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11. 发明申请

WO2011064782A3 MULTI-COMPONENT STENT-GRAFT SYSTEM FOR IMPLANTATION IN A BLOOD VESSEL WITH MULTIPLE BRANCHES 审中-公开
标题翻译：用于在具有多个分支的血管中植入的多组分STEG-GRAFT系统
公开(公告)号：WO2011064782A3
公开(公告)日：2011-10-06
申请号：PCT/IL2010000999
申请日：2010-11-30
申请人： ENDOSPAN LTD , SHALEV ALON , RAZ SAGI , BENARY RAFI
发明人： SHALEV ALON , RAZ SAGI , BENARY RAFI
IPC分类号： A61F2/06 , A61F2/07
CPC分类号： A61F2/07 , A61F2/90 , A61F2002/061 , A61F2250/0039 , A61F2250/006 , A61F2250/0065
摘要： A multi-component stent-graft system (10) comprises first, second, and third generally tubular stent-grafts (20, 22, 24), which are configured to assume radially-expanded states. The first (20) is shaped so as to define a first lateral opening (34) when radially-expanded. The second (22) is shaped so as to define a second lateral opening (44) when radially-expanded. The first and second (20, 22) are configured such that the second (22) forms a blood-impervious seal with the first (20) around the first lateral opening (34) when the second stent-graft (22) is disposed therethrough, and the first and the second (20, 22) are radially-expanded. The second and the third (22, 24) are configured such that the third (24) forms a blood-impervious seal with the second (22) around the second lateral opening (44) when the third (24) is disposed therethrough, and the second and third (22, 24) are radially-expanded. Other embodiments also described.
摘要翻译：多组分支架移植物系统（10）包括第一，第二和第三大体管状支架移植物（20,22,24），其构造成呈放射状扩张状态。第一（20）成形为当径向展开时限定第一侧向开口（34）。第二（22）成形为当径向展开时限定第二侧向开口（44）。第一和第二（20,22）构造成使得当第二支架移植物（22）穿过其中时，第二（22）在第一侧向开口（34）周围形成具有第一（20）的不透血性密封件，并且第一和第二（20,22）径向展开。第二和第三（22,24）被构造成使得当第三（24）穿过其中时，第三（24）在第二侧开口（44）周围形成具有第二（22）的不透血的密封，以及第二和第三（22,24）径向展开。还描述了其它实施例。

12. 发明申请

WO2016113731A1 SELF-CURVING STENT-GRAFT 审中-公开
标题翻译：自弯曲钢筋
公开(公告)号：WO2016113731A1
公开(公告)日：2016-07-21
申请号：PCT/IL2016/050014
申请日：2016-01-06
申请人： ENDOSPAN LTD.
发明人： MARMUR, Yaniv , TZILER, Tzachi
IPC分类号： A61F2/07
CPC分类号： A61F2/07 , A61F2210/0014 , A61F2250/0006 , A61F2250/0012 , A61F2250/0029 , A61F2250/0039
摘要： An endovascular self-curving stent-graft (20) includes a self-curving longitudinal portion (22), which is curved so as to define an innermost curve (26) and an outermost curve (28), when the stent-graft (20) is unconstrained in a radially-expanded state. The stent-graft (20) includes a plurality of circumferential strut members (30); a compression-generation spring (40), which (a) is in an elongated configuration when the stent-graft (20) is in a radially-compressed state, and (b) overlaps respective first portions (44) of at least two of the circumferential strut members (30); and an anti-buckling spring (50), which overlaps respective second portions (54) of at least two of the circumferential strut members (30). The anti-buckling spring (50) and the compression-generation spring (40) are together configured to curve the self-curving longitudinal portion (22) when the stent-graft (20) is unconstrained in the radially-expanded state, such that a lesser length of the self-curving longitudinal portion (22), measured along the innermost curve (26), is less than 80% of a greater length of the self-curving longitudinal portion (22), measured along the outermost curve (28).
摘要翻译：一种血管内自弯曲支架移植物（20）包括自弯曲纵向部分（22），其弯曲以便当支架移植物（20）处于最内侧曲线（26）和最外侧曲线（28）时）在径向展开状态下是不受约束的。支架移植物（20）包括多个圆周支柱构件（30）; 压缩发生弹簧（40），其中（a）当所述支架移植物（20）处于径向压缩状态时处于细长结构，并且（b）与相应的第一部分（44）重叠至少两个周向支柱构件（30）; 以及与所述周向支柱构件（30）中的至少两个的相应的第二部分（54）重叠的抗弯曲弹簧（50）。当抗弯曲弹簧（50）和压缩发生弹簧（40）一起被配置成当支架移植物（20）在径向展开状态下受约束时弯曲自弯曲纵向部分（22），使得沿着最内曲线（26）测量的自弯曲纵向部分（22）的较小长度小于沿着最外曲线（28）测量的自弯曲纵向部分（22）的较大长度的80％）。

