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31. 发明申请

WO2008059434A2 DIFFUSE OPTICAL TOMOGRAPHY WITH MARKERS CONTAINING FLUORESCENT MATERIAL 审中-公开
标题翻译：含有荧光材料标记的DIFFUSE光学图像
公开(公告)号：WO2008059434A2
公开(公告)日：2008-05-22
申请号：PCT/IB2007/054593
申请日：2007-11-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , ZIEGLER, Andy , KOEHLER, Thomas , NIELSEN, Tim , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
发明人： ZIEGLER, Andy , KOEHLER, Thomas , NIELSEN, Tim , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
IPC分类号： A61B5/00 , G01J3/44
CPC分类号： A61B5/4312 , A61B5/0091 , G01N21/4795 , G01N21/6456
摘要： The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.
摘要翻译：本发明涉及一种系统，医学图像采集系统和用于对浑浊介质（25）的内部进行成像的方法。本发明还涉及一种用于对浑浊介质（25）的内部进行成像的方法中使用的标记（60）。该系统，医学图像采集系统和该方法可以用于通过以下方式获得浑浊介质的内部的图像：通过在接收容积（20）内容纳混浊介质（25）; 用来自光源的光照射接收体积（20）; 通过使用光电检测器单元对来自光源的光照射接收体积（20）的结果来检测从接收体积（20）发出的光。然后使用检测到的光来重建混浊介质（25）的内部的图像。根据本发明，适配系统，医疗采集系统和方法，使得在测量期间，接收体积（20）包括至少一个包含预定浓度的所选荧光剂的标记物（60）。光源被布置成产生在标记（60）中引起荧光发射的激发光，并且光电检测器被布置成通过用激发光照射接收体积（20）来检测从接收体积（20）发出的光。使用根据本发明的标记（60）能够获得与混浊介质（25）的几何形状有关的信息。如果混浊介质（25）包含未知浓度的第二荧光剂，并且将光源和光检测器单元布置成在第二荧光剂中引起荧光并分别检测所得到的荧光，则使用标记物 60）根据本发明可以校准由该荧光产生的信号。

32. 发明申请

WO2008053405A1 IMAGING OF TURBID MEDIUM 审中-公开
标题翻译：涡轮介质成像
公开(公告)号：WO2008053405A1
公开(公告)日：2008-05-08
申请号：PCT/IB2007/054323
申请日：2007-10-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN HERPEN, Maarten, M., J., W. , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
发明人： VAN HERPEN, Maarten, M., J., W. , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
IPC分类号： A61B5/00
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312 , A61B2562/146
摘要： The invention relates to imaging of a turbid medium, for example in connection with optical mammography. A device for imaging a turbid medium (20) is disclosed, the device comprising: a holder (20) arranged for receiving the turbid medium and a matching fluid (21); one or more radiation sources (24) and one or more photodetectors (25). The matching fluid is a vapor with one or more optical properties of the matching fluid substantially matching the corresponding one or more optical properties of the turbid medium. In an embodiment, the matching fluid (21) is a composite vapor comprising at least two components.
摘要翻译：本发明涉及例如结合光学乳腺摄影术的混浊介质的成像。公开了一种用于对浑浊介质（20）进行成像的装置，该装置包括：安置用于接收混浊介质的保持器（20）和匹配流体（21）; 一个或多个辐射源（24）和一个或多个光电检测器（25）。匹配流体是具有匹配流体的一个或多个光学性质的蒸气，其基本上与混浊介质的对应的一个或多个光学特性相匹配。在一个实施例中，匹配流体（21）是包括至少两个组分的复合蒸气。

