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1. 发明申请

WO2004026114A2 QUANTIFICATION OF CARNITINE LEVELS IN DIALYSIS PATIENTS 审中-公开
标题翻译：透析患者血清胆固醇水平的定量
公开(公告)号：WO2004026114A2
公开(公告)日：2004-04-01
申请号：PCT/US0329821
申请日：2003-09-23
申请人： SIGMA TAU PHARMACEUTICALS INC
发明人： CHACE DONALD H , FORNASINI GIANFRANCO
IPC分类号： A61B20060101 , A61B1/00 , G01N24/00 , G01N33/68 , G01N33/92 , A61B
CPC分类号： G01N33/6848 , G01N33/92 , G01N2800/02 , Y10T436/173845 , Y10T436/24
摘要： Disclosed herein are methods for diagnosing carnitine deficiency in patients and quantifying that deficiency such that carnitine concentrations can be easily and accurately tracked within a given patient over time. Particular embodiments disclosed herein pertain to methods for diagnosing and quantifying the level of carnitine deficiency in patients undergoing dialysis procedures. The diagnosing and quantifying methods allow high throughput and low cost handling while providing high sensitivity and accuracy analysis such that the methods can be used frequently to monitor patient status, diagnose carnitine deficiency , and manage appropriate therapies to treat carnitine deficiency. The preferred embodiments disclosed herein utilize plasma samples taken from patients and dried on filter paper, which samples are then later analyzed using electrospray tandem mass-spectrometry and quantified in a manner that accounts for various complications that can skew free carnitine, acylcarnitine, or total carnitine concentrations.
摘要翻译：本文公开了用于诊断患者肉碱缺乏症的方法，并定量确定缺陷，使得在特定患者内随时间容易且准确地跟踪肉碱浓度。本文公开的特定实施例涉及用于诊断和量化经历透析程序的患者肉碱缺乏水平的方法。诊断和量化方法允许高通量和低成本处理，同时提供高灵敏度和精确度分析，使得该方法可以频繁地用于监测患者状态，诊断肉碱缺乏并且管理适当的治疗以治疗肉碱缺乏症。本文公开的优选实施例使用从患者取得的血浆样品并在滤纸上干燥，然后使用电喷雾串联质谱法分析该样品，并以考虑各种并发症的方式进行定量，所述并发症可以使游离的肉碱，酰基肉碱或总肉碱浓度。

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