专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO01061041A2 MULTIPLE-SITE REACTION DEVICE AND METHOD 审中-公开
标题翻译：多场反应装置及方法
公开(公告)号：WO01061041A2
公开(公告)日：2001-08-23
申请号：PCT/US2001/004884
申请日：2001-02-16
IPC分类号： G01N31/20 , B01J19/00 , B01L3/00 , B01L7/00 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/00 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/53 , G01N33/566 , G01N35/08 , G01N37/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00418 , B01J2219/00454 , B01J2219/00495 , B01J2219/00511 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502784 , B01L3/527 , B01L7/52 , B01L2200/027 , B01L2200/0673 , B01L2200/16 , B01L2300/0636 , B01L2300/087 , B01L2300/0883 , B01L2300/0887 , B01L2400/0409 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： A method and device for performing a plurality of small-volume reactions simultaneously are disclosed. The device includes an elongate or planar channel and a port for introducing such bulk-phase medium into the channel, a plurality of discrete small-volume reaction regions within the channel, and a reaction-specific reagent releasably carried on a wall portion of each reaction region. In carrying out the method of the invention, a bulk phase medium containing common reactants is added to the channel. Upon release of reaction-specific reagent from the wall portions of the reaction regions, a reagent-specific reaction can occur simultaneously in each region. The channel is dimensioned to substantially prevent convective fluid flow among the reaction regions during such reactions.
摘要翻译：公开了同时进行多个小体积反应的方法和装置。该装置包括细长或平面的通道和用于将这种体相相介质引入通道的端口，通道内的多个离散的小体积反应区域和可释放地承载在每个反应的壁部分上的反应特异性试剂地区。在实施本发明的方法时，将包含普通反应物的体相介质加入到通道中。从反应区域的壁部分释放反应特异性试剂时，可以在每个区域同时发生试剂特异性反应。该通道的尺寸被设计成基本上防止在这种反应期间反应区域之间的对流流体流动。

22. 发明申请

WO0076662A2 MICROENABLED CHEMICAL REACTION IN MICROFLUIDIC CHIPS 审中-公开
标题翻译：微流化学药剂中微量化学反应
公开(公告)号：WO0076662A2
公开(公告)日：2000-12-21
申请号：PCT/US0016056
申请日：2000-06-12
申请人： ORCHID BIOSCIENCES INC
发明人： SWENSON ROLF E , JIAN LIN , DEWITT SHEILA H
IPC分类号： B01J19/00 , B01L3/00 , C07B61/00 , C07C45/50 , C07C205/58 , C07C227/08 , C07C229/60 , C07K1/04 , C40B40/10 , C40B50/14 , C40B60/14 , B01L
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/00353 , B01J2219/00418 , B01J2219/00454 , B01J2219/00459 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/0072 , B01J2219/00725 , B01L3/5027 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2400/0487 , C07B2200/11 , C07C45/50 , C07C201/12 , C07C227/08 , C40B40/10 , C40B50/14 , C40B60/14 , C07C229/60 , C07C205/58 , C07C47/02
摘要： A chemical process to obtain products of higher purity or in shorter time is provided by performing chemical reactions in a reactions volume less than 1 microliter. The advantages of this process are due to better mixing or heat exchanche (each 10 fold decrease in reaction volume leads to a 100-fold improvement mixing or heat exchange) or better surface to volume ratio. Better surface to volume ratio is a major factor in reactions critically dependent on surface mediated events such as heterogeneous catalysis. This increase in yield and speed of reaction can be conducted in parallel sets of reaction chambers provided by multilayer glass and silicon chips. Reagents can be added via a microfluidic chip incorporating channels and orthogonal row/column reagent delivery options. This discovery is amendable to solid supported synthesis as well as solution synthesis. Because of the better surface to volume ratio, this process is particularly useful with solid catalyst on the edges of the reaction chamber and can be used for hydrogenation, and hydroformulation. This process is demonstrated in reactions involving nucleophilic aromatic substitution on a solid support.
摘要翻译：通过在小于1微升的反应体积中进行化学反应来提供获得更高纯度或更短时间的产物的化学方法。该方法的优点是由于更好的混合或热交换（反应体积的每10倍减少导致混合或热交换改善100倍）或更好的表面与体积比。更好的表面与体积比是重要依赖于表面介导的事件（如非均相催化）的反应的主要因素。反应的产率和速度的这种增加可以由多层玻璃和硅片提供的平行的反应室组进行。可以通过结合通道和正交行/列试剂递送选项的微流控芯片添加试剂。这一发现可以修改为固体支持的合成以及溶液合成。由于表面与体积之比更好，该方法对于反应室边缘的固体催化剂特别有用，可用于氢化和加氢成型。在固体支持物上涉及亲核芳香取代的反应中证明了这一过程。

