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11. 发明申请

WO2008118041A1 AN IMPLANTABLE CARDIAC DEVICE AND METHOD FOR MONITORING THE STATUS OF A CARDIOVASCULAR DISEASE 审中-公开
标题翻译：用于监测心血管疾病状态的可植入心脏装置和方法
公开(公告)号：WO2008118041A1
公开(公告)日：2008-10-02
申请号：PCT/SE2007/000288
申请日：2007-03-23
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , ÖHLANDER, Malin , NOREN, Kjell , BLOMQVIST, Andreas , LJUNGSTRÖM, Karin
发明人： HOLMSTRÖM, Nils , ÖHLANDER, Malin , NOREN, Kjell , BLOMQVIST, Andreas , LJUNGSTRÖM, Karin
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/36521 , A61B5/0215 , A61B5/02405 , A61B5/053 , A61B5/4035 , A61B5/4836 , A61B5/7257 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702
摘要： An implantable cardiac device comprises a heart stimulator (10, 12) for electricly stimulating the heart of a patient, detecting means (2, 4) for measuring a physiologic parameter which is affected by the status of a cardiovascular disease associated with sympathetic activation, signal processing means (6) for determining at least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the measured parameter, and an analysor for analyzing the determined Mayer wave component in relation to a predetermined reference value to determine the status of the cardiovascular disease. The detecting means comprise measuring means (2) arranged to measure, as said physiologic parameter, a mechanical change in at least one of the four chambers of the heart. In a corresponding method for monitoring the status of a cardiovascular disease associated with sympathetic activation of a patient having an implantable electric heart stimulator (10, 12) a physiologic parameter affected by the cardiac disease is measured. At least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the parameter is determined, and the wave component is analysed in relation to a predetermined reference value to determine the status of the cardiovascular disease. A mechanical change in at least one of the four chambers of the heart is measured as the physiologic parameter.
摘要翻译：可植入心脏装置包括用于电刺激患者心脏的心脏刺激器（10,12），用于测量受到与交感神经激活相关的心血管疾病状态影响的生理参数的检测装置（2,4），信号用于确定所测量的参数中的低频，低频和极低频，伏尔伏特梅耶波分量中的至少一个的处理装置（6），以及用于相对于预定参考值分析所确定的梅尔波分量的分析器以确定心血管疾病的状况。检测装置包括测量装置（2），其被布置成根据所述生理参数测量心脏的四个腔室中的至少一个中的机械变化。在用于监测与具有可植入电心脏刺激器（10,12）的患者的交感神经激活相关的心血管疾病的状态的相应方法中，测量受心脏病影响的生理参数。确定参数中的低频，低频和极低频VLF，梅耶波分量中的至少一个，并且相对于预定参考值分析波分量以确定心血管疾病的状态。测量心脏四个腔室中的至少一个的机械变化作为生理参数。

12. 发明申请

WO2009054758A1 METHODS AND SYSTEMS FOR DRUG TITRATION 审中-公开
标题翻译：药物治疗方法与系统
公开(公告)号：WO2009054758A1
公开(公告)日：2009-04-30
申请号：PCT/SE2007/000947
申请日：2007-10-26
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas , HOLMSTRÖM, Nils
发明人： BLOMQVIST, Andreas , HOLMSTRÖM, Nils
IPC分类号： A61M5/168 , A61N1/372
CPC分类号： A61M5/1723 , A61N1/36521 , A61N1/3702
摘要： The present invention generally relates to medical systems including an implantable medical device and an external programmer device and, in particular, to a medical system including an implantable medical device and an external programmer device, an implantable medical device, a programmer device and methods for drug titration or verification of drug dosage administration. The system comprises an extracorporeal device and an implantable medical device. The implantable medical device including an impedance measuring circuit connectable to at least one medical lead being adapted to apply excitation current pulses between at least a first electrode and at least a second electrode during consecutive heart beats and to measure the resulting impedance. Moreover, the system comprises a determining unit adapted to obtain impedance signals, and determine at least one hemodynamic parameter reflecting the hemodynamic of the heart; and an evaluation unit adapted to evaluate the hemodynamic parameters and to identify changes in the hemodynamic, wherein a verification that a proper dose of a medication has been taken by the patient can be obtained.
摘要翻译：本发明总体上涉及包括可植入医疗装置和外部编程装置的医疗系统，特别涉及包括可植入医疗装置和外部编程装置的医疗系统，可植入医疗装置，编程装置和药物方法滴定或药物剂量管理验证。该系统包括体外装置和可植入医疗装置。该可植入医疗装置包括可连接到至少一个医疗引线的阻抗测量电路，适于在连续的心跳期间在至少第一电极和至少第二电极之间施加激励电流脉冲，并测量所得到的阻抗。此外，该系统包括适于获得阻抗信号的确定单元，并且确定反映心脏血流动力学的至少一个血液动力学参数; 以及评估单元，其适于评估所述血液动力学参数并且识别所述血液动力学的变化，其中可以获得患者采取适当剂量的药物的验证。

