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11. 发明申请

WO1991001320A1 METHOD FOR RECOVERY OF RIBOFLAVIN 审中-公开
标题翻译： RIBOFLAVIN的恢复方法
公开(公告)号：WO1991001320A1
公开(公告)日：1991-02-07
申请号：PCT/US1990004077
申请日：1990-07-19
申请人： COORS BIOTECH, INC.
发明人： COORS BIOTECH, INC. , GYURE, Dale, C. , LAUDERDALE, George, W.
IPC分类号： C07D475/14
CPC分类号： C07D475/14 , C12P25/00
摘要： A method for the revovery of riboflavin from a fermentation broth or other feed stock is disclosed. The method comprises a process for the production of large, pure riboflavin crystals from an alkaline, aqueous solution containing solubilized riboflavin. The method can further comprise the process for production of large, pure riboflavin crystals in combination with two solids/liquid separation steps, the latter of which can result in a final riboflavin product purity of at least about 96 % by weight. The riboflavin recovery method, in varying degrees of details, is illustrated in Figs. 1 through 3.

12. 发明申请

WO2013018103A2 EXTRACTION OF B-VITAMINS FROM PLANT MATTER 审中-公开
标题翻译：从植物提取B维生素
公开(公告)号：WO2013018103A2
公开(公告)日：2013-02-07
申请号：PCT/IN2012/000528
申请日：2012-07-30
申请人： RAJENDRAN, Ramaswamy , RAJENDRAN, Kamala
发明人： RAJENDRAN, Ramaswamy , RAJENDRAN, Kamala
IPC分类号： C07D475/06
CPC分类号： A61K36/752 , A61K31/16 , A61K31/4406 , A61K31/4415 , A61K31/51 , A61K31/519 , A61K31/525 , A61K36/53 , A61K36/61 , C07D415/00 , C07D475/06 , C07D475/14 , C07H1/08 , C07H23/00
摘要： A process for the extraction of the B group of vitamins from a first plant matter is disclosed wherein, prior to the said extraction operation, the first plant matter is treated with a second plant matter comprising acidic compounds. The acidification converts the said vitamins into more water-soluble forms and increases the yield thereof. In one example, the first plant matter comprises guava fruit matter, holy basil leaves and lemon peels, the two last-mentioned plant species being the source of the acidic compounds. The vitamins extracted and the proportions thereof can be controlled by a suitable choice of the plant species constituting the first and second plant matters and their quantities such as to give a substantially ready formulation conforming to RDA values or other requirements. The vitamins extracted are Bl, B2, B3, B5, B6 and B9, the above combination of plant matters giving higher yield than others. The process is of general applicability to other plant constituents.
摘要翻译：公开了从第一植物物质中提取B族维生素的方法，其中在所述提取操作之前，用包含酸性化合物的第二植物物质处理第一植物物质。酸化将所述维生素转化为更多的水溶性形式并提高其产率。在一个实例中，第一植物物质包括番石榴果实物质，圣罗勒叶和柠檬皮，两种最后提到的植物物种是酸性化合物的来源。提取的维生素及其比例可以通过适当选择构成第一和第二植物物质的植物物种及其数量来控制，从而给出符合RDA值或其他要求的基本准备的制剂。提取的维生素是B1，B2，B3，B5，B6和B9，上述植物物质的组合比其他物质产生更高的产量。该方法对其他植物成分具有普遍适用性。

13. 发明申请

WO2012175729A1 10H-BENZO[G]PTERIDIN-2,4-DION-DERIVATE, VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG DERSELBEN 审中-公开
标题翻译： -10H-苯并[g]蝶-2,4-二酮衍生物，METHOD FOR生产和使用THEREOF
公开(公告)号：WO2012175729A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/062172
申请日：2012-06-22
申请人： TRIOPTO TEC GMBH , BÄUMLER, Wolfgang , MAISCH, Tim , SPÄTH, Andreas
发明人： BÄUMLER, Wolfgang , MAISCH, Tim , SPÄTH, Andreas
IPC分类号： C07D475/14 , A61K31/525 , A61K41/00 , A61P31/00
CPC分类号： C07D475/14 , A01N43/90 , A61K8/4953 , A61K31/525 , A61K41/0057 , A61L31/08 , A61L31/16 , A61L2300/404 , A61Q11/00 , A61Q11/02 , A61Q17/005 , C11D3/48
摘要： Die vorliegende Erfindung betrifft 10H-Benzo(g)pteridin-2,4-dion-Derivate, deren Herstellung und Verwendung.
摘要翻译：本发明涉及-10H-苯并（克）蝶啶-2,4-二酮衍生物，它们的制备和用途。

