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31. 发明申请

WO2008102173A1 COMPOSITIONS COMPRISING POLYSACCHARIDE CONJUGATES AND THEIR USE AS VACCINES 审中-公开
标题翻译：包含多糖共混物的组合物及其作为疫苗的使用
公开(公告)号：WO2008102173A1
公开(公告)日：2008-08-28
申请号：PCT/GB2008/050110
申请日：2008-02-20
申请人： Health Protection Agency , Serum Institute of India Limited , KAPRE, Subhash V. , GOEL, Akshay , GORRINGE, Andrew Richard , FINNEY, Michelle
发明人： KAPRE, Subhash V. , GOEL, Akshay , GORRINGE, Andrew Richard , FINNEY, Michelle
IPC分类号： A61K39/00 , A61K39/095
CPC分类号： A61K39/095 , A61K39/00 , A61K2039/55594 , Y02A50/472 , Y02A50/476 , Y02A50/484
摘要： The present invention is in the field of combination therapies, including vaccine compositions, which comprise polysaccharide-protein conjugates and outer membrane vesicles (OMVs) from commensal bacteria, particularly commensal Neisseria .
摘要翻译：本发明涉及组合治疗领域，包括疫苗组合物，其包含来自共生细菌，特别是共生奈瑟球菌的多糖 - 蛋白质缀合物和外膜囊泡（OMV）。

32. 发明申请

WO2005078131A1 TB RESISTANCE ASSAY 审中-公开
标题翻译：结核耐药性测定
公开(公告)号：WO2005078131A1
公开(公告)日：2005-08-25
申请号：PCT/GB2005/000499
申请日：2005-02-11
申请人： HEALTH PROTECTION AGENCY , BROWN, Timothy
发明人： BROWN, Timothy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6837 , C12Q2600/156 , C12Q2600/16
摘要： An assay for detecting multi-drug resistant Mycobacterium sp ., in particular Mycobacterium tuberculosis , in a sample, and corresponding reagents, uses thereof and kits therefor.
摘要翻译：用于检测样品中多药耐药性分枝杆菌，特别是结核分枝杆菌的测定法，以及相应的试剂及其试剂盒。

33. 发明申请

WO2011067587A1 ASSAY METHOD AND APPARATUS 审中-公开
标题翻译：测定方法和装置
公开(公告)号：WO2011067587A1
公开(公告)日：2011-06-09
申请号：PCT/GB2010/051992
申请日：2010-11-30
申请人： HEALTH PROTECTION AGENCY , WAKEFIELD, James
发明人： WAKEFIELD, James
IPC分类号： G01N3/12 , G01N13/00 , G01N15/08 , G01N33/50
CPC分类号： G01N3/12 , G01N3/36 , G01N2013/003 , G01N2013/006 , G01N2203/0016 , G01N2203/0051
摘要： A skin sample is mounted in a diffusion cell between a receptor and a donor chamber. A substance to be tested is provided to the skin sample via the donor chamber. The diffusion cell has a driver for applying pressure variations to fluid in the receptor chamber in order to cause repeated flexing of the skin sample to simulate the behaviour of living (moving) skin.
摘要翻译：皮肤样品安装在受体和供体室之间的扩散池中。通过供体室将待测物质提供给皮肤样品。扩散池具有用于对受体室中的流体施加压力变化的驱动器，以便引起皮肤样品的反复弯曲以模拟生物（移动）皮肤的行为。