23. 发明申请

WO00010707A1 DEVICES AND METHODS FOR ACCESSING REACTION VESSELS 审中-公开
标题翻译：用于接收反应容器的装置和方法
公开(公告)号：WO00010707A1
公开(公告)日：2000-03-02
申请号：PCT/US1999/019289
申请日：1999-08-23
IPC分类号： B01J19/00 , C40B60/14 , G01N35/10 , B01L11/00
CPC分类号： G01N35/10 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00333 , B01J2219/00351 , B01J2219/00369 , B01J2219/00389 , B01J2219/00396 , B01J2219/00398 , B01J2219/00418 , B01J2219/00423 , B01J2219/00484 , B01J2219/00495 , C40B60/14 , Y10T137/87249 , Y10T436/25 , Y10T436/2575
摘要： Devices and methods are provided for delivering fluids into reaction vessels. The device is an interface head (200) which allows a user to add reagents and wash solvents to a reaction vessel (RV).
摘要翻译：提供了将流体输送到反应容器中的装置和方法。该装置是允许用户向反应容器（RV）中添加试剂和洗涤溶剂的界面头（200）。

24. 发明申请

WO99020983A2 SYSTEMS AND METHODS USING AN OPTICAL SENSOR FOR LIQUID METERING 审中-公开
标题翻译：使用光学传感器进行液体计量的系统和方法
公开(公告)号：WO99020983A2
公开(公告)日：1999-04-29
申请号：PCT/US1998/022192
申请日：1998-10-21
IPC分类号： B01J19/00 , C40B60/14 , G01F23/292 , G01F
CPC分类号： G01F23/2928 , B01J19/0046 , B01J2219/00351 , B01J2219/00389 , B01J2219/00418 , B01J2219/00585 , B01J2219/00698 , C40B60/14 , G01F23/292
摘要： A metering assembly uses light refraction to determine the liquid level in a metering container. An image of a liquid-air boundary in the metering container is projected onto a sensor which accurately tracks the movement of the boundary. By tracking the location of this boundary, the assembly can determine when the container has the desired level of liquid being metered. In one embodiment, the assembly for use in a combinatorial chemistry synthesis apparatus has a generally transparent or translucent container adapted to hold a liquid and an optical liquid level sensor coupled to the container. The sensor comprises a light source, a photosensor, and a focusing device positioned at a distance from the light source to reproduce an image of a liquid/air boundary in the container onto the photosensor.
摘要翻译：计量组件使用光折射来确定计量容器中的液位。计量容器中液空气边界的图像被投影到精确跟踪边界运动的传感器上。通过跟踪该边界的位置，组件可以确定容器何时具有要计量的所需液体水平。在一个实施例中，用于组合化学合成装置的组件具有适于保持液体的一般透明或半透明的容器以及耦合到容器的光学液位传感器。该传感器包括光源，光传感器和聚焦装置，其位于离光源一定距离处，以将容器中的液/空气边界的图像再现到光传感器上。

25. 发明申请

WO99020395A1 SYSTEMS AND METHODS FOR COMBINATORIAL ORGANIC SYNTHESIS OF ARRAYS OF REACTION 审中-公开
标题翻译：用于组合反应阵列的组合有机合成的系统和方法
公开(公告)号：WO99020395A1
公开(公告)日：1999-04-29
申请号：PCT/US1998/022193
申请日：1998-10-21
IPC分类号： B01J4/00 , B01J19/00 , C07B39/00 , C07B61/00 , C07C45/38 , C07C45/39 , C07C45/46 , C07C45/72 , C07C201/08 , C40B60/14 , B01L3/02
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00344 , B01J2219/00351 , B01J2219/00369 , B01J2219/00389 , B01J2219/00418 , B01J2219/00423 , B01J2219/00479 , B01J2219/00481 , B01J2219/00484 , B01J2219/00493 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/0072 , C07B39/00 , C40B60/14
摘要： The present system is useful for the synthesis of chemical compounds and can be used for solid state or liquid chemistries. In one embodiment, the system (10) includes a reagent delivery/vent unit (20) and a chemical processing unit (30) containing a plurality of reaction vessels (50). The reagent delivery/vent unit has a plurality of tubular structures (100) adapted to slidably engage cavities (104) in the chemical processing unit to form a circumferential seal about each of the tubular structures. The delivery/vent unit typically uses a fluid interface head containing the tubular structures to engage the chemical processing unit. The chemical processing unit preferably uses a cassette (110) to house all of the reaction vessels and defines the plurality of elongate cavities adapted to receive the tubular structures.
摘要翻译：本系统可用于合成化合物，可用于固态或液态化学物质。在一个实施例中，系统（10）包括试剂输送/排放单元（20）和包含多个反应容器（50）的化学处理单元（30）。试剂输送/排放单元具有多个管状结构（100），其适于滑动地接合化学处理单元中的空腔（104），以围绕每个管状结构形成圆周密封。输送/排放单元通常使用包含管状结构的流体界面头来接合化学处理单元。化学处理单元优选地使用盒（110）来容纳所有反应容器并且限定适于接收管状结构的多个细长空腔。