14. 发明申请

WO2011126567A1 FLAVIN DERIVATIVES 审中-公开
标题翻译： FLAVIN衍生物
公开(公告)号：WO2011126567A1
公开(公告)日：2011-10-13
申请号：PCT/US2011/000617
申请日：2011-04-06
申请人： BIORELIX, INC. , COISH, Philip, D., G. , DIXON, Brian, R. , OSTERMAN, David , ARISTOFF, Paul, Adrian , NAVIA, Manuel , SCIAVOLINO, Frank , AVOLA, Stephanie , BABOULAS, Nick , BELLIOTTI, Thomas, R. , BELLO, Angelica , BERMAN, Judd , CHRUSCIEL, Robert, A. , EVANS, Bruce, R. , KAUR, Harpreet , MOON, David , PHAM, Vinh , ROUGHTON, Andrew , WICKENS, Phil , WILSON, Jeffrey
发明人： COISH, Philip, D., G. , DIXON, Brian, R. , OSTERMAN, David , ARISTOFF, Paul, Adrian , NAVIA, Manuel , SCIAVOLINO, Frank , AVOLA, Stephanie , BABOULAS, Nick , BELLIOTTI, Thomas, R. , BELLO, Angelica , BERMAN, Judd , CHRUSCIEL, Robert, A. , EVANS, Bruce, R. , KAUR, Harpreet , MOON, David , PHAM, Vinh , ROUGHTON, Andrew , WICKENS, Phil , WILSON, Jeffrey
IPC分类号： A01N43/58
CPC分类号： A01N43/90 , C07D475/14
摘要： The present invention relates novel flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives.
摘要翻译：本发明涉及新的黄素衍生物，其用途和用作核糖开关配体和/或抗感染剂的组合物。

15. 发明申请

WO2008114009A1 10H-BENZO(G)PTERDINE-2,4-DIONE COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开
标题翻译： 10H-BENZO（G）Pterdine-2,4-Dione化合物治疗增殖性疾病
公开(公告)号：WO2008114009A1
公开(公告)日：2008-09-25
申请号：PCT/GB2008/000962
申请日：2008-03-18
申请人： CAMBRIDGE ENTERPRISE LTD. , BALASUBRAMANIAN, Shankar , BEJUGAM, Mallesham
发明人： BALASUBRAMANIAN, Shankar , BEJUGAM, Mallesham
IPC分类号： C07D475/14 , A61K31/519
CPC分类号： C07D475/14
摘要： This invention pertains generally to the field of G-quadruplex ligands, and more particularly, to certain 10H-benzo[g]pteridine-2,4-dione compounds ("BPD compounds"), as described herein, which, inter alia , (selectively) bind (and stabilize) G-quadruplexes. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo , to (selectively) bind (and stabilize) G-quadruplexes, to inhibit telomerase, to regulate cell proliferation, and in the treatment of proliferative disorders, such as cancer. Formula (I):
摘要翻译：本发明一般涉及G-四链体配体领域，更具体地涉及如本文所述的某些10H-苯并[g]蝶啶-2,4-二酮化合物（“BPD化合物”），其特别包括（选择性地）绑定（并稳定）G-四极杆。本发明还涉及包含这种化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途（选择性地）结合（并稳定）G-四链体，抑制端粒酶调节细胞增殖，以及治疗增殖性疾病如癌症。式（I）：

