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11. 发明申请

WO2016195480A1 MICROFLUIDIC PLATE 审中-公开
标题翻译：微流感板
公开(公告)号：WO2016195480A1
公开(公告)日：2016-12-08
申请号：PCT/NL2015/050416
申请日：2015-06-05
申请人： MIMETAS B.V.
发明人： TRIETSCH, Sebastiaan Johannes , VULTO, Paul
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/0684 , B01L2200/12 , B01L2300/069 , B01L2300/0829 , B01L2300/0858 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , B01L2400/088 , C12M23/16
摘要： Microfluidic plate comprising a plurality of microfluidic networks and inlets providing access to the microfluidic networks, wherein each microfluidic network comprises a capillary pressure barrier and extends through a first plane, each inlet is formed by an inlet chamber having a bottom surface, a support structure is provided above each inlet, which support structure defines an opening and comprises at least one support member positioned at the opening such that a circle can be defined in a second plane extending parallel to the first plane, which circle has the largest possible diameter while being completely located within the opening and in contact with the at least one support member, and the support structure is configured such that a first empty space is formed, which first empty space extends from the second plane towards the inlet chamber and has the form of a right circular cone or a truncated right circle cone, wherein the circle forms a base plane of the right circular cone or the truncated right circle cone.
摘要翻译：微流体板包括多个微流体网络和入口，其提供对微流体网络的访问，其中每个微流体网络包括毛细压力屏障并且延伸穿过第一平面，每个入口由具有底表面的入口腔形成，支撑结构是设置在每个入口上方，该支撑结构限定开口并且包括定位在开口处的至少一个支撑构件，使得可以在平行于第一平面延伸的第二平面中限定圆，该圆具有最大可能的直径，同时完全位于所述开口内并且与所述至少一个支撑构件接触，并且所述支撑结构构造成使得形成第一空白空间，所述第一空白空间从所述第二平面朝向所述入口室延伸并且具有右侧的形式圆形圆锥体或截圆形圆锥体，其中圆形成右圆形co的基面 ne或截断的右圆锥体。

12. 发明申请

WO2016183521A1 METHODS AND SYSTEMS FOR BIOMONITORING 审中-公开
标题翻译：用于生物化的方法和系统
公开(公告)号：WO2016183521A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/032544
申请日：2016-05-13
申请人： NEWOMICS INC.
发明人： WANG, Daojing , MAO, Pan
IPC分类号： B01L3/00 , G01N33/48 , G01N27/62 , B01D15/08
CPC分类号： G01N33/5308 , B01L3/502715 , B01L3/502738 , B01L3/502753 , B01L3/502784 , B01L2200/0647 , B01L2300/023 , B01L2300/024 , B01L2300/0645 , B01L2300/0816 , B01L2400/0421 , B01L2400/0424 , B01L2400/0622 , G01N30/463 , G01N30/6095 , G01N30/7266 , G01N30/88 , G01N33/48 , G01N33/50 , G01N33/5038 , G01N33/57488 , G01N2030/8813
摘要： The present disclosure provides methods and systems for detecting a presence or absence of one or more analytes in small volumes of samples. The detected presence or absence of the one or more analytes can be used for a variety of applications including biomonitoring.
摘要翻译：本公开提供用于检测小体积样品中一种或多种分析物的存在或不存在的方法和系统。检测到的一种或多种分析物的存在或不存在可用于多种应用，包括生物监测。

