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1. 发明申请

WO2011141568A1 METHOD OF SYNTHESIS 审中-公开
标题翻译：合成方法
公开(公告)号：WO2011141568A1
公开(公告)日：2011-11-17
申请号：PCT/EP2011/057757
申请日：2011-05-13
申请人： GE HEALTHCARE LIMITED , BRATHE, Anders , OLSSON, Andreas , THANING, Mikkel , BUGGE, Steffen
发明人： BRATHE, Anders , OLSSON, Andreas , THANING, Mikkel , BUGGE, Steffen
IPC分类号： C07C319/14 , C07C319/20 , C07C319/24 , C07C323/44 , C07B59/00
CPC分类号： C07C319/14 , C07B59/001 , C07B2200/05 , C07C319/20 , C07C319/24 , C07C323/44
摘要： The present invention provides a method for the preparation of a radiolabeiied guanidine derivative, in particular wherein the radiolabeiied guanidine derivative is a positron emission tomography (PET) tracer. Certain intermediates useful in said method are also provided, as well as means for carrying out said method in an automated fashion. The method of the invention provides advantages over known methods for the preparation of radiolabeiied guanidine derivatives.
摘要翻译：本发明提供了一种制备放射性标记的胍衍生物的方法，特别是其中放射性标记的胍衍生物是正电子发射断层摄影（PET）示踪剂。还提供了可用于所述方法的某些中间体，以及用于以自动方式实施所述方法的装置。本发明的方法提供了优于已知的制备放射性标记的胍衍生物的方法的优点。

2. 发明申请

WO2009008734A2 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009008734A2
公开(公告)日：2009-01-15
申请号：PCT/NO2008/000255
申请日：2008-07-04
申请人： GE HEALTHCARE AS , THANING, Mikkel
发明人： THANING, Mikkel
IPC分类号： A61K49/04
CPC分类号： C07C237/46 , A61K49/0433 , A61K49/0438 , A61K49/0452
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R-N(CHO) -X-N(R 3 )-R wherein X denoted an optionally substituted alkylene group, R 3 denotes a hydrogen atom or an acyl function and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有两个通式为RN（CHO）-XN（R 3）-R 2的连接碘代苯基的化合物，其中X表示任选取代的亚烷基，R ^{3表示氢原子或酰基官能团，并且每个R表示进一步被亲水部分取代的三碘代苯基残基。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是X射线成像中的用途，以及含有这种化合物的造影剂的用途。}

3. 发明申请

WO2006054903A2 METHOD OF CARDIAC IMAGING 审中-公开
标题翻译：心脏成像方法
公开(公告)号：WO2006054903A2
公开(公告)日：2006-05-26
申请号：PCT/NO2005000434
申请日：2005-11-18
申请人： GE HEALTHCARE AS , LERCHE MATHILDE , ZANDT RENE , GOLMAN KLAES , THANING MIKKEL , ARDENKJAER-LARSEN JAN-HENRIK , PETERSSON STEFAN
发明人： LERCHE MATHILDE , ZANDT RENE , GOLMAN KLAES , THANING MIKKEL , ARDENKJAER-LARSEN JAN-HENRIK , PETERSSON STEFAN
IPC分类号： A61K49/06
CPC分类号： G01R33/5601 , A61B5/055 , A61K49/06
摘要： The invention relates to a method of cardiac imaging using hyperpolarised 13 C-pyruvate as MR imaging agent, which allows determination of the viability of cells in the myocardium.
摘要翻译：本发明涉及使用超极化的13 C-丙酮酸作为MR成像剂的心脏成像方法，其可以测定心肌细胞的存活力。

4. 发明申请

WO0237132A8 METHODS AND DEVICES FOR DISSOLVING HYPERPOLARISED SOLID MATERIAL FOR NMR ANALYSES 审中-公开
标题翻译：核磁共振分析用于溶解固体高分子材料的方法和装置
公开(公告)号：WO0237132A8
公开(公告)日：2003-12-04
申请号：PCT/EP0112736
申请日：2001-11-02
申请人： AMERSHAM HEALTH AS , ARDENKJAER-LARSEN JAN HENRIK , AXELSSON OSKAR H E , GOLMAN KLAES KOPPEL , HANSSON GEORG , JOHANNESSON H , SERVIN ROLF , THANING MIKKEL , HANSSON LENNART
发明人： ARDENKJAER-LARSEN JAN HENRIK , AXELSSON OSKAR H E , GOLMAN KLAES KOPPEL , HANSSON GEORG , JOHANNESSON H , SERVIN ROLF , THANING MIKKEL , HANSSON LENNART
IPC分类号： G01N24/00 , A61B5/055 , G01N1/28 , G01N1/44 , G01N24/08 , G01R20060101 , G01R1/00 , G01R33/28 , G01R33/30 , G01R33/31 , G01R33/32 , G01R33/62 , G01V3/00 , A61K49/06
CPC分类号： G01R33/282 , G01N1/44 , G01R33/307 , G01R33/5601 , G01R33/62
摘要： The present invention relates to devices and method for dissolving solid polarised material while retaining a high level of polarisation. In an embodiment of the present invention a material is polarised in a strong magnetic field in a cryostat 2 and then brought into solution while still inside the cryostat 2.
摘要翻译：本发明涉及用于溶解固体极化材料同时保持高水平偏振的装置和方法。在本发明的一个实施例中，材料在低温恒温器2中的强磁场中极化，然后在仍然在低温恒温器2内部的同时进入溶液中。

