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    • 14. 发明申请
    • ALTERATION OF SURFACE AFFINITIES
    • 表面附着力的改变
    • WO2004067191A2
    • 2004-08-12
    • PCT/US2004/002498
    • 2004-01-29
    • PRESIDENT AND FELLOWS OF HARWARD COLLEGEJIANG, XingyuFERRIGNO, RosariaWHITESIDES, George, M.
    • JIANG, XingyuFERRIGNO, RosariaWHITESIDES, George, M.
    • B05D3/14
    • B82Y30/00B01J20/3204B01J20/321B01J20/3212B01J20/3225B01J20/3227B01J20/3248B01J20/3251B01J20/3274B01J20/3285B01J2219/00497B01J2219/00527B01J2219/00576B01J2219/00585B01J2219/00596B01J2219/00653B01J2219/00659B01J2219/00677B01J2219/00722B01J2219/00725B01J2219/00743B05D3/14B05D3/207G01N33/54353G01N2610/00Y10S436/823Y10T436/118339
    • The present invention provides a series of methods, compositions, and articles for altering a property of a surface (for example, the cytophilicity and/or the hydrophilicity), by exposing at least a portion of the surface to a non-chemical, force-creating field and/or force, such as an electric field. The field/force may be created by any suitable technique. For instance, the field can be created by applying a voltage across the surface, by electrical induction, etc. In certain embodiments, the surface includes molecules attached thereto that can be detached when exposed to non-chemical, force-creating fields and/or forces, thereby altering the chemical composition of at least a portion of the surface. In one set of embodiments, the molecules attached to the surface may include molecules forming a self-assembled monolayer on the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in an alkanethiol), by which the molecule can become attached to the surface. In certain cases, the molecules may be terminated at the unattached end with one or more hydrophilic groups, for example, unmodified ethylene glycol moieties. In some cases, the molecules attached to the surface may include one or more moieties that can bind to various entities such as proteins, peptides, nucleic acids, drugs, cells, etc. In certain embodiments, the techniques are used to enable novel assays for cell motility and/or spreading and screening tests for determining drugs and/or treatments effective in increasing or decreasing cell shape changes and/or motility on surfaces.
    • 本发明提供了用于通过暴露至少一部分表面来改变表面性质(例如亲细胞性和/或亲水性)的一系列方法,组合物和制品 到非化学的,产生力的场和/或力,例如电场。 场/力可以通过任何合适的技术来创建。 例如,可以通过在表面上施加电压,通过电感应等来产生场。在某些实施方案中,表面包括附着于其上的分子,当暴露于非化学力产生场时可以将其分离,和/或 从而改变至少一部分表面的化学组成。 在一组实施方案中,附着于表面的分子可以包括在表面上形成自组装单层的分子。 在一些实施方案中,连接到表面的分子可以包括硫醇部分(例如,如在烷硫醇中),通过该硫醇部分该分子可以附着到表面。 在某些情况下,分子可以在一个或多个亲水基团(例如未改性的乙二醇部分)的未连接末端处终止。 在一些情况下,附着于表面的分子可以包括一个或多个可结合各种实体的部分,例如蛋白质,肽,核酸,药物,细胞等。在某些实施方案中,所述技术用于实现用于 细胞运动性和/或扩散和筛选测试以确定有效增加或减少细胞形状变化和/或表面运动性的药物和/或治疗。