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1. 发明申请

WO2008118041A1 AN IMPLANTABLE CARDIAC DEVICE AND METHOD FOR MONITORING THE STATUS OF A CARDIOVASCULAR DISEASE 审中-公开
标题翻译：用于监测心血管疾病状态的可植入心脏装置和方法
公开(公告)号：WO2008118041A1
公开(公告)日：2008-10-02
申请号：PCT/SE2007/000288
申请日：2007-03-23
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , ÖHLANDER, Malin , NOREN, Kjell , BLOMQVIST, Andreas , LJUNGSTRÖM, Karin
发明人： HOLMSTRÖM, Nils , ÖHLANDER, Malin , NOREN, Kjell , BLOMQVIST, Andreas , LJUNGSTRÖM, Karin
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/36521 , A61B5/0215 , A61B5/02405 , A61B5/053 , A61B5/4035 , A61B5/4836 , A61B5/7257 , A61N1/36564 , A61N1/36578 , A61N1/36592 , A61N1/3702
摘要： An implantable cardiac device comprises a heart stimulator (10, 12) for electricly stimulating the heart of a patient, detecting means (2, 4) for measuring a physiologic parameter which is affected by the status of a cardiovascular disease associated with sympathetic activation, signal processing means (6) for determining at least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the measured parameter, and an analysor for analyzing the determined Mayer wave component in relation to a predetermined reference value to determine the status of the cardiovascular disease. The detecting means comprise measuring means (2) arranged to measure, as said physiologic parameter, a mechanical change in at least one of the four chambers of the heart. In a corresponding method for monitoring the status of a cardiovascular disease associated with sympathetic activation of a patient having an implantable electric heart stimulator (10, 12) a physiologic parameter affected by the cardiac disease is measured. At least one of a low frequency, LF, and a very low frequency, VLF, Mayer wave component in the parameter is determined, and the wave component is analysed in relation to a predetermined reference value to determine the status of the cardiovascular disease. A mechanical change in at least one of the four chambers of the heart is measured as the physiologic parameter.
摘要翻译：可植入心脏装置包括用于电刺激患者心脏的心脏刺激器（10,12），用于测量受到与交感神经激活相关的心血管疾病状态影响的生理参数的检测装置（2,4），信号用于确定所测量的参数中的低频，低频和极低频，伏尔伏特梅耶波分量中的至少一个的处理装置（6），以及用于相对于预定参考值分析所确定的梅尔波分量的分析器以确定心血管疾病的状况。检测装置包括测量装置（2），其被布置成根据所述生理参数测量心脏的四个腔室中的至少一个中的机械变化。在用于监测与具有可植入电心脏刺激器（10,12）的患者的交感神经激活相关的心血管疾病的状态的相应方法中，测量受心脏病影响的生理参数。确定参数中的低频，低频和极低频VLF，梅耶波分量中的至少一个，并且相对于预定参考值分析波分量以确定心血管疾病的状态。测量心脏四个腔室中的至少一个的机械变化作为生理参数。

2. 发明申请

WO2007069962A1 IMPLANTABLE MEDICAL DEVICE WITH THERAPY CONTROL 审中-公开
标题翻译：具有治疗控制的可植入医疗装置
公开(公告)号：WO2007069962A1
公开(公告)日：2007-06-21
申请号：PCT/SE2005/001956
申请日：2005-12-16
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , NOREN, Kjell
发明人： HOLMSTRÖM, Nils , NOREN, Kjell
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/36514 , A61N1/36578 , A61N1/368 , A61N1/3682
摘要： The present invention relates to a method for operating an implantable medical device to control a stimulation therapy. The method comprises the steps of: sensing an acoustic energy; producing acoustic signals indicative of heart sounds of the heart of the patient over predetermined periods of a cardiac cycle during successive cardiac cycles; extracting a signal corresponding to a first heart sound (Sl) from a measured acoustic signal; calculating an energy value corresponding to the extracted signal; storing the energy value corresponding to the first heart sound; and initiating an optimization procedure, the optimization procedure comprising the steps of: iteratively controlling a delivery of the pacing pulses based on successive energy values corresponding to successive first heart sound signals and determining an optimal PV interval or AV interval with respect to the energy values. The invention also relates to a medical device, a computer program product and a computer readable medium comprising instructions for bringing a computer to perform the method.
摘要翻译：本发明涉及一种用于操作可植入医疗装置以控制刺激疗法的方法。该方法包括以下步骤：感测声能; 在连续心脏周期期间产生指示心脏周期的预定周期的患者心脏心脏的声音信号; 从测量的声信号中提取对应于第一心音（S1）的信号; 计算与所提取的信号相对应的能量值; 存储对应于第一心音的能量值; 并且启动优化过程，所述优化过程包括以下步骤：基于对应于连续的第一心音信号的连续能量值迭代地控制所述起搏脉冲的递送，并且相对于所述能量值确定最佳PV间隔或AV间隔。本发明还涉及医疗装置，计算机程序产品和包括用于使计算机执行该方法的指令的计算机可读介质。