5. 发明申请

WO2009008734A3 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009008734A3
公开(公告)日：2009-10-29
申请号：PCT/NO2008000255
申请日：2008-07-04
申请人： GE HEALTHCARE AS , THANING MIKKEL
发明人： THANING MIKKEL
IPC分类号： A61K49/04
CPC分类号： C07C237/46 , A61K49/0433 , A61K49/0438 , A61K49/0452
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R-N(CHO) -X-N(R3)-R wherein X denoted an optionally substituted alkylene group, R3 denotes a hydrogen atom or an acyl function and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有通式RN（CHO）-XN（R3）-R的两个连接的碘化苯基的化合物，其中X表示任选取代的亚烷基，R 3表示氢原子或酰基官能团， R表示进一步被亲水部分取代的三碘化苯基。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

6. 发明申请

WO2009027422A3 NOZZLE FOR A POLARIZER FOR DYNAMIC NUCLEAR SPIN POLARISATION (DNP) 审中-公开
标题翻译：用于动态核弹性极化极化的喷嘴（DNP）
公开(公告)号：WO2009027422A3
公开(公告)日：2009-09-03
申请号：PCT/EP2008061197
申请日：2008-08-27
申请人： GE HEALTHCARE LTD , ARDENKJAER-LARSEN JAN HENRIK , DIETRICH DAVID KEY , GRAM KARL ANDREAS , LEACH ANDREW M , MILLER PETER , TELFEYAN ERIC J , THANING MIKKEL , WHITT DAVID B
发明人： ARDENKJAER-LARSEN JAN HENRIK , DIETRICH DAVID KEY , GRAM KARL ANDREAS , LEACH ANDREW M , MILLER PETER , TELFEYAN ERIC J , THANING MIKKEL , WHITT DAVID B
IPC分类号： G01R33/30 , B01L99/00 , G01N1/10 , G01R33/62
CPC分类号： G01R33/307 , B01F1/0022 , B01L3/0293 , G01N1/38 , G01N2001/1025 , G01N2001/383 , G01R33/282 , G01R33/62
摘要： DNP polarizer comprising a housing receiving a free end of a tubular fluid conduit positioned in fluid communication with a nozzle supported by said housing, said nozzle including an input port, a dispense port and a tapering inner surface or a stepped inner surface defining a nozzle flowpath extending in fluid communication between said input port and said dispense port.
摘要翻译： DNP偏振器包括壳体，其容纳与由所述壳体支撑的喷嘴流体连通的管状流体导管的自由端，所述喷嘴包括输入端口，分配端口和锥形内表面或限定喷嘴流径的阶梯式内表面在所述输入端口和所述分配端口之间流体连通地延伸。

7. 发明申请

WO2006011811A2 RADICALS AND THEIR USE AS PARAMAGNETIC AGENTS IN A DNP PROCESS 审中-公开
标题翻译： RADICALS及其作为DNP方法中的参考试剂使用
公开(公告)号：WO2006011811A2
公开(公告)日：2006-02-02
申请号：PCT/NO2005/000283
申请日：2005-07-28
申请人： AMERSHAM HEALTH AS , THANING, Mikkel
发明人： THANING, Mikkel
IPC分类号： A61K49/06 , G01R33/20 , A61B5/055
CPC分类号： A61K49/06 , C07D519/00 , G01R33/5601 , G01R33/62
摘要： The invention relates to new radicals, their use as paramagnetic agents in a method for the dynamic nuclear polarisation and a method for the dynamic nuclear polarisation of compounds comprising carboxyl groups.
摘要翻译：本发明涉及新的基团，它们在动态核极化方法中作为顺磁性试剂的用途以及包含羧基的化合物的动态核极化的方法。

