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11. 发明申请

WO2012007871A1 SYSTEM AND METHOD FOR GENERATING A SYSTEM FUNCTION FOR USE IN THE RECONSTRUCTION OF IMAGES 审中-公开
标题翻译：用于生成用于重建图像的系统功能的系统和方法
公开(公告)号：WO2012007871A1
公开(公告)日：2012-01-19
申请号：PCT/IB2011/052969
申请日：2011-07-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GmbH , BORGERT, Joern , GLEICH, Bernhard , WEIZENECKER, Juergen , DAHNKE, Hannes
发明人： BORGERT, Joern , GLEICH, Bernhard , WEIZENECKER, Juergen , DAHNKE, Hannes
IPC分类号： G06T1/00 , A61B5/05
CPC分类号： G06T1/0007 , A61B5/0515
摘要： The present invention relates to a system and a corresponding method for generating a system function for use in the reconstruction of images in an imaging device for imaging the distribution of a tracer material in an object, wherein the system function describes the mapping between tracer distribution and imaging signals acquired by the imaging device. The proposed system comprises an acquisition means (220) for acquiring a first portion (SF Tr ) of the system function, said first portion describing dynamics of the tracer material, an imaging device (210) for acquiring a second portion (SF Sc ) of the system function, said second portion (SF Sc ) describing characteristics of the imaging device, and combination means (230) for combining said first and second portions to generate said system function.
摘要翻译：本发明涉及一种用于生成系统功能的系统和相应方法，所述系统功能用于成像设备中的图像的重构，用于对对象中的示踪材料的分布进行成像，其中所述系统功能描述了示踪剂分布与由成像装置获取的成像信号。所提出的系统包括用于获取系统功能的第一部分（SF Tr）的获取装置（220），所述第一部分描述示踪材料的动力学，用于获取第二部分（SF Sc）的成像装置（210）所述系统功能，描述所述成像装置的特征的所述第二部分（SF Sc）以及用于组合所述第一和第二部分以产生所述系统功能的组合装置（230）。

12. 发明申请

WO2011095924A1 APPARATUS AND METHOD FOR DETECTING MAGNETIC PARTICLES 审中-公开
标题翻译：用于检测磁性颗粒的装置和方法
公开(公告)号：WO2011095924A1
公开(公告)日：2011-08-11
申请号：PCT/IB2011/050410
申请日：2011-01-31
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , GLEICH, Bernhard , WEIZENECKER, Juergen
发明人： GLEICH, Bernhard , WEIZENECKER, Juergen
IPC分类号： A61B5/055 , A61B8/00
CPC分类号： A61B8/00 , A61B5/0515 , A61B8/4416 , A61B8/481
摘要： The present invention relates to an apparatus and a method for detecting magnetic particles in a field of view (28). More specifically, the present invention relates to the field of magnetic particle imaging (MPI). The method and arrangement according to the present invention use an acoustic MPI detection technique which detects acoustic emissions of a magnetic tracer material in an MPI setup. The apparatus according to the present invention therefore comprises an acoustic signal receiver (160) for acquiring acoustic detection signals, which detection signals depend on the magnetization in the field of view (28), which magnetization is influenced by the change in the position in space of the first and second sub-zone (52,54).
摘要翻译：本发明涉及一种用于在视野（28）中检测磁性颗粒的装置和方法。更具体地说，本发明涉及磁粉成像领域（MPI）。根据本发明的方法和装置使用在MPI设置中检测磁迹图案材料的声发射的声MPI检测技术。因此，根据本发明的装置包括用于获取声学检测信号的声学信号接收器（160），该检测信号取决于视场（28）中的磁化强度，该磁化受到空间位置变化的影响的第一和第二子区（52,54）。

