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1. 发明申请

WO2004067191A3 ALTERATION OF SURFACE AFFINITIES 审中-公开
标题翻译：表面活性物质的改变
公开(公告)号：WO2004067191A3
公开(公告)日：2004-12-23
申请号：PCT/US2004002498
申请日：2004-01-29
申请人： HARVARD COLLEGE , JIANG XINGYU , FERRIGNO ROSARIA , WHITESIDES GEORGE M
发明人： JIANG XINGYU , FERRIGNO ROSARIA , WHITESIDES GEORGE M
IPC分类号： B01J20/32 , B05D3/14
CPC分类号： B82Y30/00 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3225 , B01J20/3227 , B01J20/3248 , B01J20/3251 , B01J20/3274 , B01J20/3285 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B05D3/14 , B05D3/207 , G01N33/54353 , G01N2610/00 , Y10S436/823 , Y10T436/118339
摘要： The present invention provides a series of methods, compositions, and articles for altering a property of a surface (for example, the cytophilicity and/or the hydrophilicity), by exposing at least a portion of the surface to a non-chemical, force-creating field and/or force, such as an electric field. The field/force may be created by any suitable technique. For instance, the field can be created by applying a voltage across the surface, by electrical induction, etc. In certain embodiments, the surface includes molecules attached thereto that can be detached when exposed to non-chemical, force-creating fields and/or forces, thereby altering the chemical composition of at least a portion of the surface. In one set of embodiments, the molecules attached to the surface may include molecules forming a self-assembled monolayer on the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in an alkanethiol), by which the molecule can become attached to the surface. In certain cases, the molecules may be terminated at the unattached end with one or more hydrophilic groups, for example, unmodified ethylene glycol moieties. In some cases, the molecules attached to the surface may include one or more moieties that can bind to various entities such as proteins, peptides, nucleic acids, drugs, cells, etc. In certain embodiments, the techniques are used to enable novel assays for cell motility and/or spreading and screening tests for determining drugs and/or treatments effective in increasing or decreasing cell shape changes and/or motility on surfaces.
摘要翻译：本发明提供了一系列用于改变表面性质（例如，细胞毒性和/或亲水性）的方法，组合物和制品，通过将至少一部分表面暴露于非化学，产生场和/或力，例如电场。场/力可以通过任何合适的技术来产生。例如，可以通过在表面上施加电压，通过电感应等来产生该场。在某些实施例中，表面包括附着于其上的分子，当暴露于非化学，力产生场和/或从而改变表面的至少一部分的化学成分。在一组实施方案中，连接到表面的分子可以包括在表面上形成自组装单层的分子。在一些实施方案中，附着于表面的分子可以包括硫醇部分（例如，如在链烷硫醇中），通过该分子可以使分子附着于表面。在某些情况下，分子可以在一个或多个亲水基团例如未改性的乙二醇部分的非附着端封端。在一些情况下，附着于表面的分子可以包括可结合各种实体的一个或多个部分，例如蛋白质，肽，核酸，药物，细胞等。在某些实施方案中，该技术用于使用于确定有效增加或减少细胞形状变化和/或表面活力的药物和/或治疗的细胞运动性和/或扩散和筛选试验。

2. 发明申请

WO2008009823A2 DISPOSITIF MICROFLUIDIQUE POUR LA CRISTALLISATION ET L'ANALYSE CRISTALLOGRAPHIQUE DE MOLECULES 审中-公开
标题翻译：用于晶体结构和分子结构分析的微流体装置
公开(公告)号：WO2008009823A2
公开(公告)日：2008-01-24
申请号：PCT/FR2007/001243
申请日：2007-07-19
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS , SAUTER, Claude , LORBER, Bernard , GIEGE, Richard , THEOBALD-DIETRICH, Anne , KAHN-MALEK, Chantal , GAUTHIER-MANUEL, Bernard , THUILLIER, Gaël , FERRIGNO, Rosaria
发明人： SAUTER, Claude , LORBER, Bernard , GIEGE, Richard , THEOBALD-DIETRICH, Anne , KAHN-MALEK, Chantal , GAUTHIER-MANUEL, Bernard , THUILLIER, Gaël , FERRIGNO, Rosaria
CPC分类号： B01L3/06 , B01D9/0013 , B01D9/005 , B01D9/0054 , B01D9/0077 , B01L3/5027 , B01L3/502707 , B01L2300/0816 , B01L2300/0867 , B01L2400/0406 , G01N23/20
摘要： La présente invention concerne un dispositif microfluidique comprenant au moins une chambre de cristallisation susceptible de comprendre une solution dans laquelle au moins un composé est présent selon un gradient de concentration et dans lequel la géométrie de ladite chambre de cristallisation permet de limiter les phénomènes de convection. Elle concerne également l'utilisation dudit dispositif notamment pour la cristallisation par contre- diffusion et un procédé de cristallisation.
摘要翻译：微流体装置技术领域本发明涉及一种微流体装置，其包括至少一个结晶室，其适于包含根据浓度梯度存在至少一种化合物的溶液，并且其中所述结晶室的几何形状允许对流现象受到限制。本发明还涉及所述装置的用途，特别是通过反扩散结晶和结晶方法。

