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21. 发明申请

WO99042435A2 MYXOCHELINES 审中-公开
标题翻译： myxochelins
公开(公告)号：WO99042435A2
公开(公告)日：1999-08-26
申请号：PCT/EP1999/001131
申请日：1999-02-22
IPC分类号： A61K49/00 , C07C235/52 , C07C235/60 , C07C237/34 , C07D205/085 , C07D271/12 , C12Q1/04 , C07C231/00
CPC分类号： A61K49/0021 , A61K47/547 , C07C235/52 , C07C235/60 , C07C237/34 , C07D205/085 , C07D271/12 , C12Q1/045 , Y02A50/58
摘要： The invention relates to compounds of general formula (A), where R is COOH, COOR , CH2-OH, C(=O)NR R , CN, CH2NR R , C(=O)-Z, CH2-Z, or a substituent in accordance with formula (C), R is COOH, COOR , CH2-OH, C(=O)NR R CN, CH2NR R or a substituent in accordance with formula (D), where R is CxH2x+1 with x = 1,2,3,4,5, -CH2-C6H5 or -C6H5, R , R independently of each other are H, CxH2x+1 with x = 1,2,3,4,5, -CH2-C6H5 or -C6H5, Y independently of each other are benzoyl, formyl, acetyl, trifluoroacetyl, glycosyl or silyl; Z is an organic group linked via an O, N or S, and n is 1,2,3,4 or 5, and the absolute configuration at C* can be both S and R, as well as the salts of the compounds, especially alkali, alkaline-earth or ammonium salts, where R is not CH2NH2 or CN if n = 3 or 4 and R = formula (D) with Y = H, and R is not formula (C) with Y = H if n = 2,3,4,5 and R = formula (D) with Y = H, and R is not CH2-OH or COOH if R = formula (D) with Y = H and n = 4 and the absolute configuration at the level of C* is S.
摘要翻译：通式（A）中，化合物，其中R 1 = COOH，COOR <1>，CH 2 OH，C（= O）NR <2> [R <3>，CN，CH 2 NR <2> [R <3>，C（= O）-Z，-CH 2 Z或式（C的取代基），R <4> = COOH，COOR <1>，CH 2 OH，C（= O）NR <2> [R <3> CN，CH 2 NR < 2> [R <3>，或根据式的取代基（D）中，R <1> = C x高2X + 1，其中x = 1,2,3,4,5，-CH2-C6H5或-C 6 H 5，R <2>， [R <3> =独立地H，C x高2X + 1，其中x = 1,2,3,4,5，-CH2-C6H5，-C 6 H 5，Y =彼此独立地苯甲酰基，甲酰基，乙酰基，三氟乙酰基，糖基或甲硅烷，Z =通过O连接的基团，N，S的有机基团，且n = 1,2,3,4或5，并且在C * S和R可以是，和化合物的盐的绝对构型，特别是碱金属，碱土金属或铵的盐，其中R是未CH 2 NH 2或CN，如果n = 3或4且R <4> =式（D）其中，Y = H和R不是式（C）与Y = H，如果n = 2 = H和R是3,4,5和R <4> =式（D）其中Y不是CH 2 OH或COOH当R <4> =式（D）其中，Y = H和n = 4和绝对的conf 是C * S的iguration

