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11. 发明申请

WO2012177601A3 MICROORGANISMS FOR PRODUCING ISOBUTANOL AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产ISOBUTANOL的微生物及其相关方法
公开(公告)号：WO2012177601A3
公开(公告)日：2014-05-08
申请号：PCT/US2012043091
申请日：2012-06-19
申请人： GENOMATICA INC , BURGARD ANTHONY P , OSTERHOUT ROBIN E , SUN JUN , PHARKYA PRITI
发明人： BURGARD ANTHONY P , OSTERHOUT ROBIN E , SUN JUN , PHARKYA PRITI
IPC分类号： C07C29/00 , C12N1/00 , C12N1/20 , C12P7/16
CPC分类号： C12P7/16 , C12N15/52 , Y02E50/10
摘要： Provided herein is a non-naturally occurring microbial organism having an isopropanol pathway and comprising at least one exogenous nucleic acid encoding an isopropanol pathway enzyme. In certain embodiments, the pathway includes an enzyme selected from a 4-hydroxybutyryl-CoA dehydratase, a crotonase, a 3-hydroxybutyryl-CoA dehydrogenase, an acetoacetyl-CoA synthetase, an acetyl-CoA:acetoacetate-CoA transferase, an acetoacetyl-CoA hydrolase, an acetoacetate decarboxylase, and an acetone reductase. Also provided herein is anon-naturally occurring microbial organism having an n-butanol pathway and comprising at least one exogenous nucleic acid encoding an n-butanol pathway enzyme. Other non-naturally occurring microbial organism having n-butanol or isobutanol pathways are also provided herein. In certain embodiments, isobutanol pathways utilizing reverse TCA and/or reducing equivalents from CO and/or hydrogen are used to enhance product yields. The organisms provided herein can be cultured to produce isopropanol, n-butanol, or isobutanol.
摘要翻译：本文提供了具有异丙醇途径并且包含至少一种编码异丙醇途径酶的外源核酸的非天然存在的微生物生物。在某些实施方案中，该途径包括选自4-羟基丁酰-CoA脱水酶，巴豆酸酶，3-羟基丁酰辅酶A脱氢酶，乙酰乙酰辅酶A合成酶，乙酰辅酶A：乙酰乙酸酯-CoA转移酶，乙酰乙酰辅酶A 水解酶，乙酰乙酸脱羧酶和丙酮还原酶。本文还提供了具有正丁醇途径的非天然存在的微生物生物，并且包含至少一种编码正丁醇途径酶的外源核酸。本文还提供了其它具有正丁醇或异丁醇途径的非天然存在的微生物。在某些实施方案中，使用利用反向TCA和/或来自CO和/或氢的还原当量的异丁醇途径来提高产物产率。本文提供的生物体可以培养以产生异丙醇，正丁醇或异丁醇。

12. 发明申请

WO2012177599A3 MICROORGANISMS FOR PRODUCING N-PROPANOL 1, 3-PROPANEDIOL, 1,2-PROPANEDIOL OR GLYCEROL AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产N-丙醇1,3-丙二醇，1,2-丙二醇或甘油的微生物及其相关方法
公开(公告)号：WO2012177599A3
公开(公告)日：2013-02-21
申请号：PCT/US2012043086
申请日：2012-06-19
申请人： GENOMATICA INC , BURGARD ANTHONY P , OSTERHOUT ROBIN E , SUN JUN , PHARKYA PRITI
发明人： BURGARD ANTHONY P , OSTERHOUT ROBIN E , SUN JUN , PHARKYA PRITI
IPC分类号： C12P7/04 , C12N1/21
CPC分类号： C12P7/18 , C12N9/0008 , C12N9/0067 , C12P7/04 , C12P7/20
摘要： Provided herein is a non-naturally occurring microbial organism having a reductive TCA or Wood-Ljungdahl pathway and comprising at least one exogenous nucleic acid encoding said pathway enzymes expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. Also provided herein is a method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, and can include culturing this organism for a sufficient period of time to produce a product.
摘要翻译：本文提供了具有还原性TCA或Wood-Ljungdahl途径的非天然存在的微生物生物体，并且包含至少一种编码所述途径酶的外源核酸，其以足够的量表达以增强通过乙酰辅酶A的碳通量。本文还提供了在一氧化碳或氢气存在下增强还原当量的可用性的方法，并且可以包括在足够的时间内培养该生物体以产生产物。