26. 发明申请

WO9856506A9 SYSTEMS AND METHODS FOR PARALLEL SYNTHESIS OF COMPOUNDS 审中-公开
标题翻译：用于化合物并行合成的系统和方法
公开(公告)号：WO9856506A9
公开(公告)日：1999-04-08
申请号：PCT/US9812305
申请日：1998-06-11
申请人： ARGONAUT TECHNOLOGIES INC
发明人： KILCOIN CHRISTOPHER , MILLER STEVE , LONG TERRY
IPC分类号： B01J19/00 , B01J19/24 , B01L3/00 , C07B39/00 , C07C45/38 , C07C45/39 , C07C45/46 , C07C45/72 , C07C201/08 , C40B60/14
CPC分类号： B01L3/5025 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00344 , B01J2219/00351 , B01J2219/00369 , B01J2219/00389 , B01J2219/00418 , B01J2219/00423 , B01J2219/00479 , B01J2219/00481 , B01J2219/00484 , B01J2219/00493 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/0072 , C07B39/00 , C40B60/14
摘要： Systems and methods for synthesizing chemical compounds using a plurality reaction vessels (16). In particular, of holding a plurality of reaction vessels for parallel synthesis of multiple discrete compounds or for combinatorial libraries of compounds. In one embodiment, a synthesis apparatus comprises a frame (12) having a plurality of reaction vessel-holding openings (15) and a plurality of valves (54) for use in parallel synthesis of a plurality of compounds within reaction vessels.
摘要翻译：使用多个反应容器（16）合成化合物的系统和方法。特别地，保持用于平行合成多个离散化合物的多个反应容器或化合物的组合文库。在一个实施方案中，合成装置包括具有多个反应容器保持开口（15）的框架（12）和用于在反应容器内并行合成多种化合物的多个阀（54）。

27. 发明申请

WO98039099A1 APPARATUS AND METHODS FOR THE PREPARATION OF CHEMICAL COMPOUNDS 审中-公开
标题翻译：用于制备化学化合物的装置和方法
公开(公告)号：WO98039099A1
公开(公告)日：1998-09-11
申请号：PCT/US1998/004398
申请日：1998-03-05
IPC分类号： B01J4/02 , B01J19/00 , B01L3/00 , C07B39/00 , C07B61/00 , C07C45/38 , C07C45/39 , C07C45/46 , C07C45/72 , C07C201/08 , C40B40/10 , C40B40/18 , C40B50/08 , C40B60/00 , C40B60/14 , B01J8/18 , B01L9/00 , B01L11/00 , C12N15/00
CPC分类号： B01F11/0082 , B01F13/0818 , B01J4/02 , B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/0031 , B01J2219/00398 , B01J2219/00418 , B01J2219/00423 , B01J2219/00452 , B01J2219/00481 , B01J2219/00495 , B01J2219/00497 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00599 , B01J2219/00686 , B01J2219/00689 , B01J2219/0072 , B01J2219/00725 , B01J2219/00745 , B01L3/5025 , B01L3/50855 , C07B39/00 , C40B40/10 , C40B40/18 , C40B50/08 , C40B60/14
摘要： The present invention provides apparatus and methods for the synthesis of combinatorial chemical libraries. The apparatus comprises a plurality of reaction vessels having an inner surface, an outer surface, a first opening, and a second opening. An agitator is contained within each of the reaction vessels for stimulating liquid circulation within the vessels. The apparatus has a common gas line having a plurality of gas outlet ports, where each of the reaction vessels has at least one gas outlet port positioned to feed into the vessel. The apparatus also has a common liquid line having a plurality of liquid outlet ports, where each of the reaction vessels has at least one liquid outlet port positioned to feed into the vessel. Each reaction vessel also has at least one valve coupled to the second opening on the vessel.
摘要翻译：本发明提供用于合成组合化学文库的装置和方法。该装置包括具有内表面，外表面，第一开口和第二开口的多个反应容器。每个反应容器内装有搅拌器，用于刺激容器内的液体循环。该装置具有一个具有多个气体出口的公共气体管线，其中每个反应容器具有至少一个气体出口，该气体出口定位成供入容器。该设备还具有具有多个液体出口的公共液体管线，其中每个反应容器具有至少一个液体出口端口，定位成进料到容器中。每个反应容器还具有至少一个与容器上的第二开口连接的阀。

