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31. 发明申请

WO2003057016A2 DIAGNOSTIC ALGORITHMS FOR A CSF PHYSIOLOGIC CONTROLLER 审中-公开
标题翻译： CSF生理控制器的诊断算法
公开(公告)号：WO2003057016A2
公开(公告)日：2003-07-17
申请号：PCT/US2003/000095
申请日：2003-01-02
申请人： KUCHTA, John , REICH, Sanford , SLUETZ, James, E.
发明人： REICH, Sanford , SLUETZ, James, E.
IPC分类号： A61B
CPC分类号： A61M27/006 , A61B5/031 , A61B5/032
摘要： The Cerebrospinal Fluid (CSF) Physiologic Controller is an implantable active battery-operated device that is microprocessor controlled via algorithms stored in its memory. The controller also contains numerous diagnostic features, which enable the physician to monitor the operation of the system, as well as several key patient parameters non-invasively, by performing a set of algorithms.
摘要翻译：脑脊液（CSF）生理控制器是一种可植入的有源电池供电装置，通过存储在其存储器中的算法进行微处理器控制。控制器还包含许多诊断功能，使医师能够通过执行一组算法来非侵入性地监视系统的操作以及几个关键患者参数。

32. 发明申请

WO1995000071A1 APPARATUS AND METHOD FOR IN VIVO MONITORING OF PHYSIOLOGICAL PRESSURES 审中-公开
标题翻译：生物压力监测中的装置和方法
公开(公告)号：WO1995000071A1
公开(公告)日：1995-01-05
申请号：PCT/SE1994000636
申请日：1994-06-23
申请人： RADI MEDICAL SYSTEMS AB , TENERZ, Lars , HÖK, Bertil , BERG, Svante
发明人： RADI MEDICAL SYSTEMS AB
IPC分类号： A61B05/03
CPC分类号： A61B5/032 , A61B5/4514
摘要： The present invention provides in one aspect an apparatus for in vivo monitoring of physiological pressures, comprising a pressure sensor (2) having a pressure sensing interface, yielding a signal indicative of the pressure differential across said interface; means (3, 13) for pressurising or depressurising the sensor interior in response to a change in the signal from said sensor; pressure measuring means (5) for measuring the pressure supplied by the pressurising means yielding a signal indicative of the pressure in the sensor interior; and means (17) for registering a total pressure as the sum of the signals from said sensor and said pressure measuring means respectively. In another aspect it provides a method of localising a damaged intervertebral disk, comprising the steps of measuring the pressure in a first disk suspected to be damaged, measuring the pressure in the disks surrounding said suspected disk, preferably simultaneously with the measurements in the first disk, registering whether there is a difference in pressure between the disks, and selecting the disk with a differing pressure to be the damaged disk.
摘要翻译：本发明在一个方面提供了用于体内监测生理压力的装置，包括具有压力传感接口的压力传感器（2），产生指示所述界面上的压差的信号; 用于响应于来自所述传感器的信号的变化而对传感器内部进行加压或减压的装置（3,13）; 压力测量装置（5），用于测量由加压装置供应的压力，产生指示传感器内部压力的信号; 以及用于分别将总压力记录为来自所述传感器和所述压力测量装置的信号的总和的装置（17）。在另一方面，本发明提供了一种定位损伤的椎间盘的方法，包括以下步骤：测量怀疑被损坏的第一盘中的压力，测量围绕所述疑似盘的盘中的压力，优选地与第一盘中的测量值同时测量记录盘之间是否存在压力差，以及将不同压力的盘选择为损坏的盘。

33. 发明申请

WO1993020742A1 ENDOSCOPE FOR DIRECT VISUALIZATION OF THE SPINE AND EPIDURAL SPACE 审中-公开
标题翻译：用于直接可视化脊柱和阑尾空间的内窥镜
公开(公告)号：WO1993020742A1
公开(公告)日：1993-10-28
申请号：PCT/US1993003217
申请日：1993-04-07
申请人： DANEK MEDICAL, INC.
发明人： DANEK MEDICAL, INC. , KAGAN, Jonathan , WHITE, Roger , BRUMFIELD, David, L. , SMELSER, Ricci
IPC分类号： A61B01/06
CPC分类号： A61B1/0051 , A61B1/042 , A61B1/3135 , A61B5/032
摘要： A system (10) for direct visualization of the spine includes a catheter (12) and a fiber-optic bundle (20) disposed within the catheter (12) which is connected to a light source and camera. The optical bundle is connected (26) to the proximal end of the catheter to permit rotation of the bundle relative thereto. A mechanism for deflecting the catheter tip provides a conical viewing angle (13) for the fiber-optic bundle and assists in steering the catheter through the spinal space. The mechanism includes a deflection wire (57) extending through the catheter and affixed at the distal end (83) thereof. The proximal end of the deflection wire is affixed to a sleeve (58) slidably disposed around the catheter to contact a stop surface (59) as the catheter and deflection wire are moved. The stop surface prevents further movement of the catheter causing tension in the wire between the sleeve and the wire's securement to the catheter, thereby bending the catheter tip in the direction of the securement.
摘要翻译：用于脊柱直接可视化的系统（10）包括设置在导管（12）内的导管（12）和光纤束（20），其连接到光源和照相机。光束被连接（26）到导管的近端以允许束相对于其旋转。用于偏转导管末端的机构提供用于光纤束的锥形视角（13），并且有助于将导管转向脊柱空间。该机构包括延伸穿过导管并固定在其远端（83）处的偏转线（57）。当导管和偏转线移动时，偏转线的近端固定到可滑动地设置在导管周围的套筒（58），以接触止动表面（59）。止动表面防止导管的进一步移动，导致套管和电线的固定件之间的电线中的张力导向导管，从而沿着固定方向弯曲导管尖端。