13. 发明申请

WO2012177983A4 MICROORGANISMS FOR PRODUCING ETHYLENE GLYCOL AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产乙二醇的微生物及其相关方法
公开(公告)号：WO2012177983A4
公开(公告)日：2013-06-20
申请号：PCT/US2012043714
申请日：2012-06-22
申请人： GENOMATICA INC , BURGARD ANTHONY P , OSTERHOUT ROBIN E , SUN JUN , PHARKYA PRITI
发明人： BURGARD ANTHONY P , OSTERHOUT ROBIN E , SUN JUN , PHARKYA PRITI
IPC分类号： C12P7/18
CPC分类号： C12P7/18 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms having an ethylene glycol pathway. The invention additionally provides methods of using such organisms to produce ethylene glycol. The invention provides non-naturally occurring microbial organisms containing ethylene glycol patways comprising at least one exogenous nucleic acid encoding an ethylene glycol pathway enzyme expressed in a sufficient amount to produce ethylene glycol. The invention additionally provides methods of using such microbial organisms to produce ethylene glycol, by culturing a non-naturally occurring microbial organism containing ethylene glycol pathways as described herein under conditions and for a sufficient period of time to produce ethylene glycol.
摘要翻译：本发明提供了具有乙二醇途径的非天然存在的微生物。本发明另外提供了使用这些生物体生产乙二醇的方法。本发明提供了包含至少一种编码乙二醇途径酶的外源核酸的含有乙二醇途径酶的非天然存在的微生物体，所述外源核酸以足以产生乙二醇的量表达。本发明另外提供了通过培养如本文所述的含有乙二醇途径的非天然存在的微生物有机体，在一定条件下培养足够的时间以产生乙二醇，从而使用这些微生物生产乙二醇的方法。

14. 发明申请

WO2012177983A3 MICROORGANISMS FOR PRODUCING ETHYLENE GLYCOL AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产乙烯甘油的微生物及其相关方法
公开(公告)号：WO2012177983A3
公开(公告)日：2013-05-16
申请号：PCT/US2012043714
申请日：2012-06-22
申请人： GENOMATICA INC , BURGARD ANTHONY P , OSTERHOUT ROBIN E , SUN JUN , PHARKYA PRITI
发明人： BURGARD ANTHONY P , OSTERHOUT ROBIN E , SUN JUN , PHARKYA PRITI
IPC分类号： C12P7/18
CPC分类号： C12P7/18 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms having an ethylene glycol pathway. The invention additionally provides methods of using such organisms to produce ethylene glycol. The invention provides non-naturally occurring microbial organisms containing ethylene glycol patways comprising at least one exogenous nucleic acid encoding an ethylene glycol pathway enzyme expressed in a sufficient amount to produce ethylene glycol. The invention additionally provides methods of using such microbial organisms to produce ethylene glycol, by culturing a non-naturally occurring microbial organism containing ethylene glycol pathways as described herein under conditions and for a sufficient period of time to produce ethylene glycol.
摘要翻译：本发明提供了具有乙二醇途径的非天然存在的微生物。本发明另外提供了使用这些生物体来生产乙二醇的方法。本发明提供含有乙二醇培养物的非天然存在的微生物，所述微生物包含至少一种编码乙二醇途径酶的外源核酸，所述外源核酸以足够的量表达以产生乙二醇。本发明还提供了使用这种微生物生产乙二醇的方法，通过在条件和足够的时间内培养含有本文所述的乙二醇途径的非天然存在的微生物生物来生产乙二醇。

15. 发明申请

WO2009151728A3 MICROORGANISMS FOR THE PRODUCTION OF ADIPIC ACID AND OTHER COMPOUNDS 审中-公开
标题翻译：用于生产对苯二酸和其他化合物的微生物
公开(公告)号：WO2009151728A3
公开(公告)日：2010-05-27
申请号：PCT/US2009038663
申请日：2009-03-27
申请人： GENOMATICA INC , BURGARD ANTHONY P , PHARKYA PRITI , OSTERHOUT ROBIN E
发明人： BURGARD ANTHONY P , PHARKYA PRITI , OSTERHOUT ROBIN E
IPC分类号： C12N1/21 , C12P7/44 , C12P13/04
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/1096 , C12N9/80 , C12N9/88 , C12P7/44 , C12P7/46 , C12P7/62 , C12P13/001 , C12P13/005 , C12P13/02 , C12P17/10 , C12Y101/01035 , C12Y102/0101 , C12Y103/01031 , C12Y206/01 , C12Y402/01
摘要： The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6- aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.
摘要翻译：本发明提供了具有己二酸，6-氨基己酸或己内酰胺途径的非天然存在的微生物。微生物生物体含有至少一种编码相应己二酸，6-氨基己酸或己内酰胺途径中的酶的外源核酸。本发明另外提供了生产己二酸，6-氨基己酸或己内酰胺的方法。该方法可以包括培养己二酸，6-氨基己酸或己内酰胺生产微生物，其中微生物生物体表达至少一种编码己二酸，6-氨基己酸或己内酰胺途径酶的外源核酸，其量足以产生相应的产物在条件下和足够的时间内生产己二酸，6-氨基己酸或己内酰胺。