28. 发明申请

WO1991017823A1 METHOD AND APPARATUS FOR BIOPOLYMER SYNTHESIS 审中-公开
标题翻译：用于生物聚合物合成的方法和装置
公开(公告)号：WO1991017823A1
公开(公告)日：1991-11-28
申请号：PCT/US1991002776
申请日：1991-04-23
申请人： PROTOS CORPORATION
发明人： PROTOS CORPORATION , ZUCKERMANN, Ronald, N. , HEUBNER, Verena, D. , SANTI, Daniel, V. , SIANI, Michael, A.
IPC分类号： B01J19/00
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00308 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01J2219/00466 , B01J2219/00493 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00691 , B01J2219/00722 , B01J2219/00725 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14
摘要： Method and apparatus for synthesizing biopolymers, such as polypeptides and polynucleotides. The apparatus includes plural reaction vessels in which subunit coupling to biopolymers in a particle suspension is carried out. The vessels are connected to common valving structure for use in mixing the suspension and removing suspension liquid. In one embodiment, a robotic arm in the apparatus is operable to transfer reaction solution to the reaction vessels, and to transfer particle suspensions from the reaction vessels to a mixing vessel and back to the reaction vessels. The method can be used to produce preferably equi-molar amounts of different sequence biopolymers, such as polypeptides and polynucleotides.

29. 发明申请

WO1990002605A1 AN APPARATUS AND A METHOD FOR THE SYNTHESIS OF PEPTIDES 审中-公开
标题翻译：一种装置和一种合成肽的方法
公开(公告)号：WO1990002605A1
公开(公告)日：1990-03-22
申请号：PCT/DK1989000206
申请日：1989-09-04
申请人： MELDAL, Morten , HOLM, Arne , BUCHARDT, Ole
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00313 , B01J2219/00319 , B01J2219/00367 , B01J2219/00391 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01J2219/00497 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00725 , C40B40/10 , C40B60/14
摘要： An apparatus for use in chemical synthesis, especially peptide synthesis, comprises a synthesis chamber unit having a multiplicity of synthesis chambers, each of which has a liquid inlet and a liquid outlet, means for introducing liquid into the individual synthesis chambers and means for simultaneous removal of liquid via the liquid outlets of the synthesis chambers by regulation of the fluid pressure difference between the liquid inlets and the liquid outlets. A method for peptide synthesis using such an apparatus comprises the provision in each of the synthesis chambers of a solid-phase support material having a first, at least N-protected amino acid coupled thereto, after which a liquid deprotection reagent is introduced into the synthesis chambers. Following deprotection, the deprotection reagent is removed, after which a second, at least N-protected amino acid is introduced into each synthesis chamber in order to couple the first and second amino acids. Third, fourth, etc. amino acids may be coupled analogously. Complete removal of the deprotection reagent from the synthesis chambers and the support material can be ensured by incorporating a stable, intensely coloured dye, e.g., azorubin, in the deprotection reagent. The apparatus and the method make possible the parallel synthesis of a large number of peptides, e.g. peptides having overlapping amino acid sequences and constituting part of a longer peptide chain. The apparatus can be adapted to manual, semi-automatic or fully automatic performance of the various steps in the synthesis procedure.
摘要翻译：用于化学合成，特别是肽合成的装置包括具有多个合成室的合成室单元，每个合成室具有液体入口和液体出口，用于将液体引入各个合成室的装置和用于同时去除的装置通过调节液体入口和液体出口之间的流体压力差，通过合成腔的液体出口。使用这种装置的肽合成方法包括在每个合成室中提供固相支持材料，其具有与其偶联的第一至少N-保护的氨基酸，然后将液体去保护试剂引入合成物室。脱保护后，除去去保护试剂，之后将第二至少N-保护的氨基酸引入每个合成室中，以便连接第一和第二氨基酸。第三，第四等氨基酸可以类似地加成。通过在脱保护试剂中加入稳定的强烈着色的染料，例如偶氮染料，可以确保从合成室和载体材料中完全除去去保护试剂。该装置和方法使得大量肽的并行合成成为可能。肽具有重叠的氨基酸序列并构成较长肽链的一部分。该装置可以适用于手动，半自动或全自动执行合成过程中的各个步骤。

30. 发明申请

WO2019035998A1 SYSTEMS WITH FLUID PATH CONTROL AND REGULATION 审中-公开
公开(公告)号：WO2019035998A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/000281
申请日：2018-08-17
申请人： MODERNATX, INC.
发明人： GELDHOF, Benjamin, Frank
IPC分类号： C12N15/10
CPC分类号： C12N15/10 , B01J19/0046 , B01J2219/00286 , B01J2219/00389 , B01J2219/00418 , B01J2219/00722 , B01L3/502738
摘要： The invention provides devices, systems, and methods for carrying out reactions, e.g., producing nucleic acids, e.g., RNA having a poly(A) sequence, e.g., mRNA, for therapeutic or other use.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式