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1. 发明申请

WO2012007871A1 SYSTEM AND METHOD FOR GENERATING A SYSTEM FUNCTION FOR USE IN THE RECONSTRUCTION OF IMAGES 审中-公开
标题翻译：用于生成用于重建图像的系统功能的系统和方法
公开(公告)号：WO2012007871A1
公开(公告)日：2012-01-19
申请号：PCT/IB2011/052969
申请日：2011-07-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GmbH , BORGERT, Joern , GLEICH, Bernhard , WEIZENECKER, Juergen , DAHNKE, Hannes
发明人： BORGERT, Joern , GLEICH, Bernhard , WEIZENECKER, Juergen , DAHNKE, Hannes
IPC分类号： G06T1/00 , A61B5/05
CPC分类号： G06T1/0007 , A61B5/0515
摘要： The present invention relates to a system and a corresponding method for generating a system function for use in the reconstruction of images in an imaging device for imaging the distribution of a tracer material in an object, wherein the system function describes the mapping between tracer distribution and imaging signals acquired by the imaging device. The proposed system comprises an acquisition means (220) for acquiring a first portion (SF Tr ) of the system function, said first portion describing dynamics of the tracer material, an imaging device (210) for acquiring a second portion (SF Sc ) of the system function, said second portion (SF Sc ) describing characteristics of the imaging device, and combination means (230) for combining said first and second portions to generate said system function.
摘要翻译：本发明涉及一种用于生成系统功能的系统和相应方法，所述系统功能用于成像设备中的图像的重构，用于对对象中的示踪材料的分布进行成像，其中所述系统功能描述了示踪剂分布与由成像装置获取的成像信号。所提出的系统包括用于获取系统功能的第一部分（SF Tr）的获取装置（220），所述第一部分描述示踪材料的动力学，用于获取第二部分（SF Sc）的成像装置（210）所述系统功能，描述所述成像装置的特征的所述第二部分（SF Sc）以及用于组合所述第一和第二部分以产生所述系统功能的组合装置（230）。

2. 发明申请

WO2010134006A2 ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES 审中-公开
标题翻译：影响和/或检测磁性颗粒的装置和方法
公开(公告)号：WO2010134006A2
公开(公告)日：2010-11-25
申请号：PCT/IB2010/052111
申请日：2010-05-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BORGERT, Joern , GLEICH, Bernhard
发明人： BORGERT, Joern , GLEICH, Bernhard
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0042 , A61B5/02042 , A61B5/0515 , A61B5/6814 , A61N1/406
摘要： The present invention relates to an arrangement and a method for influencing and/or detecting magnetic particles in a region of action, in particular for monitoring of intra- cerebral or intra-cranial bleeding using Magnetic Particle Imaging (MPI). A common coupling unit per coil of a coil array is provided for coupling all signals for generating the magnetic fields to the set of common coils. Further, the same coils are used for acquiring detection signals. In this way a small scanner can be built that can be left permanently or can be provided periodically to the patient, in particular for bleeding monitoring.
摘要翻译：本发明涉及用于影响和/或检测动作区域中的磁性颗粒的装置和方法，特别是用于使用磁性颗粒成像（MPI）监测脑内或脑内出血。提供每个线圈阵列的每个线圈的公共耦合单元，用于将用于产生磁场的所有信号耦合到该组公共线圈。此外，使用相同的线圈来获取检测信号。以这种方式，可以构建可以永久地留下或可以定期向病人提供的小扫描仪，特别是用于出血监测。

3. 发明申请

WO2011045705A1 DEVICE AND METHOD FOR GENERATING SOFT TISSUE CONTRAST IMAGES 审中-公开
标题翻译：用于产生软组织对比图像的装置和方法
公开(公告)号：WO2011045705A1
公开(公告)日：2011-04-21
申请号：PCT/IB2010/054486
申请日：2010-10-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , GLEICH, Bernhard
发明人： GLEICH, Bernhard
IPC分类号： A61B6/02 , G01N23/20
CPC分类号： A61B6/482 , A61B6/4021 , A61B6/4241 , A61B6/483 , A61B6/484
摘要： The present invention relates to a device for generating soft tissue contrast images of an area of interest of an examination object (5) comprising soft tissue. The proposed device comprises: an x-ray source unit (2, 3) for emitting one or more pulsed pencil x-ray beams (4), an actuator (8, 9) for actuating said x-ray source unit (2, 3) along and/or around said area of interest to direct said one or more pencil beams (11) onto said area of interest from various directions, an electromagnetic signal receiver (11) for receiving electromagnetic signals from the area of interest resulting from absorption and scatter of x-ray photons within the area of interest, and a signal processor unit (12) for processing said received electromagnetic signals and reconstructing a soft tissue contrast image of the area of interest.
摘要翻译：本发明涉及一种用于产生包含软组织的检查对象（5）的感兴趣区域的软组织对比度图像的装置。所提出的装置包括：用于发射一个或多个脉冲的铅笔x射线束（4）的X射线源单元（2,3），用于致动所述x射线源单元（2,3）的致动器（8,9））沿着所述感兴趣区域和/或周围，以将所述一个或多个笔形射束（11）从各个方向引导到所述感兴趣的区域上;电磁信号接收器（11），用于接收来自由吸收产生的感兴趣区域的电磁信号;以及 x射线光子在感兴趣区域内的散射;以及信号处理器单元（12），用于处理所述接收的电磁信号并重建感兴趣区域的软组织对比度图像。