13. 发明申请

WO2013030818A3 STENT-GRAFTS WITH POST-DEPLOYMENT VARIABLE AXIAL AND RADIAL DISPLACEMENT 审中-公开
标题翻译：具有后置部分可变轴向和径向位移的STENT-GRAFTS
公开(公告)号：WO2013030818A3
公开(公告)日：2015-06-18
申请号：PCT/IL2012000148
申请日：2012-04-04
申请人： ENDOSPAN LTD , SHALEV ALON
发明人： SHALEV ALON
IPC分类号： A61F2/82
CPC分类号： A61F2/07 , A61F2/82 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61F2210/0057 , A61F2210/0066 , A61F2220/0075 , A61F2230/0078 , A61F2250/0007 , A61F2250/001 , A61F2250/0013 , A61F2250/0039
摘要： An endovascular stent-graft (20) includes a generally tubular body (22), which is configured to assume a radially-compressed delivery state and a radially-expanded deployment state. The body (22) includes a flexible stent member (24), and a tubular fluid flow guide (26) attached to the stent member (24). The body (22) includes a compliance-restoration body portion (34), which extends axially along a portion of the body, and which comprises a portion of the stent member (24) and a portion of the fluid flow guide (26). When the body (22) is in the radially-expanded deployment state, the compliance-restoration body portion (34) is (a) characterized by a greatest diastolic outer radius (RD) when the body (22) is internally pressurized by fluid having a pressure of 80 mmHg, and (b) radially expandable to a greatest systolic outer radius (RS) when the body (22) is internally pressurized by fluid having a pressure of 120 mmHg. The greatest systolic outer radius (RS) is at least 5% greater than the greatest diastolic outer radius (RD).
摘要翻译：血管内支架移植物（20）包括大致管状体（22），其构造为呈现径向压缩的递送状态和径向扩张的展开状态。主体（22）包括柔性支架构件（24）和连接到支架构件（24）的管状流体流动引导件（26）。主体（22）包括顺应性恢复主体部分（34），其沿主体的一部分轴向延伸，并且包括支架构件（24）的一部分和流体流动引导件（26）的一部分。当身体（22）处于径向展开的展开状态时，柔顺修复体部分（34）的特征在于当身体（22）被内部加压时具有最大的舒张外半径（RD） 80mmHg的压力，以及（b）当身体（22）由压力为120mmHg的流体内部加压时，径向可扩张至最大的收缩外半径（RS）。最大的收缩期外半径（RS）比最大舒张外半径（RD）至少大5％。