3. 发明申请

WO2007069963A1 IMPLANTABLE MEDICAL DEVICE WITH CONDITION DETECTION 审中-公开
标题翻译：具有条件检测的可植入医疗装置
公开(公告)号：WO2007069963A1
公开(公告)日：2007-06-21
申请号：PCT/SE2005/001957
申请日：2005-12-16
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , NOREN, Kjell
发明人： HOLMSTRÖM, Nils , NOREN, Kjell
IPC分类号： A61B5/02 , A61N1/37
CPC分类号： A61B7/00 , A61N1/3627 , A61N1/36514
摘要： The present invention relates to a method for operating a implantable medical device to detect a condition of a heart of a patient, comprising the steps of: sensing an activity level of the patient; sensing an acoustic energy; producing acoustic signals indicative of heart sounds of the heart of the patient over predetermined periods of a cardiac cycle during successive cardiac cycles; extracting a signal corresponding to a first heart sound (Sl) from a sensed acoustic signal of a cardiac cycle; and comparing a present signal corresponding to a first heart sound (Sl) in a first predetermined activity level range with at least one reference value to detect the condition or a change of the condition. Furthermore, the invention relates to a medical device for detecting a condition of a heart of a patient, a computer program product and a computer readable medium comprising instructions for bringing a computer to perform the inventive method.
摘要翻译：本发明涉及一种用于操作可植入医疗装置以检测患者心脏状况的方法，包括以下步骤：感测患者的活动水平; 感测声能; 在连续心脏周期期间产生指示心脏周期的预定周期的患者心脏心脏的声音信号; 从感测到的心律周期的声信号中提取对应于第一心音（S1）的信号; 以及将与第一预定活动级别范围中的与第一心音（S1）相对应的当前信号与至少一个参考值进行比较，以检测条件或条件的改变。此外，本发明涉及一种用于检测患者心脏状况的医疗装置，计算机程序产品和包括用于使计算机执行本发明方法的指令的计算机可读介质。

4. 发明申请

WO2007069961A1 IMPLANTABLE MEDICAL DEVICE WITH CONDITION DETECTING 审中-公开
标题翻译：具有条件检测的可植入医疗器械
公开(公告)号：WO2007069961A1
公开(公告)日：2007-06-21
申请号：PCT/SE2005/001955
申请日：2005-12-16
申请人： ST. JUDE MEDICAL AB , HOLMSTRÖM, Nils , NOREN, Kjell
发明人： HOLMSTRÖM, Nils , NOREN, Kjell
IPC分类号： A61B5/02 , A61N1/37
CPC分类号： A61B7/00 , A61B7/04 , A61N1/36514 , A61N1/36578
摘要： The present invention relates to a method for detecting a condition of a heart of a patient using an implantable medical device, comprising the steps of: sensing acoustic signals indicative of heart sounds of the heart of the patient; extracting signals corresponding to a first heart sound (Sl) and a second heart sound (S2) from sensed signals; calculating an energy value corresponding to a signal corresponding to the first heart sound (Sl) and an energy value corresponding to the second heart sound (S2); calculating a relation between the energy value corresponding to the first heart sound and the energy value corresponding to the second heart sound for successive cardiac cycles; and using at least one relation to detect the condition or a change of the condition. Furthermore, the invention relates to a medical device for determining the posture of a patient and a computer readable medium comprising instructions for bringing a computer to perform the inventive method.
摘要翻译：本发明涉及一种使用可植入医疗装置检测患者心脏状况的方法，包括以下步骤：感测指示患者心脏心脏的声音信号; 从感测信号中提取对应于第一心音（S1）和第二心音（S2）的信号; 计算与对应于第一心音（S1）的信号相对应的能量值和对应于第二心音（S2）的能量值; 计算对应于第一心音的能量值与对应于第二心音的能量值之间的关系，用于连续的心动周期; 并使用至少一个关系来检测条件或条件的变化。此外，本发明涉及一种用于确定患者姿势的医疗装置和包括用于使计算机执行本发明的方法的指令的计算机可读介质。

