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1. 发明申请

WO2013001295A1 NEISSERIAL COMPOSITIONS AND EXPRESSION CONSTRUCTS 审中-公开
标题翻译： NEISSERIAL组合物和表达式结构
公开(公告)号：WO2013001295A1
公开(公告)日：2013-01-03
申请号：PCT/GB2012/051505
申请日：2012-06-27
申请人： HEALTH PROTECTION AGENCY , FEAVERS, Ian , CARE, Rory , SANDERS, Holly
发明人： FEAVERS, Ian , CARE, Rory , SANDERS, Holly
IPC分类号： A61K39/095 , C12N15/74
CPC分类号： C12N15/74 , A61K39/095 , A61K2039/523
摘要： The present invention provides Outer Membrane Vesicles (OMVs) that contain an elevated concentration of Outer Membrane Protein (OMP) such as FetA. Also provided is a method for producing said OMVs, and corresponding expression constructs characterised in that the expresssion constructs comprise a promoter comprising a nucleic acid sequence with at least 80% identity to the nucleic acid sequence of any one of SEQ ID NOs. 1-21.
摘要翻译：本发明提供含有升高浓度的外膜蛋白（OMP）如FetA的外膜囊泡（OMV）。还提供了用于产生所述OMV的方法，以及相应的表达构建体，其特征在于表达构建体包含启动子，其包含与SEQ ID NO中任一个的核酸序列具有至少80％同一性的核酸序列。 1-21。

2. 发明申请

WO2009147435A1 SALMONELLA DETECTION ASSAY 审中-公开
标题翻译： SALMONELLA检测测定
公开(公告)号：WO2009147435A1
公开(公告)日：2009-12-10
申请号：PCT/GB2009/050617
申请日：2009-06-03
申请人： HEALTH PROTECTION AGENCY , HOPKINS, Katie , LAWSON, Andy
发明人： HOPKINS, Katie , LAWSON, Andy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/166 , Y02A50/451
摘要： There is provided a method and reagents for detecting S. enterica subsp . IIIa and/ or IIIb in a sample, the method comprising: (a) contacting the sample with a pair of forward and reverse oligonucleotide primers, wherein said forward and reverse primers hybridise to target nucleic acid sequences located within the lacZ gene of S. enterica subsp . Ill, or the complement thereof; (b) extending said forward and reverse primers to generate an amplification product; and (c) detecting the amplification product. There is also provided a method a reagents for detecting S. enterica subsp . I in a sample, the method comprising: (a) contacting the sample with a pair of forward and reverse oligonucleotide primers, wherein said forward and reverse primers hybridise to target nucleic acid sequences located within the hilA gene of S. enterica subsp. I, or the complement thereof; (b) extending said forward and reverse primers to generate an amplification product; and (c) detecting the amplification product.
摘要翻译：提供了一种用于检测肠杆菌亚种的方法和试剂。 IIIa和/或IIIb的方法，所述方法包括：（a）使样品与一对正向和反向寡核苷酸引物接触，其中所述正向和反向引物与位于肠杆菌lacZ基因内的靶核酸序列杂交亚种。或其补体; （b）扩展所述正向和反向引物以产生扩增产物; 和（c）检测扩增产物。还提供了一种用于检测肠炎沙门氏菌的试剂的方法。 I的方法包括：（a）使样品与一对正向和反向寡核苷酸引物接触，其中所述正向引物和反向引物与位于肠炎沙门氏菌的hILA基因内的靶核酸序列杂交。 I或其补体; （b）扩展所述正向和反向引物以产生扩增产物; 和（c）检测扩增产物。