13. 发明申请

WO2010134006A2 ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES 审中-公开
标题翻译：影响和/或检测磁性颗粒的装置和方法
公开(公告)号：WO2010134006A2
公开(公告)日：2010-11-25
申请号：PCT/IB2010/052111
申请日：2010-05-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BORGERT, Joern , GLEICH, Bernhard
发明人： BORGERT, Joern , GLEICH, Bernhard
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0042 , A61B5/02042 , A61B5/0515 , A61B5/6814 , A61N1/406
摘要： The present invention relates to an arrangement and a method for influencing and/or detecting magnetic particles in a region of action, in particular for monitoring of intra- cerebral or intra-cranial bleeding using Magnetic Particle Imaging (MPI). A common coupling unit per coil of a coil array is provided for coupling all signals for generating the magnetic fields to the set of common coils. Further, the same coils are used for acquiring detection signals. In this way a small scanner can be built that can be left permanently or can be provided periodically to the patient, in particular for bleeding monitoring.
摘要翻译：本发明涉及用于影响和/或检测动作区域中的磁性颗粒的装置和方法，特别是用于使用磁性颗粒成像（MPI）监测脑内或脑内出血。提供每个线圈阵列的每个线圈的公共耦合单元，用于将用于产生磁场的所有信号耦合到该组公共线圈。此外，使用相同的线圈来获取检测信号。以这种方式，可以构建可以永久地留下或可以定期向病人提供的小扫描仪，特别是用于出血监测。

14. 发明申请

WO2010070575A1 PERMANENT MAGNETIC ASSEMBLY FOR MAGNETIC PARTICLE IMAGING 审中-公开
标题翻译：用于磁颗粒成像的永久磁性组件
公开(公告)号：WO2010070575A1
公开(公告)日：2010-06-24
申请号：PCT/IB2009/055741
申请日：2009-12-14
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , TIMINGER, Holger , WEIZENECKER, Jürgen , GLEICH, Bernhard
发明人： TIMINGER, Holger , WEIZENECKER, Jürgen , GLEICH, Bernhard
IPC分类号： G01R33/383 , A61B5/05
CPC分类号： A61B5/055 , A61B5/0515 , G01R33/022 , G01R33/14 , G01R33/3802 , G01R33/383
摘要： The present invention relates to an arrangement (10) for influencing and/or detecting magnetic particles in a region of action (300). The arrangement (10) comprises selection means (210) for generating a magnetic selection field (211) having a pattern in space of its magnetic field strength such that a first sub-zone (301) having a low magnetic field strength and a second sub-zone (302) having a higher magnetic field strength are formed in the region of action (300), drive means (220) for changing the position in space of the two sub- zones (301, 302) in the region of action (300) by means of a magnetic drive field (221) so that the magnetization of the magnetic material changes locally, and receiving means (230) for acquiring detection signals, which detection signals depend on the magnetization in the region of action (300), which magnetization is influenced by the change in the position in space of the first and second sub-zone (301, 302). The selection means (210) comprises a permanent magnetic assembly having at least one permanent magnetic unit (213) comprising a plurality of magnetic sub-elements (214) wherein the magnetic sub-elements (214) have individually fixed magnetization orientation, and are bonded together to form said at least one permanent magnetic unit (213).
摘要翻译：本发明涉及用于在动作区域（300）中影响和/或检测磁性颗粒的装置（10）。该装置（10）包括选择装置（210），用于产生具有其磁场强度空间中的图案的磁选择场（211），使得具有低磁场强度的第一子区（301）和第二子在动作区域（300）中形成具有较高磁场强度的区域（302），用于改变动作区域中的两个子区域（301,302）的空间位置的驱动装置（220） 300），借助磁驱动场（221）使得磁性材料的磁化在局部变化，以及用于获取检测信号的接收装置（230），该检测信号取决于作用区域（300）中的磁化，该磁化受到第一和第二子区（301,302）的空间位置变化的影响。所述选择装置（210）包括具有至少一个包括多个磁性子元件（214）的永久磁性单元（213）的永久磁性组件，其中所述磁性子元件（214）具有单独固定的磁化取向，一起形成所述至少一个永磁单元（213）。