16. 发明申请

WO2013184602A3 MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS 审中-公开
标题翻译：用于生产4-羟基丁酸酯，1,4-丁二醇和相关化合物的微生物和方法
公开(公告)号：WO2013184602A3
公开(公告)日：2014-01-30
申请号：PCT/US2013043954
申请日：2013-06-03
申请人： GENOMATICA INC , BURK MARK J
发明人： BURK MARK J , PHARKYA PRITI , BURGARD ANTHONY P , VAN DIEN STEPHEN J , OSTERHOUT ROBIN E , TRAWICK JOHN D , KUCHINSKAS MICHAEL P , STEER BRIAN
IPC分类号： C12P7/52 , C12N1/20 , C12N1/21
CPC分类号： C12N1/20 , C07C31/207 , C07C59/01 , C08G18/284 , C08G18/3206 , C08G63/06 , C08G63/16 , C08G63/181 , C08G69/02 , C12N9/18 , C12N15/52 , C12N15/63 , C12P7/18 , C12P7/42 , C12Y301/01 , Y02P20/52
摘要： The invention provides non-naturally occurring microbial organisms having a 4- hydroxybutyrate, 1,4-butanediol, or other product pathway and being capable of producing 4- hydroxybutyrate, 1,4-butanediol, or other product, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4- hydroxybutyrate, 1,4-butanediol, or other product or related products using the microbial organisms.
摘要翻译：本发明提供具有4-羟基丁酸酯，1,4-丁二醇或其它产物途径的非天然存在的微生物生物，并能够生产4-羟基丁酸酯，1,4-丁二醇或其它产品，其中微生物包含一种或更多遗传修饰。本发明另外提供了使用微生物生物制备4-羟基丁酸酯，1,4-丁二醇或其它产品或相关产品的方法。

17. 发明申请

WO2015100338A3 METHODS AND ORGANISMS WITH INCREASED CARBON FLUX EFFICIENCIES 审中-公开
标题翻译：具有增加的碳通量效率的方法和生物
公开(公告)号：WO2015100338A3
公开(公告)日：2015-09-03
申请号：PCT/US2014072178
申请日：2014-12-23
申请人： GENOMATICA INC
发明人： BURGARD ANTHONY P , OSTERHOUT ROBIN E , VAN DIEN STEPHEN J , PHARKYA PRITI , YANG TAE HOON , CHOI JUNGIK
IPC分类号： C12N1/21 , C12P1/04 , C12P7/16 , C12P7/52
CPC分类号： C12P7/18 , C07K14/245 , C12N1/20 , C12N9/0036 , C12N9/0057 , C12N9/1205 , C12N9/16 , C12N9/52 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/42 , C12Y106/01002 , C12Y110/03 , C12Y207/0104 , C12Y301/00 , C12Y301/02 , C12Y301/02002 , C12Y304/21092 , C12Y401/01031 , C12Y401/01032
摘要： The invention is directed to a non-naturally occurring microbial organism comprising a first attenuation of a succinyl-CoA synthetase or transferase and at least a second attenuation of a succinyl-CoA converting enzyme or a gene encoding a succinate producing enzyme within a multi-step pathway having a net conversion of succinyl-CoA to succinate.
摘要翻译：本发明涉及非天然存在的微生物生物体，其包含琥珀酰-CoA合成酶或转移酶的第一次减毒以及多步骤中琥珀酰-CoA转化酶或编码琥珀酸生产酶的基因的至少第二次减毒具有琥珀酰-CoA到琥珀酸的净转化的途径。

18. 发明申请

WO2014176514A3 MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS 审中-公开
标题翻译：用于生产4-羟基丁酸酯，1,4-丁二醇和相关化合物的微生物和方法
公开(公告)号：WO2014176514A3
公开(公告)日：2015-01-15
申请号：PCT/US2014035475
申请日：2014-04-25
申请人： GENOMATICA INC
发明人： PHARKYA PRITI , BURGARD ANTHONY P , VAN DIEN STEPHEN J , OSTERHOUT ROBIN E , BURK MARK J , TRAWICK JOHN D , KUCHINSKAS MICHAEL P , STEER BRIAN
IPC分类号： C07H21/04 , C12N9/10 , C12N9/14 , C12N15/00 , C12P7/16 , C12P21/06
CPC分类号： C12P7/18 , C07C31/207 , C07C47/19 , C07C211/09 , C07D307/33 , C12N1/20 , C12N9/0006 , C12N9/13 , C12N15/52 , C12P7/24 , C12P7/42 , C12P7/62 , C12P13/001 , C12P13/005 , C12P17/04 , C12P19/32 , C12Y208/03
摘要： The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine or related products using the microbial organisms.
摘要翻译：本发明提供具有4-羟基丁酸酯，γ-丁内酯，1,4-丁二醇，4-羟基丁醛，4-羟基丁酰辅酶A和/或腐胺途径并且能够产生4-羟基丁酸酯的非天然存在的微生物，其中微生物生物体包含一种或多种遗传修饰。本发明另外提供使用微生物生产4-羟基丁酸酯，γ-丁内酯，1,4-丁二醇，4-羟基丁醛，4-羟基丁酰-CoA和/或腐胺或相关产品的方法。