22. 发明申请

WO9902146A8 AMINO ACID DERIVATIVES 审中-公开
标题翻译：氨基酸衍生物
公开(公告)号：WO9902146A8
公开(公告)日：1999-04-22
申请号：PCT/JP9803013
申请日：1998-07-03
申请人： ONO PHARMACEUTICAL CO , SEKO TAKUYA , KATO MASASHI
发明人： SEKO TAKUYA , KATO MASASHI
IPC分类号： A61K38/00 , C07C233/46 , C07C233/47 , C07C233/51 , C07C233/83 , C07C235/52 , C07C235/84 , C07C237/08 , C07C237/22 , C07C237/36 , C07C271/22 , C07C309/18 , C07C311/06 , C07C311/13 , C07C311/14 , C07C311/19 , C07C311/29 , C07C311/46 , C07C317/50 , C07C323/59 , C07C323/60 , C07C323/62 , C07D207/16 , C07D211/14 , C07D211/20 , C07D211/58 , C07D211/62 , C07D213/30 , C07D213/32 , C07D213/64 , C07D213/643 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/06 , C07D215/08 , C07D215/12 , C07D217/06 , C07D233/54 , C07D233/90 , C07D263/34 , C07D277/04 , C07D277/06 , C07D277/14 , C07D277/16 , C07D277/56 , C07D279/06 , C07D279/12 , C07D295/135 , C07D295/185 , C07D307/14 , C07D307/24 , C07D307/42 , C07D307/52 , C07D307/68 , C07D309/04 , C07D309/06 , C07D333/16 , C07D333/20 , C07D333/38 , C07D417/12 , C07K5/072 , C07K5/078 , A61K31/165 , A61K31/18 , A61K31/215 , A61K31/27 , A61K31/34 , A61K31/38 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/54 , A61K38/05 , C07C227/20 , C07C229/26 , C07C277/04 , C07D213/62 , C07D233/64 , C07D295/12 , C07D295/18 , C07D295/22 , C07K5/06
CPC分类号： C07D213/30 , A61K38/00 , C07C233/46 , C07C233/47 , C07C233/51 , C07C233/83 , C07C235/52 , C07C235/84 , C07C237/08 , C07C237/22 , C07C237/36 , C07C271/22 , C07C309/18 , C07C311/06 , C07C311/13 , C07C311/14 , C07C311/19 , C07C311/29 , C07C311/46 , C07C317/50 , C07C323/59 , C07C323/60 , C07C323/62 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/16 , C07D211/14 , C07D211/20 , C07D211/58 , C07D211/62 , C07D213/32 , C07D213/64 , C07D213/643 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/06 , C07D215/08 , C07D215/12 , C07D217/06 , C07D233/64 , C07D233/90 , C07D263/34 , C07D277/04 , C07D277/06 , C07D277/14 , C07D277/16 , C07D277/56 , C07D279/06 , C07D279/12 , C07D295/135 , C07D295/185 , C07D307/14 , C07D307/24 , C07D307/42 , C07D307/52 , C07D307/68 , C07D309/04 , C07D309/06 , C07D333/16 , C07D333/20 , C07D333/38 , C07D417/12 , C07K5/06113 , C07K5/06139
摘要： Compounds represented by general formula (I), salts thereof and type N calcium channel inhibitors containing the same as the active ingredient, wherein R represents optionally substituted alkyl, alkoxy or phenyl, a heterocyclic group, etc.; A represents a single bond, CO or SO2; R represents H, optionally substituted alkyl, etc.; D represents alkylene, etc.; E represents COO, OCO, O, S, SO, SO2, etc.; R represents optionally substituted alkyl, a carbocyclic group or a heterocycle group; J represents O or NR (wherein R represents H or optionally substituted alkyl); and R represents optionally substituted alkyl, a carbocyclic group or a heterocyclic group. Because of inhibiting the type N calcium channel, the compounds (I) are useful as preventives and/or remedies for cerebral infarction, transient cerebral ischemic attack, cerebrospinal disorders following heart operations, spinal vascular lesion, stress hypertension, neurosis, epilepsy, etc. or remdies for pains.
摘要翻译：通式（I）表示的化合物，其盐和含有其作为活性成分的N型钙通道抑制剂，其中R 1表示任选取代的烷基，烷氧基或苯基，杂环基等; A代表单键，CO或SO 2; R 2表示H，任选取代的烷基等; D代表亚烷基等; E代表COO，OCO，O，S，SO，SO2等; R 3代表任选取代的烷基，碳环基团或杂环基团; J表示O或NR 16（其中R 16表示H或任选取代的烷基）; 并且R 4表示任选取代的烷基，碳环基团或杂环基团。由于抑制N型钙通道，化合物（I）可用作脑梗塞，短暂性脑缺血发作，心脏手术后的脑脊髓疾病，脊髓血管病变，压力性高血压，神经官能症，癫痫等的预防和/或治疗。或改变痛苦。

