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1. 发明申请

WO2012063186A1 COLON SCREENING BY USING MAGNETIC PARTICLE IMAGING 审中-公开
标题翻译：使用磁性粒子成像进行彩色扫描
公开(公告)号：WO2012063186A1
公开(公告)日：2012-05-18
申请号：PCT/IB2011/054953
申请日：2011-11-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BORGERT, Jörn , SCHMALE, Ingo , RAHMER, Jürgen Erwin , GLEICH, Bernhard , KUHN, Michael Harald
发明人： BORGERT, Jörn , SCHMALE, Ingo , RAHMER, Jürgen Erwin , GLEICH, Bernhard , KUHN, Michael Harald
IPC分类号： A61K49/18 , A61B5/05
CPC分类号： A61B5/0515 , A61B5/05 , A61K49/1818
摘要： The present invention relates to a method for colon screening by using Magnetic Particle Imaging comprising the steps of: (a) generating an imaging magnetic field with a spatial distribution of the magnetic field strength such that the area of examination in the colon consists of a first sub-area of the colon with lower magnetic field strength, where the magnetization of a magnetic particle which was pre-delivered to the colon is not saturated, and a second sub-area of the colon with a higher magnetic field strength, where the magnetization of said magnetic particle is saturated;(b) changing the spatial location of both sub-areas in the area of examination so that the magnetization of said particles changes locally; (c) acquiring signals that depend on the magnetization in the area of examination influenced by this change; and (d) evaluating said signals to obtain information about the spatial distribution of the signals in the area of examination. The area of examination in the colon preferably comprises a portion or segment of the colon and steps (a) to (c) may be carried out during an entire peristaltic cycle in said colon portion or segment. The present invention further relates to a corresponding method for collecting data, the use of a magnetic particle for colon screening via Magnetic Particle Imaging, a food stuff or liquid for in vivo diagnostic use comprising a magnetic particle, and a method for preparing a patient for colon screening by using Magnetic Particle Imaging.
摘要翻译：本发明涉及一种通过使用磁性粒子成像进行结肠筛查的方法，包括以下步骤：（a）产生具有磁场强度的空间分布的成像磁场，使得冒号中的检查区域由第一具有较低磁场强度的结肠的子区域，其中预先输送到结肠的磁性颗粒的磁化不饱和，以及具有较高磁场强度的结肠的第二子区域，其中磁化强度的所述磁性颗粒饱和;（b）改变检查区域中两个子区域的空间位置，使得所述颗粒的磁化在局部变化; （c）获取取决于受该变化影响的检查区域的磁化强度的信号; 和（d）评估所述信号以获得关于检查区域中的信号的空间分布的信息。结肠检查的区域优选包含结肠的一部分或部分，并且步骤（a）至（c）可以在结肠部分或段中的整个蠕动循环期间进行。本发明还涉及用于收集数据的相应方法，通过磁性粒子成像进行结肠筛选的磁性颗粒的使用，用于包括磁性颗粒的体内诊断用途的食物或液体，以及用于制备患者的方法使用磁粉成像进行结肠筛查。

2. 发明申请

WO2012046157A1 APPARATUS AND METHOD FOR LOCATING MAGNETIC PARTICLES 审中-公开
标题翻译：用于定位磁性颗粒的装置和方法
公开(公告)号：WO2012046157A1
公开(公告)日：2012-04-12
申请号：PCT/IB2011/054202
申请日：2011-09-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , SCHMALE, Ingo , RAHMER, Jürgen Erwin
发明人： SCHMALE, Ingo , RAHMER, Jürgen Erwin
IPC分类号： A61K49/18 , A61B5/05 , A61N1/40 , A61B5/145 , A61B5/01
CPC分类号： A61B5/0515 , A61B5/015 , A61B5/021 , A61B5/14539 , A61N1/406
摘要： The present invention relates to an apparatus (100) and a method for detecting and/or locating at least two different types of magnetic particles in a field of view (28), in particular for magnetic particle imaging (MPI). While generally only a single type of magnetic particles is used, i.e. provided in the field of view, according to the present invention at least two different types are used. The system function data related to said different types of magnetic particles are acquired in advance and are used during reconstruction to distinguish and process the detection signals resulting from said different types of magnetic particles.
摘要翻译：本发明涉及一种用于在视野（28），特别是磁性粒子成像（MPI）中检测和/或定位至少两种不同类型的磁性颗粒的装置（100）和方法。虽然通常只使用一种类型的磁性颗粒，即在视场中提供的，但根据本发明，使用至少两种不同的类型。预先获取与所述不同类型的磁性粒子相关的系统功能数据，并且在重构期间使用以区分并处理由所述不同类型的磁性粒子产生的检测信号。