8. 发明申请

WO2003089657A1 METHOD FOR PHENOTYPING USING NMR SPECTROSCOPY 审中-公开
标题翻译：使用NMR光谱法进行合成的方法
公开(公告)号：WO2003089657A1
公开(公告)日：2003-10-30
申请号：PCT/NO2003/000126
申请日：2003-04-15
申请人： AMERSHAM HEALTH AS , ARDENKJÆR-LARSEN, Jan-Henrik , CLARKE, Bill , GOLMAN, Klaes , LERCHE, Mathilde, H. , LOOKER, Mike , O'SULLIVAN, Mike , SANTOS, Albie , SERVIN, Rolf , THANING, Mikkel
发明人： CLARKE, Bill , GOLMAN, Klaes , LERCHE, Mathilde, H. , LOOKER, Mike , O'SULLIVAN, Mike , SANTOS, Albie , SERVIN, Rolf , THANING, Mikkel
IPC分类号： C12Q1/00
CPC分类号： G01N24/08 , G01N24/12 , G01R33/281 , G01R33/465 , G01R33/62
摘要： The invention relates to methods for phenotyping by determining protein activity in vivo using at least one probe compound and enhancing the nuclear polarisation of NMR active nuclei present in the probe compound (hereinafter termed "hyperpolarisation") prior to NMR analysis.
摘要翻译：本发明涉及通过使用至少一种探针化合物在体内测定蛋白质活性并增强存在于探针化合物中的NMR活性核的核极化（以下称为“超极化”）在NMR分析之前的表型分析方法。

9. 发明申请

WO1996009285A1 IODINATED X-RAY-CONTRAST MEDIA 审中-公开
公开(公告)号：WO1996009285A1
公开(公告)日：1996-03-28
申请号：PCT/GB1995002264
申请日：1995-09-22
申请人： NYCOMED IMAGING AS , REED, Michael, Antony , RYDBECK, Anna , ALMÉN, Torsten , THANING, Mikkel , ANDERSSON, Sven , WISTRAND, Lars-Göran , GOLMAN, Klaes
发明人： NYCOMED IMAGING AS , REED, Michael, Antony
IPC分类号： C07C275/42
CPC分类号： C07C237/46 , A61K49/0433 , C07C233/25 , C07C235/16 , C07C275/42
摘要： The invention provides iodinated bis phenyl compounds, useful as X-ray contrast agents, of formula (I) (wherein each C6R5 moiety may be the same or different; each R denotes a hydrogen or iodine atom or a group M, two or three non-adjacent R groups on each C6R5 moiety denoting iodine atoms and one, two or three R groups on each C6R5 moiety denoting M groups; X denotes a group providing a 1, 2 or 3 atom chain linking the two C6R5 groups, preferably where X is or contains in the bridging chain a carbonyloxy group each C6R5 group being a triodophenyl group or a group in which each R is other than hydrogen; and each M is independently a non-ionic hydrophilic moiety, M preferably being a non-ionic hydrophilic moiety comprising a monohydroxy- or polyhydroxy-alkyl group) and isomers, especially stereoisomers and rotamers, thereof.
摘要翻译：本发明提供了可用作式（I）的X射线造影剂的碘化双苯基化合物（其中每个C 6 R 5部分可以相同或不同;每个R表示氢或碘原子或基团M，两个或三个非 - 在每个表示碘原子的C 6 R 5部分上相邻的R基团和表示M基团的每个C 6 R 5部分上的一个，两个或三个R基团; X表示提供连接两个C 6 R 5基团的1,2或3个原子链的基团，优选X为或在桥连环中含有碳氧基，每个C 6 R 5基团是三苯基或每个R不是氢的基团;并且每个M独立地是非离子亲水部分，M优选是非离子亲水部分，其包含单羟基或多羟基 - 烷基）和异构体，特别是立体异构体和旋转异构体。

10. 发明申请

WO2010079201A1 CONTRAST MEDIA COMPOSITIONS 审中-公开
标题翻译：对比媒体组成
公开(公告)号：WO2010079201A1
公开(公告)日：2010-07-15
申请号：PCT/EP2010/050118
申请日：2010-01-08
申请人： GE HEALTHCARE AS , WISTRAND, Lars-Göran , THANING, Mikkel
发明人： WISTRAND, Lars-Göran , THANING, Mikkel
IPC分类号： A61K49/04
CPC分类号： A61K49/0438
摘要： Contrast media compositions comprising iodine containing contrast enhancing compounds of one or more monomeric non-ionic triiodinated aryl compounds and one or more dimeric non-ionic triiodinated aryl compounds. The bridge linking the two triiodinated aryl group of the dimeric compounds is substituted with a formyl function at least one nitrogen bridge atom.
摘要翻译：对比介质组合物，其包含含有一种或多种单体非离子三碘化芳基化合物和一种或多种二聚非离子三碘化芳基化合物的对比增强化合物的碘。连接二聚化合物的两个三碘化芳基的桥被甲酰基官能团取代至少一个氮桥原子。

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