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1. 发明申请

WO03038395A8 REMOTE NMR/MRI DETECTION OF LASER POLARIZED GASES 审中-公开
标题翻译：远程NMR / MRI检测激光极化气体
公开(公告)号：WO03038395A8
公开(公告)日：2004-04-29
申请号：PCT/US0232471
申请日：2002-10-09
申请人： UNIV CALIFORNIA , PINES ALEXANDER , SAXENA SUNIL , SPENCE MEGAN , MOULE ADAM , SEELEY JULIETTE A , PIERCE KIMBERLY L , HAN SONG-I , GRANWEHR JOSEPH
发明人： PINES ALEXANDER , SAXENA SUNIL , SPENCE MEGAN , MOULE ADAM , SEELEY JULIETTE A , PIERCE KIMBERLY L , HAN SONG-I , GRANWEHR JOSEPH
IPC分类号： G01N24/08 , A61B5/055 , A61K49/18 , G01N24/00 , G01R33/28 , G01R33/46 , G01N
CPC分类号： G01R33/281 , A61K49/1815 , G01R33/46 , G01R33/5601
摘要： An apparatus and method for remote NMR/MRI spectroscopy having an encoding Gail with a sample chamber, a supply of signal carriers, preferably hyperpolarized xenon and a detector allowing the spatial and temporal separation of signal preparation and signal detection steps, This separation allows the physical conditions and methods of the encoding and detection steps to be optimized independently. The encoding of the carrier molecules may take place in a high or a low magnetic field and conventional NMR pulse sequences can be split between encoding and detection steps. In one embodiment, the detector is a high magnetic field NMR apparatus. In another embodiment, the detector is a superconducting quantum interference device. A further embodiment uses optical detection of Rb-Xe spin exchange. Another embodiment uses an optical magnetometer using non-linear Faraday rotation. Concentration of the signal carriers in the detector can greatly improve the signal to noise ratio.
摘要翻译：一种用于远程NMR / MRI光谱的装置和方法，其具有带有样本室的编码Gail，信号载体的供应，优选为超极化氙，以及允许信号准备和信号检测步骤的空间和时间分离的检测器。该分离允许物理编码和检测步骤的条件和方法要独立优化。载体分子的编码可以在高或低磁场中进行，并且常规NMR脉冲序列可以在编码和检测步骤之间分离。在一个实施例中，检测器是高磁场NMR装置。在另一个实施例中，检测器是超导量子干涉装置。另一实施例使用Rb-Xe自旋交换的光学检测。另一实施例使用使用非线性法拉第旋转的光学磁力计。检测器中信号载波的集中度可以大大提高信噪比。

2. 发明申请

WO2008154059A3 ROTATING FRAME GRADIENT FIELDS FOR MRI AND NMR IN LOW POLARIZING MAGNETIC FIELDS 审中-公开
标题翻译：在低极化磁场中用于MRI和NMR的旋转框架梯度场
公开(公告)号：WO2008154059A3
公开(公告)日：2009-04-02
申请号：PCT/US2008059183
申请日：2008-04-02
申请人： UNIV CALIFORNIA , BOUCHARD LOUIS-SERGE , PINES ALEXANDER , DEMAS VASILIKI
发明人： BOUCHARD LOUIS-SERGE , PINES ALEXANDER , DEMAS VASILIKI
IPC分类号： G01R33/48 , G01R33/483 , G01R33/565
CPC分类号： G01R33/48 , G01R33/445 , G01R33/483 , G01R33/4833 , G01R33/56341 , G01R33/56581
摘要： A system and method for Fourier encoding a nuclear magnetic resonance (NMR) signal is disclosed. A static magnetic field is provided along a first direction. An NMR signal from the sample is Fourier encoded by applying a rotating-frame gradient field superimposed on the, where the comprises a vector component rotating in a plane perpendicular to the first direction at an angular frequency in a laboratory frame. The Fourier-encoded NMR signal is detected. The rotating frame gradient field according to the invention reduces distortions in Fourier encoded imaging and volume selection caused by untruncated concomitant gradients.
摘要翻译：公开了一种用于傅里叶编码核磁共振（NMR）信号的系统和方法。沿着第一方向设置静磁场。来自样本的NMR信号通过施加叠加在其上的旋转帧梯度场进行傅里叶编码，其中包括在实验室框架中以角频率在垂直于第一方向的平面中旋转的矢量分量。检测傅里叶编码的NMR信号。根据本发明的旋转框架梯度场减少了傅里叶编码成像中的失真和由未被截断的伴随梯度引起的体积选择。

