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1. 发明申请

WO2012127248A1 METHOD FOR THE PRODUCTION OF PROTEIN COMPLEXES AND VACCINE COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译：用于生产蛋白复合物的方法和包含其的疫苗组合物
公开(公告)号：WO2012127248A1
公开(公告)日：2012-09-27
申请号：PCT/GB2012/050650
申请日：2012-03-23
申请人： IMMUNOBIOLOGY LIMITED , COLACO, Camilo , McENTEE, Ian
发明人： COLACO, Camilo , McENTEE, Ian
IPC分类号： A61K39/385 , A61K38/16 , A61K39/00
CPC分类号： C12P21/00 , A61K38/1709 , A61K39/0002 , A61K39/0011 , A61K39/04 , A61K39/08 , A61K39/092 , A61K39/095 , Y02A50/403 , Y02A50/478 , Y02A50/48
摘要： The present invention relates to methods for the production of heat shock protein complexes for use in vaccine compositions. In particular, there is provided a method for increasing the level and immunogenicity of heat shock protein complexes produced in cells by subjecting the cells to specific stress inducing stimuli. The invention further extends to the use of heat shock protein complexes produced according to the methods of the invention in the preparation of vaccine compositions for the prevention and treatment of infectious diseases and cancerous conditions.
摘要翻译：本发明涉及生产用于疫苗组合物的热休克蛋白复合物的方法。特别地，提供了一种通过使细胞经受特定应激诱导刺激而增加细胞中产生的热休克蛋白复合物的水平和免疫原性的方法。本发明进一步延伸到根据本发明的方法制备的热休克蛋白复合物在制备用于预防和治疗感染性疾病和癌症病症的疫苗组合物中的应用。

2. 发明申请

WO2009152452A1 FERMENTATION METHOD FOR THE PRODUCTION OF SOLUBLE BOTULINUM NEUROTOXIN PROTEINS 审中-公开
标题翻译：用于生产可溶性白细胞神经毒素蛋白的发酵方法
公开(公告)号：WO2009152452A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/047240
申请日：2009-06-12
申请人： YANG, Huei-Hsiung , MCENTEE, Ian
发明人： YANG, Huei-Hsiung , MCENTEE, Ian
IPC分类号： G01N33/53
CPC分类号： C07K14/33
摘要： A method is provided for the production of soluble Clostridium neurotoxins or neurotoxin fragments, for instance, LH N fragments from botulinum neurotoxins. Proteins made according to the method of the invention are useful, for example, as immunodiagnostic agents and vaccine components.
摘要翻译：提供了用于生产可溶性梭菌属神经毒素或神经毒素片段的方法，例如来自肉毒杆菌神经毒素的LHN片段。根据本发明方法制备的蛋白质可用作例如免疫诊断剂和疫苗组分。

3. 发明申请

WO2005123764A1 PREPARATION OF PROTECTIVE ANTIGEN FROM BACILLUS ANTHRACIS 审中-公开
标题翻译：保护性抗生素从巴氏杆菌的制备
公开(公告)号：WO2005123764A1
公开(公告)日：2005-12-29
申请号：PCT/GB2005/002360
申请日：2005-06-16
申请人： HEALTH PROTECTION AGENCY , DYNPORT VACCINE COMPANY LLC , BREHM, John , MCENTEE, Ian , VINCENT, Philip , ALLISON, Nigel , BREHM, Rossalyn , JACK, George , HERBERT, Michael , SOLOW, Barbara, T. , ARROYO, Juan , LAPCEVICH, Randall, K.
发明人： BREHM, John , MCENTEE, Ian , VINCENT, Philip , ALLISON, Nigel , BREHM, Rossalyn , JACK, George , HERBERT, Michael , SOLOW, Barbara, T. , ARROYO, Juan , LAPCEVICH, Randall, K.
IPC分类号： C07K14/32
CPC分类号： C07K14/32 , A61K39/00
摘要： A polynucleotide sequence is provided, comprising: a nucleic acid sequence having at least 75 % identity to SEQ ID NO: 1, wherein said nucleic acid sequence encodes recombinant Bacillus anthracis Protective Antigen (rPA); or a fragment of said nucleic acid sequence wherein said fragment encodes a fragment of recombinant Bacillus anthracis Protective Antigen (rPA). Also provided are expression vectors and host cells comprising the polynucleotide sequence of the invention, and methods for producing rPA or a fragment thereof. The invention further provides antigenic compositions and. corresponding methods and uses for inducing an immune response.
摘要翻译：提供多核苷酸序列，其包含：与SEQ ID NO：1具有至少75％同一性的核酸序列，其中所述核酸序列编码重组炭疽芽孢杆菌保护性抗原（rPA）; 或所述核酸序列的片段，其中所述片段编码重组炭疽芽孢杆菌保护性抗原（rPA）的片段。还提供了包含本发明的多核苷酸序列的表达载体和宿主细胞，以及用于产生rPA或其片段的方法。本发明进一步提供抗原组合物。诱导免疫应答的相应方法和用途。

4. 发明申请

WO1989002917A1 PRODUCTION OF PLASMINOGEN ACTIVATOR FROM CELLS AT WHICH LECTIN IS ADDED TO THE CULTURE MEDIUM 审中-公开
标题翻译：从培养基中添加培养基的细胞培养细胞激活剂
公开(公告)号：WO1989002917A1
公开(公告)日：1989-04-06
申请号：PCT/GB1988000758
申请日：1988-09-16
申请人： PORTON PRODUCTS LIMITED , KEARNS, Michael, John , McENTEE, Ian, David , NORTH, John, Robert
发明人： PORTON PRODUCTS LIMITED
IPC分类号： C12N09/64
CPC分类号： C12N9/6459 , C12Y304/21069
摘要： Increased yields of enzymes, particularly tissue plasminogen activator (tPA), are produced from cells, particularly CNCM I-222 cells, by a process using less concentrated lectin, particularly concanavalin A, in culture medium added to replace initial growth medium than has been used hitherto. After first harvesting of enzyme in supernatants, the culture can be reactivated by the addition of fresh culture medium containing an even lower lectin concentration, and a further harvest of enzyme obtained. The two harvests of enzyme together can give a greater overall yield than a single harvest after a single induction step employing the conventionally used higher lectin concentration. Enzyme yield can be further increased by repeating the last incubation step once or twice to obtain one or two further harvests.
摘要翻译：通过使用较少浓缩的凝血素（特别是伴刀豆球蛋白A）的方法在细胞，特别是CNCM I-222细胞中提高酶的产量，特别是组织纤溶酶原激活物（tPA）的产量，在添加以替代初始生长培养基的培养基中比已经使用迄今。在上清液中首次收获酶后，可以通过加入含有甚至更低凝集素浓度的新鲜培养基来再培养培养物，并进一步收获获得的酶。在采用常规使用的较高凝集素浓度的单一诱导步骤之后，酶的两次收获可以比单次收获更大的总产量。通过重复最后一次孵育步骤一次或两次可以进一步提高酶产量，以获得一个或两个进一步收获。

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