34. 发明申请

WO1992015256A1 METHOD AND APPARATUS FOR LOCATING ANATOMICAL CAVITIES 审中-公开
标题翻译：用于定位解剖学的方法和装置
公开(公告)号：WO1992015256A1
公开(公告)日：1992-09-17
申请号：PCT/ES1991000011
申请日：1991-02-28
申请人： INDUSTRIAS PALEX, S.A. , UCHA CALVO, Eloy
发明人： INDUSTRIAS PALEX, S.A.
IPC分类号： A61B17/34
CPC分类号： A61B5/4896 , A61B5/032 , A61B17/3401 , A61B2090/064
摘要： The present invention relates to a method and apparatus for locating anatomical cavities such as the epidural space. The puncture will be made on the basis of the loss of resistance technique with a seringe (12). The tapping is facilitated by taking some measurements in the operation region (15) and by the emission of acoustic and visual warning signals, as well as by the provision of data displayed on a screen (16), all of which quantify and corroborate the tactile feelings of the operator, influencing the operator's work and allowing the operator to make proximal trials which are not harmful or damaging, and to be extremely sure that the cavity has been reached. The method is applicable independently of the pressure characteristics of the space to be detected, and uses a conventional needle, which also makes an apprenticeship possible in optimal safety conditions.

35. 发明申请

WO2016132176A1 SYSTEMS AND METHODS FOR MEASURING GLOBAL GLYMPHATIC FLOW USING MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：使用磁共振成像测量全球GLYMPHAIC流量的系统和方法
公开(公告)号：WO2016132176A1
公开(公告)日：2016-08-25
申请号：PCT/IB2015/051285
申请日：2015-02-19
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC.
发明人： PIRON, Cameron , STAINSBY, Jeff , HARRIS, Chad
IPC分类号： A61B5/03 , A61B5/055
CPC分类号： A61B5/055 , A61B5/031 , A61B5/032 , A61B5/4058 , A61B5/4076 , A61B5/4809 , A61B2576/00 , G01R33/56341 , G01R33/56366
摘要： Systems and methods for providing quantitative measurements of global glymphatic flow of cerebrospinal fluid ("CSF") using magnetic resonance imaging ("MRI") are described. In general, images are obtained from a subject using flow- sensitive MRI techniques that are designed to be particularly sensitive to the glymphatic flow of CSF. Measures of glymphatic flow can be obtained while the subject is in an awake state and again while the subject is in a sleep state. Based on these two measurements, a biomarker that indicates a neurological state or disease can be generated.
摘要翻译：描述了使用磁共振成像（“MRI”）提供脑脊液（“CSF”）的全局血液流量定量测量的系统和方法。一般来说，使用被设计为对CSF的淋巴管流特别敏感的流敏MRI技术从受试者获得图像。当受试者处于清醒状态时，并且当受试者处于睡眠状态时，可以获得血液流量的测量。基于这两个测量，可以产生指示神经系统状态或疾病的生物标志物。