14. 发明申请

WO2014108895A3 MINIMIZATION OF STENT-GRAFT MIGRATION DURING IMPLANTATION 审中-公开
标题翻译：植入过程中支架移植的最小化
公开(公告)号：WO2014108895A3
公开(公告)日：2014-09-18
申请号：PCT/IL2014050019
申请日：2014-01-07
申请人： ENDOSPAN LTD
发明人： SHALEV ALON , MARMUR YANIV , NISSAN ORI , NAE NIR SHALOM
IPC分类号： A61F2/07 , A61F2/06 , A61F2/966
CPC分类号： A61F2/962 , A61F2/07 , A61F2/966 , A61F2002/061 , A61F2002/067 , A61F2002/075 , A61F2002/9665 , A61F2230/0069
摘要： An endovascular system (10) includes an endovascular implant (20) and a delivery tool (30). The implant (20) is configured to assume a radially-compressed delivery state, and a radially-expanded deployment state. The delivery tool (30) includes a proximal main delivery catheter (36), having a distal portion (46) in which the implant (20) is disposed while in the radially-compressed delivery state; and a distal restraining assembly (50), which includes a restraining-assembly tubular shaft (52) disposed distal to the proximal main delivery catheter (36). The distal restraining assembly (50) is configured to assume an engaged state, in which the distal restraining assembly (50) prevents proximal displacement of the implant (20) relative to the distal restraining assembly (50), and a disengaged state, in which the distal restraining assembly (50) allows proximal displacement of the implant (20) relative to the distal restraining assembly (50). Other embodiments are also described.
摘要翻译：血管内系统（10）包括血管内植入物（20）和输送工具（30）。植入物（20）构造成呈现径向压缩递送状态和径向扩张部署状态。递送工具（30）包括近侧主输送导管（36），其具有远侧部分（46），植入物（20）在处于径向压缩递送状态时被布置在远侧部分（46）中; 和远侧限制组件（50），所述远侧限制组件（50）包括设置在所述近侧主输送导管（36）远侧的限制组件管状轴（52）。远端限制组件（50）构造成呈现接合状态和脱离状态，其中远端限制组件（50）防止植入物（20）相对于远端限制组件（50）的近端位移，其中，远端限制组件50允许植入物20相对于远端限制组件50的近端位移。还描述了其他实施例。

15. 发明申请

WO2013030818A2 STENT-GRAFTS WITH POST-DEPLOYMENT VARIABLE AXIAL AND RADIAL DISPLACEMENT 审中-公开
标题翻译：具有后置部分可变轴向和径向位移的STENT-GRAFTS
公开(公告)号：WO2013030818A2
公开(公告)日：2013-03-07
申请号：PCT/IL2012/000148
申请日：2012-04-04
申请人： ENDOSPAN LTD. , SHALEV, Alon
发明人： SHALEV, Alon
IPC分类号： A61F2/94
CPC分类号： A61F2/07 , A61F2/82 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61F2210/0057 , A61F2210/0066 , A61F2220/0075 , A61F2230/0078 , A61F2250/0007 , A61F2250/001 , A61F2250/0013 , A61F2250/0039
摘要： An endovascular stent-graft (20) includes a generally tubular body (22), which is configured to assume a radially-compressed delivery state and a radially-expanded deployment state. The body (22) includes a flexible stent member (24), and a tubular fluid flow guide (26) attached to the stent member (24). The body (22) includes a compliance-restoration body portion (34), which extends axially along a portion of the body, and which comprises a portion of the stent member (24) and a portion of the fluid flow guide (26). When the body (22) is in the radially-expanded deployment state, the compliance-restoration body portion (34) is (a) characterized by a greatest diastolic outer radius (R D ) when the body (22) is internally pressurized by fluid having a pressure of 80 mmHg, and (b) radially expandable to a greatest systolic outer radius (R S ) when the body (22) is internally pressurized by fluid having a pressure of 120 mmHg. The greatest systolic outer radius (R S ) is at least 5% greater than the greatest diastolic outer radius (R D ).
摘要翻译：血管内支架移植物（20）包括大致管状体（22），其构造为呈现径向压缩的递送状态和径向扩张的展开状态。主体（22）包括柔性支架构件（24）和连接到支架构件（24）的管状流体流动引导件（26）。主体（22）包括顺应性恢复主体部分（34），其沿主体的一部分轴向延伸，并且包括支架构件（24）的一部分和流体流动引导件（26）的一部分。当身体（22）处于径向展开的展开状态时，柔顺修复体部分（34）的特征在于当身体（22）被内部加压时具有最大的舒张外半径（RD） 80mmHg的压力，以及（b）当身体（22）由压力为120mmHg的流体内部加压时，径向可扩张至最大的收缩外半径（RS）。最大的收缩期外半径（RS）比最大舒张外半径（RD）至少大5％。