13. 发明申请

WO2016172724A1 FLUIDIC TEST CASSETTE 审中-公开
标题翻译：流体测试CASSETTE
公开(公告)号：WO2016172724A1
公开(公告)日：2016-10-27
申请号：PCT/US2016/029246
申请日：2016-04-25
申请人： MESA BIOTECH, INC.
发明人： NOWAKOWSKI, Mark , WANG, Michael , CARY, Robert, B. , CAI, Hong , LINDBERG, Conrad , BOULIANE, Martin , THOMAS, Donald, J.
IPC分类号： G01N21/05 , G01N21/13 , G01N21/65
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/0621 , B01L2200/0689 , B01L2200/147 , B01L2200/16 , B01L2300/0883 , B01L2300/123 , B01L2300/1827 , B01L2400/0406 , B01L2400/0457 , B01L2400/0677 , B01L2400/0694 , C12Q1/6816 , C12Q2565/629
摘要： A disposable cassette for detecting nucleic acids or performing other assays. The cassette can be inserted into a base station during use. The cassette has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The cassette also can have a gasket to ensure free air movement between open vent pockets. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with the vent pockets and the chambers. The detection chamber, which houses a lateral flow detection strip can have a space below the strip that has sufficient capacity to accommodate an entire volume of the sample fluid entering the detection chamber at a height that enables the fluid to flow up the detection strip by capillary action without flooding or otherwise bypassing regions of the detection strip. The space can also contain detection particles. Recesses in in the cassette channels or chambers can have structures such as ridges or grooves to direct fluid flow to enhance rehydration of lyophilized reagents disposed in the recess. Flow diverters in the chambers can reduce the flow velocity of the sample fluid and increase the effective fluid flow path length, enabling more accurate control of fluid flow in the cassette.
摘要翻译：用于检测核酸或执行其他测定的一次性盒。在使用过程中，盒可插入基站。该盒具有许多特征，以确保装置在重力作用下的正确操作，例如当排气口未密封时能使样品流体从一个室流到下一个室的通气口。排气口具有突起，有助于防止意外重新密封。盒式磁带还可以具有垫圈，以确保敞开的排气口之间的自由空气运动。具有设置在热稳定材料上的图案化金属电气部件的柔性电路可以与腔室中的流体直接接触并且具有与排气口和腔室对准的电阻加热元件。容纳侧向流动检测条的检测室可以具有在条带下方的空间，其具有足够的容量以容纳进入检测室的整个体积的样品流体，使得流体能够通过毛细管向上流过检测条动作不会溢出或以其他方式绕过检测条的区域。该空间还可以包含检测颗粒。盒式通道或腔室中的凹陷可以具有诸如脊或凹槽的结构，以引导流体流动以增强设置在凹部中的冻干试剂的再水化。腔室中的分流器可以减少样品流体的流速并增加有效的流体流动路径长度，从而能更准确地控制盒中的流体流动。

14. 发明申请

WO2016164359A1 RARE CELL ISOLATION DEVICE AND METHOD OF USE THEREOF 审中-公开
标题翻译：稀有细胞分离装置及其使用方法
公开(公告)号：WO2016164359A1
公开(公告)日：2016-10-13
申请号：PCT/US2016/026041
申请日：2016-04-05
申请人： TUMORGEN MDX LLC
发明人： ALLEN, Jeffrey, K. , ALLEN, Alexander, G. , ALLEN, Austin, E.
IPC分类号： B01L3/00 , C12M1/34 , G01N30/80 , G01N33/50 , G01N35/02
CPC分类号： G01N33/57407 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L2200/0652 , B01L2200/12 , B01L2300/0636 , B01L2300/0816 , B01L2300/0851 , B01L2300/0883 , B01L2300/1822 , B01L2400/0415 , B01L2400/0418 , B01L2400/0677 , B01L2400/086 , C12M47/04 , C12Q1/68 , C12Q1/6869 , G01N27/44791 , G01N33/54386 , G01N33/548 , G01N33/57492 , G01N33/582 , G01N2030/8813 , G01N2800/52
摘要： This invention concerns patentable devices configured to capture cancer stem cells and cell clusters. After capturing such cells and/or clusters, the cancerous cells are subjected to whole genome sequencing. The resulting genomic sequence information is then compared to that for "normal" or non-diseased tissue (obtained, for example, from either the same patient, or a population sample, etc.) in order to identify the specific genetic mutation(s) present in the CSCs. Further analysis then correlates the genetic mutations with cell growth signaling pathways typically found with tumor metastases. Armed with this information, an oncologist can then develop a specifically targeted therapy that utilizes approved drugs or drug candidates undergoing clinical testing to address the identified driver mutations and thus effect a "targeted" therapy tailored to the particular patient's disease.
摘要翻译：本发明涉及被配置为捕获癌症干细胞和细胞簇的可专利的装置。在捕获这样的细胞和/或簇后，对癌细胞进行全基因组测序。然后将得到的基因组序列信息与“正常”或非病变组织（例如，从相同的患者或群体样品等获得）进行比较，以鉴定特异性遗传突变存在于CSCs中。然后进一步分析将遗传突变与通常与肿瘤转移发现的细胞生长信号通路相关联。随着这些信息，肿瘤学家可以开发专门针对性的治疗方法，利用经过临床测试的经批准的药物或药物候选者来解决所识别的驱动突变，从而实现针对特定患者疾病的“靶向”治疗。