3. 发明申请

WO2006028588A2 NUCLEAR MAGNETIC RESONANCE DETECTION IN INHOMOGENEOUS MAGNETIC FIELDS 审中-公开
标题翻译：非均质磁场中的核磁共振检测
公开(公告)号：WO2006028588A2
公开(公告)日：2006-03-16
申请号：PCT/US2005026229
申请日：2005-07-21
申请人： UNIV CALIFORNIA , PINES ALEXANDER , TOPGAARD DANIEL , SAKELLARIOU DEMITRIS , MARTIN RACHEL W , MERILES CARLOS A
发明人： PINES ALEXANDER , TOPGAARD DANIEL , SAKELLARIOU DEMITRIS , MARTIN RACHEL W , MERILES CARLOS A
IPC分类号： G01R19/18
CPC分类号： G01R33/36 , G01R33/3808 , G01R33/385 , G01R33/445 , G01R33/4616 , G01R33/56563
摘要： Methods and systems for compensating for static magnetic field inhomogeneities during nuclear magnetic resonance detection are disclosed. Application of radio frequency pulses and/or magnetic field gradients may be used to correct for spin dephasing caused by the inhomogeneities. The methods and system may be used to improve signal-to-noise ratios in NMR and MRI systems where magnetic field inhomogeneity may have an effect.
摘要翻译：公开了用于在核磁共振检测期间补偿静态磁场不均匀性的方法和系统。可以使用射频脉冲和/或磁场梯度来校正由不均匀性引起的自旋去相位。该方法和系统可用于提高NMR和MRI系统中的磁场不均匀性可能具有影响的信噪比。

4. 发明申请

WO2006023208A3 LOW FIELD MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：低场磁共振成像
公开(公告)号：WO2006023208A3
公开(公告)日：2006-07-06
申请号：PCT/US2005026264
申请日：2005-07-21
申请人： UNIV CALIFORNIA , PINES ALEXANDER , MERILES CARLOS A , SAKELLARIOU DEMITRIS , TRABESINGER ANDREAS H
发明人： PINES ALEXANDER , MERILES CARLOS A , SAKELLARIOU DEMITRIS , TRABESINGER ANDREAS H
IPC分类号： G01V3/00
CPC分类号： G01R33/445
摘要： A method and system of magnetic resonance imaging does not need a large homogenous field to truncate a gradient field. Spatial information is encoded into the spin magnetization by allowing the magnetization to evolve in a non-truncated gradient field and inducing a set of 180 degree rotations prior to signal acquisition.
摘要翻译：磁共振成像的方法和系统不需要大的均匀场来截断梯度场。空间信息通过允许磁化在非截断梯度场中演化并在信号采集之前诱导一组180度旋转而被编码为自旋磁化。

5. 发明申请

WO2009029880A3 ULTRAHIGH TIME RESOLUTION MAGNETIC RESONANCE 审中-公开
标题翻译：超声时间分辨率磁共振
公开(公告)号：WO2009029880A3
公开(公告)日：2009-04-23
申请号：PCT/US2008074904
申请日：2008-08-29
申请人： UNIV CALIFORNIA , PINES ALEXANDER , HAREL ELAD
发明人： PINES ALEXANDER , HAREL ELAD
IPC分类号： G01R33/32 , G01N24/08
CPC分类号： G01R33/56316 , G01N24/081 , G01R33/302 , G01R33/307 , G01R33/485
摘要： Ultrahigh time resolution magnetic resonance is achieved in a flow-through device such as a microfluidic chip by imaging along the flow dimension. Position within the one- dimensional image may be related to time by the flow velocity. Thus, a time resolution corresponding to the one-dimensional image resolution is obtainable.
摘要翻译：通过沿着流动尺寸进行成像，在诸如微流体芯片的流通装置中实现超高时间分辨率磁共振。一维图像内的位置可以通过流速与时间相关。因此，可获得对应于一维图像分辨率的时间分辨率。