13. 发明申请

WO2010039063A1 HEART FAILURE DETECTOR 审中-公开
标题翻译：心脏故障检测器
公开(公告)号：WO2010039063A1
公开(公告)日：2010-04-08
申请号：PCT/SE2008/000537
申请日：2008-09-30
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BROOMÉ, Michael , BLOMQVIST, Andreas
发明人： HOLMSTRÖM, Nils , BROOMÉ, Michael , BLOMQVIST, Andreas
IPC分类号： A61B5/053 , A61B5/0452 , A61N1/37
CPC分类号： A61N1/36521 , A61B5/0452 , A61B5/0472 , A61B5/053 , A61N1/36578
摘要： The present invention relates to an apparatus and method for detecting incipient heart failure of a patient. Impedance signals reflecting volume changes of the right ventricle and/or the right atrium of a heart of the patient are required. The impedance signals are processed to determine a first impedance parameter substantially reflecting a volume of the right ventricle, and a heart failure status is determined based on the first impedance parameter, wherein a decreasing first impedance parameter is determined to be an indication of a deterioration of the heart failure status.
摘要翻译：本发明涉及用于检测患者初期心力衰竭的装置和方法。需要反映患者心脏右心室和/或右心房体积变化的阻抗信号。处理阻抗信号以确定基本上反映右心室体积的第一阻抗参数，并且基于第一阻抗参数确定心力衰竭状态，其中减小的第一阻抗参数被确定为恶化的指示心力衰竭状态。

14. 发明申请

WO2009096819A1 IMPLANTABLE HEART STIMULATOR FOR MEASURING DYSSYNCHRONY USING IMPEDANCE 审中-公开
标题翻译：用于测量使用阻抗的DYSSYNCHRONY的可植入心脏刺激仪
公开(公告)号：WO2009096819A1
公开(公告)日：2009-08-06
申请号：PCT/SE2008/000077
申请日：2008-01-28
申请人： ST.JUDE MEDICAL AB , BLOMQVIST, Andreas , HOLMSTRÖM, Nils , ÖHLANDER, Malin , HEDBERG, Sven-Erik
发明人： BLOMQVIST, Andreas , HOLMSTRÖM, Nils , ÖHLANDER, Malin , HEDBERG, Sven-Erik
IPC分类号： A61N1/365 , A61B5/053
CPC分类号： A61N1/36521 , A61B5/053 , A61B5/0538 , A61N1/3684
摘要： Implantable heart stimulator connectable to an electrode arrangement comprising a pulse generator adapted to deliver stimulation pulses to a heart of a subject; an impedance measurement unit adapted monitor at least one heart chamber of the heart of the subject to measure the impedance in the at least one monitored heart chamber for generating an impedance signal corresponding to the measured impedance. The impedance signal is applied to a processing means where the signal is processed, according to specified criteria, and a fractionation index value is determined represented by the curve length of the impedance signal during a predetermined measurement period. The fractionation index value being a measure of different degrees of mechanical dyssynchrony of the heart.
摘要翻译：可植入心脏刺激器，其可连接到电极装置，所述电极装置包括适于将刺激脉冲输送到对象的心脏的脉冲发生器; 阻抗测量单元适于监测所述受试者心脏的至少一个心室，以测量所述至少一个监测的心室中的阻抗，以产生对应于所测量的阻抗的阻抗信号。根据规定的标准将阻抗信号施加到处理信号的处理装置，并且在预定测量周期期间由阻抗信号的曲线长度确定分数指数值。分离指数值是心脏不同程度的机械不同步的量度。