5. 发明申请

WO2007001219A1 MEDICAL DEVICE FOR DETERMINING THE POSTURE OF PATIENT 审中-公开
标题翻译：用于确定患者症状的医疗装置
公开(公告)号：WO2007001219A1
公开(公告)日：2007-01-04
申请号：PCT/SE2005/001030
申请日：2005-06-29
申请人： ST. JUDE MEDICAL AB , ÖHLANDER, Malin , HOLMSTRÖM, Nils , NOREN, Kjell
发明人： ÖHLANDER, Malin , HOLMSTRÖM, Nils , NOREN, Kjell
IPC分类号： A61B5/053 , A61B5/103 , A61B5/11
CPC分类号： G06F19/34 , A61B5/0031 , A61B5/01 , A61B5/029 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/4561 , A61B5/686
摘要： The present invention relates to a method for determining the posture of a patient. The method comprises the steps of: initiating (50, 52) a patient posture determining session by performing an electrical bio-impedance measurement session in at least one of a number of different electrode configurations in order to measure an impedance value for the at least one configuration; obtaining reference impedance values (54) stored in advance for the at least one configuration and for at least one potential posture of the patient; comparing (54) the measured impedance value for the at least one configuration with corresponding stored reference impedance values for at least one potential posture of the patient; and determining (56) the present posture of the patient by using results from the comparison between measured impedance values and the stored reference impedance values. Furthermore, the invention relates to a medical device for determining the posture of a patient and a computer readable medium comprising instructions for bringing a computer to perform the inventive method.
摘要翻译：本发明涉及一种用于确定患者姿势的方法。该方法包括以下步骤：通过在多个不同电极配置中的至少一个中执行电生物阻抗测量会话来启动（50,52）患者姿势确定会话，以便测量所述至少一个组态; 获得针对所述至少一个配置预先存储的参考阻抗值（54）和所述患者的至少一个潜在姿势; 将所述至少一个配置的测量阻抗值与所述患者的至少一个潜在姿势的相应存储的参考阻抗值进行比较（54）以及通过使用测量的阻抗值与存储的参考阻抗值之间的比较的结果来确定（56）患者的当前姿势。此外，本发明涉及一种用于确定患者的姿势的医疗装置和包括用于使计算机执行本发明的方法的指令的计算机可读介质。

6. 发明申请

WO2008103077A1 DETECT EATING TO INITIATE GASTRIC PACING 审中-公开
标题翻译：检测启动烟道喷雾
公开(公告)号：WO2008103077A1
公开(公告)日：2008-08-28
申请号：PCT/SE2007/000154
申请日：2007-02-21
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , NOREN, Kjell , ÖHLANDER, Malin
发明人： BJÖRLING, Anders , NOREN, Kjell , ÖHLANDER, Malin
IPC分类号： A61N1/08 , A61N1/36 , A61B5/026 , A61B8/06
CPC分类号： A61N1/36007 , A61B5/026 , A61B5/0261 , A61B5/0265 , A61B5/028 , A61B5/0295 , A61B5/0535 , A61B5/4238 , A61B5/6876 , A61B5/6884 , A61B8/06
摘要： Methods and devices for detecting the intake of food in a subject wherein at least one parameter related to the blood flow and/or perfusion of a blood vessel and/or an organ in the digestive system of a patient is monitored by a sensor attached to, or in, a blood vessel or organ of the digestive system. The value of each monitored parameter is analysed and may b used to control the activity of a gastric stimulator.
摘要翻译：用于检测受试者中食物摄入的方法和装置，其中与患者的消化系统中的血流和/或器官的血流和/或器官的血流和/或灌注有关的至少一个参数由附接到患者的传感器监测，或在消化系统的血管或器官中。分析每个监测参数的值，并且可以用于控制胃刺激剂的活性。