6. 发明申请

WO2009108791A8 DIAGNOSTIC SKIN MAPPING BY MRS, MRI AND OTHER METHODS 审中-公开
标题翻译： MRS，MRI和其他方法诊断皮肤图
公开(公告)号：WO2009108791A8
公开(公告)日：2009-10-29
申请号：PCT/US2009035308
申请日：2009-02-26
申请人： UNIV CALIFORNIA , GLOGAU RICHARD G , BLUEMICH BERNHARD P J , PINES ALEXANDER
发明人： GLOGAU RICHARD G , BLUEMICH BERNHARD P J , PINES ALEXANDER
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/441 , A61B5/7257 , A61B5/7264 , G01N24/08 , G01R33/50 , G01R33/56341 , G06F19/324 , G06T7/0012 , G06T2207/10088 , G06T2207/30088 , G16H10/60 , G16H50/20 , G16H50/70
摘要： This invention pertains to improved methods of classifying skin types as well as improved methods for determining the appropriateness of products and evaluating methods for treating particular skin. The methods typically utilize a "skin type" database containing one or more quantitative measures (e.g., NMR data) of skin properties. The database can optionally include various qualitative measures of skin as well (e.g., Glogau scale and/or Fitzpatrick scale values).
摘要翻译：本发明涉及分类皮肤类型的改进方法以及用于确定产品的合适性和用于治疗特定皮肤的评估方法的改进方法。该方法通常利用包含皮肤特性的一种或多种定量度量（例如NMR数据）的“皮肤类型”数据库。该数据库还可以可选地包括皮肤的各种定性度量（例如，Glogau尺度和/或Fitzpatrick尺度值）。

7. 发明申请

WO2009079054A3 RADIO FREQUENCY ATOMIC MAGNETOMETER 审中-公开
标题翻译：无线电频率原子磁力计
公开(公告)号：WO2009079054A3
公开(公告)日：2009-09-11
申请号：PCT/US2008077113
申请日：2008-09-19
申请人： UNIV CALIFORNIA , BUDKER DIMITRY , PINES ALEXANDER , LEDBETTER MICHAH
发明人： BUDKER DIMITRY , PINES ALEXANDER , LEDBETTER MICHAH
IPC分类号： G01R33/02
CPC分类号： G01R33/26
摘要： An atomic magnetometer is used to detect radio frequency magnetic fields, such as those generated in nuclear resonance experiments. The magnetometer is based on nonlinear magneto-optical rotation and pumps an atomic vapor into a quadrupole aligned state. Detection of the modulation of the polarization of a linearly polarized beam provides the radio frequency signal, which can then be processed to extract the component frequencies.
摘要翻译：原子磁力计用于检测射频磁场，例如核谐振实验中产生的射频磁场。该磁力计基于非线性磁光旋转并将原子蒸汽泵入四极对准状态。检测线性偏振光束的偏振调制提供了射频信号，然后可以处理该射频信号以提取分量频率。

8. 发明申请

WO2008154059A9 ROTATING FRAME GRADIENT FIELDS FOR MAGNITIC RESONANCE IMAGING AND NUCLEAR MAGNETIC RESONANCE IN LOW FIELDS 审中-公开
标题翻译：用于磁场共振成像的转动框架梯度场和低场中的核磁共振
公开(公告)号：WO2008154059A9
公开(公告)日：2009-02-19
申请号：PCT/US2008059183
申请日：2008-04-02
申请人： UNIV CALIFORNIA , BOUCHARD LOUIS-SERGE , PINES ALEXANDER , DEMAS VASILIKI
发明人： BOUCHARD LOUIS-SERGE , PINES ALEXANDER , DEMAS VASILIKI
IPC分类号： G01R33/48 , G01R33/483 , G01R33/565
CPC分类号： G01R33/48 , G01R33/445 , G01R33/483 , G01R33/4833 , G01R33/56341 , G01R33/56581
摘要： A system and method for Fourier encoding a nuclear magnetic resonance (NMR) signal is disclosed. A static magnetic field B0 is provided along a first direction. An NMR signal from the sample is Fourier encoded by applying a rotating-frame gradient field BG superimposed on the B0, where the BG comprises a vector component rotating in a plane perpendicular to the first direction at an angular frequency ? in a laboratory frame. The Fourier-encoded NMR signal is detected.
摘要翻译：公开了一种用于傅里叶编码核磁共振（NMR）信号的系统和方法。沿着第一方向设置静磁场B0。来自样本的NMR信号通过施加叠加在B0上的旋转帧梯度场BG进行傅里叶编码，其中BG包括在垂直于第一方向的平面中以角频率ω旋转的矢量分量，在实验室框架。检测傅里叶编码的NMR信号。

