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31. 发明申请

WO2010045303A3 PYRROLIDINE, PIPERIDINE AND PIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF 审中-公开
标题翻译：吡咯啉，哌啶和哌嗪衍生物及其使用方法
公开(公告)号：WO2010045303A3
公开(公告)日：2010-08-05
申请号：PCT/US2009060610
申请日：2009-10-14
申请人： SCHERING CORP , PALANI ANANDAN , BERLIN MICHAEL Y , ASLANIAN ROBERT G , VACCARO HENRY M , CHAN TIN-YAU , XIAO DONG , DEGRADO SYLVIA , RAO ASHWIN U , CHEN XIAO , LEE YOON JOO , SOFOLARIDES MICHAEL J , SHAO NING , HUANG YING R , LIU ZHIDAN , WANG LI YUAN , PU HAIYAN
发明人： PALANI ANANDAN , BERLIN MICHAEL Y , ASLANIAN ROBERT G , VACCARO HENRY M , CHAN TIN-YAU , XIAO DONG , DEGRADO SYLVIA , RAO ASHWIN U , CHEN XIAO , LEE YOON JOO , SOFOLARIDES MICHAEL J , SHAO NING , HUANG YING R , LIU ZHIDAN , WANG LI YUAN , PU HAIYAN
IPC分类号： C07D417/04 , A61K31/4355 , A61K31/437 , A61K31/4439 , A61K31/444 , A61P3/10 , C07D271/113 , C07D285/135 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107
CPC分类号： C07D285/135 , C07D271/113 , C07D417/04 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107
摘要： The present invention relates to novel Pyrrolidine, Piperidine and Piperazine Derivatives, pharmaceutical compositions comprising the Pyrrolidine, Piperidine and Piperazine Derivatives and the use of these compounds for treating or preventing treating allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disoder, a metabolic disorder, obesity, an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.
摘要翻译：本发明涉及新颖的吡咯烷，哌啶和哌嗪衍生物，包含吡咯烷，哌啶和哌嗪衍生物的药物组合物以及这些化合物用于治疗或预防治疗过敏，使用过敏引起的气道反应，充血，心血管疾病，糖尿病，糖尿病并发症，葡萄糖耐量减低或空腹血糖受损。

32. 发明申请

WO2009143039A3 HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS 审中-公开
标题翻译：异构化合物作为因子IXA抑制剂
公开(公告)号：WO2009143039A3
公开(公告)日：2010-07-08
申请号：PCT/US2009044291
申请日：2009-05-18
申请人： SCHERING CORP , CLASBY MARTIN C , GREENLEE WILLIAM J , CHACKALAMANNIL SAMUEL , XIA YAN , GAO XIAOBANG , CHELLIAH MARIAPPAN V , EAGEN KEITH A , VACCARO HENRY , CHAN TIN-YAU , MCKITTRICK BRIAN , WANG LI YUAN , PU HAIYAN
发明人： CLASBY MARTIN C , GREENLEE WILLIAM J , CHACKALAMANNIL SAMUEL , XIA YAN , GAO XIAOBANG , CHELLIAH MARIAPPAN V , EAGEN KEITH A , VACCARO HENRY , CHAN TIN-YAU , MCKITTRICK BRIAN , WANG LI YUAN , PU HAIYAN
IPC分类号： C07D231/18 , A61K31/415 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61P7/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D487/04
CPC分类号： C07D487/04 , C07D231/18 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention relates to novel heterocyclic compounds of Formulae I-III; as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are pharmaceutical compositions comprising said compounds, and methods for using said compounds for treating or preventing a thromboembolic disorder.
摘要翻译：本发明涉及式I-III的新型杂环化合物; 如本文所公开的或其药学上可接受的盐，溶剂化物，酯，前药或立体异构体。还公开了包含所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓栓塞性疾病的方法。

33. 发明申请

WO2010065347A3 SELF-ADAPTIVE STUDY EVALUATION 审中-公开
公开(公告)号：WO2010065347A3
公开(公告)日：2010-06-10
申请号：PCT/US2009/065379
申请日：2009-11-20
申请人： SHANGHAI XYZ KNOWLEDGE TECHNOLOGY CO. , LIANG, Changnian , YAN, Pingyi , ZHANG, Xiaofeng , LI, Yuan
发明人： LIANG, Changnian , YAN, Pingyi , ZHANG, Xiaofeng , LI, Yuan
IPC分类号： G06Q50/00
摘要： A study evaluation system used for computer-based learning uses evaluation contents arranged in a multilevel arrangement for self-adaptive study evaluation. The study evaluation system provides a present evaluation content to a user through user interaction, and determines a subsequent evaluation content or a subsequent knowledge point to be studied by the user at least partially based on the user feedback on the present evaluation content, the multilevel arrangement of the evaluation contents, and a characteristic information of the user. The study evaluation system may further establish a data set for each user to record the user feedbacks on the evaluation contents, and use the data set in combination with certain basic user information to realize individualized study evaluation.