15. 发明申请

WO2009057022A2 SEPARATOR COLUMN, SEPARATOR SYSTEM, METHOD OF FRACTIONATING MAGNETIC PARTICLES, METHOD OF MANUFACTURING A SEPARATOR COLUMN AND USE OF A SEPARATOR COLUMN 审中-公开
标题翻译：分离柱，分离器系统，分离磁性颗粒的方法，制造分离柱的方法和分离柱的使用
公开(公告)号：WO2009057022A2
公开(公告)日：2009-05-07
申请号：PCT/IB2008/054393
申请日：2008-10-24
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , MARKOV, Denis , BOEVE, Hans, M., B. , GLEICH, Bernhard , WEIZENECKER, Juergen
发明人： MARKOV, Denis , BOEVE, Hans, M., B. , GLEICH, Bernhard , WEIZENECKER, Juergen
IPC分类号： B03C1/28 , B03C1/033
CPC分类号： B03C1/286 , A61B5/0515 , B03C1/01 , B03C1/0335 , B03C2201/18
摘要： A separator system with a separator column and a method of fractionating magnetic particles, preferably using field-flow fractionation is proposed, which allows for more effective fractionation of magnetic particles with respect to their dynamic magnetic response in a wide frequency and amplitude range of an applied magnetic field, in particular relevant for magnetic particle imaging (MPI).
摘要翻译：提出了具有分离器柱的分离器系统和优选使用场流分馏的分馏磁性粒子的方法，其允许磁性粒子相对于其动态磁响应的更有效的分级应用磁场的宽频率和幅度范围，特别是与磁性粒子成像（MPI）有关。

16. 发明申请

WO2008078262A2 ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING AND/OR LOCATING MAGNETIC PARTICLES IN A REGION OF ACTION 审中-公开
标题翻译：在行动区域影响和/或检测和/或定位磁性颗粒的装置和方法
公开(公告)号：WO2008078262A2
公开(公告)日：2008-07-03
申请号：PCT/IB2007/055158
申请日：2007-12-17
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , GLEICH, Bernhard , WEIZENECKER, Juergen
发明人： GLEICH, Bernhard , WEIZENECKER, Juergen
IPC分类号： G01N27/00
CPC分类号： A61B5/05 , A61B5/0515
摘要： An arrangement and a method for influencing and/or detecting and/or locating magnetic particles in a region of action is disclosed, which arrangement comprises: - drive means for generating a magnetic drive field so that the magnetization of the magnetic particles changes, wherein the magnetic particles comprise at least a first and a second magnetic particle, - the receiving means comprising at least a first receiving probe providing a first signal (231') and a second receiving probe providing a second signal - detection means for determining signal features arising from the first particle in the first signal and in the second signal.
摘要翻译：公开了一种用于影响和/或检测和/或定位作用区域中的磁性颗粒的装置和方法，该装置包括： - 用于产生磁驱动场的驱动装置，以便磁化，其中所述磁性颗粒至少包括第一和第二磁性颗粒， - 所述接收装置至少包括提供第一信号的第一接收探头（231'）和提供第二信号的第二接收探头 - 检测装置，用于确定在第一信号和第二信号中由第一粒子产生的信号特征。

17. 发明申请

WO2008023321A2 INTERVENTIONAL DEVICE FOR RF ABLATION FOR USE IN RF FIELDS 审中-公开
标题翻译：用于射频场的射频消融的介入装置
公开(公告)号：WO2008023321A2
公开(公告)日：2008-02-28
申请号：PCT/IB2007/053311
申请日：2007-08-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WEISS, Steffen , GLEICH, Bernhard
发明人： WEISS, Steffen , GLEICH, Bernhard
IPC分类号： A61B5/00
CPC分类号： G01R33/34084 , A61B5/042 , A61B5/06 , A61B18/1492 , A61B2034/2051 , A61B2090/374 , A61B2562/222 , G01R33/287 , G01R33/288 , G01R33/34053 , G01R33/3628
摘要： A interventional device for RF ablation for use in a RF electrical and/or magnetic field especially of a MR imaging system is disclosed, comprising an ablation catheter which is preferably trackable or can be guided or visualized in the image generated by the MR imaging system by means of a MR micro-coil (102), and which is provided with an ablation electrode (101). The interventional device further comprises a transmission path (103) with line segments (104', 104") and transformers (105) therebetween, for connecting the MR micro-coil (102) in a differential mode with a MR receiver (108) and for connecting a RF amplifier (107) in a common mode with the ablation electrode (101) for conveying RF ablation power.
摘要翻译：公开了一种用于射频电场和/或磁场尤其是MR成像系统的射频消融的介入装置，其包括消融导管，该消融导管优选是可跟踪的或可以在消融导管中被引导或可视化由MR成像系统借助MR微型线圈（102）产生的图像，并且其设置有消融电极（101）。介入装置还包括具有线段（104'，104“）和位于其间的变压器（105）的传输路径（103），用于以差分模式将MR微线圈（102）与MR接收器（108）连接;以及用于以共同模式将射频放大器（107）与消融电极（101）连接以传送RF消融功率。