23. 发明申请

WO2015025164A1 AMIDE DERIVATIVES AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS 审中-公开
标题翻译：酰胺衍生物作为赖氨酸磷酸受体拮抗剂
公开(公告)号：WO2015025164A1
公开(公告)日：2015-02-26
申请号：PCT/GB2014/052558
申请日：2014-08-20
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , TAKEDA CAMBRIDGE LIMITED
发明人： BUFFHAM, William , CANNING, Hannah , DAVENPORT, Richard , FARNABY, William , MACK, Stephen , PARMAR, Alka , WRIGHT, Susanne
IPC分类号： C07C235/52 , C07D213/81 , C07D239/34 , A61K31/44 , A61K31/505 , A61P9/10 , A61P29/00
CPC分类号： C07D239/34 , A61K31/195 , A61K31/277 , A61K31/44 , A61K31/505 , C07C235/44 , C07C235/46 , C07C235/52 , C07C255/54 , C07C2601/02 , C07C2601/04 , C07D213/78 , C07D213/81
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, formula (I) wherein R 1 . X, m. R 2 , Y, R 3 , Z, n, R 4 . A and B are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，式（I）其中R 1。 X，m。 R2，Y，R3，Z，n，R4。 A和B如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

24. 发明申请

WO2008053393A8 ROTARY ACTUATOR 审中-公开
标题翻译：旋转执行器
公开(公告)号：WO2008053393A8
公开(公告)日：2008-08-21
申请号：PCT/IB2007054076
申请日：2007-10-08
申请人： NICE SPA , GALBERTI LORENZO , FURLANETTO CRISTIAN
发明人： GALBERTI LORENZO , FURLANETTO CRISTIAN
IPC分类号： C07C235/52 , A61K31/216 , A61K31/40 , A61K31/4025 , A61K31/5377 , A61K31/55 , C07C231/02 , C07C231/16 , C07C233/57 , C07C233/78 , C07C235/54 , C07C235/60 , C07D207/14 , C07D223/12 , C07D265/30
CPC分类号： E06B9/11 , E05F15/603 , E05F15/611 , E05F15/63 , E05Y2201/224 , E05Y2201/624 , E05Y2201/644 , E05Y2600/324 , E05Y2600/33 , E05Y2900/40
摘要： Electromechanical rotary actuator (52) for moving shutters (13) of gates or doors, comprising a motor enclosed in a casing (50), a rotating arm (56) connected to the motor for moving the shutter or swinging door, a movable catcher (72) for defining a stop of the rotating arm (56), a cover (58) over the rotation centre of the arm (56), characterised in that the catcher (72) is mounted outside the cover (58).
摘要翻译：用于移动门或门的百叶窗（13）的机电旋转致动器（52），包括封闭在壳体（50）中的电动机，连接到电动机的用于移动快门或摆动门的旋转臂（56），可移动捕获器 72），用于限定所述旋转臂（56）的止动件，所述臂（56）的旋转中心上方的盖（58），其特征在于，所述捕获器（72）安装在所述盖（58）的外部。

25. 发明申请

WO2008053393A2 ROTARY ACTUATOR 审中-公开
公开(公告)号：WO2008053393A2
公开(公告)日：2008-05-08
申请号：PCT/IB2007054076
申请日：2007-10-08
申请人： NICE SPA , GALBERTI LORENZO , FURLANETTO CHRISTIAN
发明人： GALBERTI LORENZO , FURLANETTO CHRISTIAN
IPC分类号： C07C235/52 , C07C231/02 , C07C233/57 , C07C235/54 , E05F15/12
CPC分类号： E06B9/11 , E05F15/603 , E05F15/611 , E05F15/63 , E05Y2201/224 , E05Y2201/624 , E05Y2201/644 , E05Y2600/324 , E05Y2600/33 , E05Y2900/40
摘要： Electromechanical rotary actuator (52) for moving shutters (13) of gates or doors, comprising a motor enclosed in a casing (50), a rotating arm (56) connected to the motor for moving the shutter or swinging door, a movable catcher (72) for defining a stop of the rotating arm (56), a cover (58) over the rotation centre of the arm (56), characterised in that the catcher (72) is mounted outside the cover (58).

