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1. 发明申请

WO2009143039A3 HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS 审中-公开
标题翻译：异构化合物作为因子IXA抑制剂
公开(公告)号：WO2009143039A3
公开(公告)日：2010-07-08
申请号：PCT/US2009044291
申请日：2009-05-18
申请人： SCHERING CORP , CLASBY MARTIN C , GREENLEE WILLIAM J , CHACKALAMANNIL SAMUEL , XIA YAN , GAO XIAOBANG , CHELLIAH MARIAPPAN V , EAGEN KEITH A , VACCARO HENRY , CHAN TIN-YAU , MCKITTRICK BRIAN , WANG LI YUAN , PU HAIYAN
发明人： CLASBY MARTIN C , GREENLEE WILLIAM J , CHACKALAMANNIL SAMUEL , XIA YAN , GAO XIAOBANG , CHELLIAH MARIAPPAN V , EAGEN KEITH A , VACCARO HENRY , CHAN TIN-YAU , MCKITTRICK BRIAN , WANG LI YUAN , PU HAIYAN
IPC分类号： C07D231/18 , A61K31/415 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61P7/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D487/04
CPC分类号： C07D487/04 , C07D231/18 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention relates to novel heterocyclic compounds of Formulae I-III; as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are pharmaceutical compositions comprising said compounds, and methods for using said compounds for treating or preventing a thromboembolic disorder.
摘要翻译：本发明涉及式I-III的新型杂环化合物; 如本文所公开的或其药学上可接受的盐，溶剂化物，酯，前药或立体异构体。还公开了包含所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓栓塞性疾病的方法。

2. 发明申请

WO2006068954A3 PYRAZOLO[1,5-A]PYRIMIDINE ADENOSINE A2a RECEPTOR ANTAGONISTS 审中-公开
标题翻译：吡咯并[1,5-A]吡嗪酮腺苷A2a受体拮抗剂
公开(公告)号：WO2006068954A3
公开(公告)日：2006-12-07
申请号：PCT/US2005045658
申请日：2005-12-19
申请人： SCHERING CORP , CLASBY MARTIN C , CHACKALAMANNIL SAMUEL , NEUSTADT BERNARD R , GAO XIAOBANG
发明人： CLASBY MARTIN C , CHACKALAMANNIL SAMUEL , NEUSTADT BERNARD R , GAO XIAOBANG
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00 , A61P25/16 , A61P25/18
CPC分类号： C07D487/04
摘要： Compounds having the structural formula (I) are disclosed, wherein A is alkylene, or optionally substituted arylene, cycloalkylene or heteroaryldiyl; X is -C(O)- or -S(O) 2 -; R 1 is alkyl or cycloalkyl; R 2 is hydrogen, halo or -CN; R 3 is hydrogen or alkyl; R 4 is hydrogen, alkyl, alkoxy, hydroxyalkyl, aminoalkyl-, cycloalkyl, heterocycloalkyl, heterocycloalkyl substituted by alkyl, optionally substituted arylalkyl or optionally substituted heteroarylalkyl; or R 3 and R 4 , form an optionally substituted 5-7 membered ring, said ring optionally comprising an additional heteroatom ring member; R 7 is alkyl, optionally substituted phenyl, optionally substituted heteroaryl, cycloalkyl, halo, morpholinyl, optionally substituted piperazinyl, or optionally substituted azacycloalkyl. Also disclosed is the use of the compounds in the treatment of Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, pharmaceutical compositions comprising them and kits comprising the components of the combinations.
摘要翻译：公开了具有结构式（I）的化合物，其中A是亚烷基或任选取代的亚芳基，亚环烷基或杂芳基二基; X是-C（O） - 或-S（O）2 - 。 R 1是烷基或环烷基; R 2是氢，卤素或-CN; R 3是氢或烷基; R 4是氢，烷基，烷氧基，羟基烷基，氨基烷基 - ，环烷基，杂环烷基，被烷基，任选取代的芳基烷基或任选取代的杂芳基烷基取代的杂环烷基; 或R 3和R 4，形成任选取代的5-7元环，所述环任选地包含另外的杂原子环成员; R 7是烷基，任选取代的苯基，任选取代的杂芳基，环烷基，卤素，吗啉基，任选取代的哌嗪基或任选取代的氮杂环烷基。还公开了化合物在治疗帕金森病中的用途，单独或与其他治疗帕金森病的药物组合，包含它们的药物组合物和包含组合组分的试剂盒的用途。

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