3. 发明申请

WO2008009823A3 MICROFLUIDIC DEVICE FOR CRYSTALLIZATION AND CHRYSTALLOGRAPHIC ANALYSIS OF MOLECULES 审中-公开
标题翻译：微流控装置用于结晶和键合分子的分子结构分析
公开(公告)号：WO2008009823A3
公开(公告)日：2008-03-27
申请号：PCT/FR2007001243
申请日：2007-07-19
申请人： CENTRE NAT RECH SCIENT , SAUTER CLAUDE , LORBER BERNARD , GIEGE RICHARD , THEOBALD-DIETRICH ANNE , KAHN-MALEK CHANTAL , GAUTHIER-MANUEL BERNARD , THUILLIER GAEL , FERRIGNO ROSARIA
发明人： SAUTER CLAUDE , LORBER BERNARD , GIEGE RICHARD , THEOBALD-DIETRICH ANNE , KAHN-MALEK CHANTAL , GAUTHIER-MANUEL BERNARD , THUILLIER GAEL , FERRIGNO ROSARIA
IPC分类号： B01D9/00 , B01L3/00 , B81B1/00 , B81C1/00 , C12Q1/00 , G01N23/20
CPC分类号： B01L3/06 , B01D9/0013 , B01D9/005 , B01D9/0054 , B01D9/0077 , B01L3/5027 , B01L3/502707 , B01L2300/0816 , B01L2300/0867 , B01L2400/0406 , G01N23/20
摘要： The present invention relates to a microfluidic device comprising at least one crystallization chamber adapted for comprising a solution in which at least one compound is present according to a concentration gradient and in which the geometry of said crystallization chamber allows for the convection phenomena to be limited. The invention also relates to the use of said device, in particular for the crystallization by counter diffusion and to a crystallization method.
摘要翻译：本发明涉及包含至少一个结晶室的微流体装置，所述结晶室适于包含其中存在至少一种根据浓度梯度存在的化合物的溶液，并且其中所述结晶室的几何结构允许限制对流现象。本发明还涉及所述装置的用途，特别是用于通过反扩散结晶和结晶方法。

4. 发明申请

WO2004067191A2 ALTERATION OF SURFACE AFFINITIES 审中-公开
标题翻译：表面附着力的改变
公开(公告)号：WO2004067191A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/002498
申请日：2004-01-29
申请人： PRESIDENT AND FELLOWS OF HARWARD COLLEGE , JIANG, Xingyu , FERRIGNO, Rosaria , WHITESIDES, George, M.
发明人： JIANG, Xingyu , FERRIGNO, Rosaria , WHITESIDES, George, M.
IPC分类号： B05D3/14
CPC分类号： B82Y30/00 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3225 , B01J20/3227 , B01J20/3248 , B01J20/3251 , B01J20/3274 , B01J20/3285 , B01J2219/00497 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B05D3/14 , B05D3/207 , G01N33/54353 , G01N2610/00 , Y10S436/823 , Y10T436/118339
摘要： The present invention provides a series of methods, compositions, and articles for altering a property of a surface (for example, the cytophilicity and/or the hydrophilicity), by exposing at least a portion of the surface to a non-chemical, force-creating field and/or force, such as an electric field. The field/force may be created by any suitable technique. For instance, the field can be created by applying a voltage across the surface, by electrical induction, etc. In certain embodiments, the surface includes molecules attached thereto that can be detached when exposed to non-chemical, force-creating fields and/or forces, thereby altering the chemical composition of at least a portion of the surface. In one set of embodiments, the molecules attached to the surface may include molecules forming a self-assembled monolayer on the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in an alkanethiol), by which the molecule can become attached to the surface. In certain cases, the molecules may be terminated at the unattached end with one or more hydrophilic groups, for example, unmodified ethylene glycol moieties. In some cases, the molecules attached to the surface may include one or more moieties that can bind to various entities such as proteins, peptides, nucleic acids, drugs, cells, etc. In certain embodiments, the techniques are used to enable novel assays for cell motility and/or spreading and screening tests for determining drugs and/or treatments effective in increasing or decreasing cell shape changes and/or motility on surfaces.
摘要翻译：本发明提供了用于通过暴露至少一部分表面来改变表面性质（例如亲细胞性和/或亲水性）的一系列方法，组合物和制品到非化学的，产生力的场和/或力，例如电场。场/力可以通过任何合适的技术来创建。例如，可以通过在表面上施加电压，通过电感应等来产生场。在某些实施方案中，表面包括附着于其上的分子，当暴露于非化学力产生场时可以将其分离，和/或从而改变至少一部分表面的化学组成。在一组实施方案中，附着于表面的分子可以包括在表面上形成自组装单层的分子。在一些实施方案中，连接到表面的分子可以包括硫醇部分（例如，如在烷硫醇中），通过该硫醇部分该分子可以附着到表面。在某些情况下，分子可以在一个或多个亲水基团（例如未改性的乙二醇部分）的未连接末端处终止。在一些情况下，附着于表面的分子可以包括一个或多个可结合各种实体的部分，例如蛋白质，肽，核酸，药物，细胞等。在某些实施方案中，所述技术用于实现用于细胞运动性和/或扩散和筛选测试以确定有效增加或减少细胞形状变化和/或表面运动性的药物和/或治疗。

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