3. 发明申请

WO2012077015A1 APPARATUS AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES 审中-公开
标题翻译：影响和/或检测磁性颗粒的装置和方法
公开(公告)号：WO2012077015A1
公开(公告)日：2012-06-14
申请号：PCT/IB2011/055353
申请日：2011-11-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , GLEICH, Bernhard , RAHMER, Jürgen Erwin
发明人： GLEICH, Bernhard , RAHMER, Jürgen Erwin
IPC分类号： A61B5/05
CPC分类号： G01R33/28 , A61B5/0515 , G01R33/1276 , G01R33/44
摘要： The present invention relates to an apparatus (100) and a corresponding method for operation in a magnetic particle imaging mode for influencing and/or detecting magnetic particles in a field of view (28) and for operation in a magnetic resonance imaging mode, which apparatus comprises selection means comprising a selection field signal generator unit (110) and selection field coils (116), drive means comprising a drive field signal generator unit (130) and drive field coils (136a, 136b, 136c) for changing the position in space of the two sub-zones (52, 54) in the field of view (28) by means of a magnetic drive field so that the magnetization of the magnetic material changes locally, and focus means comprising a focus field signal generator unit (120) and a focus field coil unit (126) for changing the position in space of the field of view (28) by means of a magnetic focus field, wherein said focus field coil unit (126) comprises at least six focus field coils (32a-32d, 34a- 34d; 33a-33f) arranged for generating magnetic focus field components in different directions, wherein a first set of at least three focus field coils (32a, 32c, 34a, 34c; 33a-33c) is arranged on a first side of the field of view (28) and a second set of at least three focus field coils (32b, 32d, 34b, 34d; 33d-33f) is arranged on a second side of the field of view (28) opposite said first side.
摘要翻译：本发明涉及一种用于在磁场成像模式中操作以在视场（28）中影响和/或检测磁性颗粒并用于磁共振成像模式操作的装置（100）和相应的方法，该装置包括选择装置，包括选择场信号发生器单元（110）和选择场线圈（116），驱动装置包括用于改变空间位置的驱动场信号发生器单元（130）和驱动场线圈（136a，136b，136c）通过磁驱动场在视野（28）中的两个子区（52,54）中的磁化，使得磁性材料的磁化在局部变化，并且聚焦装置包括聚焦场信号发生器单元（120）以及用于通过磁场来改变所述视场（28）的空间位置的聚焦场线圈单元（126），其中所述聚焦场线圈单元（126）包括至少六个聚焦场线圈（32a- 32d，34a-34d; 33a-3 3f），其布置成用于在不同方向上产生磁焦点分量，其中至少三个聚焦场线圈（32a，32c，34a，34c; 33a-33c）布置在视场（28）的第一侧上，并且第二组至少三个聚焦场线圈（32b，32d，34b，34d; 33d-33f）布置在视野（28）与第一侧相对。

4. 发明申请

WO2011101767A1 RF ANTENNA ARRANGEMENT AND METHOD FOR MULTI NUCLEI MR IMAGE RECONSTRUCTION INVOLVING PARALLEL MRI 审中-公开
标题翻译：涉及并行MRI的多核MR图像重构的RF天线布置方法
公开(公告)号：WO2011101767A1
公开(公告)日：2011-08-25
申请号：PCT/IB2011/050483
申请日：2011-02-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , STEHNING, Christian , RAHMER, Jürgen Erwin , BOERNERT, Peter
发明人： STEHNING, Christian , RAHMER, Jürgen Erwin , BOERNERT, Peter
IPC分类号： G01R33/3415 , G01R33/36 , G01R33/54
CPC分类号： G01R33/3635 , G01R33/3415 , G01R33/4828 , G01R33/5611
摘要： A multi nuclei RF antenna arrangement for use in a multi nuclei MRI system or an MR scanner, for transmitting RF excitation signals (B 1 field) for exciting nuclear magnetic resonances (NMR), and/or for receiving NMR relaxation signals for multi nuclei MR (magnetic resonance) image reconstruction is disclosed, wherein the RF antenna arrangement is tuned to the Larmor frequencies of at least two different species of nuclei having at least two different gyromagnetic rations like 1 H, 14 N, 31 P, 13 C, 23 Na, 39 K, 17 O and hyperpolarized gases like 129 Xe or other isotopes having a nuclear spin. Further, a method for reconstructing a multi nuclei MR image especially by means of the above RF antenna arrangement is disclosed. The method involves reducing back-folding artifacts of the species having the higher gyromagnetic ration by parallel MRI reconstruction.
摘要翻译：用于多核MRI系统或MR扫描器的多核RF天线装置，用于发射用于激发核磁共振（NMR）的RF激励信号（B1场）和/或用于接收多核MR的NMR松弛信号（磁共振）图像重建，其中RF天线布置被调谐到具有至少两个不同回旋磁性比例的至少两种不同种类的Larmor频率，如1H，14N，31P，13C，23Na，39K，17O和超极化气体如129Xe或具有核旋转的其他同位素。此外，公开了一种用于重建多核MR图像的方法，特别是通过上述RF天线布置。该方法涉及通过平行MRI重建来减少具有较高回旋磁性比例的物种的折叠假象。