36. 发明申请

WO2015042421A1 BIOPSY-FREE DETECTION AND STAGING OF CANCER USING A VIRTUAL STAGING SCORE 审中-公开
标题翻译：使用虚拟分类分数进行生物免疫检测和分析
公开(公告)号：WO2015042421A1
公开(公告)日：2015-03-26
申请号：PCT/US2014/056589
申请日：2014-09-19
申请人： SIEMENS AKTIENGESELLSCHAFT , SIEMENS CORPORATION
发明人： EL-ZEHIRY, Noha Youssry
IPC分类号： G06F19/00
CPC分类号： G16H50/30 , A61B5/0066 , A61B5/032 , A61B5/037 , A61B5/055 , A61B8/08 , G06F19/00 , G06K9/4604 , G06K9/6269 , G06N99/005 , G06T7/0012 , G06T7/11 , G06T7/62 , G06T2207/10081 , G06T2207/10088 , G06T2207/10101 , G06T2207/10104 , G06T2207/10108 , G06T2207/10132 , G06T2207/30096 , G06T2207/30101 , G16H50/20 , G16H50/70
摘要： A method for predicting a cancer staging score from medical image data includes receiving (11, 12, 13, 14) patient data for a plurality of patients, where patient data for each of the plurality of patients includes one or more of an image volume of a suspected tumor in an organ, blood test data, demographic data, and ground truth tumor staging scores (15) for the suspected tumor in the organ, extracting features (16) from the patient data, and using the features extracted from the patient data to train (17) a classifier to predict (18) a cancer staging score for a new patient from one or more of an image volume of a suspected tumor in the organ, patient blood test data and patient demographic data of that new patient.
摘要翻译：用于从医学图像数据预测癌症分期评分的方法包括：接收（11,12,13,14）多个患者的患者数据，其中所述多个患者中的每一个患者的患者数据包括一个或多个图像体积手术中的疑似肿瘤，血液检查数据，人口统计学数据和实体肿瘤分期评分（15），从患者数据中提取特征（16），并使用从患者数据中提取的特征训练（17）分类器以预测（18）来自该器官的可疑肿瘤的图像体积，该新患者的患者血液测试数据和患者人口统计学数据中的一个或多个新患者的癌症分期评分。

37. 发明申请

WO2013153454A3 MEASUREMENT OF CELEBRAL PHYSIOLOGIC PARAMETERS USING BIOIMPEDANCE 审中-公开
标题翻译：使用生物利用度测定生理参数
公开(公告)号：WO2013153454A3
公开(公告)日：2014-02-27
申请号：PCT/IB2013001105
申请日：2013-04-12
申请人： BEN-ARI SHLOMI , MARCOVITCH SHMUEL
发明人： BEN-ARI SHLOMI , MARCOVITCH SHMUEL
IPC分类号： A61B5/0295 , A61B5/053
CPC分类号： A61B5/0205 , A61B5/031 , A61B5/032 , A61B5/0535 , A61B5/6814 , A61B5/6831
摘要： Devices and methods for monitoring intracranial physiological parameters, including intracranial pressure, cerebral perfusion pressure, cerebral blood flow, cerebral blood volume, edema status, and brain compliance are disclosed. In one aspect, an apparatus may involve receiving at least one impedance plethysmography signal. Waveforms may be extracted from the impedance plethysmography signals and used for estimating the intracranial physiological parameters. Various characteristics may be determined from the waveforms to aid in the estimation of intracranial physiological parameters.
摘要翻译：公开了用于监测颅内生理参数的装置和方法，包括颅内压，脑灌注压，脑血流量，脑血容量，水肿状态和大脑依从性。在一个方面，装置可以包括接收至少一个阻抗体积描记信号。可以从阻抗体积描记信号中提取波形，并用于估计颅内生理参数。可以从波形确定各种特征以帮助估计颅内生理参数。

38. 发明申请

WO2014007949A8 DRUG INFUSION WITH PRESSURE SENSING AND NON-CONTINUOUS FLOW WITH INDENTIFICATION OF AND INJECTION INTO FLUID-FILLED ANATOMIC SPACES 审中-公开
标题翻译：具有压力感知和非连续流动的药物注射，注射和注射到流体填充的解剖空间
公开(公告)号：WO2014007949A8
公开(公告)日：2014-02-20
申请号：PCT/US2013045142
申请日：2013-06-11
申请人： MILESTONE SCIENTIFIC INC
发明人： HOCHMAN MARK N
IPC分类号： A61M5/00
CPC分类号： A61M5/168 , A61B5/032 , A61F9/0008 , A61M19/00 , A61M2205/581 , A61M2205/583
摘要： An automatic injection apparatus uses non-continuous fluid-flow of drugs to identify an intended injection site and includes a drive mechanism, a sensor and a controller for establishing fluid flow and pressure and preventing fluid flow until the pressure drops below a predetermined threshold. The pressure threshold is determined based on an internal pressure generated during an injection and more fluid will not flow until it drops below a predetermined pressure. An injection is performed to establish an initial pressure threshhold and then to stop the fluid flow into a patient until the pressure drops below a predetermined pressure which allows fluid flow to resume, thus identifying a fluid filled tissue space. The initial pressure threshold is used as a control parameter to a microprocessor below which controls the rate of injection. Fluid flows below certain pressures are also used to identify a specific location within the body during injections.
摘要翻译：自动注射装置使用药物的不连续流体流动来识别预期的注射部位，并且包括驱动机构，传感器和控制器，用于建立流体流动和压力并防止流体流动，直到压力下降到预定阈值以下。基于注射期间产生的内部压力来确定压力阈值，并且更多流体将不会流动，直到其下降到预定压力以下。执行注射以建立初始压力阈值，然后停止流体流入患者，直到压力下降到允许流体流动恢复的预定压力以下，从而识别流体填充的组织空间。初始压力阈值用作控制参数，控制下面的微处理器控制喷射速率。低于一定压力的流体流动也用于在注射期间识别身体内的特定位置。