9. 发明申请

WO2008024092A2 NMR, MRI, AND SPECTROSCOPIC MRI IN INHOMOGENEOUS FIELDS 审中-公开
标题翻译：核磁共振，磁共振成像和光谱学在非均匀磁场中的磁共振成像
公开(公告)号：WO2008024092A2
公开(公告)日：2008-02-28
申请号：PCT/US2006023787
申请日：2006-06-16
申请人： UNIV CALIFORNIA
发明人： DEMAS VASILIKI , PINES ALEXANDER , MARTIN RACHEL , FRANCK JOHN , REIMER JEFFREY
CPC分类号： G01R33/4833 , G01N24/084 , G01R33/3808 , G01R33/445 , G01R33/485 , G01R33/56563
摘要： A method for locally creating effectively homogeneous or "clean" magnetic field gradients (of high uniformity) for imaging (with NMR, MRI, or spectroscopic MRI) both in in-situ and ex-situ systems with high degrees of inhomogeneous field strength. The method of imaging comprises: a) providing a functional approximation of an inhomogeneous static magnetic field strength B
摘要翻译：一种用于在具有高度不均匀场强度的原位和非原位系统中成像（使用NMR，MRI或光谱MRI）的有效均匀或“干净”磁场梯度（高均匀度）的方法。成像方法包括：a）提供非均匀静态磁场强度B的函数近似

10. 发明申请

WO0205803A8 FUNCTIONALIZED ACTIVE-NUCLEUS COMPLEX SENSOR 审中-公开
标题翻译：功能活性核复合传感器
公开(公告)号：WO0205803A8
公开(公告)日：2002-03-21
申请号：PCT/US0122050
申请日：2001-07-12
申请人： UNIV CALIFORNIA
发明人： PINES ALEXANDER , WEMMER DAVID E , SPENCE MEGAN , RUBIN SETH
IPC分类号： A61K49/18 , A61K31/045 , A61B5/055 , A61K31/05 , A61K49/06 , A61K49/12
CPC分类号： A61K49/1815 , Y10S977/915 , Y10T436/24
摘要： A functionalized active-nucleus complex sensor that selectively associates with one or more target species. The functionalized active-nucleus complex comprises an active-nucleus and a targeting carrier wherein the targeting carrier comprises a first binding region having at least a minimal transient binding of the active-nucleus to form the functionalized active-nucleus complex that produces a detectable signal when the functionalized active-nucleus complex associates with the target species and a second binding region that selectively associates with the target species. Included is also method for assaying and screening for one or a plurality of target species utilizing one or a plurality of functionalized active-nucleus cmplexes with at least two of the functionalized active-nucleus complexes having an attraction affinity to different corresponding target species.
摘要翻译：选择性地与一种或多种目标物种结合的功能化活性核复合物传感器。功能化的活性核复合物包含活性核和靶向载体，其中靶向载体包含具有活性核至少最小的瞬时结合以形成官能化的活性核复合物的第一结合区，其产生可检测信号，官能化的活性核复合物与目标物质和选择性地与目标物质缔合的第二结合区域相关联。还包括利用一个或多个官能化活性核复合物测定和筛选一种或多种目标物种的方法，其中至少两种官能化活性核复合物对不同的相应靶物种具有吸引亲和力。

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