15. 发明申请

WO2011069538A1 IMPLANTABLE MEDICAL DEVICE FOR CARDIAC THERAPY 审中-公开
标题翻译：用于心脏治疗的可植入医疗器械
公开(公告)号：WO2011069538A1
公开(公告)日：2011-06-16
申请号：PCT/EP2009/066647
申请日：2009-12-08
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , BROOMÉ, Michael , GUSTAFSSON, John
发明人： HOLMSTRÖM, Nils , BROOMÉ, Michael , GUSTAFSSON, John
IPC分类号： A61N1/362 , A61N1/05 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N2001/0585
摘要： An implantable medical device, IMD, (100) is connectable to at least one ventricular lead (210) having a ventricular basal electrode (214) and a ventricular apical electrode (212). The IMD (100) comprises a pulse generator (120) for generating pacing pulses applied to a heart (10) through the ventricular lead (210). The operation of this pulse generator (120) is controlled by a controller (130) that is configured to control the pulse generator to first deliver a pacing pulse to the ventricular basal electrode (214) to stimulate the basal portion of the ventricle (12, 14) before a pacing pulse is delivered to the apical portion of the ventricle (12, 14) by the ventricular apical electrode (212). This pulse sequence achieves a biologically more correct cardiac stimulation and a contraction pattern that reduces the risk for valvular regurgitation.
摘要翻译：植入式医疗装置IMD（100）可连接到至少一个具有心室基底电极（214）和心室顶端电极（212）的心室引线（210）。 IMD（100）包括用于产生通过心室引线（210）施加到心脏（10）的起搏脉冲的脉冲发生器（120）。该脉冲发生器（120）的操作由控制器（130）控制，控制器（130）被配置为控制脉冲发生器首先将起搏脉冲递送至心室基底电极（214）以刺激心室的基部（12， 14）在通过心室顶端电极（212）将起搏脉冲输送到心室（12,14）的顶端部分之前。该脉冲序列实现了生物学更正确的心脏刺激和减少瓣膜反流风险的收缩模式。

16. 发明申请

WO2006135290A1 A HEART MONITORING DEVICE, A SYSTEM INCLUDING SUCH A DEVICE AND USE OF THE SYSTEM 审中-公开
标题翻译：心脏监测装置，包括这种装置的系统和系统的使用
公开(公告)号：WO2006135290A1
公开(公告)日：2006-12-21
申请号：PCT/SE2005/000942
申请日：2005-06-16
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils
发明人： HOLMSTRÖM, Nils
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/36521 , A61B5/029 , A61B5/0295 , A61N1/3627 , A61N1/3682 , A61N1/3702
摘要： The invention concerns an implantable heart monitoring device (10) comprising a control circuit (14), adapted to communicate with one or more sensor members (31, 32, 35, 41, 42, 51, 52, 61, 62) and arranged to at least enable the following: derive a first value, related to the volume of a first part (RV) of the heart, and derive a second value, related to the volume of a second part (LV) of the heart. The control circuit (14) is arranged to store in a memory (15) information of the variation of said values in order to enable the derivation of a relationship between said first and second values including information of how said relationship varies over at least a substantial portion of a heart cycle. The invention also concerns an implantable heart monitoring system including such a device (10) as well as the use of such a system.
摘要翻译：本发明涉及一种可植入心脏监测装置（10），其包括控制电路（14），其适于与一个或多个传感器构件（31,32,35,41,42,51,52,61,62）连通并且被布置成至少启用以下内容：导出与心脏的第一部分（RV）的体积相关的第一值，并且导出与心脏的第二部分（LV）的体积相关的第二值。控制电路（14）被布置为在存储器（15）中存储所述值的变化的信息，以便能够导出所述第一和第二值之间的关系，包括所述关系如何在至少实质上变化的信息心脏周期的一部分。本发明还涉及包括这种装置（10）以及这种系统的使用的可植入心脏监测系统。