18. 发明申请

WO2012063186A1 COLON SCREENING BY USING MAGNETIC PARTICLE IMAGING 审中-公开
标题翻译：使用磁性粒子成像进行彩色扫描
公开(公告)号：WO2012063186A1
公开(公告)日：2012-05-18
申请号：PCT/IB2011/054953
申请日：2011-11-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BORGERT, Jörn , SCHMALE, Ingo , RAHMER, Jürgen Erwin , GLEICH, Bernhard , KUHN, Michael Harald
发明人： BORGERT, Jörn , SCHMALE, Ingo , RAHMER, Jürgen Erwin , GLEICH, Bernhard , KUHN, Michael Harald
IPC分类号： A61K49/18 , A61B5/05
CPC分类号： A61B5/0515 , A61B5/05 , A61K49/1818
摘要： The present invention relates to a method for colon screening by using Magnetic Particle Imaging comprising the steps of: (a) generating an imaging magnetic field with a spatial distribution of the magnetic field strength such that the area of examination in the colon consists of a first sub-area of the colon with lower magnetic field strength, where the magnetization of a magnetic particle which was pre-delivered to the colon is not saturated, and a second sub-area of the colon with a higher magnetic field strength, where the magnetization of said magnetic particle is saturated;(b) changing the spatial location of both sub-areas in the area of examination so that the magnetization of said particles changes locally; (c) acquiring signals that depend on the magnetization in the area of examination influenced by this change; and (d) evaluating said signals to obtain information about the spatial distribution of the signals in the area of examination. The area of examination in the colon preferably comprises a portion or segment of the colon and steps (a) to (c) may be carried out during an entire peristaltic cycle in said colon portion or segment. The present invention further relates to a corresponding method for collecting data, the use of a magnetic particle for colon screening via Magnetic Particle Imaging, a food stuff or liquid for in vivo diagnostic use comprising a magnetic particle, and a method for preparing a patient for colon screening by using Magnetic Particle Imaging.
摘要翻译：本发明涉及一种通过使用磁性粒子成像进行结肠筛查的方法，包括以下步骤：（a）产生具有磁场强度的空间分布的成像磁场，使得冒号中的检查区域由第一具有较低磁场强度的结肠的子区域，其中预先输送到结肠的磁性颗粒的磁化不饱和，以及具有较高磁场强度的结肠的第二子区域，其中磁化强度的所述磁性颗粒饱和;（b）改变检查区域中两个子区域的空间位置，使得所述颗粒的磁化在局部变化; （c）获取取决于受该变化影响的检查区域的磁化强度的信号; 和（d）评估所述信号以获得关于检查区域中的信号的空间分布的信息。结肠检查的区域优选包含结肠的一部分或部分，并且步骤（a）至（c）可以在结肠部分或段中的整个蠕动循环期间进行。本发明还涉及用于收集数据的相应方法，通过磁性粒子成像进行结肠筛选的磁性颗粒的使用，用于包括磁性颗粒的体内诊断用途的食物或液体，以及用于制备患者的方法使用磁粉成像进行结肠筛查。