33. 发明申请

WO2008029354A2 OPTICAL TOMOGRAPHY MEASUREMENT USING AN ADAPTED BRIM FOR THE RECEIVING VOLUME 审中-公开
标题翻译：使用适配BRIM进行光学测量的接收体积
公开(公告)号：WO2008029354A2
公开(公告)日：2008-03-13
申请号：PCT/IB2007/053568
申请日：2007-09-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , VAN DER MARK, Martinus, B. , VAN DER BRUG, Willem, P. , NIELSEN, Tim
发明人： VAN DER MARK, Martinus, B. , VAN DER BRUG, Willem, P. , NIELSEN, Tim
IPC分类号： A61B5/00
CPC分类号： A61B5/415 , A61B5/0091 , A61B5/418 , A61B5/4312
摘要： The invention relates to a device for imaging an interior of a turbid medium comprising: a) a receiving volume for receiving at least a part of the turbid medium, with the receiving volume being bound by a boundary having an opening bound by a brim, b) a light source for irradiating the turbid medium, and c) a photodetector unit for detecting light emanating from the volume as a result of irradiating the turbid medium. The device is adapted such that the brim is arranged for optically coupling the light source to the turbid medium and the turbid medium to the photodetector unit. One embodiment of the invention relates to a device for imaging an interior of a female breast comprising a cup-like receptacle (20) for accommodating the breast. The receptacle (20) comprises a convex shaped brim (60) arranged for optically coupling the light source to the patient's (55) breast and the breast to the photodetector unit.
摘要翻译：本发明涉及一种用于对浑浊介质内部进行成像的装置，包括：a）用于接收混浊介质的至少一部分的接收体积，其中接收体积被具有边缘边界的边界限制，b ）用于照射混浊介质的光源，以及c）用于通过照射混浊介质来检测从体积发出的光的光电检测器单元。该装置适于使得边缘布置成将光源光学耦合到混浊介质和混浊介质到光电检测器单元。本发明的一个实施例涉及一种用于对女性乳房内部进行成像的装置，其包括用于容纳乳房的杯状容器（20）。插座（20）包括凸形的边缘（60），该凸缘布置用于将光源光学地耦合到患者的（55）乳房和乳房到光电检测器单元。

34. 发明申请

WO2007144810A1 BODY MONITORING DEVICE, BODY DATA ACQUIRING METHOD AND METHOD OF DETERMINING THE PRESENCE, LOCATION AND/OR STAGE OF A WOUND 审中-公开
标题翻译：身体监测装置，身体数据获取方法和确定存在，位置和/或阶段的方法
公开(公告)号：WO2007144810A1
公开(公告)日：2007-12-21
申请号：PCT/IB2007/052171
申请日：2007-06-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DE KOK, Margreet , VAN PIETERSON, Liesbeth , VAN DER MARK, Martinus, B.
发明人： DE KOK, Margreet , VAN PIETERSON, Liesbeth , VAN DER MARK, Martinus, B.
IPC分类号： A61B5/00 , A61N5/06
CPC分类号： A61B5/14551 , A61B5/0059 , A61B5/0071 , A61B5/0084 , A61B5/06 , A61B5/065 , A61B5/14552 , A61B5/444 , A61B5/445 , A61B2017/00061 , A61B2562/0242 , A61N5/0616 , A61N2005/0652 , A61N2005/0653 , A61N2005/0662
摘要： Body monitoring device, having a surface and configured to be applied to and/or near the body, comprising at least one light source and at least one photo detector, wherein the at least one light source emits light in at least a direction away from said surface and wherein the at least one photo detector is configured to detect light that is emitted by the at least one light source and reflected by the body in a direction towards said surface.
摘要翻译：具有表面并被配置为施加到身体和/或身体附近的身体监测装置包括至少一个光源和至少一个光电检测器，其中至少一个光源沿至少一个远离所述光源的方向发光，表面，并且其中所述至少一个光电检测器被配置为检测由所述至少一个光源发射并被所述主体在朝向所述表面的方向上反射的光。

35. 发明申请

WO2007057798A3 DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM 审中-公开
标题翻译：用于成像涡轮介质内部的装置
公开(公告)号：WO2007057798A3
公开(公告)日：2007-09-27
申请号：PCT/IB2006053972
申请日：2006-10-27
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P , RAS ARNOLDUS J M J
发明人： VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P , RAS ARNOLDUS J M J
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0073 , A61B5/0091 , A61B2562/146
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (55) comprising a receptacle (20) with the receptacle (20) comprising a measurement volume (15) for receiving the turbid medium (55). The device (1) is adapted such that the device (1) further comprises a further receptacle (60), arranged to be inserted into the receptacle (20), with the further receptacle (60) comprising a restricted measurement volume (75) for receiving the turbid medium (55).
摘要翻译：本发明涉及一种用于对包括容器（20）的混浊介质（55）的内部进行成像的设备（1），容器（20）包括用于接收混浊介质（55）的测量容积（15）。所述装置（1）适于使得所述装置（1）还包括布置成插入到所述容器（20）中的另外的容器（60），其中所述另外的容器（60）包括限制的测量容积（75），用于接收混浊介质（55）。

