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1. 发明申请

WO2013033646A1 IN VIVO CONVERSION OF LIGHT ENERGY INTO HYDROGEN GAS 审中-公开
标题翻译：将光能转换为氢气
公开(公告)号：WO2013033646A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/053539
申请日：2012-08-31
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LUDWIG, Robert A.
发明人： LUDWIG, Robert A.
IPC分类号： C12N15/11 , C12N15/63 , C12N3/00 , C12N9/10 , C12N1/21
CPC分类号： C12P3/00 , C07K14/195 , C12N9/0067
摘要： The present disclosure provides isolated phototrophic cells for producing hydrogen and methods for thereof. The methods involve inducing endo-hydrogenase expression in the phototrophic cells through the use of a regulatable promoter and harvesting light energy for hydrogen production. In preferred embodiments the hydrogenase is a member of the Hyq family of endo-hydrogenases and the isolated phototrophic cell is a Rhodopseudomonas palustris cell.
摘要翻译：本公开提供用于产生氢的分离的光养细胞及其用于其的方法。所述方法包括通过使用可调节的启动子诱导光合细胞中的内切酶表达，并收获用于氢产生的光能。在优选的实施方案中，氢化酶是Hyq家族内切酶酶的成员，分离的光合细胞是红假单胞菌（Palopus）。

2. 发明申请

WO2012177599A2 MICROORGANISMS FOR PRODUCING N-PROPANOL 1, 3-PROPANEDIOL, 1,2-PROPANEDIOL OR GLYCEROL AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产N-丙醇1,3-丙二醇，1,2-丙二醇或甘油的微生物及其相关方法
公开(公告)号：WO2012177599A2
公开(公告)日：2012-12-27
申请号：PCT/US2012/043086
申请日：2012-06-19
申请人： GENOMATICA, INC. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
发明人： BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , SUN, Jun , PHARKYA, Priti
IPC分类号： C12P7/04 , C12P7/20
CPC分类号： C12P7/18 , C12N9/0008 , C12N9/0067 , C12P7/04 , C12P7/20
摘要： Provided herein is a non-naturally occurring microbial organism having a reductive TCA or Wood-Ljungdahl pathway and comprising at least one exogenous nucleic acid encoding said pathway enzymes expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. Also provided herein is a method for enhancing carbon flux through acetyl-CoA and in some embodiments includes culturing these non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism provided herein includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. Also provided herein is a method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, and can include culturing this organism for a sufficient period of time to produce a product.
摘要翻译：本文提供了具有还原性TCA或Wood-Ljungdahl途径的非天然存在的微生物生物体，并且包含至少一种编码所述途径酶的外源核酸，其以足够的量表达以增强通过乙酰辅酶A的碳通量。本文还提供了通过乙酰辅酶A增强碳通量的方法，并且在一些实施方案中包括在条件和足够的时间段内培养这些非天然存在的微生物生物体以产生具有乙酰辅酶A作为结构单元的产物。本文提供的另一种非天然存在的微生物包括至少一种编码以足够量表达的酶的外源核酸，以增强在一氧化碳或氢气存在下还原当量的可用性，从而通过经由碳水化合物碳原料。本文还提供了在一氧化碳或氢气存在下增强还原当量的可用性的方法，并且可以包括在足够的时间内培养该生物体以产生产物。

3. 发明申请

WO2011140386A3 DETOXIFICATION OF BIOMASS DERIVED ACETATE VIA METABOLIC CONVERSION TO ETHANOL, ACETONE, ISOPROPANOL, OR ETHYL ACETATE 审中-公开
标题翻译：通过代谢转化成乙醇，乙腈，异丙醇或乙酸乙酯的生物质衍生的乙酸脱氧
公开(公告)号：WO2011140386A3
公开(公告)日：2012-01-05
申请号：PCT/US2011035416
申请日：2011-05-05
申请人： MASCOMA CORP , SILLERS WILLIAM RYAN , VAN DIJKEN HANS , LICHT STEVE , SHAW IV ARTHUR J , GILBERT ALAN BENJAMIN , ARGYROS AARON , FROEHLICH ALLAN C , MCBRIDE JOHN E , XU HAOWEN , HOGSETT DAVID A , RAJGARHIA VINEET B
发明人： SILLERS WILLIAM RYAN , VAN DIJKEN HANS , LICHT STEVE , SHAW IV ARTHUR J , GILBERT ALAN BENJAMIN , ARGYROS AARON , FROEHLICH ALLAN C , MCBRIDE JOHN E , XU HAOWEN , HOGSETT DAVID A , RAJGARHIA VINEET B
IPC分类号： C12N1/18 , C12N9/02 , C12N9/04 , C12P7/02 , C12P7/06 , C12P7/08 , C12P7/28 , C12P7/62
CPC分类号： C12N15/81 , C12N1/16 , C12N1/18 , C12N9/0006 , C12N9/0008 , C12N9/0067 , C12N15/74 , C12P7/02 , C12P7/04 , C12P7/06 , C12P7/10 , C12P7/28 , C12P7/62 , C12R1/01 , C12R1/645 , C12R1/865 , C12Y102/01012 , C12Y112/99006 , Y02E50/16 , Y02E50/17 , Y02P20/52
摘要： One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.
摘要翻译：本发明的一个方面涉及经遗传修饰的嗜热或嗜温微生物，其中第一天然基因部分，基本上或完全缺失，沉默，失活或下调，所述第一天然基因编码参与代谢产生有机酸或其盐，从而增加所述嗜热或嗜温微生物产生作为发酵产物的乳酸盐或乙酸盐的天然能力。在某些实施方案中，上述微生物还包含第一非天然基因，其第一非天然基因编码参与乳酸盐或乙酸盐的代谢产生的第一非天然酶。本发明的另一方面涉及将木质纤维素生物质转化为乳酸盐或乙酸盐的方法，包括使木质纤维素生物质与遗传修饰的嗜热或嗜温微生物接触。