34. 发明申请

WO2010079357A1 RAPID BIOLUMINESCENCE DETECTION SYSTEM 审中-公开
标题翻译：快速生物荧光检测系统
公开(公告)号：WO2010079357A1
公开(公告)日：2010-07-15
申请号：PCT/GB2010/050018
申请日：2010-01-07
申请人： HEALTH PROTECTION AGENCY , SUTTON, Mark, J. , POOLMAN, Toryn , HESP, Richard, J.
发明人： SUTTON, Mark, J. , POOLMAN, Toryn , HESP, Richard, J.
IPC分类号： C12Q1/48 , C12Q1/66 , G01N33/53
CPC分类号： G01N33/581 , C12Q1/485 , C12Q1/66
摘要： An assay is provided for detecting the activity of a reporter kinase comprising (i) adding said reporter kinase to an assay mixture wherein said reporter kinase is contacted with bioluminescent reagent no more than minutes after being contacted with ADP, and wherein, prior to contacting the reporter kinase with ADP, the assay mixture is substantially free from kinase other than reporter kinase; and (ii) detecting light output from the assay mixture. Methods for detecting the presence of an analyte in a sample and methods for validating a treatment process using the above assay are also provided. Further provided are devices for conducting these assays and methods.
摘要翻译：提供了用于检测报道激酶活性的测定法，其包括（i）将所述报道激酶加入到测定混合物中，其中所述报道激酶在与ADP接触后不超过几分钟与生物发光试剂接触，并且其中在接触报告基因激酶与ADP，测定混合物基本上不含激酶以外的报告基因激酶; 和（ii）检测来自测定混合物的光输出。还提供了用于检测样品中分析物的存在的方法和使用上述测定验证治疗过程的方法。进一步提供用于进行这些测定和方法的装置。

35. 发明申请

WO2010004336A2 STIMULATED CELL STANDARDS 审中-公开
标题翻译：刺激细胞标准
公开(公告)号：WO2010004336A2
公开(公告)日：2010-01-14
申请号：PCT/GB2009/050815
申请日：2009-07-09
申请人： HEALTH PROTECTION AGENCY , STEBBINGS, Richard John
发明人： STEBBINGS, Richard John
IPC分类号： G01N33/96
CPC分类号： G01N33/96
摘要： Methods for producing stimulated, positive and negative control reference standard for monitoring intracellular cytokine levels and cytokine release in test samples by stimulating cells to produce cytokines in the presence of a cytokine release inhibitor, fixing the stimulated cells with a fixative such as paraformaldehyde, washing to remove excess fixatives and freeze-drying the stimulated, fixed cells. Methods for producing labelled reference standards for cell proliferation assays are also disclosed, in which proliferation-competent mammalian cells, isolated from a human or animal body are labelled with a label, such as a dye, that is divided between daughter cells during cell proliferation (e.g. carboxyfluorescein succinimidyl ester), the cells are stimulated to proliferate, the proliferated cells are fixed by addition of a fixative and then preserved by freeze drying or cryopreservation.
摘要翻译：用于产生用于通过刺激细胞在细胞因子释放抑制剂存在下产生细胞因子的细胞内细胞因子水平和细胞因子释放来监测细胞内细胞因子水平和细胞因子释放的方法，用固定剂如多聚甲醛固定刺激的细胞，洗涤至去除多余的固定剂并冷冻干燥受刺激的固定细胞。还公开了用于产生细胞增殖测定的标记参考标准的方法，其中从人或动物体分离的增殖能力的哺乳动物细胞用细胞增殖期间在子细胞之间划分的标记（例如染料）进行标记（例如羧基荧光素琥珀酰亚胺酯），刺激细胞增殖，通过加入固定剂固定增殖的细胞，然后通过冷冻干燥或冷冻保存来保存细胞。

36. 发明申请

WO2009104013A1 COVALENTLY LINKED THERMOSTABLE KINASE FOR DECONTAMINATION PROCESS VALIDATION 审中-公开
标题翻译：用于去除过程验证的共同连接的热稳定性激酶
公开(公告)号：WO2009104013A1
公开(公告)日：2009-08-27
申请号：PCT/GB2009/050158
申请日：2009-02-18
申请人： HEALTH PROTECTION AGENCY , SUTTON, J., Mark , HESP, J., Richard , UNGURS, Michael
发明人： SUTTON, J., Mark , HESP, J., Richard , UNGURS, Michael
IPC分类号： C12Q1/48 , G01N33/58
CPC分类号： C12Q1/485 , C12Q1/66 , G01N33/581 , G01N2333/9121 , Y02A50/53
摘要： A biological process indicator is provided for validating a treatment process in which the amount or activity of a contaminant in a sample is reduced. The indicator comprises a thermostable kinase covalently linked to a biological component, with the proviso that the biological component is not an antibody. Methods of preparing the indicator, and methods of using the indicator, are also provided.
摘要翻译：提供了一种生物过程指示器，用于验证样品中污染物的量或活性降低的处理过程。该指标包括与生物组分共价连接的热稳定激酶，条件是生物成分不是抗体。还提供了制备指示剂的方法和使用指示剂的方法。