3. 发明申请

WO2007135385A1 CHEMICALLY DEFINED CULTURE MEDIUM FOR NEISSERIA 审中-公开
标题翻译：化学定义文化中介为NEISSERIA
公开(公告)号：WO2007135385A1
公开(公告)日：2007-11-29
申请号：PCT/GB2007/001831
申请日：2007-05-18
申请人： HEALTH PROTECTION AGENCY , WADE, Jim , GRAVER, Michelle
发明人： WADE, Jim , GRAVER, Michelle
IPC分类号： C12N1/20 , A61K39/095 , C12Q1/18 , C12Q1/04 , G01N33/50
CPC分类号： C12N1/20
摘要： There is provided a chemically-defined liquid culture medium comprising an energy source, a carbon source, a nitrogen source, an amino acid source, a purine synthesis source, a pyrimidine synthesis source and a buffer; characterised in that the culture medium has a pH less than 7, preferably less than 6.9, most preferably about 6.8.
摘要翻译：提供了一种化学定义的液体培养基，其包含能量源，碳源，氮源，氨基酸源，嘌呤合成来源，嘧啶合成源和缓冲液; 其特征在于培养基的pH小于7，优选小于6.9，最优选约6.8。

4. 发明申请

WO2005093085A1 BIOLOGICAL INDICATOR 审中-公开
标题翻译：生物指标
公开(公告)号：WO2005093085A1
公开(公告)日：2005-10-06
申请号：PCT/GB2005/001056
申请日：2005-03-22
申请人： HEALTH PROTECTION AGENCY , SUTTON, J., Mark , RAVEN, Neil, David, Hammond
发明人： SUTTON, J., Mark , RAVEN, Neil, David, Hammond
IPC分类号： C12Q1/22
CPC分类号： C12Q1/485 , C12Q1/22
摘要： A kinase is used in a biological indicator for validation of treatment processes designed to reduce the amount or activity of a biological agent in a sample. The indication can be used for validation of sterilisation treatment. The formation of ATP from a substrate comprising ADP is measured via the liciferin/luciferate system in a luminameter. Thermostable adenylate kinase from sulfolobus acidocaldarius is especially suitable for the validation of procedures to inactivate transmissable spongiform encephalopathy agents.
摘要翻译：激酶用于生物学指标，用于验证设计用于减少样品中生物制剂的量或活性的处理过程。该指示可用于灭菌处理的验证。在含有ADP的底物中形成ATP通过发光体中的无花果素/萤光素体系进行测定。来自硫酸杆菌的热稳定腺苷酸激酶特别适用于灭活可透过性海绵状脑病的药物。

5. 发明申请

WO2004009126A1 TARGETED AGENTS FOR NERVE REGENERATION 审中-公开
标题翻译：用于神经再生的目标药剂
公开(公告)号：WO2004009126A1
公开(公告)日：2004-01-29
申请号：PCT/GB2003/003082
申请日：2003-07-15
申请人： HEALTH PROTECTION AGENCY , SHONE, Clifford, Charles , SUTTON, John, Mark
发明人： SHONE, Clifford, Charles , SUTTON, John, Mark
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/60 , A61K47/641 , A61K47/66 , C07K14/005 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/34 , C07K19/00 , C07K2319/00 , C12N2760/16022 , Y02A50/469
摘要： A conjugate, for delivery of a therapeutic agent to a neuronal cell, comprises the therapeutic agent, a binding domain that binds to the neuronal cell, and a translocation domain that translocates the therapeutic agent into the neuronal cell, wherein the binding domain is H c of botulinum C 1 toxin or is based thereon.
摘要翻译：用于将治疗剂递送至神经元细胞的缀合物包含治疗剂，结合神经元细胞的结合结构域和将治疗剂转位入神经元细胞的易位结构域，其中结合域为Hc 肉毒杆菌C1毒素或基于此。