16. 发明申请

WO2012176187A1 ENDOVASCULAR SYSTEM WITH CIRCUMFERENTIALLY-OVERLAPPING STENT-GRAFTS 审中-公开
标题翻译：具有循环超声心动图的内部系统
公开(公告)号：WO2012176187A1
公开(公告)日：2012-12-27
申请号：PCT/IL2012/000241
申请日：2012-06-19
申请人： ENDOSPAN LTD. , SHALEV, Alon
发明人： SHALEV, Alon
IPC分类号： A61F2/06
CPC分类号： A61F2/852 , A61F2/07 , A61F2/89 , A61F2/962 , A61F2002/075 , A61F2002/8486 , A61F2230/0091 , A61F2250/0063
摘要： A multi-component endovascular stent-graft system (10) includes a body portion (16), which includes a plurality of stent-grafts (20), which include: (a) respective stent members (22), which are shaped, when the stent-grafts (20) are in respective radially-expanded states, so as to define respective tubes, each of which is circumferentially complete at at least one longitudinal location therealong; and (b) respective graft members (24), which circumscribe respective circumferential arcs (40) of the respective stent members (22). The circumferential arcs (40) have respective extents that are less than entire circumferences of the respective stent members (22) at least partially along respective axial lengths of the stent members (22).
摘要翻译：多组分血管内支架移植物系统（10）包括主体部分（16），其包括多个支架移植物（20），其包括：（a）相应的支架构件（22），其形状为支架移植物（20）处于相应的径向展开状态，以便限定相应的管，每个管在其沿着至少一个纵向位置周向地完成; 和（b）各自的移植部件（24），其分别围绕相应的支架部件（22）的相应圆周弧（40）。周向弧（40）具有至少部分地沿支架构件（22）的相应轴向长度小于相应支架构件（22）的整个圆周的相应范围。

17. 发明申请

WO2010150208A3 VASCULAR PROSTHESES FOR TREATING ANEURYSMS 审中-公开
公开(公告)号：WO2010150208A3
公开(公告)日：2010-12-29
申请号：PCT/IB2010/052861
申请日：2010-06-23
申请人： ENDOSPAN LTD. , SHALEV, Alon , BENARY, Rafi
发明人： SHALEV, Alon , BENARY, Rafi
IPC分类号： A61F2/06
摘要： An endovascular stent-graft (5) is configured to initially be positioned in a delivery catheter (30) in a radially-compressed state, and to assume a radially-expanded state upon being deployed from the delivery catheter (30). The stent-graft (5) includes a structural member (10), including a plurality of structural stent elements (15), at least a portion of which structural stent elements (15) define a stent body (8) when the stent-graft (5) assumes the radially-expanded state. The stent-graft (5) further includes a fluid flow guide (16), including at least one biologically-compatible substantially fluid-impervious flexible sheet, and coupled to the stent body (8). When the stent-graft (5) assumes the radially-expanded state, the fluid flow guide (16) is shaped so as to define radially- diverging and radially-converging portions (13, 19), which together define a bulge (20) that extends radially outward, and has a greatest cross-sectional area that is equal to at least 120% of a cross-sectional area of a narrowest portion (17) of the stent-graft (5) rostral to the bulge (20). Other embodiments are also described.

18. 发明申请

WO2018173056A1 STENT-GRAFTS FOR SEALING AROUND EXTERNAL DISTURBANCES 审中-公开
公开(公告)号：WO2018173056A1
公开(公告)日：2018-09-27
申请号：PCT/IL2018/050325
申请日：2018-03-21
申请人： ENDOSPAN LTD.
发明人： ZIGELBOIM, Or , MARMUR, Yaniv , SHALEV, Alon
IPC分类号： A61F2/07
摘要： An endovascular stent-graft (10, 110, 210, 310) is provided that includes elastic struts (20) and a fluid flow guide (30) that is fixed to first and second subsets (32, 34) of the struts (20). The struts (20) of the first subset (32) are arranged as circumferential cells (80) in circumferentially-continuous rings (56), which cause the fluid flow guide (30) to define substantially cylindrical tubular portions (40). The struts (20) of the second subset (34) cause the fluid flow guide (30) to define a bulge (42) having a greatest bulge radius from a central longitudinal axis (38) that is at least 5% greater than an average radius of the substantially cylindrical tubular portions (40) proximally and distally adjacent the bulge (42). The struts (20) of the second subset (34) define tip portions (50). The number of the tip portions (50) of the struts (20) of the second subset (34) that define the bulge (42) is at least 50% greater than the average number of circumferential cells (80) in the two circumferentially-continuous rings (56) proximally and distally adjacent the bulge (42).