7. 发明申请

WO2007100283A1 MEDICAL DEVICE AND METHOD FOR MONITORING HEMATOCRIT AND SVO2 审中-公开
标题翻译：用于监测血液透析和SVO2的医疗装置和方法
公开(公告)号：WO2007100283A1
公开(公告)日：2007-09-07
申请号：PCT/SE2007/000165
申请日：2007-02-22
申请人： ST. JUDE MEDICAL AB , ÖHLANDER, Malin , NOREN, Kjell , ECKERDAL, Johan , HIETANEN, Mika , NILSSON, Kenth , LÖNN, Urban
发明人： ÖHLANDER, Malin , NOREN, Kjell , ECKERDAL, Johan , HIETANEN, Mika , NILSSON, Kenth , LÖNN, Urban
IPC分类号： A61B5/02 , A61B5/1455
CPC分类号： A61B5/02055 , A61B5/0086 , A61B5/053 , A61B5/0538 , A61B5/14535 , A61N1/36521 , G06F19/00 , G06Q50/22
摘要： The present invention generally relates to cardiac pacing systems and, in particular, to a method and an implantable medical device (2; 20) for monitoring physiological parameters such as hematocrit and SvO2 levels of a patient to determine a patient status. The implantable medical device (2; 20) comprises a blood constituent determining device (30) adapted to determine a present hematocrit level and a SvO2 level and a patient status determining device (31) adapted to determine a patient status based on an evaluation of a present hematocrit level and a present SvO2 level, wherein a change of a condition of the patient can be derived.
摘要翻译：本发明一般涉及心脏起搏系统，尤其涉及一种用于监测患者的生理参数例如血细胞比容和SvO2水平以确定患者状态的方法和可植入医疗装置（2; 20）。可植入医疗装置（2; 20）包括适于确定当前血细胞比容水平和SvO2水平的血液成分确定装置（30）和适于基于对所述血液成分确定装置的评估来确定患者状态的患者状态确定装置（31）目前的血细胞比容水平和目前的SvO2水平，其中可以导出患者状况的改变。

8. 发明申请

WO2008026970A1 DETERMINING THE VARIATION OVER THE TIME OF A MEDICAL PARAMETER OF A HUMAN BEING 审中-公开
标题翻译：确定人类医学参数时间的变化
公开(公告)号：WO2008026970A1
公开(公告)日：2008-03-06
申请号：PCT/SE2006/000985
申请日：2006-08-28
申请人： ST. JUDE MEDICAL AB , JÄRVERUD, Karin , NOREN, Kjell
发明人： JÄRVERUD, Karin , NOREN, Kjell
IPC分类号： A61N1/365
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/1116 , A61B5/686 , A61B5/7239 , A61N1/36564 , A61N1/3702
摘要： An apparatus for determining variation over time of a medical parameter of a human being obtained from a sensed signal comprises a sensor (12, 14, 16, 18, 20) implantable in the human being for sensing the signal. A comparing means (8, 30) compares at least one characteristic property, derived from the sensed signal obtained for at least one predetermined first level of activity of the human being, with corresponding reference property of a sensed reference signal, obtained for a predetermined reference level of activity of the human being, for determining a relation between the characteristic property of the sensed signal and the reference property. Trend determining means (10, 30) determine trends in the medical parameter by analysing the relation between the characteristic property of the sensed signal obtained at different times and the reference property. A corresponding method is also disclosed, as well as an implant for heart failure diagnostics comprising an apparatus as described. A sensor (12, 14, 16, 18, 20) is then arranged to pick up dynamic mechanical information from the heart of the human being and generate a corresponding signal. A heart stimulator comprises such an implant and a control means (34) arranged to control stimulation of the heart depending on determined trends in the medical parameter.
摘要翻译：用于确定从感测信号获得的人的医学参数随时间变化的装置包括可植入人体中的用于感测信号的传感器（12,14,16,18,20）。比较装置（8,30）将从针对人的至少一个预定的第一活动水平获得的感测信号导出的至少一个特征属性与针对预定参考获得的感测参考信号的相应参考特性进行比较用于确定感测信号的特性与参考属性之间的关系的人的活动水平。趋势确定装置（10,30）通过分析在不同时间获得的感测信号的特性与参考属性之间的关系来确定医疗参数的趋势。还公开了相应的方法，以及用于心力衰竭诊断的植入物，其包括所述的装置。然后布置传感器（12,14,16,18,20）以从人的心脏拾取动态机械信息并产生相应的信号。心脏刺激器包括这样的植入物和控制装置（34），其被布置成根据医学参数中确定的趋势来控制心脏的刺激。