6. 发明申请

WO2003033530A3 MYCOBACTERIAL ANTIGENS EXPRESSED UNDER HIGH OXYGEN TENSION 审中-公开
公开(公告)号：WO2003033530A3
公开(公告)日：2003-04-24
申请号：PCT/GB2002/004647
申请日：2002-10-14
申请人： HEALTH PROTECTION AGENCY , JAMES, Brian , BACON, Joanna , MARCH, Philip
发明人： JAMES, Brian , BACON, Joanna , MARCH, Philip
IPC分类号： C12N15/31
摘要： A method is provided for identifying mycobacterial genes the expression of which is induced or up-regulated under continuous culture conditions defined by a dissolved oxygen tension of at least 30 % air saturation measured at 37 °C when compared with a dissolved oxygen tension of up to 10 % air saturation measured at 37 °C. The described method optionally provides for identifying mycobacterial genes that are simultaneously induced or up-regulated under continuous culture conditions that are iron-limiting. Said induced or up-regulated genes form the basis of nucleic acid vaccines, or provide targets to allow preparation of attenuated mycobacteria for vaccines against mycobacterial infections. Similarly, peptides encoded by said induced or up-regulated genes are employed in vaccines. In a further embodiment, the identified genes/peptides provide the means for identifying the presence of a mycobacterial infection in a clinical sample by nucleic acid probe or antibody detection.

7. 发明申请

WO2002077648A3 PATHOGENIC AND COMMENSAL VACCINE ANTIGENS 审中-公开
公开(公告)号：WO2002077648A3
公开(公告)日：2002-10-03
申请号：PCT/GB2002/001399
申请日：2002-03-22
申请人： HEALTH PROTECTION AGENCY , IMPERIAL COLLEGE INNOVATIONS LIMITED , ROBINSON, Andrew , GORRINGE, Andrew, Richard , HUDSON, Michael, John , BRACEGIRDLE, Philippa , WEST, David, McKay , OLIVER, Kerry, Jane , KROLL, John, Simon , LANGFORD, Paul, Richard
发明人： ROBINSON, Andrew , GORRINGE, Andrew, Richard , HUDSON, Michael, John , BRACEGIRDLE, Philippa , WEST, David, McKay , OLIVER, Kerry, Jane , KROLL, John, Simon , LANGFORD, Paul, Richard
IPC分类号： C07K14/22
摘要： The invention provides methods of screening commensal and pathogenic bacteria for previously unidentified vaccine antigens, based upon identifying polypeptide antigens that bind to sera raised against commensal bacterial proteins. Also provided are vaccine compositions and methods of preparing vaccine compositions comprising the antigens identified by the screening methods. Antigens and uses thereof are also described.

8. 发明申请

WO2012046061A2 CLOSTRIDIUM DIFFICILE ANTIGENS 审中-公开
标题翻译：胶原蛋白抗体
公开(公告)号：WO2012046061A2
公开(公告)日：2012-04-12
申请号：PCT/GB2011/051910
申请日：2011-10-05
申请人： HEALTH PROTECTION AGENCY , MICROPHARM LIMITED , SHONE, Clifford , ROBERTS, April , AHERN, Helen , MAYNARD-SMITH, Michael , LANDON, John
发明人： SHONE, Clifford , ROBERTS, April , AHERN, Helen , MAYNARD-SMITH, Michael , LANDON, John
IPC分类号： C07K14/435
CPC分类号： A61K39/08 , A61K38/164 , A61K39/40 , A61K2039/505 , C07K14/33 , C07K16/1282 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to recombinant Clostridium difficile antigens based on a fusion protein that consists of or comprises a first amino acid sequence and a second amino acid sequence, wherein: a) the first amino acid sequence is provided by an amino acid sequence that has at least 80% sequence identity with an amino acid sequence consisting of residues 500-1850 of a C. difficile Toxin A sequence or residues 1500-1851 of a C. difficile Toxin B sequence; and b) the second amino acid sequence is provided by an amino acid sequence that has at least 80% sequence identity with an amino acid sequence consisting of a long repeat unit located within amino acid residues 1851-2710 of a C. difficile Toxin A sequence or within amino acid residues 1852-2366 of a C. difficile Toxin B sequence; though with the proviso that the fusion protein is not a polypeptide comprising amino acid residues 543-2710 of a C. difficile Toxin A and with the proviso that the fusion protein is not a polypeptide comprising amino acid residues 543-2366 of a C. difficile Toxin B. Also provided is the use of said antigens for the prevention/ treatment/ suppression of Clostridium difficile infection (CDI), together with methods for generating said antigens, methods for generating antibodies that bind to said antigens, and the use of said antibodies for the prevention/ treatment/ suppression of CDI.
摘要翻译：本发明涉及基于由第一氨基酸序列和第二氨基酸序列组成或包含第一氨基酸序列和第二氨基酸序列的融合蛋白的重组艰难梭菌抗原，其中：a）第一个氨基酸序列由具有与艰难梭菌毒素A序列的残基500-1850和艰难梭菌毒素B序列的残基1500-1851组成的氨基酸序列具有至少80％的序列同一性; 和b）第二个氨基酸序列由氨基酸序列提供，该氨基酸序列与由位于艰难梭菌毒素A序列的氨基酸残基1851-2710内的长重复单元组成的氨基酸序列具有至少80％的序列同一性或艰难梭菌毒素B序列的氨基酸残基1852-2366内; 尽管条件是融合蛋白不是包含艰难梭菌毒素A的氨基酸残基543-2710的多肽，条件是融合蛋白不是包含艰难梭菌的氨基酸残基543-2366的多肽毒素B.还提供了所述抗原用于预防/治疗/抑制艰难梭菌感染（CDI）的用途，以及产生所述抗原的方法，产生结合所述抗原的抗体的方法和所述抗体的使用用于预防/治疗/抑制CDI。