16. 发明申请

WO2004043338A2 FLAVIN N-OXIDES: NEW ANTI-CANCER AGENTS AND PATHOGEN ERADICATION AGENTS 审中-公开
标题翻译： FLAVIN N-OXIDES：新型抗癌药物和病毒侵袭剂
公开(公告)号：WO2004043338A2
公开(公告)日：2004-05-27
申请号：PCT/US0314673
申请日：2003-05-12
申请人： UNIV OHIO STATE , PLATZ MATTHEW S
发明人： PLATZ MATTHEW S
IPC分类号： A61K31/525 , A61K31/7056 , A61K39/245 , A61K41/00 , A61K45/06 , C07D475/14 , C12N5/08 , A61K
CPC分类号： C07D475/14 , A61K31/525 , A61K31/7056 , A61K41/00 , A61K41/0019 , A61K41/0038 , A61K45/06 , A61K2300/00
摘要： Compounds comprising flavin N-oxides for treatments of solid tumors, non-solid tumor masses, leukemias, and non-small cell lung cancers and for eradicating contaminants in blood products. Methods of treating patients having solid type cancers comprising administering a therapeutically effective amount of flavin N-oxide to a subject in need of treatment and exposing the flavin n-oxide to an activator such that activation of the flavin N-oxide results in damage to the DNA in the cancer cells without substantial damage to the DNA of normal cells are also provided. Methods of using a flavin N-oxide as part of a combination therapy with chemotherapy, radiation therapy, or both are also provided. methods of reducing pathogenic bacterial or rival contamination in a composition comprising a) mixing the composition with an efficacious amount of flavin N-oxide and b) exposing the mixture of the composition and the flavin N-oxide to an activator for a period of time sufficient to activate the flavin N-oxide such that the flavin N-oxide reduces the contamination in the composition are also provided. Preferably, the composition is a blood product selected from plasma, platelets, and red blood cells, and the activator is an enzyme.
摘要翻译：包含用于治疗实体瘤，非固体肿瘤块，白血病和非小细胞肺癌的黄素N-氧化物的化合物和用于消除血液制品中的污染物。治疗患有固体型癌症的患者的方法包括向需要治疗的受试者施用治疗有效量的黄素N-氧化物，并将黄素N-氧化物暴露于活化剂，使得黄素N-氧化物的活化导致对还提供了对正常细胞的DNA没有实质损伤的癌细胞中的DNA。还提供了使用黄素N-氧化物作为化疗，放射治疗或两者的组合疗法的一部分的方法。减少组合物中致病性细菌或对抗污染的方法，其包括：a）将组合物与有效量的黄素N-氧化物混合，和b）将组合物和黄素N-氧化物的混合物暴露于活化剂足够长的时间以激活黄素N-氧化物，使得黄素N-氧化物还减少组合物中的污染物。优选地，组合物是选自血浆，血小板和红细胞的血液制品，并且活化剂是酶。

17. 发明申请

WO2003075935A1 リボフラビン系化合物を含む医薬审中-公开
标题翻译：含有RIBOFLAVIN型化合物的药物
公开(公告)号：WO2003075935A1
公开(公告)日：2003-09-18
申请号：PCT/JP2003/002868
申请日：2003-03-11
申请人：エーザイ株式会社 , 荒木誠一 , 鈴木護 , 児玉耕太郎 , 豊澤逸生
发明人：荒木誠一 , 鈴木護 , 児玉耕太郎 , 豊澤逸生
IPC分类号： A61K31/675
CPC分类号： C07F9/65618 , A61K31/525 , A61K31/675 , C07D475/14
摘要： It is intended to provide drugs which contain as the active ingredient at least one member selected from among riboflavin, riboflavin derivatives and pharmacologically acceptable salts thereof and have an effect of inhibiting a cytokine such as IL-1beta, IL-6, IL-10, INF-gamma, TNF-alpha, GM-CSF, IL-8 or MCP-1; and preventives or remedies for inflammatory diseases accompanied by hypercytokinemia which have an excellent cytokine inhibitory effect.
摘要翻译：旨在提供含有作为活性成分的至少一种选自核黄素，核黄素衍生物及其药理学上可接受的盐的药物，并且具有抑制细胞因子如IL-1β，IL-6，IL-10， INF-γ，TNF-α，GM-CSF，IL-8或MCP-1; 以及伴有高细胞因子抑制作用的高细胞因子血症的炎性疾病的预防药物或治疗药物。