26. 发明申请

WO2008049808A1 MTP INHIBITING TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译： MTP抑制四氢萘-1-羧酸衍生物
公开(公告)号：WO2008049808A1
公开(公告)日：2008-05-02
申请号：PCT/EP2007/061289
申请日：2007-10-22
申请人： JANSSEN PHARMACEUTICA NV , MEERPOEL, Lieven , BACKX, Leo Jacobus Jozef , TEN HOLTE, Peter , BUSSCHER, Guuske Frederike
发明人： MEERPOEL, Lieven , BACKX, Leo Jacobus Jozef , TEN HOLTE, Peter , BUSSCHER, Guuske Frederike
IPC分类号： C07C235/52 , C07C235/54 , C07C233/57 , C07C231/02 , C07C231/16 , C07C233/78 , C07C235/60 , C07D207/14 , C07D223/12 , C07D265/30 , A61K31/216 , A61K31/4025 , A61K31/40 , A61K31/5377 , A61K31/55
CPC分类号： C07C235/60 , C07C233/78 , C07C2602/10 , C07D207/14 , C07D213/82 , C07D223/12 , C07D265/30 , C07D401/12 , C07D413/12
摘要： The present invention is concerned with novel tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes. Formula (I).
摘要翻译：本发明涉及具有apoB分泌/ MTP抑制活性和伴随降脂活性的新型四氢萘-1-羧酸衍生物。本发明还涉及制备这些化合物的方法，包含所述化合物的药物组合物以及所述化合物作为治疗动脉粥样硬化，胰腺炎，肥胖症，高甘油三酯血症，高胆固醇血症，高脂血症，糖尿病和II型糖尿病的药物的用途。式（I）。

28. 发明申请

WO2006063819A3 MANUFACTURE PROCESS OF N-SUBSTITUTED SALICYLAMIDES 审中-公开
标题翻译： N-取代的SALICYLAMIDES的制备方法
公开(公告)号：WO2006063819A3
公开(公告)日：2006-09-14
申请号：PCT/EP2005013452
申请日：2005-12-14
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , RISS BERNHARD
发明人： RISS BERNHARD
IPC分类号： C07C231/02 , A61K31/197 , C07C231/12 , C07C235/52
CPC分类号： C07C231/02 , C07C231/12 , C07C235/52
摘要： The present invention relates to a method of preparing N-substituted salicylamides or derivatives thereof and their derivatives, e.g. their salts. In particular, the present invention relates to a method of preparing (N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC) and its corresponding disodium monohydrate.
摘要翻译：本发明涉及制备N-取代的水杨酰胺或其衍生物及其衍生物的方法，例如，他们的盐特别地，本发明涉及制备（N-（5-氯水杨酰基）-8-氨基辛酸（5-CNAC）及其相应的一水合二钠的方法。