34. 发明申请

WO2009151860A1 DIFFERENTIATED, INTEGRATED AND INDIVIDUALIZED EDUCATION 审中-公开
标题翻译：差异化，一体化和个性化教育
公开(公告)号：WO2009151860A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/043806
申请日：2009-05-13
申请人： LIANG, Changnian , LI, Yuan , YAN, Pingyi , ZHANG, Xiaofeng
发明人： LIANG, Changnian , LI, Yuan , YAN, Pingyi , ZHANG, Xiaofeng
IPC分类号： G06N5/00
CPC分类号： G06Q50/20
摘要： A computer-based learning system uses knowledge points organized with a predefined multilevel arrangement. Each knowledge point has an information set which may include a knowledge content, an evaluation content and a solution content. For a given knowledge point, the learning system provides the knowledge content and evaluation content, analyzes the user's answers to the evaluation content and determines the next knowledge point to be studied by the user based on the user's answers and the predefined multilevel arrangement of the knowledge points. The learning system thus provides a different learning course for different users to achieve individualized learning. User's learning history may be recorded to facilitate reviews by the user and improve the selection of the next knowledge point. Users may provide feedbacks on knowledge contents and evaluation contents, and may even suggest their own knowledge contents and evaluation contents to improve the learning system and user participation.
摘要翻译：基于计算机的学习系统使用以预定义多级布置组织的知识点。每个知识点具有可以包括知识内容，评估内容和解决方案内容的信息集。对于给定的知识点，学习系统提供知识内容和评估内容，分析用户对评估内容的答案，并根据用户的答案和知识的预定义多层次排列确定用户要研究的下一个知识点点。因此，学习系统为不同用户提供了不同的学习课程，以实现个性化学习。可以记录用户的学习历史以促进用户的评论并改进下一个知识点的选择。用户可以提供知识内容和评估内容的反馈意见，甚至可以提出自己的知识内容和评估内容，以改善学习系统和用户参与。

35. 发明申请

WO2006053441A1 IMPROVED PROCESS FOR THE PREPARATION OF (S)-ALPHA-ETYL-2-OXO-1-PYRROLIDINEACETAMIDE AND (R)-ALPHA-ETHYL-2-OXO-1-PYRROLIDINEACETAMIDE 审中-公开
标题翻译：（S）-ALPHA-ETYL-2-氧代-1-吡咯烷胺乙酰胺和（R）-ALPHA-乙基-2-氧代-1-吡咯烷胺乙酰胺的改进方法
公开(公告)号：WO2006053441A1
公开(公告)日：2006-05-26
申请号：PCT/CA2005/001758
申请日：2005-11-21
申请人： APOTEX PHARMACHEM INC. , LI, Yuan, Qiang , WANG, Zhi-Xian , GUNTOORI, Bhaskar, Reddy
发明人： LI, Yuan, Qiang , WANG, Zhi-Xian , GUNTOORI, Bhaskar, Reddy
IPC分类号： C07D207/277
CPC分类号： C07D207/27
摘要： A process provided for the preparation of the (S)- and (R)- alpha- ethyl-2-oxo-1- pyrrolidineacetamide of formula:(1) from (RS)-alpha-ethyl-2-oxo-l-pyrrolidineacetic acid of formula: (2) comprising: i) combining the (RS)-2 with a chiral base (resolving agent) in a resolution solvent and crystallizing from the said mixture the diastereomeric salt of (S)- or (R)-2 and chiral base; ii) regenerating (S)- or (R)-2 from the crystallized diastereomeric salt by treating with a suitable acid or acidic ion-exchange resin; iii) optionally regenerating (R)- or (S)-2 or their mixture (predominantly one enantiomer) from the crystallization mother liquor by treating with a suitable acid or acidic ion-exchange resin; iv) optionally epimerizing (RS)-2 by treating (R)- or (S)-2 or their mixture (predominantly one enantiomer) of step iii with an acid anhydride; V) optionally converting (RS)-2 of step iv into enantiomerically enriched (S)- or (R)-2 through steps i and ii; vi) formation of the mixed anhydride by reacting (R)- or (S)-2 with an alkyl or aryl sulfonyl halogen compound RSO2X in the presence of a suitable base; and vii) reacting the mixed anhydride with ammonia; wherein R represents C 1 to C 15 alkyl or aryl groups such as methyl, ethyl, p-toluenyl, 2,4,6-trimethylbenzyl, 2,4,6-trichloribenzyl, and X represents a halogen atom such as F, Cl and Br atoms.
摘要翻译：（S） - （R）-α-乙基-2-氧代-1-吡咯烷乙酰胺由（RS）-α-乙基-2-氧代-1-吡咯烷乙酸制备的（S） - 和（R）-α-乙基-2-氧代-1-吡咯烷乙酰胺式（2）的酸包括：i）将（RS）-2与分解溶剂中的手性碱（拆分剂）组合并从所述混合物中结晶出（S） - 或（R）-2的非对映体盐和手性基; ii）通过用合适的酸或酸性离子交换树脂处理从结晶的非对映体盐再生（S） - 或（R）-2） iii）通过用合适的酸或酸性离子交换树脂处理任选地从结晶母液中再生（R） - 或（S）-2或它们的混合物（主要是一种对映异构体） iv）通过用酸酐处理（R） - 或（S）-2或它们的步骤iii的混合物（主要是一个对映异构体）任选差向异构化（RS）-2; V）任选地通过步骤i和ii将步骤iv的（RS）-2转化成对映异构体富集的（S） - 或（R） vi）通过使（R） - 或（S）-2与烷基或芳基磺酰基卤化合物RSO 2 X在合适的碱存在下反应形成混合酸酐; 和vii）使混合酸酐与氨反应; 其中R表示C 1至C 15烷基或芳基如甲基，乙基，对甲苯基，2,4,6-三甲基苄基，2,4,6-三氯苄基，X表示卤素原子如F，Cl和 Br原子。