17. 发明申请

WO2009082286A1 IMPLANTABLE ANALYTE RF SPECTROSCOPY MEASURING SYSTEM 审中-公开
标题翻译：可伸缩分析仪射频光谱测量系统
公开(公告)号：WO2009082286A1
公开(公告)日：2009-07-02
申请号：PCT/SE2007/001157
申请日：2007-12-21
申请人： ST. JUDE MEDICAL AB , ABRAHAMSON, Hans , BJÖRLING, Anders , SNITTING, Tomas , HOLMSTRÖM, Nils , ERIKSSON, Tom
发明人： ABRAHAMSON, Hans , BJÖRLING, Anders , SNITTING, Tomas , HOLMSTRÖM, Nils , ERIKSSON, Tom
IPC分类号： G01N33/483 , A61B5/145 , A61N1/372 , G01N22/00
CPC分类号： A61B5/05 , A61B5/14546 , A61B5/7253 , A61N1/36557 , A61N1/3702 , A61N1/37252
摘要： An analyte measuring system (1) comprises and implantable medical device (100; 400) having a RF signal source (120; 420) arranged for generating a RF signal and a transmitting antenna (300) for transmitting the RF signal into a surrounding tissue (10) in a subject body (5). The system (1) has a receiving RF antenna (310) for receiving the RF signal from the tissue (10) and a signal processor (130; 530) arranged for generating an estimate of a concentration of an analyte in the tissue (10) based on a spectrum analysis of the received RF signal.
摘要翻译：分析物测量系统（1）包括具有设置用于产生RF信号的RF信号源（120; 420）和用于将RF信号传输到周围组织的发射天线（300）的可植入医疗设备（100; 400） 10）在主体（5）中。系统（1）具有用于接收来自组织（10）的RF信号的接收RF天线（310）和布置成用于产生组织（10）中分析物浓度的估计的信号处理器（130; 530）基于所接收的RF信号的频谱分析。

18. 发明申请

WO2009082285A1 IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：WO2009082285A1
公开(公告)日：2009-07-02
申请号：PCT/SE2007/001156
申请日：2007-12-21
申请人： ST. JUDE MEDICAL AB , ABRAHAMSON, Hans , BJÖRLING, Anders , SNITTING, Tomas , HOLMSTRÖM, Nils
发明人： ABRAHAMSON, Hans , BJÖRLING, Anders , SNITTING, Tomas , HOLMSTRÖM, Nils
IPC分类号： A61B5/053 , A61N1/365
CPC分类号： A61B5/053 , A61B5/14546 , A61N1/36557
摘要： An analyte measuring system (1) comprises and implantable medical device (100) having a signal source (120) arranged for generating a current signal and electrodes (202, 204; 212, 214) for applying the current signal to a surrounding tissue (10) in a subject body (5). The device (100) measures a resulting voltage signal with the electrodes (202, 204; 212, 214) and calculates an impedance signal therefrom. The system (1) comprises a signal processor (150; 550) arranged for generating an estimate of a concentration of an analyte in the tissue (10) based on a spectrum analysis of the determined impedance signal.
摘要翻译：分析物测量系统（1）包括可植入医疗设备（100），其具有布置成产生电流信号的信号源（120）和用于将电流信号施加到周围组织（10,20）的电极（202,204; 212,214））在主体（5）中。装置（100）利用电极（202,204; 212,214）测量得到的电压信号，并从其计算阻抗信号。系统（1）包括信号处理器（150; 550），信号处理器被设置用于基于所确定的阻抗信号的频谱分析来生成组织（10）中的分析物的浓度的估计。