39. 发明申请

WO2013159072A1 SYSTEMS AND METHODS FOR A COMPUTATIONAL MEDICAL DEVICE IN DYNAMIC BODY SYSTEMS 审中-公开
标题翻译：动态体系中计算医疗器械的系统与方法
公开(公告)号：WO2013159072A1
公开(公告)日：2013-10-24
申请号：PCT/US2013/037491
申请日：2013-04-19
申请人： RADOJICIC, Milan
发明人： RADOJICIC, Milan
IPC分类号： A61M25/01 , A61M25/16 , A61M25/095
CPC分类号： A61B5/6852 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/032 , A61B5/4839 , A61B2560/0223 , A61M25/0082 , A61M2025/0002 , A61M2025/0166
摘要： A computational catheter device including at least one lumen, pressure sensor(s), external sensor(s), a signal modeler, and a signal analyzer is provided. The pressure sensor generates a pressure signal for a dynamic body system, whereas the external sensor determines the fundamental frequency caused by cardiovascular pulsation or external oscillator. The signal modeler uses catheter location and the fundamental frequency to generate a predicted signal. This predicted signal may be compared to the actual pressure signal by the signal analyzer to generate a calibration. This calibration may include any of a measure of perivascular state, a waveform output which causes standing waves within the dynamic body system, a boundary condition for safe operations, and an indication of abnormal physiology for assistance in catheter navigation. The catheter device may also include an actuator which uses the calibration to achieve homeostasis by fluxing fluids and/or guiding catheter movements.
摘要翻译：提供了包括至少一个内腔，压力传感器，外部传感器，信号建模器和信号分析器的计算导管装置。压力传感器产生用于动态体系的压力信号，而外部传感器确定由心血管搏动或外部振荡器引起的基频。信号建模者使用导管位置和基频产生预测信号。该预测信号可以通过信号分析仪与实际压力信号进行比较，以产生校准。该校准可以包括血管周围状态的测量，在动态体系中引起驻波的波形输出，用于安全操作的边界条件以及用于辅助导管导航的异常生理学的指示中的任何一种。导管装置还可以包括致动器，其使用校准来通过助熔流体和/或引导导管运动来实现体内平衡。

40. 发明申请

WO2013063696A1 MANOMETER FOR USE IN TESTING SPINAL REGION AND RELATED METHOD 审中-公开
标题翻译：用于测试脊柱区域的测量仪及相关方法
公开(公告)号：WO2013063696A1
公开(公告)日：2013-05-10
申请号：PCT/CA2012/050683
申请日：2012-09-28
申请人： KIMBERLY-CLARK, INC.
发明人： GODARA, Neil , NAJAFE, Mirvise
IPC分类号： A61B5/03
CPC分类号： A61B5/032 , A61B5/4514 , A61B5/4824 , A61B17/8805
摘要： A manometer for measuring a differential pressure within a patient's disc includes a housing attachable to a device that is in fluid communication with the patient's disc, a pressure transducer within the housing for measuring a pressure in the patient's disc, a memory within the manometer for saving a pressure measured by the transducer, an input device on the housing for receiving input from a user to save an initial pressure measured by the transducer in the memory, and a display on the housing. The display provides an indication of an initial pressure in the patient's disc measured by the transducer before the user provides input via the input device and an indication of a differential pressure between a subsequent pressure and the initial pressure in the patient's disc after the user provides input via the input device. Related methods are also disclosed.
摘要翻译：用于测量患者盘内的压力差的压力计包括可附接到与患者盘流体连通的装置的壳体，用于测量患者盘内的压力的壳体内的压力传感器，用于保存的压力计内的存储器由换能器测量的压力，壳体上的输入装置，用于接收来自用户的输入，以将由换能器测量的初始压力保存在存储器中，以及在壳体上显示。在用户通过输入设备提供输入之前，显示器提供由换能器测量的患者盘中的初始压力的指示，以及在用户提供输入之后在患者盘中的随后压力和初始压力之间的差压指示通过输入设备。还公开了相关方法。

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