37. 发明申请

WO2008152429A1 CHEMICALLY MODIFIED PEPTIDES WITH IMPROVED IMMUNOGENICITY 审中-公开
标题翻译：具有改善免疫原性的化学修饰的肽
公开(公告)号：WO2008152429A1
公开(公告)日：2008-12-18
申请号：PCT/GB2008/050449
申请日：2008-06-13
申请人： HEALTH PROTECTION AGENCY , EMERGENT BIOSOLUTIONS, INC. , SHONE, Clifford , XIAOMI, Tong , CLANCY, Joanna , GU, Mili
发明人： SHONE, Clifford , XIAOMI, Tong , CLANCY, Joanna , GU, Mili
IPC分类号： A61K39/02 , A61K39/07 , A61K39/08
CPC分类号： A61K39/07 , A61K39/08 , A61K2039/55505
摘要： The invention provides processes for improving the ability of a peptide to stimulate an immune response, comprising exposing the peptide to a chemical modifying agent. It further provides compositions comprising an antigenic peptide, wherein the peptide has been treated with a chemical modifying agent to improve its ability to stimulate an immune response. It also provides methods of stimulating an immune response in a mammal, comprising administering to the mammal an effective amount of a vaccine.
摘要翻译：本发明提供了改善肽刺激免疫应答能力的方法，包括将肽暴露于化学改性剂。它进一步提供包含抗原肽的组合物，其中肽已用化学改性剂处理以改善其刺激免疫应答的能力。它还提供刺激哺乳动物免疫应答的方法，包括向哺乳动物施用有效量的疫苗。

38. 发明申请

WO2008096177A2 DETECTION OF HUMAN PAPILLOMAVIRUS 审中-公开
标题翻译：人类斑马鱼的检测
公开(公告)号：WO2008096177A2
公开(公告)日：2008-08-14
申请号：PCT/GB2008/050080
申请日：2008-02-08
申请人： HEALTH PROTECTION AGENCY , CORLESS, Caroline , GUIVER, Malcolm
发明人： CORLESS, Caroline , GUIVER, Malcolm
IPC分类号： C12Q1/68
CPC分类号： C12Q1/708
摘要： There is provided an in vitro method of detecting human papillomavirus nucleic acid in a sample, comprising: (a) contacting said sample with forward and reverse oligonucleotide primers, wherein said primers bind to target sites in the human papillomavirus L1 gene, or the complement thereof, under conditions suitable to promote amplification of a portion of said human papillomavirus L1 gene or complement, thereby generating an amplicon; (b) contacting said amplicon with a probe, wherein the probe binds to a target site within said amplicon; and (c) detecting binding of said probe to said amplicon; wherein said forward primer binds to a target site having the sequence SEQ ID NO: 1; and wherein said reverse primer binds to a target site having the sequence SEQ ID NO: 2.
摘要翻译：提供了一种在样品中检测人乳头瘤病毒核酸的体外方法，包括：（a）使所述样品与正向和反向寡核苷酸引物接触，其中所述引物结合人乳头瘤病毒L1基因或其补体中的靶位点在适于促进部分所述人乳头瘤病毒L1基因或补体的扩增的条件下，从而产生扩增子; （b）使所述扩增子与探针接触，其中探针结合所述扩增子内的靶位点; 和（c）检测所述探针与所述扩增子的结合; 其中所述正向引物与具有序列SEQ ID NO：1的靶位点结合; 并且其中所述反向引物与具有序列SEQ ID NO：2的靶位点结合。