9. 发明申请

WO2011067616A1 THERAPIES FOR PREVENTING OR SUPPRESSING CLOSTRIDIUM DIFFICILE INFECTION 审中-公开
标题翻译：用于预防或抑制闭锁性感染的治疗方法
公开(公告)号：WO2011067616A1
公开(公告)日：2011-06-09
申请号：PCT/GB2010/052035
申请日：2010-12-06
申请人： HEALTH PROTECTION AGENCY , MICROPHARM LIMITED , SHONE, Clifford , ROBERTS, April , LANDON, John
发明人： SHONE, Clifford , ROBERTS, April , LANDON, John
IPC分类号： A61K39/40 , C07K16/12
CPC分类号： C07K16/1282 , A61K2039/505 , A61K2039/542 , C07K2317/20
摘要： The present invention provides an antibody composition comprising ovine antibodies, for use in the prevention or treatment of C. difficile infection wherein the antibodies bind to a C. difficile toxin, and wherein said prevention or treatment is by oral delivery of the antibody composition. Also provided is a pharmaceutical composition of ovine antibodies for oral delivery, which further comprises one or more means for protecting the antibodies from trypsin and/ or chymotrypsin and/ or stomach acid.
摘要翻译：本发明提供了一种抗体组合物，其包含用于预防或治疗艰难梭菌感染的羊抗体，其中所述抗体与艰难梭菌毒素结合，并且其中所述预防或治疗是通过口服递送所述抗体组合物。还提供了用于口服递送的羊抗体的药物组合物，其还包含用于保护来自胰蛋白酶和/或胰凝乳蛋白酶和/或胃酸的抗体的一种或多种方法。

10. 发明申请

WO2011033319A1 COMMENSAL NEISSERIAL STRESS PROTEIN PREPARATIONS 审中-公开
标题翻译：通用的NEISSERIAL应变蛋白制备
公开(公告)号：WO2011033319A1
公开(公告)日：2011-03-24
申请号：PCT/GB2010/051581
申请日：2010-09-21
申请人： HEALTH PROTECTION AGENCY , GORRINGE, Andrew , MCNULTY, Shaun , IMMUNOBIOLOGY LIMITED
发明人： GORRINGE, Andrew , MCNULTY, Shaun
IPC分类号： A61K39/095 , A61P31/04
CPC分类号： A61K39/095 , A61K2039/55516
摘要： There is provided an immunogenic preparation, comprising a commensal Neisserial stress protein and an antigenic polypeptide.
摘要翻译：提供了一种免疫原性制剂，其包含共生的奈瑟氏球菌应激蛋白和抗原多肽。

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