4. 发明申请

WO2008143630A2 RECOMBINANT HYDROGEN-PRODUCING CYANOBACTERIUM AND USES THEREOF 审中-公开
标题翻译：重组氢生产天然产物及其用途
公开(公告)号：WO2008143630A2
公开(公告)日：2008-11-27
申请号：PCT/US2007022099
申请日：2007-10-16
申请人： CRAIG VENTER INST J , XU QING , SMITH HAMILTON O
发明人： XU QING , SMITH HAMILTON O
IPC分类号： C12N1/21 , C12N5/10 , C12N9/02 , C12N15/53 , C12P3/00
CPC分类号： C12P3/00 , C12N9/0067 , C12N13/00 , Y02P20/134
摘要： A recombinant cyanobacterium comprising an oxygen-tolerant, hydrogen-evolving hydrogenase, kit, and methods of use.
摘要翻译：包含耐氧性，析氢氢化酶，试剂盒和使用方法的重组蓝细菌。

5. 发明申请

WO2005086669A3 HYDROGENASE DEFICIENT BACTERIAL STRAINS 审中-公开
标题翻译：氢化缺乏菌株
公开(公告)号：WO2005086669A3
公开(公告)日：2006-03-30
申请号：PCT/US2005006638
申请日：2005-02-28
申请人： UNIV GEORGIA RES FOUND , UNIV OHIO STATE , MAIER ROBERT J , GUNN JOHN S
发明人： MAIER ROBERT J , GUNN JOHN S
IPC分类号： C12N9/02 , A61K39/108 , A01N63/00 , A61K39/00 , A61K39/02 , A61K39/112
CPC分类号： C12N9/0067 , A61K39/0258 , A61K39/0275 , A61K39/105 , A61K2039/522 , C12Y112/01002 , Y10S435/879
摘要： The present disclosure describes pathogenic bacteria that have been modified to be deficient in NiFe hydrogenase activity; compositions comprising such modified bacteria, and the use of such bacteria to protect animals from pathogenic enteric bacterial infections.
摘要翻译：本公开描述已经被修饰为缺乏NiFe氢化酶活性的病原菌; 包含这种修饰细菌的组合物，以及使用这种细菌来保护动物免受致病性肠道细菌感染。