19. 发明申请

WO2015075708A1 STENT SYSTEM WITH RADIAL-EXPANSION LOCKING 审中-公开
标题翻译：具有径向膨胀锁定的STENT系统
公开(公告)号：WO2015075708A1
公开(公告)日：2015-05-28
申请号：PCT/IL2014/050973
申请日：2014-11-06
申请人： ENDOSPAN LTD.
发明人： MARMUR, Yaniv , ZIGELBOIM, Or , NAE, Nir Shalom
IPC分类号： A61F2/95
CPC分类号： A61F2/966 , A61F2/07 , A61F2002/061 , A61F2002/065 , A61F2002/9517 , A61F2002/9665 , A61F2250/006
摘要： A deployment system (10, 410) includes an inner shaft (36, 436), removably disposed in a self-expanding stent-graft (40), and shaped so as to define (a) at least one conduit therealong (50, 450), which is (i) not coaxial with the inner shaft (36, 436), and (ii) shaped so as to define at least first (52, 452) and second enclosed longitudinal segments (54, 454), and (b) a restraining longitudinal portion (56, 456) that is longitudinally disposed between the first (52, 452) and second enclosed longitudinal segments (54, 454). The deployment system (10, 410) is configured such that (a) when a restraining wire (60, 460) thereof is removably disposed in the first (52, 452) and second enclosed longitudinal segments (54, 454), a portion (62, 463) of the restraining wire (60, 460) disposed alongside the restraining longitudinal portion (56, 456) prevents full radial expansion of a longitudinal portion (70, 470) of the stent-graft (40) by physically engaging the stent-graft longitudinal portion (70, 470), and (b) when the restraining wire (60, 460) has been withdrawn from at least the first enclosed longitudinal segment (52, 452), the restraining wire (60, 460) does not prevent the full radial expansion of the stent-graft longitudinal portion (70, 470).
摘要翻译：展开系统（10,410）包括可拆卸地设置在自膨胀支架移植物（40）中的内轴（36,463），并且成形为限定（a）至少一个导管（50,450）），其是（i）不与内轴（36,436）同轴，和（ii）成形为至少限定第一（52,452）和第二封闭纵向段（54,454），并且（b））纵向设置在第一（52,452）和第二封闭纵向段（54,454）之间的约束纵向部分（56,456）。配置系统（10,410）被构造成使得（a）当限制线（60,460）可拆卸地设置在第一（52,452）和第二封闭的纵向段（54,454）中时，一部分沿着限制纵向部分（56,456）设置的约束线（60,460）的62,663,462,463,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,4 移动纵向部分（70,470），和（b）当约束线（60,460）至少从第一封闭纵向段（52,452）撤回时，限制线（60,460）不防止支架 - 移植物纵向部分（70,470）的完全径向膨胀。

20. 发明申请

WO2014020609A1 STENT-GRAFTS CONFIGURED FOR POST-IMPLANTATION EXPANSION 审中-公开
标题翻译：配置用于后植入扩张的STENT-GRAFTS
公开(公告)号：WO2014020609A1
公开(公告)日：2014-02-06
申请号：PCT/IL2013/050656
申请日：2013-07-31
申请人： ENDOSPAN LTD.
发明人： SHALEV, Alon , NAE, Nir Shalom
IPC分类号： A61F2/89
CPC分类号： A61F2/93 , A61F2/07 , A61F2/89 , A61F2002/075
摘要： An endovascular stent-grafl includes a generally tubular body, which is shaped so as to define a stepwise expanding portion, and is configured to assume (a) a radially-compressed delivery state and (b) at least first and second radially expanded deployment states, of which the second has a greater internal penmeter than the first. The tubular body is restrained from transitioning from the first radially expanded deployment state to the second. The tubular body includes a self expandable flexible stent member, and a generally tubular fluid flow guide attached to the stent member and includes a graft material. When the tubular body is in the first radially expanded deployment state, one or more folds of the graft material is radially outside the stent member.
摘要翻译：血管内支架植入物包括大体管状体，其形状为限定了逐步扩张部分，并且构造成呈现（a）径向压缩的输送状态和（b）至少第一和第二径向扩张的展开状态，其中第二个具有比第一个更大的内部penmeter。管状体被限制从第一径向扩张展开状态转移到第二径向展开状态。管状体包括自扩张的柔性支架构件和连接到支架构件并且包括移植材料的大体上管状的流体流动引导件。当管状体处于第一径向展开展开状态时，移植材料的一个或多个折叠部位在支架构件的径向外侧。

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