39. 发明申请

WO2006059113A2 FUSION PROTEINS 审中-公开
标题翻译：融合蛋白
公开(公告)号：WO2006059113A2
公开(公告)日：2006-06-08
申请号：PCT/GB2005/004606
申请日：2005-12-01
申请人： HEALTH PROTECTION AGENCY , FOSTER, Keith , CHADDOCK, John , MARKS, Philip , STANCOMBE, Patrick , DUROSE, Lyndsey
发明人： FOSTER, Keith , CHADDOCK, John , MARKS, Philip , STANCOMBE, Patrick , DUROSE, Lyndsey
IPC分类号： C07K14/33
CPC分类号： C12N9/50 , A61K38/00 , C07K14/33 , C07K2319/06 , C07K2319/50 , C12N15/62
摘要： The invention provides a single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a target cell; a Targeting Moiety that is capable of binding to a Binding Site on the target cell, which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the target cell; a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the non-cytotoxic protease or fragment thereof and the Targeting Moiety; and a translocation domain that is capable of translocating the protease or protease fragment from within an endosome, across the endosomal membrane and into the cytosol of the target cell.
摘要翻译：本发明提供了一种单链多肽融合蛋白，其包含：非细胞毒性蛋白酶或其片段，所述蛋白酶或蛋白酶片段能够切割靶细胞的胞外融合装置的蛋白质; 能够结合目标细胞上的结合位点的靶向物质，所述结合位点能够经历内吞作用以掺入靶细胞内的内体; 蛋白酶切割位点，其中融合蛋白可被蛋白酶切割，其中蛋白酶切割位点位于非细胞毒性蛋白酶或其片段与靶向部位之间; 以及能够将位于内体内的蛋白酶或蛋白酶片段穿过内体膜并转移到靶细胞的胞质溶胶中的易位结构域。

40. 发明申请

WO2005123764A1 PREPARATION OF PROTECTIVE ANTIGEN FROM BACILLUS ANTHRACIS 审中-公开
标题翻译：保护性抗生素从巴氏杆菌的制备
公开(公告)号：WO2005123764A1
公开(公告)日：2005-12-29
申请号：PCT/GB2005/002360
申请日：2005-06-16
申请人： HEALTH PROTECTION AGENCY , DYNPORT VACCINE COMPANY LLC , BREHM, John , MCENTEE, Ian , VINCENT, Philip , ALLISON, Nigel , BREHM, Rossalyn , JACK, George , HERBERT, Michael , SOLOW, Barbara, T. , ARROYO, Juan , LAPCEVICH, Randall, K.
发明人： BREHM, John , MCENTEE, Ian , VINCENT, Philip , ALLISON, Nigel , BREHM, Rossalyn , JACK, George , HERBERT, Michael , SOLOW, Barbara, T. , ARROYO, Juan , LAPCEVICH, Randall, K.
IPC分类号： C07K14/32
CPC分类号： C07K14/32 , A61K39/00
摘要： A polynucleotide sequence is provided, comprising: a nucleic acid sequence having at least 75 % identity to SEQ ID NO: 1, wherein said nucleic acid sequence encodes recombinant Bacillus anthracis Protective Antigen (rPA); or a fragment of said nucleic acid sequence wherein said fragment encodes a fragment of recombinant Bacillus anthracis Protective Antigen (rPA). Also provided are expression vectors and host cells comprising the polynucleotide sequence of the invention, and methods for producing rPA or a fragment thereof. The invention further provides antigenic compositions and. corresponding methods and uses for inducing an immune response.
摘要翻译：提供多核苷酸序列，其包含：与SEQ ID NO：1具有至少75％同一性的核酸序列，其中所述核酸序列编码重组炭疽芽孢杆菌保护性抗原（rPA）; 或所述核酸序列的片段，其中所述片段编码重组炭疽芽孢杆菌保护性抗原（rPA）的片段。还提供了包含本发明的多核苷酸序列的表达载体和宿主细胞，以及用于产生rPA或其片段的方法。本发明进一步提供抗原组合物。诱导免疫应答的相应方法和用途。

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