4. 发明申请

WO2008078276A1 ARRANGEMENT AND METHOD FOR DETECTING AND/OR LOCATING A MAGNETIC MATERIAL IN A REGION OF ACTION, USE OF AN ARRANGEMENT IN THE EXAMINATION OF BUILDINGS 审中-公开
标题翻译：在行动区域检测和/或定位磁性材料的安排和方法，在检查建筑物时使用安排
公开(公告)号：WO2008078276A1
公开(公告)日：2008-07-03
申请号：PCT/IB2007/055178
申请日：2007-12-17
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen
IPC分类号： G01V3/08 , G01R33/60
CPC分类号： G01R33/12
摘要： An arrangement and a method for detecting and/or locating magnetic material, and the use of an arrangement in the examination of buildings is disclosed, which arrangement comprises: selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic material changes locally, receiving means for acquiring detection signals, which detection signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the magnetic selection field comprises at least a time-variable field component varying at a frequency of at least about 100 Hz.
摘要翻译：公开了一种用于检测和/或定位磁性材料的装置和方法，以及在建筑物检查中使用一种装置，该装置包括：用于产生具有其磁场强度空间中的图案的磁选择场的选择装置使得具有低磁场强度的第一子区域和具有较高磁场强度的第二子区域形成在作用区域中，用于改变该区域中两个子区域的空间位置的驱动装置通过磁驱动场的作用，使得磁性材料的磁化在局部变化，用于获取检测信号的接收装置，该检测信号取决于作用区域中的磁化强度，该磁化受位置变化的影响在所述第一和第二子区域的空间中，其中所述磁选择场包括至少一个随时间变化的场分量至少约100Hz。

5. 发明申请

WO2008078269A3 ARRANGEMENT AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A REGION OF ACTION, COIL ARRANGEMENT 审中-公开
公开(公告)号：WO2008078269A3
公开(公告)日：2008-07-03
申请号：PCT/IB2007/055165
申请日：2007-12-17
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , GLEICH, Bernhard , WEIZENECKER, Juergen
发明人： GLEICH, Bernhard , WEIZENECKER, Juergen
IPC分类号： G01N27/00
摘要： An arrangement and a method for influencing and/or detecting magnetic particles in a region of action is disclosed, which arrangement comprises: selection means for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action, drive means for changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, receiving means for acquiring signals, which signals depend on the magnetization in the region of action, which magnetization is influenced by the change in the position in space of the first and second sub-zone, wherein the arrangement comprises a coil arrangement comprising a surrounding coil and a magnetic field generator such that the surrounding coil almost completely surrounds the magnetic field generator.

6. 发明申请

WO2008078266A3 METHOD AND ARRANGEMENT FOR LOCATING MAGNETIC MARKERS IN A REGION OF ACTION 审中-公开
公开(公告)号：WO2008078266A3
公开(公告)日：2008-07-03
申请号：PCT/IB2007/055162
申请日：2007-12-17
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , GLEICH, Bernhard
发明人： GLEICH, Bernhard
IPC分类号： A61B5/00 , G01N27/00
摘要： A method and an arrangement for influencing and/or detecting and/or locating magnetic markers in a region of action is disclosed, which method comprises the steps of: generating a magnetic drive field so that the magnetization of the magnetic marker changes, generating a magnetic selection field having a pattern in space of its magnetic field strength providing a magnetic field gradient in the region of action, acquiring a first signal by means of a first receiving probe and acquiring a second signal by means of a second receiving probe, the first receiving probe and the second receiving probe being located at different locations relative to the region of action, the first signal and the second signal depending on the magnetization of the magnetic marker in the drive field and in the selection field and further depending on the location of the magnetic marker, the magnetic selection field having a first magnetic field strength configuration, repeating at least once the acquisition of the first signal and of the second signal in the presence of the selection field having a second magnetic field strength configuration, computing an estimation of the location of the magnetic marker by means of the acquired signals.