9. 发明申请

WO2008105698A1 DEVICE AND METHOD OF A MEDICAL IMPLANT FOR MONITORING PROGRESSION OF HEART FAILURE IN A HUMAN HEART 审中-公开
标题翻译：用于监测人心脏心脏衰竭进展的医用植入物的装置和方法
公开(公告)号：WO2008105698A1
公开(公告)日：2008-09-04
申请号：PCT/SE2007/000855
申请日：2007-09-27
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , ÖHLANDER, Malin , ERIKSSON, Tom , ECKERDAL, Johan , LÖNN, Urban , NILSSON, Kenth , TUVSTEDT, Cecilia , SVAHN, Johan , JOHANSSON, Anna-Karin , NOREN, Kjell , BROOME, Michael
发明人： BJÖRLING, Anders , ÖHLANDER, Malin , ERIKSSON, Tom , ECKERDAL, Johan , LÖNN, Urban , NILSSON, Kenth , TUVSTEDT, Cecilia , SVAHN, Johan , JOHANSSON, Anna-Karin , NOREN, Kjell , BROOME, Michael
IPC分类号： A61N1/372 , A61B5/0205 , A61B5/145
CPC分类号： A61B5/14542 , A61B5/0031 , A61B5/076 , A61B5/1459 , A61B2562/0219 , A61N1/3627 , A61N1/36542 , A61N1/36557 , A61N1/36585
摘要： A device and method of a medical implant for monitoring progression of heart failure in a human heart. An activity sensor provides information related to the activity level of a patient and an oxygen sensor provides information related to the level of oxygen content in venous blood. A determined level of venous oxygen content at a determined activity level is obtained, and that level of venous oxygen content is compared to stored values at a corresponding activity level. The result of the comparison is used as a basis for determining a degree of heart failure.
摘要翻译：用于监测人类心脏心脏衰竭进展的医用植入物的装置和方法。活动传感器提供与患者的活动水平相关的信息，氧传感器提供与静脉血中氧含量水平相关的信息。在确定的活性水平获得确定水平的静脉氧含量，并将静脉氧含量的水平与在相应活动水平的储存值进行比较。将比较结果用作确定心力衰竭程度的基础。

10. 发明申请

WO2007064260A1 IMPLANTABLE MEDICAL DEVICE WITH THERAPY CONTROL 审中-公开
标题翻译：具有治疗控制的可植入医疗装置
公开(公告)号：WO2007064260A1
公开(公告)日：2007-06-07
申请号：PCT/SE2005/001807
申请日：2005-11-30
申请人： ST. JUDE MAEDICAL AB , HOLMSTRÖM, Nils , NOREN, Kjell
发明人： HOLMSTRÖM, Nils , NOREN, Kjell
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/36514 , A61B7/04 , A61N1/3627 , A61N1/36578 , A61N1/3684
摘要： The present invention relates to a method for operating an implantable medical device to obtain substantially synchronized closure of the mitral and tricuspid valves based on sensed heart sounds comprising sensing an acoustic energy; producing signals indicative of heart sounds of the heart of the patient over predetermined periods of a cardiac cycle during successive cardiac cycles; calculating a pulse width of such a signal; and iteratively controlling a delivery of the ventricular pacing pulses based on calculated pulse widths of successive heart sound signals to identify an RV interval or W interval that causes a substantially synchronized closure of the mitral and tricuspid valve. Furthermore, the invention relates to a medical device for optimizing an RV interval or W interval based on sensed heart sounds and a computer readable medium comprising instructions for bringing a computer to perform the method.
摘要翻译：本发明涉及一种用于操作可植入医疗装置的方法，以基于感测到的心音来获得二尖瓣和三尖瓣的基本上同步的闭合，包括感测声能; 在连续心脏周期期间产生指示心脏周期的预定周期的患者心脏的心脏声音的信号; 计算这种信号的脉冲宽度; 并且基于所计算的连续心脏声音信号的脉冲宽度迭代地控制心室起搏脉冲的递送，以识别导致二尖瓣和三尖瓣的基本上同步闭合的RV间隔或W间隔。此外，本发明涉及一种用于基于感测到的心脏声音优化RV间隔或W间隔的医疗装置以及包括用于使计算机执行该方法的指令的计算机可读介质。

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