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1. 发明申请

WO2012063186A1 COLON SCREENING BY USING MAGNETIC PARTICLE IMAGING 审中-公开
标题翻译：使用磁性粒子成像进行彩色扫描
公开(公告)号：WO2012063186A1
公开(公告)日：2012-05-18
申请号：PCT/IB2011/054953
申请日：2011-11-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BORGERT, Jörn , SCHMALE, Ingo , RAHMER, Jürgen Erwin , GLEICH, Bernhard , KUHN, Michael Harald
发明人： BORGERT, Jörn , SCHMALE, Ingo , RAHMER, Jürgen Erwin , GLEICH, Bernhard , KUHN, Michael Harald
IPC分类号： A61K49/18 , A61B5/05
CPC分类号： A61B5/0515 , A61B5/05 , A61K49/1818
摘要： The present invention relates to a method for colon screening by using Magnetic Particle Imaging comprising the steps of: (a) generating an imaging magnetic field with a spatial distribution of the magnetic field strength such that the area of examination in the colon consists of a first sub-area of the colon with lower magnetic field strength, where the magnetization of a magnetic particle which was pre-delivered to the colon is not saturated, and a second sub-area of the colon with a higher magnetic field strength, where the magnetization of said magnetic particle is saturated;(b) changing the spatial location of both sub-areas in the area of examination so that the magnetization of said particles changes locally; (c) acquiring signals that depend on the magnetization in the area of examination influenced by this change; and (d) evaluating said signals to obtain information about the spatial distribution of the signals in the area of examination. The area of examination in the colon preferably comprises a portion or segment of the colon and steps (a) to (c) may be carried out during an entire peristaltic cycle in said colon portion or segment. The present invention further relates to a corresponding method for collecting data, the use of a magnetic particle for colon screening via Magnetic Particle Imaging, a food stuff or liquid for in vivo diagnostic use comprising a magnetic particle, and a method for preparing a patient for colon screening by using Magnetic Particle Imaging.
摘要翻译：本发明涉及一种通过使用磁性粒子成像进行结肠筛查的方法，包括以下步骤：（a）产生具有磁场强度的空间分布的成像磁场，使得冒号中的检查区域由第一具有较低磁场强度的结肠的子区域，其中预先输送到结肠的磁性颗粒的磁化不饱和，以及具有较高磁场强度的结肠的第二子区域，其中磁化强度的所述磁性颗粒饱和;（b）改变检查区域中两个子区域的空间位置，使得所述颗粒的磁化在局部变化; （c）获取取决于受该变化影响的检查区域的磁化强度的信号; 和（d）评估所述信号以获得关于检查区域中的信号的空间分布的信息。结肠检查的区域优选包含结肠的一部分或部分，并且步骤（a）至（c）可以在结肠部分或段中的整个蠕动循环期间进行。本发明还涉及用于收集数据的相应方法，通过磁性粒子成像进行结肠筛选的磁性颗粒的使用，用于包括磁性颗粒的体内诊断用途的食物或液体，以及用于制备患者的方法使用磁粉成像进行结肠筛查。

2. 发明申请

WO2012168869A1 MEDICAL IMAGING SYSTEM WITH MOTION DETECTION 审中-公开
标题翻译：具有运动检测的医学成像系统
公开(公告)号：WO2012168869A1
公开(公告)日：2012-12-13
申请号：PCT/IB2012/052839
申请日：2012-06-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , FORTHMANN, Peter , AMTHOR, Thomas Erik , KRUEGER, Sascha , KUHN, Michael Harald
发明人： FORTHMANN, Peter , AMTHOR, Thomas Erik , KRUEGER, Sascha , KUHN, Michael Harald
IPC分类号： A61B5/055 , A61B5/107 , A61B5/113 , G01R33/565
CPC分类号： A61B5/1128 , A61B5/0082 , A61B5/055 , A61B5/1077 , A61B5/113 , A61B5/6804 , A61B5/6823 , A61B5/7278 , A61B6/4417 , A61B6/527 , A61B8/5276 , A61B2562/0266 , G01R33/28 , G01R33/34084 , G01R33/3415 , G01R33/4808 , G01R33/56509 , G01R33/5673
摘要： A medical imaging system comprises an image data acquisition module to acquire imaging data and a motion detection module to acquire motion information. A reconstruction module reconstructs image datasets from the imaging data and with use of the motion information to correct for motion. The motion detection module is provided with a shape-sensing photonic fibre system to provide a photonic output representative of the spatial shape of the photonic fibre and an arithmetic unit to compute the motion information on the basis of the photonic output.
摘要翻译：医疗成像系统包括：图像数据获取模块，用于获取成像数据;以及运动检测模块，用于获取运动信息。重建模块从成像数据中重建图像数据集，并利用运动信息来校正运动。运动检测模块设置有形状感测光子纤维系统，以提供表示光子纤维的空间形状的光子输出和运算单元，以基于光子输出来计算运动信息。