7. 发明申请

WO2006067703A2 TRANSMISSION PATH FOR USE IN RF FIELDS 审中-公开
标题翻译：传输路径用于射频场
公开(公告)号：WO2006067703A2
公开(公告)日：2006-06-29
申请号：PCT/IB2005/054267
申请日：2005-12-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , GLEICH, Bernhard , VERNICKEL, Peter , WEISS, Steffen , LUEDEKE, Kai-Michael
发明人： GLEICH, Bernhard , VERNICKEL, Peter , WEISS, Steffen , LUEDEKE, Kai-Michael
IPC分类号： G01R33/36
CPC分类号： G01R33/287 , G01R33/3642 , G01R33/3685
摘要： A transmission path (13) for transmitting high frequency (RF) signals is disclosed, which comprises a plurality of lead segments (20, 21, 22) which are coupled to one another on one end by a capacitive coupling element (30) and on the other end by an inductive coupling element (31) and which each have an effective length of approximately λ i /4, wherein λ i is the wavelength of a differential mode signal to be transmitted over the path (13). By providing these element (30, 31) in the form of distributed elements which electrically extend over at least a part of adjacent lead segments (20, 21; 21, 22) a very thin transmission path (13) can be realized, which is especially suitable for use with invasive catheters. Furthermore, this path (13) can be guided through RF fields of a magnetic resonance (MR) imaging system because common mode resonances are effectively suppressed.
摘要翻译：公开了一种用于传输高频（RF）信号的传输路径（13），其包括在一端彼此耦合的多个引线段（20,21,22）电容耦合元件（30），另一端由电感耦合元件（31）耦合，并且每一个都具有大约λ1/4的有效长度，其中λ1，是通过路径（13）传输的差模信号的波长。通过以在相邻引线段（20,21; 21,22）的至少一部分上电延伸的分布元件的形式提供这些元件（30,31），可以实现非常薄的传输路径（13），其是特别适用于侵入性导管。此外，由于共模共振被有效地抑制，所以该路径（13）可以被引导通过磁共振（MR）成像系统的RF场。

8. 发明申请

WO2012077035A1 APPARATUS AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES 审中-公开
标题翻译：影响和/或检测磁性颗粒的装置和方法
公开(公告)号：WO2012077035A1
公开(公告)日：2012-06-14
申请号：PCT/IB2011/055456
申请日：2011-12-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BONTUS, Claas , GLEICH, Bernhard
发明人： BONTUS, Claas , GLEICH, Bernhard
IPC分类号： A61B5/05
CPC分类号： A61B5/0515
摘要： The present invention relates to an apparatus and a method for influencing and/or detecting magnetic particles in a field of view (28), in particular for magnetic particle imaging (MPI). The proposed apparatus comprises selection means for generating a magnetic selection field (50) and drive means for generating a magnetic drive field for moving a field- free point along a predetermined trajectory through the field of view so that the magnetization of the magnetic material changes locally. According to the present invention a time-dependent oscillating drive field current is provided per drive field coil for driving the respective drive field coil, each drive field current having one or more individual oscillating frequencies and one or more individual current amplitudes and being generated by a corresponding drive field voltage per drive field coil (136a, 136b, 136c), each drive field voltage being generated by a superposition of a number of drive field voltage components including a drive field voltage component per drive field coil, wherein a drive field voltage component corresponding to a particular drive field coil comprises one or more sub¬ components, a sub-component having an individual voltage amplitude and having the same individual oscillating frequency as the respective drive field current of said particular drive field coil.
摘要翻译：本发明涉及一种用于影响和/或检测视场（28）中的磁性颗粒的设备和方法，特别是用于磁性颗粒成像（MPI）。所提出的装置包括用于产生磁选区（50）的选择装置和用于产生磁驱动场的驱动装置，用于沿着预定轨迹沿视场移动无场点，使得磁性材料的磁化在局部变化。根据本发明，每个驱动励磁线圈提供时间依赖的振荡驱动场电流，用于驱动相应的驱动场线圈，每个驱动场电流具有一个或多个单个振荡频率和一个或多个单独的电流幅度，并由每个驱动场线圈（136a，136b，136c）的对应的驱动场电压，每个驱动场电压由多个驱动场电压分量的叠加产生，每个驱动场电压分量包括每个驱动场线圈的驱动场电压分量，其中驱动场电压分量对应于特定的驱动场线圈包括一个或多个子组件，具有单个电压振幅并且具有与所述特定驱动场线圈的相应驱动场电流相同的独立振荡频率的子分量。

