者肉碱缺乏水平的方法。诊断和量化方法允许高通量和低成本处理，同时提供高灵敏度和精确度分析，使得该方法可以频繁地用于监测患者状态，诊断肉碱缺乏并且管理适当的治疗以治疗肉碱缺乏症。本文公开的优选实施例使用从患者取得的血浆样品并在滤纸上干燥，然后使用电喷雾串联质谱法分析该样品，并以考虑各种并发症的方式进行定量，所述并发症可以使游离的肉碱，酰基肉碱或总肉碱浓度。

46. 发明申请

WO03097202B1 PARTICLE SEPARATION 审中-公开
标题翻译：颗粒分离
公开(公告)号：WO03097202B1
公开(公告)日：2004-03-25
申请号：PCT/GB0302124
申请日：2003-05-16
申请人： SHORTIS GRAEME STEWART
发明人： SHORTIS GRAEME STEWART
IPC分类号： G01N24/00 , B01D17/06 , B01D45/12 , B01J19/08 , B03C1/00 , B03C1/023 , B03C1/035 , C02F1/00 , C02F1/38 , C02F1/46 , C02F1/48
CPC分类号： B03C1/32 , B01D45/12 , B03C1/023 , B03C1/035 , B03C3/15 , B03C2201/02 , C02F1/38 , C02F1/4604 , C02F1/48 , C02F2101/20 , C02F2103/08 , C02F2103/10 , C02F2201/46175 , C02F2201/483 , C02F2301/022 , C02F2301/026
摘要： A laminar or cyclonic particle separator for gas, liquid-liquid and fluidizable solids separation comprised of a section with a non-metallic housing having an annulus and a chamber, an optional anode cooled with a first coolant in and a first coolant out disposed in the chamber, a DC or pulsating DC power source connected to the anode, at least one magnetic coil disposed adjacent the chamber and cooled with a second coolant, a high voltage pulsating DC power source connected to the magnetic coil, and a fluid (gas, liquid or fluidizable solids) inlet port connected to the housing, and also a section with a non-metallic separator tube connected to the housing and disposed within the housing, a first fluid outlet connected to the annulus through the housing. This device can then separate a stream rich in a targeted element (first fluid) and a stream lean in a targeted element (second fluid) from the device and thus discharge a stream almost free of the targeted element or almost 100 % the targeted element.
摘要翻译：用于气体，液 - 液和可流化固体分离的层状或旋流颗粒分离器，包括具有非金属外壳的部分，所述非金属外壳具有环形空间和腔室，任选的阳极用第一冷却剂进入，冷却剂出口设置在连接到阳极的直流或脉动直流电源，与该室相邻设置并用第二冷却剂冷却的至少一个磁性线圈，连接到磁性线圈的高压脉动直流电源和流体（气体，液体或可流化的固体）入口端口，以及具有连接到壳体并设置在壳体内的非金属分离器管的部分，第一流体出口通过壳体连接到环形空间。然后，该装置可以将富含目标元素（第一流体）的流与目标元素（第二流体）中的贫流从装置中分离，并因此排出几乎不含目标元素或几乎100％目标元素的流。

47. 发明申请

WO03102539A2 AUTOMATED PROTEIN ANALYSIS SYSTEM 审中-公开
标题翻译：自动蛋白质分析系统
公开(公告)号：WO03102539A2
公开(公告)日：2003-12-11
申请号：PCT/US0316899
申请日：2003-05-30
申请人： UNIV MICHIGAN , LUBMAN DAVID M , PARUS STEVEN J , YOO CHUL S
发明人： LUBMAN DAVID M , PARUS STEVEN J , YOO CHUL S
IPC分类号： C07K1/26 , C07K1/36 , C12M1/34 , G01N24/00 , G01N27/447 , G01N30/02 , G01N30/72 , G01N33/00 , G01N33/48 , G01N33/50 , G06F19/00 , G01N
CPC分类号： G01N27/44717 , C07K1/26 , C07K1/285 , C07K1/36 , G01N30/02 , G01N30/7266 , B01D15/325
摘要： The present invention relates to automated methods, systems, and apparatuses for protein separation and analysis. In particular, the present invention provides an automated system for the separation, identification, and characterization of protein samples. The present invention thus provides improved methods for the separation and analysis of samples containing a plurality of proteins (e.g., cells).
摘要翻译：本发明涉及用于蛋白质分离和分析的自动化方法，系统和装置。特别地，本发明提供了用于蛋白质样品的分离，鉴定和表征的自动化系统。因此，本发明提供了用于分离和分析含有多种蛋白质（例如细胞）的样品的改进方法。