6. 发明申请

WO2004076615A3 IMMUNOMODULATING PROBIOTIC COMPOUNDS 审中-公开
标题翻译：免疫调节化学物质
公开(公告)号：WO2004076615A3
公开(公告)日：2004-12-09
申请号：PCT/DK2004000138
申请日：2004-02-27
申请人： BIONEER AS , PROBI AB , ISRAELSEN HANS , MADSEN SOEREN MICHAEL , GLENTING JACOB , VRANG ASTRID , NOERRELYKKE METTE RINDOM , HANSEN ANNE MARIA , AHRNE SIV ELSA INGEGERD , MOLIN GOERAN , RAVN PETER , BECK HANS CHRISTIAN
发明人： ISRAELSEN HANS , MADSEN SOEREN MICHAEL , GLENTING JACOB , VRANG ASTRID , NOERRELYKKE METTE RINDOM , HANSEN ANNE MARIA , AHRNE SIV ELSA INGEGERD , MOLIN GOERAN , RAVN PETER , BECK HANS CHRISTIAN
IPC分类号： C12N1/20 , C12N1/21 , C12N9/02 , C12N9/12 , C12N9/88 , C12N9/90 , C12N15/01 , C12N15/60 , C12N15/61 , A61K35/74 , A61K38/44 , A61K38/45 , A61K38/51 , C12N15/53 , C12N15/54 , C12Q1/02
CPC分类号： C12Y102/01012 , C12N1/20 , C12N9/0067 , C12N9/1217 , C12N9/88 , C12N9/90 , C12N15/01 , C12Y207/02003 , C12Y402/01011 , C12Y503/01001
摘要： The present invention relates to methods for modulating i) an immune response and/or ii) the amount and/or composition of mucosal mucins, by contacting a cell forming part of mucosalassociated lymphoid tissue (MALT), or an epithelial cell, with a microbial cell surface polypeptide. The modulation of the immune response preferably involves the induction of one or more cytokines. The microbial cell surface polypeptide is preferably a polypeptide obtained from probiotic species of Lactobacillus or Bifidobacterium. It has surprisingly been found that intracellular enzymes acting in metabolic pathways in Lactobacillus and Bifidobacterium, or polypeptides substantially identical with such intracellular enzymes, are transported to the surface of the cell where they may become at least partially exposed to the extracellular medium. Accordingly, preferred cell surface polypeptides have intracellular (i.e. cytoplasm associated) equivalents acting in metabolic pathways, such as e.g. glycolysis, in probiotic species of Lactobacillus and/or Bifidobacterium. The surface associated polypeptides and their intracellular equivalents share an extended stretch of consecutive amino acid residues, but are located in different parts of a cell.
摘要翻译：本发明涉及通过使形成粘膜相关淋巴组织（MALT）或上皮细胞的一部分的细胞与微生物接触来调节i）免疫应答和/或ii）粘膜粘蛋白的量和/或组成的方法细胞表面多肽。免疫应答的调节优选涉及一种或多种细胞因子的诱导。微生物细胞表面多肽优选为从益生菌种类的乳杆菌或双歧杆菌获得的多肽。已经令人惊奇地发现，在乳杆菌和双歧杆菌的代谢途径中起作用的细胞内酶或与这种细胞内酶基本相同的多肽被转移到细胞表面，在那里它们可能至少部分暴露于细胞外培养基。因此，优选的细胞表面多肽具有在代谢途径中起作用的细胞内（即细胞质相关）等价物，例如，糖酵解，乳酸杆菌和/或双歧杆菌的益生菌。表面相关多肽及其细胞内等同物具有延伸的连续氨基酸残基，但位于细胞的不同部分。

7. 发明申请

WO2016097325A1 PLASTIC COMPOUND AND PREPARATION PROCESS 审中-公开
标题翻译：塑料化合物和制备方法
公开(公告)号：WO2016097325A1
公开(公告)日：2016-06-23
申请号：PCT/EP2015/080557
申请日：2015-12-18
申请人： CARBIOS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE POITIERS
发明人： FERREIRA, Thierry , GUILLAMOT, Frédérique , COLAS, Steven
IPC分类号： C08J11/10 , C12N9/02 , C08L23/02
CPC分类号： C08J11/105 , C08J2323/02 , C08J2323/06 , C12N9/0006 , C12N9/0008 , C12N9/0061 , C12N9/0065 , C12N9/0067 , C12N9/0069 , C12N9/0071 , C12N9/0073 , C12N9/0077 , C12Y110/03002 , Y02W30/702
摘要： The invention relates to a plastic compound comprising at least one polyolefin and a biological entity that degrades said polyolefin. The invention further relates to a process for preparing a plastic article wherein at least one polyolefin and one biological entity that degrades said polyolefin are mixed at a temperature at which the polyolefin is in a partially or totally molten state.
摘要翻译：本发明涉及包含至少一种聚烯烃和降解所述聚烯烃的生物实体的塑料化合物。本发明还涉及一种制备塑料制品的方法，其中至少一种聚烯烃和一种降解所述聚烯烃的生物实体在聚烯烃处于部分或全部熔融状态的温度下混合。

8. 发明申请

WO2010036880A3 SELECTION SYSTEM FOR DI-IRON [FEFE] HYDROGENASE PROPERTIES 审中-公开
标题翻译：氢离子选择系统[FEFE]氢化物质
公开(公告)号：WO2010036880A3
公开(公告)日：2010-07-29
申请号：PCT/US2009058361
申请日：2009-09-25
申请人： HARVARD COLLEGE , WINTERMUTE EDWIN H , AGAPAKIS CHRISTINA , BOYLE PATRICK , SILVER PAMELA A
发明人： WINTERMUTE EDWIN H , AGAPAKIS CHRISTINA , BOYLE PATRICK , SILVER PAMELA A
IPC分类号： C12N1/21 , C12N9/04 , C12N15/53 , C12R1/19 , C12R1/42
CPC分类号： C12N9/0067 , C12N15/1034 , C12N15/70
摘要： The present invention provides engineered microorganisms such as E.coli and methods for selecting for desired biological properties of hydrogenase enzymes in vivo. Using the methods of the invention, hydrogenase enzymes are selected for properties including, but not limited to, oxygen tolerance, thermostability, and increased catalytic rate.
摘要翻译：本发明提供工程微生物如大肠杆菌，以及用于在体内选择所需生物学性质的氢化酶的方法。使用本发明的方法，选择氢化酶用于性能，包括但不限于耐氧性，热稳定性和提高的催化速率。