36. 发明申请

WO2004032347A8 RECEIVER HAVING A SIGNAL RECONSTRUCTING SECTION FOR NOISE REDUCTION, SYSTEM AND METHOD THEREOF 审中-公开
标题翻译：具有减少噪声的信号重建部分的接收机及其系统及方法
公开(公告)号：WO2004032347A8
公开(公告)日：2005-11-17
申请号：PCT/SG0200194
申请日：2002-08-28
申请人： AGENCY SCIENCE TECH & RES , LEI ZHONGDING , WU YAN , HO CHIN KEONG , SUN SUMEI , HE PING , LI YUAN
发明人： LEI ZHONGDING , WU YAN , HO CHIN KEONG , SUN SUMEI , HE PING , LI YUAN
IPC分类号： H04J11/00 , H04L5/02 , H04L27/26 , H04B1/10 , H04B7/216
CPC分类号： H04L25/067 , H04J11/0026 , H04J13/0077 , H04L5/0021 , H04L25/022 , H04L25/0244 , H04L25/0256 , H04L25/03159 , H04L25/03299 , H04L27/2647 , H04L2025/03414
摘要： A signal reconstructing section (50), a receiver having the signal reconstructing section (50), a communication system having the receiver, and a method for reducing noise in a transformed signal having a plurality of signal components and using the signal reconstructing section (50) are described. The signal reconstructing section (50) of the receiver has a detector (52) for detecting the transformed signal, decision modules (54) each having an input (58) coupled to output (60) of the detector, and a reconstructing module (56) having inputs (62) respectively coupled to output (64) of the decision modules (54). The reconstructing module (56) is adapted to reconstruct one or more subcarriers of the plurality of subcarriers a predetermined number of times to thereby form a noise- reduced transformed signal. Reconstruction of the one or more subcarriers is performed one at a time or two or more simultaneously.
摘要翻译：信号重建部分（50），具有信号重建部分（50）的接收机，具有接收机的通信系统，以及用于减少具有多个信号分量的变换信号中的噪声并使用信号重构部分（50 ）。接收机的信号重建部分（50）具有用于检测变换后的信号的检测器（52），每个具有耦合到检测器的输出（60）的输入端（58）的决定模块（54）和重构模块（56 ）具有分别耦合到所述决定模块（54）的输出（64）的输入（62）。重建模块（56）适于重建多个子载波中的一个或多个子载波预定次数，从而形成噪声降低的变换信号。一个或多个副载波的重构一次一个或两个或更多次同时执行。

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