48. 发明申请

WO0237132A8 METHODS AND DEVICES FOR DISSOLVING HYPERPOLARISED SOLID MATERIAL FOR NMR ANALYSES 审中-公开
标题翻译：核磁共振分析用于溶解固体高分子材料的方法和装置
公开(公告)号：WO0237132A8
公开(公告)日：2003-12-04
申请号：PCT/EP0112736
申请日：2001-11-02
申请人： AMERSHAM HEALTH AS , ARDENKJAER-LARSEN JAN HENRIK , AXELSSON OSKAR H E , GOLMAN KLAES KOPPEL , HANSSON GEORG , JOHANNESSON H , SERVIN ROLF , THANING MIKKEL , HANSSON LENNART
发明人： ARDENKJAER-LARSEN JAN HENRIK , AXELSSON OSKAR H E , GOLMAN KLAES KOPPEL , HANSSON GEORG , JOHANNESSON H , SERVIN ROLF , THANING MIKKEL , HANSSON LENNART
IPC分类号： G01N24/00 , A61B5/055 , G01N1/28 , G01N1/44 , G01N24/08 , G01R20060101 , G01R1/00 , G01R33/28 , G01R33/30 , G01R33/31 , G01R33/32 , G01R33/62 , G01V3/00 , A61K49/06
CPC分类号： G01R33/282 , G01N1/44 , G01R33/307 , G01R33/5601 , G01R33/62
摘要： The present invention relates to devices and method for dissolving solid polarised material while retaining a high level of polarisation. In an embodiment of the present invention a material is polarised in a strong magnetic field in a cryostat 2 and then brought into solution while still inside the cryostat 2.
摘要翻译：本发明涉及用于溶解固体极化材料同时保持高水平偏振的装置和方法。在本发明的一个实施例中，材料在低温恒温器2中的强磁场中极化，然后在仍然在低温恒温器2内部的同时进入溶液中。

49. 发明申请

WO02066952A3 MASS DEFECT LABELING FOR THE DETERMINATION OF OLIGOMER SEQUENCES 审中-公开
标题翻译：用于确定低分子序列的质量缺陷标签
公开(公告)号：WO02066952A3
公开(公告)日：2003-09-04
申请号：PCT/US0149951
申请日：2001-10-19
申请人： TARGET DISCOVERY INC , SCHNEIDER LUKE V , HALL MICHAEL P , PETESCH ROBERT
发明人： SCHNEIDER LUKE V , HALL MICHAEL P , PETESCH ROBERT
IPC分类号： G01N27/62 , C12N15/09 , C12Q1/68 , G01N33/48 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/68 , G06F19/00 , H01J49/00 , H01J49/04 , C12P19/34 , G01N24/00 , G01N33/00
CPC分类号： G01N33/6848 , C12Q1/6872 , H01J49/0045 , Y10T436/105831 , Y10T436/143333 , Y10T436/24 , Y10T436/25125
摘要： Mass tagging methods are provided that lead to mass spectrometer detection sensitivities and molecular discriminations that are improved over other methods. In particular the methods are useful for discriminating tagged molecules and fragments of molecules from chemical noise in the mass spectrum. These mass tagging methods are useful for oligomer sequencing, determining the relative abundances of molecules from different samples, and identifying individual molecules or chemical processing steps in combinatorial chemical libraries. The methods provided are useful for the simultaneous analysis of multiple molecules and reaction mixtures by mass spectrometric methods.
摘要翻译：提供了质量标记方法，其导致与其他方法相比改进的质谱仪检测灵敏度和分子鉴别。特别地，该方法可用于区分标签分子和分子片段与质谱中的化学噪声。这些质量标签方法可用于寡聚体测序，确定来自不同样品的分子的相对丰度，以及鉴定组合化学文库中的单个分子或化学处理步骤。所提供的方法可用于通过质谱法同时分析多个分子和反应混合物。

50. 发明申请

WO0214856A3 MASS SPECTROMETRY 审中-公开
标题翻译：质谱
公开(公告)号：WO0214856A3
公开(公告)日：2002-12-27
申请号：PCT/GB0103604
申请日：2001-08-09
申请人： ISIS INNOVATION
发明人： SHCHEPINOV MIKHAIL SERGEEVICH
IPC分类号： G01N27/62 , G01N23/00 , G01N24/00 , G01N33/58 , H01J49/04
CPC分类号： G01N33/58 , G01N2458/15 , H01J49/0009 , H01J49/04 , Y10T436/10 , Y10T436/24
摘要： The invention provides a method of measuring the molecular mass of a compound Y of unknown molecular mass by mass spectrometry, comprising providing a sample of compound Y, providing samples of at least two different compounds each of formula (I) R-X in which R is a trityl group and X is cleavable to form a charged species for mass spectrometry, and recording the molecular mass of compound Y and the at least two compounds of formula (I) may be used as calibration compounds for mass spectrometry. They may also be used in a kit for the production of calibration compounds mass spectrometry comprising: (a) at least one base reactant of formula (I) R-X where R is a trityl group and X is cleavable to form a charged species for mass spectrometry and (b) at least two different amine compounds which are of different molecular masses and which are each capable of reacting with the base reactant and base reactant (a) is packaged separately from amine compounds (b).
摘要翻译：本发明提供了通过质谱法测量未知分子量化合物Y的分子量的方法，包括提供化合物Y的样品，提供至少两种不同的式（I）RX化合物的样品，其中R是三苯甲基并且X可裂解以形成用于质谱的带电物质，并且记录化合物Y和至少两种式（I）化合物的分子量可以用作用于质谱的校准化合物。它们也可用于生产校准化合物质谱的试剂盒中，该试剂盒包含：（a）至少一种式（I）RX的碱性反应物，其中R是三苯甲基，X是可裂解的以形成用于质谱的带电物质和（b）至少两种不同分子量且能够与碱反应物和碱反应物（a）反应的胺化合物与胺化合物（b）分开包装。

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