9. 发明申请

WO2010027233A2 NOVEL HYDROGENASE ISOLATED FROM THERMOCOCCUS SP., GENE ENCODING THE SAME, AND METHOD FOR PRODUCING HYDROGEN USING MICROORGANISMS WITH THE GENE 审中-公开
标题翻译：从热休克菌属分离的新氢化酶，编码该菌株的基因，以及使用该基因的微生物生产氢的方法
公开(公告)号：WO2010027233A2
公开(公告)日：2010-03-11
申请号：PCT/KR2009005060
申请日：2009-09-07
申请人： KOREA OCEAN RES & DEV I , LEE JUNG HYUN , KANG SUNG GYUN , LEE HYUN SOOK , KIM SANG JIN , KWON KAE KYOUNG , CHA SUN SHIN , JEON JUNG HO , CHO YONA , KIM YUN JAE , BAE SEUNG SEOP , LIM JAE KYU , JEONG IN SOON , LHO TAE OK
发明人： LEE JUNG HYUN , KANG SUNG GYUN , LEE HYUN SOOK , KIM SANG JIN , KWON KAE KYOUNG , CHA SUN SHIN , JEON JUNG HO , CHO YONA , KIM YUN JAE , BAE SEUNG SEOP , LIM JAE KYU , JEONG IN SOON , LHO TAE OK
IPC分类号： C12N9/04 , C12N15/53 , C12P3/00
CPC分类号： C12N9/0006 , C12N9/0067 , C12P3/00 , C12R1/01 , Y02P20/132 , Y02P20/52
摘要： The present invention relates to a novel hydrogenase isolated from a novel hyperthermophilic strain which belongs to Thermococcus sp., a gene encoding the same, and a method for producing hydrogen using the hydrogenase and gene. According to the hydrogen production method of the present invention, a large amount of hydrogen can be generated by only culturing the strain under specific culture conditions. Therefore, the method is economical and efficient compared to a conventional hydrogen production method and is able to produce hydrogen at a high temperature.
摘要翻译：本发明涉及从属于Thermococcus sp。的新型超嗜热菌株分离的新型氢化酶，编码其的基因以及使用该氢化酶和基因产生氢的方法。根据本发明的氢生产方法，通过仅在特定培养条件下培养菌株可以产生大量的氢。因此，与传统的氢气生产方法相比，该方法经济并且高效，并且能够在高温下产生氢气。

10. 发明申请

WO2009114531A2 IN VIVO EVOLUTION OF HYDROGENASES USING A HYDROGEN-SENSING SYSTEM 审中-公开
标题翻译：使用氢传感系统进行水力发展
公开(公告)号：WO2009114531A2
公开(公告)日：2009-09-17
申请号：PCT/US2009/036669
申请日：2009-03-10
申请人： ALLIANCE FOR SUSTAINABLE ENERGY, LLC , GHIRARDI, Maria Lucia , POSEWITZ, Matthew , WECKER, Matt
发明人： GHIRARDI, Maria Lucia , POSEWITZ, Matthew , WECKER, Matt
IPC分类号： C12Q1/26 , C12Q1/68 , C12N15/63
CPC分类号： C12Q1/6897 , C12N9/0067 , C12N9/0095 , C12P3/00 , C12Q1/02 , C12Q1/26 , G01N2333/90238
摘要： Provided herein are methods for measuring H2 production by a hydrogenase. Also provided are methods for evolving a hydrogenase or hydrogen-sensing system by comparing the level of production of H2 by the hydrogenase to the level Of H2 produced by a wild-type hydrogenase cultured under the same conditions and selecting a microorganism with increased H2 production over the H2 production by a microorganism having a wild-type hydrogenase. Further provided herein are microorganisms and plasmids comprising a hupSL promoter coupled with a reporter gene.
摘要翻译：本文提供了通过氢化酶测量H2产生的方法。还提供了通过将氢化酶的H 2生成水平与在相同条件下培养的野生型氢化酶产生的H 2水平进行比较来选择氢化酶或氢感测系统的方法，并选择具有增加的H 2产生的微生物由具有野生型氢化酶的微生物产生H2。本文还提供了微生物和质粒，其包含与报道基因偶联的hupSL启动子。

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