15. 发明申请

WO2016153428A1 FLOW CELL APPARATUS AND METHOD OF ANALYSING BIOFILM DEVELOPMENT 审中-公开
标题翻译：流式细胞仪和分析生物膜发育方法
公开(公告)号：WO2016153428A1
公开(公告)日：2016-09-29
申请号：PCT/SG2016/050131
申请日：2016-03-22
申请人： NANYANG TECHNOLOGICAL UNIVERSITY , NATIONAL UNIVERSITY OF SINGAPORE
发明人： LAM, Yee Cheong , LIM, Chun Ping , NGUYEN, Quoc Mai Phuong , COHEN, Yehuda
IPC分类号： C12M1/00 , B01L3/00 , C12Q1/00
CPC分类号： C12Q1/02 , B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L3/502746 , B01L9/52 , B01L2200/025 , B01L2200/0636 , B01L2200/0689 , B01L2300/0822 , B01L2300/0861 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/161 , C12Q1/001
摘要： A flow cell apparatus including a channel plate having a channel recessed into a surface of the channel plate, and a groove recessed into the surface of the channel plate, the groove configured to surround the channel and preferably along a boundary of the channel. The flow cell apparatus further includes a seal shaped and receivable in the groove, a substrate, a backing plate, and a fastening element configured to removably attach the channel plate to the backing plate with the substrate sandwiched between the channel plate and the backing plate to bear the seal against the channel plate with the substrate.
摘要翻译：一种流通池装置，包括通道板，该通道板具有凹入通道板的表面的通道，以及凹入到通道板的表面中的凹槽，所述凹槽被构造成围绕通道并且优选沿着通道的边界。流动池装置还包括形成并可容纳在凹槽中的密封件，基底，背板和紧固元件，其构造成将通道板可移除地附接到背板，衬底夹在通道板和背板之间，用衬底承受通道板的密封。

16. 发明申请

WO2016127009A1 ACTUATED VALVE OR PUMP FOR MICROFLUIDIC DEVICES 审中-公开
标题翻译：用于微流体装置的致动阀或泵
公开(公告)号：WO2016127009A1
公开(公告)日：2016-08-11
申请号：PCT/US2016/016666
申请日：2016-02-04
申请人： THE CHARLES STARK DRAPER LABORATORY, INC.
发明人： MESCHER, Mark Joseph , COPPETA, Jonathan Robert , SPENCER, Abigail June , ISENBERG, Brett
IPC分类号： F16K99/00
CPC分类号： B01L3/502738 , B01L2200/027 , B01L2300/0816 , B01L2300/12 , B01L2300/123 , B01L2300/14 , B01L2400/0638 , B01L2400/082 , C12M21/08 , C12M23/16 , F16K7/126 , F16K99/0015 , F16K2099/008
摘要： Systems and methods disclosed herein related to an apparatus including a fluid flow plate and a microfluidic valve assembly. The fluid flow plate includes a plurality of polymer layers that define a fluid flow passage through the microfluidic valve assembly. The microfluidic valve assembly includes a valve seat, a flexible membrane, a valve cavity, a valve head, and an actuator. The actuator is configured to selectively control pressure applied by the valve head to the flexible membrane, such that in a first actuator state the valve head depresses the flexible membrane into the valve cavity and into contact with the valve seat, thereby preventing fluid flow through the valve assembly, and in a second state, the valve head and the flexible membrane are retracted substantially out of the valve cavity allowing fluid to flow through the valve assembly. In various implementations, the valve seat and/or the flexible membrane include an elastomer layer.
摘要翻译：本文公开的系统和方法涉及包括流体流动板和微流体阀组件的装置。流体流动板包括限定通过微流体阀组件的流体流动通道的多个聚合物层。微流体阀组件包括阀座，柔性膜，阀腔，阀头和致动器。致动器构造成选择性地控制由阀头施加到柔性膜的压力，使得在第一致动器状态下，阀头将柔性膜压入阀腔并与阀座接触，从而防止流体流过阀组件，并且在第二状态下，阀头和柔性膜基本上缩回到阀腔外，允许流体流过阀组件。在各种实施方案中，阀座和/或柔性膜包括弹性体层。