36. 发明申请

WO2007060598A3 A METHOD OF, SYSTEM FOR, AND MEDICAL IMAGE ACQUISITION SYSTEM FOR IMAGING AN INTERIOR OF A TURBID MEDIUM TAKING INTO ACCOUNT THE GEOMETRY OF THE TURBID MEDIUM 审中-公开
标题翻译：用于形成涡轮介质的内部的系统和用于摄像机的医疗图像采集系统的方法，用于涡轮介质的几何
公开(公告)号：WO2007060598A3
公开(公告)日：2007-09-07
申请号：PCT/IB2006054341
申请日：2006-11-20
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P
发明人： VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P
IPC分类号： G01N21/49 , A61B5/00
CPC分类号： G01N21/4795 , G01N2021/1787 , G01N2021/4766 , G01N2021/6439
摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume; coupling transmission input light (65) from a transmission light source into the receiving volume, with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45); detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light from the light source into the receiving volume through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and to a medical image acquisition system both using the method. The method, system, and medical image acquisition system are adapted such that an improved way of obtaining data relating to the exterior of the turbid medium (45) is realized. The object of the invention is realized in that the method further comprises the following steps: - coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume, with the receiving volume comprising the turbid medium (45) and with the combination of the geometry input light (70, 75, 80) and the interface (60) being chosen for creating a contrast between the turbid medium (45) and its surroundings; detection of the contrast (60) between the turbid medium (45) and its surroundings through use of a contrast photodetector unit; reconstructing an image of an interior of the turbid medium (45) using a the detected contrast (60). The system for imaging an interior of a turbid medium (45) and the medical image acquisition device are adapted to further comprise a geometry light source and a contrast photodetector unit.
摘要翻译：本发明涉及一种对混浊介质（45）内部进行成像的方法，包括以下步骤：在接收容积内容纳混浊介质（45）; 将透射输入光（65）从透射光源耦合到接收体积中，所述透射输入光（65）被选择为使得其能够传播通过混浊介质（45）; 通过使用传输光电检测器单元将从光源的输入光耦合到接收体积中的结果，检测从接收体积发出的透射输出光。本发明还涉及一种用于使浑浊介质（45）的内部成像和使用该方法的医学图像采集系统的成像系统。调整方法，系统和医学图像采集系统，从而实现获得与混浊介质（45）的外部相关的数据的改进方式。本发明的目的是通过该方法进一步包括以下步骤：将几何输入光（70,75,80）从几何光源耦合到接收体积中，其中接收体积包括混浊介质（45）并且选择所述几何输入光（70,75,80）和所述界面（60）的组合以在所述混浊介质（45）及其周围环境之间产生对比度; 通过使用对比度光电检测器单元检测混浊介质（45）与其周围环境之间的对比度（60）; 使用检测到的对比度（60）重建混浊介质（45）的内部的图像。用于对浑浊介质（45）和医学图像采集装置的内部成像的系统适于进一步包括几何光源和对比度光电检测器单元。

37. 发明申请

WO2007060586A3 METHOD AND DEVICE FOR OPTICAL IMAGING OF A TURBID MEDIUM 审中-公开
标题翻译：用于光学介质的光学成像的方法和装置
公开(公告)号：WO2007060586A3
公开(公告)日：2007-09-07
申请号：PCT/IB2006054317
申请日：2006-11-17
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P
发明人： VAN DER MARK MARTINUS B , VAN BEEK MICHAEL C , BAKKER LEVINUS P
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0091 , A61B5/1455 , A61B5/14551
摘要： Disclosed is a method and a device for optical imaging of a turbid medium. This method comprises a reference measurement of reference intensities of light emanating from the turbid medium at a reference blood oxygen saturation (SaO2) in the turbid medium and a reference imaging step for reconstructing a reference image of the turbid medium from the measured reference intensities. Furthermore the method comprises a contrast measurement of the contrast intensity of the light emanating from the turbid medium at a contrast blood oxygen saturation (SaO2) level in the turbid medium and a contrast imaging step for reconstructing a contrast image of the turbid medium from the measured contrast intensities. A comparison is made between the contrast image to the reference image of the turbid medium.
摘要翻译：公开了一种用于混浊介质的光学成像的方法和设备。该方法包括在混浊介质中的参考血氧饱和度（SaO 2）下从混浊介质发出的光的参考强度的参考测量和用于从测量的参考强度重建混浊介质的参考图像的参考成像步骤。此外，该方法包括在混浊介质中的对比度血氧饱和度（SaO 2）水平上对从混浊介质发出的光的对比度强度进行对比度测量，以及对比度成像步骤，用于从测量值中重建混浊介质的对比度图像对比强度。对比图像与混浊介质的参考图像进行比较。