18. 发明申请

WO1997003208A1 RIBOFLAVIN-PRODUCTION PROCESS BY MEANS OF MICRO-ORGANISMS WITH MODIFIED ISOCITRATLYASE ACTIVITY 审中-公开
标题翻译：与改进的工艺用于生产核黄素用微生物异柠檬酸活动
公开(公告)号：WO1997003208A1
公开(公告)日：1997-01-30
申请号：PCT/EP1996003009
申请日：1996-07-10
申请人： BASF AKTIENGESELLSCHAFT , FORSCHUNGSZENTRUM JÜLICH GMBH , KÄSLER, Bruno , SAHM, Hermann , STAHMANN, Klaus-Peter , SCHMIDT, Georg , BÖDDECKER, Theo , SEULBERGER, Harald
发明人： BASF AKTIENGESELLSCHAFT , FORSCHUNGSZENTRUM JÜLICH GMBH
IPC分类号： C12P25/00
CPC分类号： C07D475/14 , A23K20/174 , C12P25/00
摘要： A microbial riboflavin-production process is disclosed. Riboflavin-producing micro-organisms are cultivated in a culture medium and the thus produced riboflavin is then isolated. The process is characterised in that the endogenous isocitratlyase activity (ICL) of the micro-organisms used has been modified.
摘要翻译：一种用于通过在营养培养基和核黄素生产，随后分离培养核黄素生产微生物的微生物制剂核黄素的方法，其特征在于，微生物是使用其中的内源性异柠檬酸裂合酶（ICL）的活性已被改变。

19. 发明申请

WO2016153910A1 METHOD OF STABILIZING RIBOFLAVIN 审中-公开
标题翻译：稳定RIBOFLAVIN的方法
公开(公告)号：WO2016153910A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/022816
申请日：2016-03-17
申请人： ELC MANAGEMENT LLC
发明人： SOJKA, Milan Franz , STANGANELLI, Kerri
IPC分类号： A61K8/49 , A61K8/73 , A61K31/519 , A61Q19/08 , A61Q19/06 , A61P17/00
CPC分类号： C07D475/14 , A61K8/0241 , C08B37/0072
摘要： A method of stabilizing riboflavin by affixing the riboflavin to at least one substrate for the riboflavin by covalent bonding, hydrogen bonding, Van der Waals forces, or a combination thereof, to form an optically-activated complex, is provided. When activated by absorption of light in the ultraviolet (UV) to visible region of the electromagnetic spectrum the riboflavin in the complex re-emits light of longer wavelength in the blue-green-yellow region of the electromagnetic spectrum.
摘要翻译：提供了通过共价键合，氢键合，范德华力或其组合将核黄素固定在核黄素的至少一个底物上以形成光学活化复合物来稳定核黄素的方法。当通过紫外线（UV）中的光吸收到电磁光谱的可见区域而激活时，复合物中的核黄素在电磁光谱的蓝绿色 - 黄色区域中再发射较长波长的光。

20. 发明申请

WO2013018103A3 EXTRACTION OF B-VITAMINS FROM PLANT MATTER 审中-公开
标题翻译：从植物提取B维生素
公开(公告)号：WO2013018103A3
公开(公告)日：2014-06-19
申请号：PCT/IN2012000528
申请日：2012-07-30
申请人： RAJENDRAN RAMASWAMY , RAJENDRAN KAMALA
发明人： RAJENDRAN RAMASWAMY , RAJENDRAN KAMALA
IPC分类号： C07D475/06
CPC分类号： A61K36/752 , A61K31/16 , A61K31/4406 , A61K31/4415 , A61K31/51 , A61K31/519 , A61K31/525 , A61K36/53 , A61K36/61 , C07D415/00 , C07D475/06 , C07D475/14 , C07H1/08 , C07H23/00
摘要： A process for the extraction of the B group of vitamins from a first plant matter is disclosed wherein, prior to the said extraction operation, the first plant matter is treated with a second plant matter comprising acidic compounds. The acidification converts the said vitamins into more water-soluble forms and increases the yield thereof. In one example, the first plant matter comprises guava fruit matter, holy basil leaves and lemon peels, the two last-mentioned plant species being the source of the acidic compounds. The vitamins extracted and the proportions thereof can be controlled by a suitable choice of the plant species constituting the first and second plant matters and their quantities such as to give a substantially ready formulation conforming to RDA values or other requirements.
摘要翻译：公开了从第一植物物质中提取B族维生素的方法，其中在所述提取操作之前，用包含酸性化合物的第二植物物质处理第一植物物质。酸化将所述维生素转化为更多的水溶性形式并提高其产率。在一个实例中，第一植物物质包括番石榴果实物质，圣罗勒叶和柠檬皮，两种最后提到的植物物种是酸性化合物的来源。提取的维生素及其比例可以通过适当选择构成第一和第二植物物质的植物物种及其数量来控制，从而给出符合RDA值或其他要求的基本准备的制剂。

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