17. 发明申请

WO2016116790A1 MICRODIALYSIS DEVICE 审中-公开
标题翻译： MICRODIALYSIS设备
公开(公告)号：WO2016116790A1
公开(公告)日：2016-07-28
申请号：PCT/IB2015/059719
申请日：2015-12-17
申请人： KWAZULU-NATAL RESEARCH INSTITUTE FOR TB-HIV (K-RITH) NPC
发明人： BALAGADDÉ, Frederick Kiguli , LUTHULI, Brilliant Bonisile
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L2300/0819 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2400/0472 , B01L2400/0487 , C12Q1/18
摘要： This invention relates to microfluidics and provides a microfluidic device comprising a fluid flow circuit that includes an array of microfluidic chemical reaction chambers (100) with differing internal volumes, the reaction chambers (100) being configured to receive a chemical- containing fluid by way of the fluid flow circuit and to retain the fluid for the duration of all or part of a chemical reaction involving one or more of the chemicals contained in the fluid. The reaction chambers (100) are configured in groups in which each reaction chamber in a group has a similar volumetric size to the other reaction chambers in that group of reaction chambers (100).
摘要翻译：本发明涉及微流体并且提供了一种微流体装置，其包括流体流动回路，该流体流动回路包括具有不同内部体积的微流体化学反应室（100）的阵列，所述反应室（100）构造成通过以下方式接收含化学物质的流体：流体流动回路并且在所有或部分化学反应的持续时间内保持流体，所述化学反应涉及包含在流体中的一种或多种化学物质。反应室（100）以组中的每个反应室具有与该组反应室（100）中的其它反应室相似的体积尺寸的组构成。

18. 发明申请

WO2016084381A1 微細液送構造体、及び分析装置审中-公开
标题翻译：微液体转移结构与分析装置
公开(公告)号：WO2016084381A1
公开(公告)日：2016-06-02
申请号：PCT/JP2015/005904
申请日：2015-11-27
申请人：東洋製罐グループホールディングス株式会社
发明人：大貫　隆司 , 國則　正弘 , 岩崎　力
IPC分类号： G01N35/08 , B01J19/00 , B81B1/00 , G01N33/543 , G01N37/00 , C12M1/00
CPC分类号： B01L3/50273 , B01J19/00 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0877 , B01L2300/165 , B01L2400/0406 , B01L2400/0688 , B01L2400/084 , B01L2400/086 , B81B1/00 , C12M1/00 , G01N33/543 , G01N33/54366 , G01N35/08 , G01N37/00
摘要：　複数の微細突起６０が一列に並び、かつ、隣接する微細突起６０の間隙を液送路６１とする単位列が周期的に列設され、それぞれの微細突起６０の間隔が、毛細管現象を引き起こす間隔となるように配列し、単位列ごとに、液送路６１のうち少なくとも一つを、他の液送路６１ｂよりも流動抵抗を相対的に低減させた低流動抵抗液送路６１ａとするとともに、低流動抵抗液送路６１ａが所定の液送方向に沿って配置されるように、微細突起６０を配列する。これにより、液送方向に偏りが生じることなく、液送方向を再現性よく任意に制御することができる。
摘要翻译：在本发明中，由排列成一列的多个微突起60构成的单元行，使得相邻的微突起60之间的间隙为液体传递路径61周期性地设置; 微突起60之间的间隙设置为引起毛细作用的间隙; 在每个单元行中，至少一个液体传送路径61被制成具有比其它液体传送路径61b的流动阻力低的低阻力液体传送路径61a; 并且微突起60排列成使得低流阻电阻流体传送通道61a沿着规定的液体输送方向设置。结果，可以以高再现性任意地控制液体流动方向，而不会发生液体转移方向偏差。