9. 发明申请

WO2011095924A1 APPARATUS AND METHOD FOR DETECTING MAGNETIC PARTICLES 审中-公开
标题翻译：用于检测磁性颗粒的装置和方法
公开(公告)号：WO2011095924A1
公开(公告)日：2011-08-11
申请号：PCT/IB2011/050410
申请日：2011-01-31
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , GLEICH, Bernhard , WEIZENECKER, Juergen
发明人： GLEICH, Bernhard , WEIZENECKER, Juergen
IPC分类号： A61B5/055 , A61B8/00
CPC分类号： A61B8/00 , A61B5/0515 , A61B8/4416 , A61B8/481
摘要： The present invention relates to an apparatus and a method for detecting magnetic particles in a field of view (28). More specifically, the present invention relates to the field of magnetic particle imaging (MPI). The method and arrangement according to the present invention use an acoustic MPI detection technique which detects acoustic emissions of a magnetic tracer material in an MPI setup. The apparatus according to the present invention therefore comprises an acoustic signal receiver (160) for acquiring acoustic detection signals, which detection signals depend on the magnetization in the field of view (28), which magnetization is influenced by the change in the position in space of the first and second sub-zone (52,54).
摘要翻译：本发明涉及一种用于在视野（28）中检测磁性颗粒的装置和方法。更具体地说，本发明涉及磁粉成像领域（MPI）。根据本发明的方法和装置使用在MPI设置中检测磁迹图案材料的声发射的声MPI检测技术。因此，根据本发明的装置包括用于获取声学检测信号的声学信号接收器（160），该检测信号取决于视场（28）中的磁化强度，该磁化受到空间位置变化的影响的第一和第二子区（52,54）。

10. 发明申请

WO2010070575A1 PERMANENT MAGNETIC ASSEMBLY FOR MAGNETIC PARTICLE IMAGING 审中-公开
标题翻译：用于磁颗粒成像的永久磁性组件
公开(公告)号：WO2010070575A1
公开(公告)日：2010-06-24
申请号：PCT/IB2009/055741
申请日：2009-12-14
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , TIMINGER, Holger , WEIZENECKER, Jürgen , GLEICH, Bernhard
发明人： TIMINGER, Holger , WEIZENECKER, Jürgen , GLEICH, Bernhard
IPC分类号： G01R33/383 , A61B5/05
CPC分类号： A61B5/055 , A61B5/0515 , G01R33/022 , G01R33/14 , G01R33/3802 , G01R33/383
摘要： The present invention relates to an arrangement (10) for influencing and/or detecting magnetic particles in a region of action (300). The arrangement (10) comprises selection means (210) for generating a magnetic selection field (211) having a pattern in space of its magnetic field strength such that a first sub-zone (301) having a low magnetic field strength and a second sub-zone (302) having a higher magnetic field strength are formed in the region of action (300), drive means (220) for changing the position in space of the two sub- zones (301, 302) in the region of action (300) by means of a magnetic drive field (221) so that the magnetization of the magnetic material changes locally, and receiving means (230) for acquiring detection signals, which detection signals depend on the magnetization in the region of action (300), which magnetization is influenced by the change in the position in space of the first and second sub-zone (301, 302). The selection means (210) comprises a permanent magnetic assembly having at least one permanent magnetic unit (213) comprising a plurality of magnetic sub-elements (214) wherein the magnetic sub-elements (214) have individually fixed magnetization orientation, and are bonded together to form said at least one permanent magnetic unit (213).
摘要翻译：本发明涉及用于在动作区域（300）中影响和/或检测磁性颗粒的装置（10）。该装置（10）包括选择装置（210），用于产生具有其磁场强度空间中的图案的磁选择场（211），使得具有低磁场强度的第一子区（301）和第二子在动作区域（300）中形成具有较高磁场强度的区域（302），用于改变动作区域中的两个子区域（301,302）的空间位置的驱动装置（220） 300），借助磁驱动场（221）使得磁性材料的磁化在局部变化，以及用于获取检测信号的接收装置（230），该检测信号取决于作用区域（300）中的磁化，该磁化受到第一和第二子区（301,302）的空间位置变化的影响。所述选择装置（210）包括具有至少一个包括多个磁性子元件（214）的永久磁性单元（213）的永久磁性组件，其中所述磁性子元件（214）具有单独固定的磁化取向，一起形成所述至少一个永磁单元（213）。

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