19. 发明申请

WO2011030249A1 APPARATUS AND METHOD FOR MEASURING THE INTERNAL PRESSURE OF AN EXAMINATION OBJECT 审中-公开
标题翻译：用于测量检查对象内部压力的装置和方法
公开(公告)号：WO2011030249A1
公开(公告)日：2011-03-17
申请号：PCT/IB2010/053702
申请日：2010-08-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , GLEICH, Bernhard , SCHMALE, Ingo
发明人： GLEICH, Bernhard , SCHMALE, Ingo
IPC分类号： A61B5/021 , A61B5/05
CPC分类号： A61B5/05 , A61B5/02007 , A61B5/021 , A61B5/0515
摘要： The present invention relates to an apparatus (100) for measuring the internal pressure of an examination object, in particular the internal pressure of a blood vessel, by use of a magnetic pressure measurement device (60, 70) introduced into the examination object, which apparatus comprises: - magnetic field generating means comprising magnetic field signal generator units (130) and magnetic field coils (136a, 136b, 136c) for generating a magnetic field for influencing the magnetization of the magnetic pressure measurement device (60, 70), receiving means comprising at least one signal receiving unit (140) and at least one receiving coil (148) for acquiring detection signals, which detection signals depend on the changes in magnetization of the magnetic pressure measurement device (60, 70) caused by the magnetic field and on the changes of the physical properties of the magnetic pressure measurement device caused by the internal pressure of the examination object, and evaluation means (153) for evaluating the detection signals of the magnetic pressure measurement device (60, 70) for determining the internal pressure of the examination object.
摘要翻译：本发明涉及一种用于通过使用引入检查对象的磁压力测量装置（60,70）来测量检查对象的内部压力，特别是血管的内部压力的装置（100），其中装置包括： - 磁场产生装置，包括磁场信号发生器单元（130）和用于产生用于影响磁压力测量装置（60,70）的磁化的磁场的磁场线圈（136a，136b，136c）），包括至少一个信号接收单元（140）和用于获取检测信号的至少一个接收线圈（148）的装置，所述检测信号取决于由磁场引起的磁压力测量装置（60,70）的磁化变化以及由检查对象的内部压力引起的磁压力测量装置的物理性质的变化以及评价装置（153），用于评估用于确定检查对象的内部压力的磁压力测量装置（60,70）的检测信号。

20. 发明申请

WO2011030247A1 APPARATUS AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A FIELD OF VIEW 审中-公开
标题翻译：在视场中影响和/或检测磁性颗粒的装置和方法
公开(公告)号：WO2011030247A1
公开(公告)日：2011-03-17
申请号：PCT/IB2010/053684
申请日：2010-08-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , RAHMER, Jürgen, Erwin , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： RAHMER, Jürgen, Erwin , GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0515
摘要： The present invention relates to an apparatus (100) for influencing and/or detecting magnetic particles in a field of view (28), wherein the field of view (28) comprises at least one sub field of interest covering at least a portion of an object of interest containing magnetic particles. The apparatus (100) applying the known principle of Magnetic Particle Imaging (MPI) comprises selection means for generating a magnetic selection field (50) having the known field pattern showing a field free point (FFP), drive means for changing the position in space of the FFP by means of a magnetic drive field, receiving means for acquiring detection signals depending on the magnetization of the magnetic particles within the field of view (28), a control unit (150) for controlling a signal receiving unit (140) comprised in the receiving means for acquiring a set of high resolution detection signals and a set of low resolution detection signals, wherein the set of high resolution detection signals depends on the magnetization of at least one subfield of interest and the set of low resolution detection signals depends on the magnetization of at least one adjacent subfield being arranged adjacent to the at least one subfield of interest, and a reconstruction unit (152) for reconstructing a particle distribution quantity depending on the set of high resolution detection signals and the set of low resolution detection signals. The present invention further relates to a corresponding method as well as to a computer program.
摘要翻译：本发明涉及一种用于在视场（28）中影响和/或检测磁性颗粒的设备（100），其中视场（28）包括至少一个感兴趣的子场，其覆盖至少一部分感兴趣的物体包含磁性颗粒。应用已知的磁性粒子成像原理（MPI）的装置（100）包括选择装置，用于产生具有示出场自由点（FFP）的已知场模式的磁选择场（50），用于改变空间位置的驱动装置通过磁驱动场的FFP的接收装置，用于获取取决于视野内的磁性颗粒的磁化强度的检测信号的接收装置，用于控制信号接收单元（140）的控制单元（150）在用于获取一组高分辨率检测信号和一组低分辨率检测信号的接收装置中，其中该组高分辨率检测信号取决于至少一个感兴趣的子场的磁化，并且该组低分辨率检测信号取决于在与至少一个感兴趣的子场相邻地布置的至少一个相邻子场的磁化上，以及用于重构的重建单元（152）根据高分辨率检测信号和一组低分辨率检测信号来设定粒子分布量。本发明还涉及相应的方法以及计算机程序。

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