3. 发明申请

WO2008012701A1 CAPSULE CAMERA WITH VARIABLE ILLUMINATION OF THE SURROUNDING TISSUE 审中-公开
标题翻译：胶囊相机与周边组织的可变照明
公开(公告)号：WO2008012701A1
公开(公告)日：2008-01-31
申请号：PCT/IB2007/051323
申请日：2007-04-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , U.S. PHILIPS CORPORATION , HENDRIKS, Bernardus Hendrikus Wilhelmus , KUHN, Michael Harald , ZAENGEL, Thomas , VAN DER VAART, Nijs Cornelis
发明人： HENDRIKS, Bernardus Hendrikus Wilhelmus , KUHN, Michael Harald , ZAENGEL, Thomas , VAN DER VAART, Nijs Cornelis
IPC分类号： A61B1/04 , A61B1/06
CPC分类号： A61B1/00087 , A61B1/00165 , A61B1/00188 , A61B1/0019 , A61B1/041 , A61B1/042 , A61B1/043 , A61B1/06 , A61B5/0066 , A61B5/0071 , A61B5/0084 , A61B18/20 , A61B2018/00482 , A61B2018/00577 , A61B2018/00589 , A61B2018/00642 , A61B2018/00904 , A61N5/0601 , A61N5/0603 , A61N5/062 , A61N2005/0609 , G03B15/02
摘要： The application relates to an ingestible capsule and method for in vivo imaging and/or treatment of one or more diseased areas of interest within the gastrointestinal tract of an animal or human being. The capsule comprises an image sensor; a lens system for focusing images onto the image sensor; at least one light source for illumination of the tissue area of interest, the at least one light source optionally being capable of providing optical therapeutic treatment to the diseased areas; a variable lens system located in front of the at least one light source, wherein the variable lens system comprises beam steering means and focusing means for directing and focusing the light beams from the at least one light source onto the diseased tissue areas,- a control unit in communication with the image sensor, the at least one light source, and variable lens system, a power source for powering the image sensor, the at least one light source and the control unit; and a non-digestible, transparent outer protective shell configured to pass through the gastrointestinal tract, housing within the image sensor, the lens system, the at least one light source, the variable lens system, the control unit and the power source.
摘要翻译：本申请涉及用于体内成像和/或治疗在动物或人的胃肠道内的一个或多个感兴趣的感兴趣区域的可摄取胶囊和方法。胶囊包括图像传感器; 用于将图像聚焦到图像传感器上的透镜系统; 用于照射所述组织区域的至少一个光源，所述至少一个光源任选地能够向所述患病区域提供光学治疗性治疗; 位于所述至少一个光源前面的可变透镜系统，其中所述可变透镜系统包括光束转向装置和用于将来自所述至少一个光源的光束引导和聚焦到所述病变组织区域上的聚焦装置， - 控制与图像传感器，至少一个光源和可变透镜系统连通的单元，用于为图像传感器供电的电源，至少一个光源和控制单元; 以及构造成穿过胃肠道，容纳在图像传感器，透镜系统，至少一个光源，可变透镜系统，控制单元和电源中的不可消化，透明的外保护壳。

4. 发明申请

WO2013114247A2 MULTIMODAL FIDUCIAL MARKER AND MARKER ARRANGEMENT 审中-公开
标题翻译：多模糊标记和标记布置
公开(公告)号：WO2013114247A2
公开(公告)日：2013-08-08
申请号：PCT/IB2013/050541
申请日：2013-01-22
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS INTELLECTUAL PROPERTY&STANDARDS GMBH
发明人： RAHMER, Jürgen Erwin , GLEICH, Bernhard , BORGERT, Jörn , KUHN, Michael Harald
IPC分类号： A61B19/00
CPC分类号： A61B90/39 , A61B5/0071 , A61B5/0515 , A61B2090/3933 , A61B2090/3941 , A61B2090/3954 , A61B2090/3995 , A61B2576/00
摘要： The present invention relates to a multimodal fiducial marker (10) for registration of multimodal data, comprising a first portion (12) comprising magnetic material visible in MPI data obtained by a magnetic particle imaging method and a second portion (14) comprising a second material visible in image data obtained by another imaging method, which image data shall be registered with said MPI data. Further, the present invention relates to a marker arrangement (20).
摘要翻译：本发明涉及一种用于多模态数据登记的多模态基准标记（10），包括：第一部分（12），包括通过磁性粒子成像方法获得的MPI数据中可见的磁性材料和包括第二材料的第二部分（14）在通过另一成像方法获得的图像数据中可见，哪个图像数据应该与所述MPI数据一起登记。此外，本发明涉及一种标记装置（20）。

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