38. 发明申请

WO2007060586A2 METHOD AND DEVICE FOR OPTICAL IMAGING OF A TURBID MEDIUM 审中-公开
标题翻译：涡轮介质的光学成像的方法和装置
公开(公告)号：WO2007060586A2
公开(公告)日：2007-05-31
申请号：PCT/IB2006/054317
申请日：2006-11-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C. , BAKKER, Levinus, P.
发明人： VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C. , BAKKER, Levinus, P.
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0091 , A61B5/1455 , A61B5/14551
摘要： Disclosed is a method and a device for optical imaging of a turbid medium. This method comprises a reference measurement of reference intensities of light emanating from the turbid medium at a reference blood oxygen saturation (SaO2) in the turbid medium and a reference imaging step for reconstructing a reference image of the turbid medium from the measured reference intensities. Furthermore the method comprises a contrast measurement of the contrast intensity of the light emanating from the turbid medium at a contrast blood oxygen saturation (SaO2) level in the turbid medium and a contrast imaging step for reconstructing a contrast image of the turbid medium from the measured contrast intensities. A comparison is made between the contrast image to the reference image of the turbid medium.
摘要翻译：公开了一种用于浑浊介质的光学成像的方法和装置。该方法包括在混浊介质中以参考血氧饱和度（SaO2）从混浊介质发出的光的参考光强度的参考测量值，以及用于根据测量的参考光强度重建浊度介质的参考图像的参考成像步骤。此外，该方法包括在浑浊培养基中以对比血氧饱和度（SaO2）水平从浑浊培养基发出的光的对比度强度的对比度测量，以及用于从所测量的重量中重建浑浊培养基的对比度图像的对比度成像步骤对比强度。对比图像与混浊介质的参考图像之间进行比较。

39. 发明申请

WO2007057798A2 DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM 审中-公开
标题翻译：用于成像涡轮介质内部的装置
公开(公告)号：WO2007057798A2
公开(公告)日：2007-05-24
申请号：PCT/IB2006/053972
申请日：2006-10-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C. , BAKKER, Levinus, P. , RAS, Arnoldus, J., M., J.
发明人： VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C. , BAKKER, Levinus, P. , RAS, Arnoldus, J., M., J.
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0073 , A61B5/0091 , A61B2562/146
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (55) comprising a receptacle (20) with the receptacle (20) comprising a measurement volume (15) for receiving the turbid medium (55). The device (1) is adapted such that the device (1) further comprises a further receptacle (60), arranged to be inserted into the receptacle (20), with the further receptacle (60) comprising a restricted measurement volume (75) for receiving the turbid medium (55).
摘要翻译：本发明涉及一种用于对包含容器（20）的混浊介质（55）的内部成像的装置（1），所述容器（20）包括用于接收混浊介质（55）的测量体积（15）。装置（1）适于使得装置（1）还包括设置成插入到容器（20）中的另一个容器（60），另外的容器（60）包括限制的测量体积（75），用于接收混浊介质（55）。

40. 发明申请

WO2005104114A1 OPTICAL DATA STORAGE SYSTEM AND METHOD OF OPTICAL RECORDING AND/OR READING 审中-公开
标题翻译：光学数据存储系统和光学记录和/或读取方法
公开(公告)号：WO2005104114A1
公开(公告)日：2005-11-03
申请号：PCT/IB2005/051244
申请日：2005-04-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DER MARK, Martinus, B. , ZIJP, Ferry
发明人： VAN DER MARK, Martinus, B. , ZIJP, Ferry
IPC分类号： G11B7/24
CPC分类号： G11B7/1374 , G11B7/0908 , G11B7/1387 , G11B2007/13727
摘要： An optical data storage system for recording and/or reading, using a radiation beam having a wavelength X is described. The radiation beam is focused onto a data storage layer of an optical data storage medium. The medium has a cover layer that is transparent to the focused radiation beam. The cover layer has a thickness h smaller than 5 µm. A cover layer with thickness variation of substantially less than the focal depth, i.e. 50 nm, eliminates the need of dynamic focus control of the objective which is otherwise required in addition to the gap servo. Further a method of optical recording is described using such an optical data storage system by which a static focus control and spherical aberration correction to accommodate medium-to-medium variance is achieved. The static focus control can be realised by optimising the modulation depth of a known signal, e.g. from a lead-in track.
摘要翻译：描述了使用具有波长X的辐射束进行记录和/或读取的光学数据存储系统。辐射束被聚焦到光学数据存储介质的数据存储层上。介质具有对聚焦辐射束透明的覆盖层。覆盖层的厚度h小于5μm。具有基本上小于焦深（即50nm）的厚度变化的覆盖层消除了除了间隙伺服以外另外需要的物镜的动态聚焦控制的需要。此外，使用这样的光学数据存储系统来描述光学记录的方法，通过该光学数据存储系统实现了适应中等到中等方差的静态聚焦控制和球面像差校正。静态聚焦控制可以通过优化已知信号的调制深度来实现，例如，从导入轨道。

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