29. 发明申请

WO01092201A1 SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVES 审中-公开
标题翻译：取代的苯甲酸衍生物
公开(公告)号：WO01092201A1
公开(公告)日：2001-12-06
申请号：PCT/JP2001/004385
申请日：2001-05-25
IPC分类号： A61P3/06 , A61P9/10 , A61P43/00 , C07C59/68 , C07C69/734 , C07C69/738 , C07C229/34 , C07C233/51 , C07C233/55 , C07C233/87 , C07C235/34 , C07C235/38 , C07C235/52 , C07C251/48 , C07C323/56 , A61K31/192 , C07C233/81 , C07C235/44 , C07C235/78
CPC分类号： C07C59/68 , C07C69/734 , C07C69/738 , C07C229/34 , C07C233/51 , C07C233/55 , C07C233/87 , C07C235/34 , C07C235/38 , C07C235/52 , C07C251/48 , C07C323/56
摘要： Novel substituted phenylpropionic acid derivatives of the general formula (1), which bind to human peroxisome proliferator activated receptor alpha (PPAR alpha ) as ligand to activate the receptor and thereby exhibit a potent lipid-decreasing effect; and use thereof as drugs: (1) wherein R is lower alkyl, lower alkoxy, trifluoromethyl, trifluoromethoxy, optionally substituted phenyl, optionally substituted phenoxy, or optionally substituted benzyloxy; R is hydrogen, lower alkyl, or lower alkoxy; R is lower alkoxy; and A is -CH2CONH-, -NHCOCH2-, -CH2CH2CO-, CH2CH2CH2-, -CH2CH2O-, -CONHCH2-, -CH2NHCH2-, -COCH2O-, -OCH2CO-, -COCH2NH-, or NHCH2CO-.
摘要翻译：通式（1）的新型取代的苯基丙酸衍生物，其结合人过氧化物酶体增殖物激活受体α（PPARα）作为配体以激活受体，从而表现出有效的降脂作用; 和其用作药物：（1）其中R 1是低级烷基，低级烷氧基，三氟甲基，三氟甲氧基，任选取代的苯基，任选取代的苯氧基或任选取代的苄氧基; R 2是氢，低级烷基或低级烷氧基; R 3是低级烷氧基; 并且A是-CH 2 CONH - ， - NHCOCH 2 - ， - CH 2 CH 2 CO-，CH 2 CH 2 CH 2 - ， - CH 2 CH 2 O-，-CONHCH 2 - ， - CH 2 NHCH 2 - ， - COCH 2 O-，-OCH 2 CO-，-COCH 2 NH-或NHCH 2 CO-。

30. 发明申请

WO01025181A1 CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME 审中-公开
标题翻译：羧酸衍生物和含有其的药物
公开(公告)号：WO01025181A1
公开(公告)日：2001-04-12
申请号：PCT/JP2000/006788
申请日：2000-09-29
IPC分类号： C07C59/66 , C07C59/68 , C07C233/51 , C07C233/55 , C07C233/87 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/60 , C07C235/78 , C07C235/84 , C07C255/57 , C07D209/14 , C07D209/42 , C07D213/30 , C07D213/55 , C07D213/56 , C07D213/81 , C07D213/82 , C07D215/04 , C07D217/26 , C07D231/14 , C07D233/90 , C07D239/52 , C07D241/24 , C07D261/18 , C07D263/26 , C07D263/32 , C07D277/20 , C07D277/30 , C07D277/34 , C07D277/56 , C07D307/54 , C07D307/79 , C07D333/24 , C07D401/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07C69/734 , C07C271/22 , C07D213/64 , C07D307/78 , C07D333/28
CPC分类号： C07D213/30 , C07C59/66 , C07C59/68 , C07C233/51 , C07C233/55 , C07C233/87 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/60 , C07C235/78 , C07C235/84 , C07C255/57 , C07C2601/08 , C07C2601/14 , C07D209/14 , C07D209/42 , C07D213/55 , C07D213/56 , C07D213/81 , C07D213/82 , C07D215/04 , C07D217/26 , C07D231/14 , C07D233/90 , C07D239/52 , C07D241/24 , C07D261/18 , C07D263/26 , C07D263/32 , C07D277/20 , C07D277/30 , C07D277/34 , C07D277/56 , C07D307/54 , C07D307/79 , C07D333/24 , C07D401/04 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R is hydrogen, hydroxyl, alkyl, or the like; L is a single bond, a double bond, alkylene, or the like; M is a single bond, alkylene, or the like; T is a single bond, alkylene, or the like; W is carboxyl, -CON(R )R , or the like; ...... represents a single or double bond; X is oxygen, alkenylene, or the like; Y is an aromatic hydrocarbon group which may contain a heteroatom, or the like; and Z is an aromatic hydrocarbon group which may contain a heteroatom.
摘要翻译：通式（I）的新型羧酸衍生物，它们的盐，它们的酯或它们的水合物，它们可用作胰岛素抵抗性改进剂; 和含有衍生物作为活性成分的药物。在所述式中，R 1是氢，羟基，烷基等; L是单键，双键，亚烷基等; M是单键，亚烷基等; T是单键，亚烷基等; W是羧基，-CON（R W1）R W 2等; ...... 表示单键或双键; X是氧，亚烯基等; Y是可以含有杂原子的芳族烃基等; Z是可以含有杂原子的芳族烃基。

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