19. 发明申请

WO2007069963A1 IMPLANTABLE MEDICAL DEVICE WITH CONDITION DETECTION 审中-公开
标题翻译：具有条件检测的可植入医疗装置
公开(公告)号：WO2007069963A1
公开(公告)日：2007-06-21
申请号：PCT/SE2005/001957
申请日：2005-12-16
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , NOREN, Kjell
发明人： HOLMSTRÖM, Nils , NOREN, Kjell
IPC分类号： A61B5/02 , A61N1/37
CPC分类号： A61B7/00 , A61N1/3627 , A61N1/36514
摘要： The present invention relates to a method for operating a implantable medical device to detect a condition of a heart of a patient, comprising the steps of: sensing an activity level of the patient; sensing an acoustic energy; producing acoustic signals indicative of heart sounds of the heart of the patient over predetermined periods of a cardiac cycle during successive cardiac cycles; extracting a signal corresponding to a first heart sound (Sl) from a sensed acoustic signal of a cardiac cycle; and comparing a present signal corresponding to a first heart sound (Sl) in a first predetermined activity level range with at least one reference value to detect the condition or a change of the condition. Furthermore, the invention relates to a medical device for detecting a condition of a heart of a patient, a computer program product and a computer readable medium comprising instructions for bringing a computer to perform the inventive method.
摘要翻译：本发明涉及一种用于操作可植入医疗装置以检测患者心脏状况的方法，包括以下步骤：感测患者的活动水平; 感测声能; 在连续心脏周期期间产生指示心脏周期的预定周期的患者心脏心脏的声音信号; 从感测到的心律周期的声信号中提取对应于第一心音（S1）的信号; 以及将与第一预定活动级别范围中的与第一心音（S1）相对应的当前信号与至少一个参考值进行比较，以检测条件或条件的改变。此外，本发明涉及一种用于检测患者心脏状况的医疗装置，计算机程序产品和包括用于使计算机执行本发明方法的指令的计算机可读介质。

20. 发明申请

WO2007069961A1 IMPLANTABLE MEDICAL DEVICE WITH CONDITION DETECTING 审中-公开
标题翻译：具有条件检测的可植入医疗器械
公开(公告)号：WO2007069961A1
公开(公告)日：2007-06-21
申请号：PCT/SE2005/001955
申请日：2005-12-16
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , NOREN, Kjell
发明人： HOLMSTRÖM, Nils , NOREN, Kjell
IPC分类号： A61B5/02 , A61N1/37
CPC分类号： A61B7/00 , A61B7/04 , A61N1/36514 , A61N1/36578
摘要： The present invention relates to a method for detecting a condition of a heart of a patient using an implantable medical device, comprising the steps of: sensing acoustic signals indicative of heart sounds of the heart of the patient; extracting signals corresponding to a first heart sound (Sl) and a second heart sound (S2) from sensed signals; calculating an energy value corresponding to a signal corresponding to the first heart sound (Sl) and an energy value corresponding to the second heart sound (S2); calculating a relation between the energy value corresponding to the first heart sound and the energy value corresponding to the second heart sound for successive cardiac cycles; and using at least one relation to detect the condition or a change of the condition. Furthermore, the invention relates to a medical device for determining the posture of a patient and a computer readable medium comprising instructions for bringing a computer to perform the inventive method.
摘要翻译：本发明涉及一种使用可植入医疗装置检测患者心脏状况的方法，包括以下步骤：感测指示患者心脏心脏的声音信号; 从感测信号中提取对应于第一心音（S1）和第二心音（S2）的信号; 计算与对应于第一心音（S1）的信号相对应的能量值和对应于第二心音（S2）的能量值; 计算对应于第一心音的能量值与对应于第二心音的能量值之间的关系，用于连续的心动周期; 并使用至少一个关系来检测条件或条件的变化。此外，本发明涉及一种用于确定患者姿势的医疗装置和包括用于使计算机执行本发明的方法的指令的计算机可读介质。

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