19. 发明申请

WO2014152434A3 MICROORGANISMS AND METHODS FOR PRODUCING BUTADIENE AND RELATED COMPOUNDS BY FORMATE ASSIMILATION 审中-公开
标题翻译：微生物和通过正式评估生产丁二烯及相关化合物的方法
公开(公告)号：WO2014152434A3
公开(公告)日：2014-12-11
申请号：PCT/US2014027337
申请日：2014-03-14
申请人： GENOMATICA INC
发明人： BURGARD ANTHONY P , OSTERHOUT ROBIN E , PHARKYA PRITI , ANDRAE STEFAN , LIS EWA T , RISSO CARLA , TRAWICK JOHN D
IPC分类号： C12P7/16 , C12N1/00 , C12N1/12 , C12N1/20
CPC分类号： C12N15/63 , C07C1/24 , C07C11/167 , C07C31/207 , C07C33/025 , C07K14/195 , C09D147/00 , C09J147/00 , C12N9/1022 , C12N9/88 , C12N9/90 , C12N15/52 , C12P5/026 , C12P7/04 , C12P7/18 , Y02E50/343
摘要： Provided herein are non-naturally occurring microbial organisms having a FaldFP, a FAP and/or metabolic modifications which can further include a MMP, a MOP, a hydrogenase and/or a CODH. These microbial organisms can further include a butadiene, 13BDO, CrotOH, MVC or 3-buten-1-ol pathway. Additionally provided are methods of using such microbial organisms to produce butadiene, 13BDO, CrotOH, MVC or 3-buten-1-ol.
摘要翻译：本文提供了具有FaldFP，FAP和/或代谢修饰的非天然存在的微生物，其可进一步包括MMP，MOP，氢化酶和/或CODH。这些微生物可以进一步包括丁二烯，13BDO，CrotOH，MVC或3-丁烯-1-醇途径。另外提供了使用这种微生物生物来生产丁二烯，13BDO，CrotOH，MVC或3-丁烯-1-醇的方法。

20. 发明申请

WO2013109865A3 MICROORGANISMS AND PROCESSES FOR PRODUCING TEREPHTHALIC ACID AND ITS SALTS 审中-公开
标题翻译：微生物和生产对苯二甲酸及其盐的工艺
公开(公告)号：WO2013109865A3
公开(公告)日：2013-09-12
申请号：PCT/US2013022113
申请日：2013-01-18
申请人： GENOMATICA INC
发明人： OSTERHOUT ROBIN E , BURGARD ANTHONY P , BURK MARK J
IPC分类号： C12N9/02 , C07C63/04 , C07C63/26 , C07F9/09 , C08G63/183 , C08L67/02 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/88 , C12P7/24 , C12P7/40 , C12P7/44 , C12P9/00
CPC分类号： C12P7/44 , C07C51/43 , C07F9/091 , C08G63/183 , C12N9/0004 , C12N9/0006 , C12N9/0008 , C12N9/1007 , C12N9/1022 , C12N9/1085 , C12N9/1205 , C12N9/88 , C12P7/24 , C12P7/40 , C12P7/62 , C12P9/00 , C07C63/26 , C07C63/04
摘要： The invention provides non-naturally occurring microbial organisms having a (2- hydroxy-3-methyl-4-oxobutoxy) phosphonate (2H3M40P) pathway, p-toluate pathway, and/or terephthalate pathway. The invention additionally provides methods of using such organisms to produce 2H3M40P, p-toluate or terephthalate. Also provided herein are processes for isolating bio-based aromatic carboxylic acid, in particular, p-toluic acid or terephthalic acid, from a culture medium, wherein the processes involve contacting the culture medium with sufficient carbon dioxide (C02) to lower the pH of the culture medium to produce a precipitate comprised of the aromatic carboxylic acid.
摘要翻译：本发明提供具有（2-羟基-3-甲基-4-氧代丁氧基）膦酸酯（2H3M40P）途径，对甲苯甲酸酯途径和/或对苯二甲酸酯途径的非天然存在的微生物生物体。本发明另外提供了使用这种有机体生产2H 3 M40P，对甲苯甲酸或对苯二甲酸的方法。本文还提供了用于从培养基中分离生物基芳族羧酸，特别是对甲苯甲酸或对苯二甲酸的方法，其中所述方法涉及使培养基与足够的二氧化碳（CO 2）接触以降低培养基产生由芳族羧酸组成的沉淀物。

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