19. 发明申请

WO2016020775A1 DIAGNOSTIC, PROGNOSTIC, AND ANALYTICAL SYSTEM 审中-公开
标题翻译：诊断，预防和分析系统
公开(公告)号：WO2016020775A1
公开(公告)日：2016-02-11
申请号：PCT/IB2015/055117
申请日：2015-07-07
申请人： KIMIYA PTY. LTD.
发明人： AZIMI, Mehdi , WORSMAN, Matthew Taylor , ALAVIOON, Sara , VONWILLER, Simone Charlotte
IPC分类号： G01N21/00 , G01N33/48 , G01N33/487 , G01N21/85 , G01N21/01 , G01N21/75 , G01N33/574
CPC分类号： C12Q1/6818 , A61B10/0041 , A61B10/0045 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/12 , B01L2200/14 , B01L2300/023 , B01L2300/0654 , B01L2300/0877 , B01L2300/0887 , B01L2300/1805 , B01L2400/0478 , B01L2400/0633 , C12Q1/6825 , G01N21/00 , G01N21/01 , G01N21/66 , G01N21/75 , G01N21/85 , G01N33/48 , G01N33/54366 , G01N33/57415
摘要： A device for analyzing a liquid sample. The device includes an inlet for receiving the sample, a reaction chamber, an analysis module, and at least one pump for moving fluid within the one or more flow paths. The device includes one or more flow paths arranged so as to provide a fluid flow path between the inlet and the reaction chamber, and a fluid flow path between the reaction chamber and the analysis module. The device may be used for analysing a liquid sample, such as, but not limited to nipple aspirate fluid (NAF).
摘要翻译：用于分析液体样品的装置。该装置包括用于接收样品的入口，反应室，分析模块和用于在一个或多个流动路径内移动流体的至少一个泵。该装置包括一个或多个流动路径，其布置成在入口和反应室之间提供流体流动路径，以及在反应室和分析模块之间的流体流动路径。该装置可用于分析液体样品，例如但不限于乳头抽吸液（NAF）。

20. 发明申请

WO2015150429A3 PASSIVE MICRO-VESSEL AND SENSOR 审中-公开
标题翻译：被动微型船和传感器
公开(公告)号：WO2015150429A3
公开(公告)日：2016-01-21
申请号：PCT/EP2015057126
申请日：2015-03-31
申请人： FLUIDION
发明人： ANGELESCU DAN , HAUSOT ANDREAS
IPC分类号： G01N1/10 , A61B5/00 , A61B5/06 , A61B10/00 , A61J1/00 , A61M31/00 , B01L3/00 , E21B41/00 , E21B49/08 , G01N1/16 , G01N33/18 , G01T7/02
CPC分类号： G01N1/10 , A61B5/061 , A61B10/0035 , A61B10/0045 , A61B2010/008 , A61M31/002 , B01L3/502715 , B01L3/502738 , B01L2200/027 , B01L2300/0816 , B01L2400/0683 , E21B49/081 , G01N1/16 , G01N2001/1031 , G01N2001/1056 , G01V1/02
摘要： An electrically passive device and method for in-situ acoustic emission, and/or releasing, sampling and/or measuring of a fluid or various material(s) is provided. The device may provide a robust timing mechanism to release, sample and/or perform measurements on a predefined schedule, and, in various embodiments, emits an acoustic signal sequence(s) that may be used for triangulation of the device position within, for example, a hydrocarbon reservoir or a living body.
摘要翻译：提供了一种用于原位声发射，和/或释放，采样和/或测量流体或各种材料的电动被动装置和方法。该设备可以提供鲁棒的定时机制来以预定的时间表发布，采样和/或执行测量，并且在各种实施例中，发射可用于例如在设备位置的三角测量的声信号序列，油气藏或生物体。

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