5. 发明申请

WO2010043997A1 FLOW INSENSITIVE MAGNETIZATION PREPARATION PULSE FOR T2* CONTRAST 审中-公开
标题翻译：用于T2 *对比度的流动敏感磁化准备脉冲
公开(公告)号：WO2010043997A1
公开(公告)日：2010-04-22
申请号：PCT/IB2009/054338
申请日：2009-10-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , STEHNING, Christian , RAHMER, Jürgen Erwin , REMMELE, Stefanie , BLUME, Ulrike , SCHAEFFTER, Tobias Richard
发明人： STEHNING, Christian , RAHMER, Jürgen Erwin , REMMELE, Stefanie , BLUME, Ulrike , SCHAEFFTER, Tobias Richard
IPC分类号： G01R33/50
CPC分类号： G01R33/50 , A61B5/055 , G01R33/4828 , G01R33/5602
摘要： A magnetic resonance system comprises a magnetic resonance scanner (10) including a main magnet (12) generating a static magnetic field biasing nuclear spins toward aligning along a direction of the static magnetic field, magnetic field gradient coils (14), a radio frequency coil (16), and a controller (20, 22) configured to: (a) drive the radio frequency coil to selectively tip spins predominantly of short T2* out of the direction of the static magnetic field; (b) drive at least one of the magnetic field gradient coils and the radio frequency coil to dephase said spins predominantly of short T2* tipped out of the direction of the static magnetic field; and (c) drive the magnetic field gradient coils and the radio frequency coil to acquire magnetic resonance data that is predominantly T2* weighted due to preceding operations (a) and (b).
摘要翻译：磁共振系统包括磁共振扫描器（10），该磁共振扫描器（10）包括主磁体（12），该主磁体产生静磁场，该静磁场偏置核自旋以沿着静磁场的方向排列，磁场梯度线圈（14），射频线圈（16），以及控制器（20,22），其被配置为：（a）驱动所述射频线圈以选择性地使所述静止磁场方向上的主要具有短T2 *的自旋尖端; （b）驱动所述磁场梯度线圈和所述射频线圈中的至少一个，以使所述自旋以主要从所述静态磁场方向倾斜的短T2 *去除; 和（c）驱动磁场梯度线圈和射频线圈以获得由于先前操作（a）和（b）而主要为T2 *加权的磁共振数据。

6. 发明申请

WO2013114247A2 MULTIMODAL FIDUCIAL MARKER AND MARKER ARRANGEMENT 审中-公开
标题翻译：多模糊标记和标记布置
公开(公告)号：WO2013114247A2
公开(公告)日：2013-08-08
申请号：PCT/IB2013/050541
申请日：2013-01-22
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS INTELLECTUAL PROPERTY&STANDARDS GMBH
发明人： RAHMER, Jürgen Erwin , GLEICH, Bernhard , BORGERT, Jörn , KUHN, Michael Harald
IPC分类号： A61B19/00
CPC分类号： A61B90/39 , A61B5/0071 , A61B5/0515 , A61B2090/3933 , A61B2090/3941 , A61B2090/3954 , A61B2090/3995 , A61B2576/00
摘要： The present invention relates to a multimodal fiducial marker (10) for registration of multimodal data, comprising a first portion (12) comprising magnetic material visible in MPI data obtained by a magnetic particle imaging method and a second portion (14) comprising a second material visible in image data obtained by another imaging method, which image data shall be registered with said MPI data. Further, the present invention relates to a marker arrangement (20).
摘要翻译：本发明涉及一种用于多模态数据登记的多模态基准标记（10），包括：第一部分（12），包括通过磁性粒子成像方法获得的MPI数据中可见的磁性材料和包括第二材料的第二部分（14）在通过另一成像方法获得的图像数据中可见，哪个图像数据应该与所述MPI数据一起登记。此外，本发明涉及一种标记装置（20）。

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